163 research outputs found
Design Practice and âDesigning for Allâ
Accepted for publicationIt is essential that all designers with responsibility for the human-machine interface have access to information on the anthropometry and capabilities of the whole population of people who may wish to interact with the design in question. Current databases used by designers typically present only very limited information concerning people who are older and/or disabled. Furthermore, tables of data are known to be largely ineffective and designers prefer to see visualisations of design data. In order to establish the current situation regarding design in relation to the needs of older and disabled people, existing products, procedures and systems were investigated. The objective was to identify current practice and the needs of designers whilst attempting to âdesign for allâ. This paper will report on the findings from these interviews to date, which will ultimately lead to a requirements specification to aid design for the needs of older and disabled people
Time dependent mean field theory of the superfluid-insulator phase transition
We develop a time-dependent mean field approach, within the time-dependent
variational principle, to describe the Superfluid-Insulator quantum phase
transition. We construct the zero temperature phase diagram both of the
Bose-Hubbard model (BHM), and of a spin-S Heisenberg model (SHM) with the XXZ
anisotropy. The phase diagram of the BHM indicates a phase transition from a
Mott insulator to a compressibile superfluid phase, and shows the expected
lobe-like structure. The SHM phase diagram displays a quantum phase transition
between a paramagnetic and a canted phases showing as well a lobe-like
structure. We show how the BHM and Quantum Phase model (QPM) can be rigorously
derived from the SHM. Based on such results, the phase boundaries of the SHM
are mapped to the BHM ones, while the phase diagram of the QPM is related to
that of the SHM. The QPM's phase diagram obtained through the application of
our approach to the SHM, describes the known onset of the macroscopic phase
coherence from the Coulomb blockade regime for increasing Josephson coupling
constant. The BHM and the QPM phase diagrams are in good agreement with Quantum
Monte Carlo results, and with the third order strong coupling perturbative
expansion.Comment: 15 pages, 8 figures. To be published in Phys. Rev.
Chemical composition and dry matter digestibility of sugar cane oxide treated with calcium
The effectiveness of neighborhood watch
Background: Neighborhood watch (also known as block watch, apartment watch, home watch and
community watch) grew out of a movement in the US during the late 1960s that promoted
greater involvement of citizens in the prevention of crime. Since then, interest in
neighborhood watch has grown considerably and recent estimates suggest that over a quarter
of the UK population and over forty per cent of the US population live in areas covered by
neighborhood watch schemes.
Objectives: The primary aim of this review is to assess the effectiveness of neighborhood watch in
reducing crime
Dense Stellar Populations: Initial Conditions
This chapter is based on four lectures given at the Cambridge N-body school
"Cambody". The material covered includes the IMF, the 6D structure of dense
clusters, residual gas expulsion and the initial binary population. It is aimed
at those needing to initialise stellar populations for a variety of purposes
(N-body experiments, stellar population synthesis).Comment: 85 pages. To appear in The Cambridge N-body Lectures, Sverre Aarseth,
Christopher Tout, Rosemary Mardling (eds), Lecture Notes in Physics Series,
Springer Verla
CaracterĂsticas de fermentação da silagem de cana-de-açĂșcar tratada com urĂ©ia, zeĂłlita, inoculante bacteriano e inoculante bacteriano/enzimĂĄtico
Desempenho de ovinos e respostas de pastagens de tifton 85 (Cynodon spp.) sob lotação contĂnua
Produção e qualidade do pasto de coastcross consorciado ou nĂŁo com amendoim forrageiro com ou sem aplicação de nitrogĂȘnio
Measurement of CP observables in B± â D(â)K± and B± â D(â)ϱ decays
Measurements of CP observables in B ± âD (â) K ± and B ± âD (â) Ï Â± decays are presented, where D (â) indicates a neutral D or D â meson that is an admixture of D (â)0 and DÂŻ (â)0 states. Decays of the D â meson to the DÏ 0 and DÎł final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± Ï â , K + K â and Ï + Ï â final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb â1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± âD â K ± and B ± âD â Ï Â± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± âDK ± and B ± âDÏ Â± decays is an update of previous LHCb measurements. The B ± âDK ± results are the most precise to date
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Peer reviewe
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