No Evidence of Gouléako and Herbert Virus Infections in Pigs, Côte d’Ivoire and Ghana

A recent report suggested that 2 novel bunyaviruses discovered in insects in Côte d’Ivoire caused lethal disease in swine in South Korea. We conducted cell culture studies and tested serum from pigs exposed to mosquitoes in Côte d’Ivoire and Ghana and found no evidence for infection in pigs

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Comparative Evaluation of the Anaesthetic Indices of Propofol in Varying Combinations With Diclofenac and Tramadol in Dogs

This study compared the anaesthetic indices and vital parameters of dogs given propofol with varying analgesic combinations. Nine dogs assigned into three groups were administered Propofol 8mg (IV) combined with Diclofenac 2mg/kg IM -DP group; Tramadol 5mg/kg IM- TP group and Diclofenac 2mg/kg + Tramadol 5mg/kg IM-DTP group. Heart and respiratory rates, temperature and selected anaesthetic indices were determined over a 40-minute period. Onset and duration of analgesia were statistically significant (p<0.05) among groups. Onset of analgesia was D-T-P < T-P < D-P. Duration of analgesia was longest in the T-P group and shortest in D-P group. The duration of anaesthesia was statistically significant (p<0.05) among groups, however onset of drug action was not (p>0.05). In conclusion, the three analgesic-propofol combinations produced anaesthesia of moderate duration. However, the T-P and D-T-P had better outcome based on their faster onset and longer duration of analgesia

No Evidence of Gouléako and Herbert Virus Infections in Pigs, Côte d’Ivoire and Ghana

A recent report suggested that 2 novel bunyaviruses discovered in insects in Côte d’Ivoire caused lethal disease in swine in South Korea. We conducted cell culture studies and tested serum from pigs exposed to mosquitoes in Côte d’Ivoire and Ghana and found no evidence for infection in pigs

Intersex piglet with bilobed urinary bladder in Kumasi, Ghana: A case report

This paper reports a case of a true intersex in a pig in Kumasi, Ghana. The diagnosis was based on gross and histomorphological assessment of the genital organs which consist of a left ovary, two uterine horns and body of uterus, along with a right testis without an epididymis. Vagina and vulva were also absent. A perineal scrotal pouch and a tubular tract connection with an intra-abdominal urinary bladder conducting urine through a miniature paraphimotic sigmoid shaped penis were observed. A rectal prolapse was consequent to rectal compression by the inadequately voided urinary bladder. Gonadal hormonal profiles were analysed and compared in the true intersex and those of the males and female siblings using standard techniques. The embryologic, reproductive, and swine production cost implications of intersex were discussed.Keywords: Intersex pig, Gross histology, Genital organs, Hormonal profil

No Evidence of Gouléako and Herbert Virus Infections in Pigs, Côte d’Ivoire and Ghana

A recent report suggested that 2 novel bunyaviruses discovered in insects in Côte d’Ivoire caused lethal disease in swine in South Korea. We conducted cell culture studies and tested serum from pigs exposed to mosquitoes in Côte d’Ivoire and Ghana and found no evidence for infection in pigs

Datasets for reporting of soft-tissue sarcoma: recommendations from the International Collaboration on Cancer Reporting (ICCR)

AimsSoft-tissue tumours are rare and both accurate diagnosis and proper treatment represent a global challenge. Current treatment guidelines also recommend review by specialised pathologists. Here we report on international consensus-based datasets for the pathology reporting of biopsy and resection specimens of soft-tissue sarcomas. The datasets were produced under the auspices of the International Collaboration on Cancer Reporting (ICCR), a global alliance of international pathology and cancer organisations. Methods and resultsAccording to the ICCR's guidelines for dataset development, an international expert panel consisting of pathologists, a surgical oncologist, and a medical oncologist produced a set of core and noncore data items for biopsy and resection specimens based on a critical review and discussion of current evidence. All professionals involved were subspecialised soft-tissue sarcoma experts and affiliated with tertiary referral centres. Commentary was provided for each data item to explain the rationale for selecting it as a core or noncore element, its clinical relevance, and to highlight potential areas of disagreement or lack of evidence, in which case a consensus position was formulated. Following international public consultation, the documents were finalised and ratified, and the datasets, which included a synoptic reporting guide, were published on the ICCR website. ConclusionThese first international datasets for soft-tissue sarcomas are aimed to promote high-quality, standardised pathology reporting. Their adoption will improve consistency of reporting, facilitate multidisciplinary communication, and enhance comparability of data, all of which will help to improve patient's management