SI-Traceable Calibration of Satellite Microwave Radiometers

Background (what): SI (International System of Units)-traceable Microwave Radiometer calibration; Motivation (why): NWP (Numerical Weather Prediction), FCDR (Fundamental Climate Data Record); Technology (how): NIST (National Inst. of Standards and Technology) blackbody target for ; Standards: Status & Future Plans. Development of a National Standard for Microwave Brightness Temperature (TB) at NIST

Estudio de experiencias y buenas prácticas comunitarias vinculadas a sistemas de restauración de paisajes forestales, en dos microrregiones del Departamento De San Marcos, Guatemala, C.A.

El presente trabajo de graduación se desarrolló en el altiplano del departamento de San Marcos, en las microrregiones Esquichá y Ricardo Chávez de la parte alta de la cuenca del río Coatán y del río Suchiate respectivamente. Tuvo la finalidad de apuntalar los esfuerzos regionales de desarrollo humano y conservación de los recursos naturales, coordinados por el Mecanismo de Restauración de Bosques y Paisajes y en la mejora de los medios de vida de las comunidades locales; enfocado a la restauración del paisaje forestal, entiéndase los bienes y servicios ambientales asociados a éste. El objetivo primordial del diagnóstico de las microrregiones, consistió en conocer la coyuntura ambiental y social del paisaje forestal en el área. La determinación de los factores de degradación del paisaje y los componentes sociales y ambientales, permitieron conocer hacia dónde orientar las acciones para la restauración del paisaje forestal, haciendo de éste un proceso sostenible. En tal sentido, la investigación se orientó al estudio y documentación de las buenas prácticas y sistemas tradicionales vinculados a la restauración del paisaje forestal en el altiplano occidental. Se documentaron un total de 18 buenas prácticas, algunas de éstas se implementaron a través del establecimiento de 10 sitios demostrativos, los cuales constituyen parcelas modelo de cómo restaurar el paisaje en diferentes condiciones edafoclimáticas y ecológicas, características de la región. Se realizó una caracterización biofísica detallada de cada uno de éstos sitios, incluyendo un análisis microbiológico del suelo, el cual constituye un pilar fundamental en el estudio de la degradación de los suelos de las tierras forestales. Dentro de los principales ejes de trabajo del mecanismo se encuentran la sensibilización, el fortalecimiento de capacidades y la implementación de sitios demostrativos de prácticas y sistemas de restauración del paisaje forestal; en respuesta a estos tres objetivos generales se desarrollaron los servicios profesionales

Early Career Aquatic Scientists Forge New Connections at Eco-DAS XV

A sense of kuleana (personal responsibility) in caring for the land and sea. An appreciation for laulima (many hands cooperating). An understanding of aloha ’āina (love of the land). The University of Hawai’i at Manoa hosted the 2023 Ecological Dissertations in Aquatic Sciences (Eco-DAS) program, which fostered each of these intentions by bringing together a team of early career aquatic ecologists for a week of networking and collaborative, interdisciplinary project development (Fig. 1)

Australian clinical practice guidelines for the diagnosis and management of Barrett's esophagus and early esophageal adenocarcinoma

Author version made available following 12 month embargo from date of publication according to publisher copyright policy.Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances in knowledge and practice about the management of BE and early EAC. To aid clinical decision making in this rapidly moving field, Cancer Council Australia convened an expert working party to identify pertinent clinical questions. The questions covered a wide range of topics including endoscopic and histological definitions of BE and early EAC; prevalence, incidence, natural history, and risk factors for BE; and methods for managing BE and early EAC. The latter considered modification of lifestyle factors; screening and surveillance strategies; and medical, endoscopic, and surgical interventions. To answer each question, the working party systematically reviewed the literature and developed a set of recommendations through consensus. Evidence underpinning each recommendation was rated according to quality and applicability

Status, challenges and pathways to the sustainable use of wild species

DATA AVAILABILITY : Data will be made available on request.The use of wild species is extensive in both high- and low-income countries. At least 50,000 wild species are used by billions of people around the world for food, energy, medicine, material, education or recreation, contributing significantly to efforts to achieve the United Nations Sustainable Development Goals. However, overexploitation remains a major threat to many wild species. Ensuring and enhancing the sustainability of use of wild species is thus essential for human well-being and biodiversity conservation. Globally, the use of wild species is increasing due to growing human demand and efficiency, but its sustainability varies and depends on the social-ecological contexts in which the use occurs. Multiple environmental and social (including economic) drivers affect the sustainability of use of wild species, posing major current and future challenges. In particular, climate change has already increased the vulnerability of many uses and is expected to increase it further in the coming decades, while global and illegal trades are, in many cases, key drivers of unsustainability. There is no single “silver bullet” policy to address these and other major challenges in the sustainable use of wild species. Rather, effective policies need to integrate inclusive actions at multiple scales that adopt right-based approaches, pay attention to equitable distribution of access and costs and benefits, employ participatory processes, strengthen monitoring programs, build robust customary or government institutions and support context-specific policies, as well as adaptive management.http://www.elsevier.com/locate/gloenvchahj2023Plant Production and Soil Scienc

The First Post-Kepler Brightness Dips of KIC 8462852

We present a photometric detection of the first brightness dips of the unique variable star KIC 8462852 since the end of the Kepler space mission in 2013 May. Our regular photometric surveillance started in October 2015, and a sequence of dipping began in 2017 May continuing on through the end of 2017, when the star was no longer visible from Earth. We distinguish four main 1-2.5% dips, named "Elsie," "Celeste," "Skara Brae," and "Angkor", which persist on timescales from several days to weeks. Our main results so far are: (i) there are no apparent changes of the stellar spectrum or polarization during the dips; (ii) the multiband photometry of the dips shows differential reddening favoring non-grey extinction. Therefore, our data are inconsistent with dip models that invoke optically thick material, but rather they are in-line with predictions for an occulter consisting primarily of ordinary dust, where much of the material must be optically thin with a size scale <<1um, and may also be consistent with models invoking variations intrinsic to the stellar photosphere. Notably, our data do not place constraints on the color of the longer-term "secular" dimming, which may be caused by independent processes, or probe different regimes of a single process

Case Reports1. A Late Presentation of Loeys-Dietz Syndrome: Beware of TGFβ Receptor Mutations in Benign Joint Hypermobility

Background: Thoracic aortic aneurysms (TAA) and dissections are not uncommon causes of sudden death in young adults. Loeys-Dietz syndrome (LDS) is a rare, recently described, autosomal dominant, connective tissue disease characterized by aggressive arterial aneurysms, resulting from mutations in the transforming growth factor beta (TGFβ) receptor genes TGFBR1 and TGFBR2. Mean age at death is 26.1 years, most often due to aortic dissection. We report an unusually late presentation of LDS, diagnosed following elective surgery in a female with a long history of joint hypermobility. Methods: A 51-year-old Caucasian lady complained of chest pain and headache following a dural leak from spinal anaesthesia for an elective ankle arthroscopy. CT scan and echocardiography demonstrated a dilated aortic root and significant aortic regurgitation. MRA demonstrated aortic tortuosity, an infrarenal aortic aneurysm and aneurysms in the left renal and right internal mammary arteries. She underwent aortic root repair and aortic valve replacement. She had a background of long-standing joint pains secondary to hypermobility, easy bruising, unusual fracture susceptibility and mild bronchiectasis. She had one healthy child age 32, after which she suffered a uterine prolapse. Examination revealed mild Marfanoid features. Uvula, skin and ophthalmological examination was normal. Results: Fibrillin-1 testing for Marfan syndrome (MFS) was negative. Detection of a c.1270G > C (p.Gly424Arg) TGFBR2 mutation confirmed the diagnosis of LDS. Losartan was started for vascular protection. Conclusions: LDS is a severe inherited vasculopathy that usually presents in childhood. It is characterized by aortic root dilatation and ascending aneurysms. There is a higher risk of aortic dissection compared with MFS. Clinical features overlap with MFS and Ehlers Danlos syndrome Type IV, but differentiating dysmorphogenic features include ocular hypertelorism, bifid uvula and cleft palate. Echocardiography and MRA or CT scanning from head to pelvis is recommended to establish the extent of vascular involvement. Management involves early surgical intervention, including early valve-sparing aortic root replacement, genetic counselling and close monitoring in pregnancy. Despite being caused by loss of function mutations in either TGFβ receptor, paradoxical activation of TGFβ signalling is seen, suggesting that TGFβ antagonism may confer disease modifying effects similar to those observed in MFS. TGFβ antagonism can be achieved with angiotensin antagonists, such as Losartan, which is able to delay aortic aneurysm development in preclinical models and in patients with MFS. Our case emphasizes the importance of timely recognition of vasculopathy syndromes in patients with hypermobility and the need for early surgical intervention. It also highlights their heterogeneity and the potential for late presentation. Disclosures: The authors have declared no conflicts of interes

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV