Accomodation to a ”New Normality” – Risk or Benefit?

The pandemia generated by the COVID-19 represents first of all a human tragedy, affecting society at its basis, and the effects induced by this boomerang are reflected on the labour market as well. The pandemia has accentuated the need of automation, even on the level of the insurance market, a fact that creates a lot of stress among the employees. The main purpose of the paper is to highlight the situation of the persons employed in various sectors of activity during the current pandemic conditions. The pandemic in the last year prompted large companies to explore more actively the opportunities to automate their activities. In the paper, the authors present the effects of automation on employed  people in various fields of activity, including the field of insurance, which has the effect of losing jobs and replacing human staff with the assistance of artificial technology. After the implementation of automation technologies, the roles and way of working of about a quarter of employees have changed globally, while one of ten employees already needed retraining. This trend will continue to grow, with respondents stating that they will have to retrain a third of the workforce in the next three years as a result of the changing roles. The impact upon sales of goods and services is of a lasting nature and the insurance companies have to adapt their methods to reach their clients where they are, as well as in way of selling an insurance police as in ascertainment of damage and risk inspection. &nbsp

Accomodation to a "new normality" - risk or benefit?

The pandemia generated by the COVID-19 represents first of all a human tragedy, affecting society at its basis, and the effects induced by this boomerang are reflected on the labour market as well. The pandemia has accentuated the need of automation, even on the level of the insurance market, a fact that creates a lot of stress among the employees. The main purpose of the paper is to highlight the situation of the persons employed in various sectors of activity during the current pandemic conditions. The pandemic in the last year prompted large companies to explore more actively the opportunities to automate their activities. In the paper, the authors present the effects of automation on employed  people in various fields of activity, including the field of insurance, which has the effect of losing jobs and replacing human staff with the assistance of artificial technology. After the implementation of automation technologies, the roles and way of working of about a quarter of employees have changed globally, while one of ten employees already needed retraining. This trend will continue to grow, with respondents stating that they will have to retrain a third of the workforce in the next three years as a result of the changing roles. The impact upon sales of goods and services is of a lasting nature and the insurance companies have to adapt their methods to reach their clients where they are, as well as in way of selling an insurance police as in ascertainment of damage and risk inspection

A narrative review of central nervous system involvement in acute leukemias.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadAcute leukemias (both myeloid and lymphoblastic) are a group of diseases for which each year more successful therapies are implemented. However, in a subset of cases the overall survival (OS) is still exceptionally low due to the infiltration of leukemic cells in the central nervous system (CNS) and the subsequent formation of brain tumors. The CNS involvement is more common in acute lymphocytic leukemia (ALL), than in adult acute myeloid leukemia (AML), although the rates for the second case might be underestimated. The main reasons for CNS invasion are related to the expression of specific adhesion molecules (VLA-4, ICAM-1, VCAM, L-selectin, PECAM-1, CD18, LFA-1, CD58, CD44, CXCL12) by a subpopulation of leukemic cells, called "sticky cells" which have the ability to interact and adhere to endothelial cells. Moreover, the microenvironment becomes hypoxic and together with secretion of VEGF-A by ALL or AML cells the permeability of vasculature in the bone marrow increases, coupled with the disruption of blood brain barrier. There is a single subpopulation of leukemia cells, called leukemia stem cells (LSCs) that is able to resist in the new microenvironment due to its high adaptability. The LCSs enter into the arachnoid, migrate, and intensively proliferate in cerebrospinal fluid (CSF) and consequently infiltrate perivascular spaces and brain parenchyma. Moreover, the CNS is an immune privileged site that also protects leukemic cells from chemotherapy. CD56/NCAM is the most important surface molecule often overexpressed by leukemic stem cells that offers them the ability to infiltrate in the CNS. Although asymptomatic or with unspecific symptoms, CNS leukemia should be assessed in both AML/ALL patients, through a combination of flow cytometry and cytological analysis of CSF. Intrathecal therapy (ITT) is a preventive measure for CNS involvement in AML and ALL, still much research is needed in finding the appropriate target that would dramatically lower CNS involvement in acute leukemia. Keywords: Acute leukemias; central nervous system involvement (CNS involvement); clinical management; pathophysiology.Iuliu Hatieganu University-School of Doctoral Studies (PCD 2019-2021) Romanian Government Ion Chiricuta Oncology Institute Cluj Napoca European Economic Spac

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements