278 research outputs found
Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures
Vesivirus 2117 is an adventitious agent that in 2009, was identified as a contaminant of CHO cells propagated in bioreactors at a pharmaceutical manufacturing plant belonging to Genzyme. The consequent interruption in supply of Fabrazyme and Cerezyme (drugs used to treat Fabry and Gaucher disease respectively), caused significant economic losses. Vesivirus 2117 is a member of the Caliciviridae; a family of small icosahedral viruses encoding a positive sense RNA genome. We have used cryo-electron microscopy and three dimensional image reconstruction to calculate a structure of vesivirus 2117 virus like particles as well as feline calicivirus and a chimeric sapovirus. We present a structural comparison of several members of the Caliciviridae, showing that the distal P domain of vesivirus 2117 is morphologically distinct from that seen in other known vesivirus structures. Furthermore, at intermediate resolutions we found a high level of structural similarity between vesivirus 2117 and Caliciviridae from other genera, such as sapovirus and rabbit haemorrhagic disease virus. Phylogenetic analysis confirms vesivirus 2117 as a vesivirus closely related to canine vesiviruses. We postulate that morphological differences in virion structure seen between vesivirus clades may reflect differences in receptor usage
The Carnegie Supernova Project: First Near-Infrared Hubble Diagram to z~0.7
The Carnegie Supernova Project (CSP) is designed to measure the luminosity
distance for Type Ia supernovae (SNe Ia) as a function of redshift, and to set
observational constraints on the dark energy contribution to the total energy
content of the Universe. The CSP differs from other projects to date in its
goal of providing an I-band {rest-frame} Hubble diagram. Here we present the
first results from near-infrared (NIR) observations obtained using the Magellan
Baade telescope for SNe Ia with 0.1 < z < 0.7. We combine these results with
those from the low-redshift CSP at z <0.1 (Folatelli et al. 2009). We present
light curves and an I-band Hubble diagram for this first sample of 35 SNe Ia
and we compare these data to 21 new SNe Ia at low redshift. These data support
the conclusion that the expansion of the Universe is accelerating. When
combined with independent results from baryon acoustic oscillations (Eisenstein
et al. 2005), these data yield Omega_m = 0.27 +/- 0.0 (statistical), and
Omega_DE = 0.76 +/- 0.13 (statistical) +/- 0.09 (systematic), for the matter
and dark energy densities, respectively. If we parameterize the data in terms
of an equation of state, w, assume a flat geometry, and combine with baryon
acoustic oscillations, we find that w = -1.05 +/- 0.13 (statistical) +/- 0.09
(systematic). The largest source of systematic uncertainty on w arises from
uncertainties in the photometric calibration, signaling the importance of
securing more accurate photometric calibrations for future supernova cosmology
programs. Finally, we conclude that either the dust affecting the luminosities
of SNe Ia has a different extinction law (R_V = 1.8) than that in the Milky Way
(where R_V = 3.1), or that there is an additional intrinsic color term with
luminosity for SNe Ia independent of the decline rate.Comment: 44 pages, 23 figures, 9 tables; Accepted for publication in the
Astrophysical Journa
Disentangling a group of lensed submm galaxies at z∼ 2.9
MS0451.6−0305 is a rich galaxy cluster whose strong lensing is particularly prominent at submm wavelengths. We combine new Submillimetre Common-User Bolometer Array (SCUBA)-2 data with imaging from Herschel Spectral and Photometric Imaging Receiver (SPIRE) and PACS and Hubble Space Telescope in order to try to understand the nature of the sources being lensed. In the region of the ‘giant submm arc', we uncover seven multiply imaged galaxies (up from the previously known four), of which six are found to be at a redshift of z∼2.9, and possibly constitute an interacting system. Using a novel forward-modelling approach, we are able to simultaneously deblend and fit spectral energy distributions to the individual galaxies that contribute to the giant submm arc, constraining their dust temperatures, far-infrared luminosities, and star formation rates (SFRs). The submm arc first identified by SCUBA can now be seen to be composed of at least five distinct sources, four of these within a galaxy group at z∼2.9. Only a handful of lensed galaxy groups at this redshift are expected on the sky, and thus this is a unique opportunity for studying such systems in detail. The total unlensed luminosity for this galaxy group is (3.1±0.3)×1012 L⊙, which gives an unlensed SFR of (450±50) M⊙yr−1. This finding suggests that submm source multiplicity, due to physically associated groupings as opposed to chance alignment, extends to fainter flux densities than previously discovered. Many of these systems may also host optical companions undetected in the submm, as is the case her
HerMES: Candidate Gravitationally Lensed Galaxies and Lensing Statistics at Submillimeter Wavelengths
We present a list of 13 candidate gravitationally lensed submillimeter
galaxies (SMGs) from 95 square degrees of the Herschel Multi-tiered
Extragalactic Survey, a surface density of 0.14\pm0.04deg^{-2}. The selected
sources have 500um flux densities (S_500) greater than 100mJy. Gravitational
lensing is confirmed by follow-up observations in 9 of the 13 systems (70%),
and the lensing status of the four remaining sources is undetermined. We also
present a supplementary sample of 29 (0.31\pm0.06deg^{-2}) gravitationally
lensed SMG candidates with S_500=80--100mJy, which are expected to contain a
higher fraction of interlopers than the primary candidates. The number counts
of the candidate lensed galaxies are consistent with a simple statistical model
of the lensing rate, which uses a foreground matter distribution, the intrinsic
SMG number counts, and an assumed SMG redshift distribution. The model predicts
that 32--74% of our S_500>100mJy candidates are strongly gravitationally lensed
(mu>2), with the brightest sources being the most robust; this is consistent
with the observational data. Our statistical model also predicts that, on
average, lensed galaxies with S_500=100mJy are magnified by factors of ~9, with
apparently brighter galaxies having progressively higher average magnification,
due to the shape of the intrinsic number counts. 65% of the sources are
expected to have intrinsic 500micron flux densities less than 30mJy. Thus,
samples of strongly gravitationally lensed SMGs, such as those presented here,
probe below the nominal Herschel detection limit at 500 micron. They are good
targets for the detailed study of the physical conditions in distant dusty,
star-forming galaxies, due to the lensing magnification, which can lead to
spatial resolutions of ~0.01" in the source plane.Comment: ApJ in press. 31 pages, 16 figures, 5 tables. This version updated to
match accepted versio
Recommended from our members
The clustering of galaxies in the SDSS-III Baryon Oscillation Spectroscopic Survey: cosmological implications of the large-scale two-point correlation function
We obtain constraints on cosmological parameters from the spherically
averaged redshift-space correlation function of the CMASS Data Release 9 (DR9)
sample of the Baryonic Oscillation Spectroscopic Survey (BOSS). We combine this
information with additional data from recent CMB, SN and BAO measurements. Our
results show no significant evidence of deviations from the standard
flat-Lambda CDM model, whose basic parameters can be specified by Omega_m =
0.285 +- 0.009, 100 Omega_b = 4.59 +- 0.09, n_s = 0.96 +- 0.009, H_0 = 69.4 +-
0.8 km/s/Mpc and sigma_8 = 0.80 +- 0.02. The CMB+CMASS combination sets tight
constraints on the curvature of the Universe, with Omega_k = -0.0043 +- 0.0049,
and the tensor-to-scalar amplitude ratio, for which we find r < 0.16 at the 95
per cent confidence level (CL). These data show a clear signature of a
deviation from scale-invariance also in the presence of tensor modes, with n_s
<1 at the 99.7 per cent CL. We derive constraints on the fraction of massive
neutrinos of f_nu < 0.049 (95 per cent CL), implying a limit of sum m_nu < 0.51
eV. We find no signature of a deviation from a cosmological constant from the
combination of all datasets, with a constraint of w_DE = -1.033 +- 0.073 when
this parameter is assumed time-independent, and no evidence of a departure from
this value when it is allowed to evolve as w_DE(a) = w_0 + w_a (1 - a). The
achieved accuracy on our cosmological constraints is a clear demonstration of
the constraining power of current cosmological observations.Comment: 26 pages, 15 figures. Minor changes to match version accepted by
MNRA
Evaluation Research and Institutional Pressures: Challenges in Public-Nonprofit Contracting
This article examines the connection between program evaluation research and decision-making by public managers. Drawing on neo-institutional theory, a framework is presented for diagnosing the pressures and conditions that lead alternatively toward or away the rational use of evaluation research. Three cases of public-nonprofit contracting for the delivery of major programs are presented to clarify the way coercive, mimetic, and normative pressures interfere with a sound connection being made between research and implementation. The article concludes by considering how public managers can respond to the isomorphic pressures in their environment that make it hard to act on data relating to program performance.This publication is Hauser Center Working Paper No. 23. The Hauser Center Working Paper Series was launched during the summer of 2000. The Series enables the Hauser Center to share with a broad audience important works-in-progress written by Hauser Center scholars and researchers
The type Ia supernova SNLS-03D3bb from a super-Chandrasekhar-mass white dwarf star
The acceleration of the expansion of the universe, and the need for Dark
Energy, were inferred from the observations of Type Ia supernovae (SNe Ia).
There is consensus that SNe Ia are thermonuclear explosions that destroy
carbon-oxygen white dwarf stars that accrete matter from a companion star,
although the nature of this companion remains uncertain. SNe Ia are thought to
be reliable distance indicators because they have a standard amount of fuel and
a uniform trigger -- they are predicted to explode when the mass of the white
dwarf nears the Chandrasekhar mass -- 1.4 solar masses. Here we show that the
high redshift supernova SNLS-03D3bb has an exceptionally high luminosity and
low kinetic energy that both imply a super-Chandrasekhar mass progenitor.
Super-Chandrasekhar mass SNe Ia should preferentially occur in a young stellar
population, so this may provide an explanation for the observed trend that
overluminous SNe Ia only occur in young environments. Since this supernova does
not obey the relations that allow them to be calibrated as standard candles,
and since no counterparts have been found at low redshift, future cosmology
studies will have to consider contamination from such events.Comment: 9 pages, 4 figures. To appear in Nature Sept. 21. Accompanying News &
Views in same issue. Supplementary information available at
www.nature.com/natur
The Baryon Oscillation Spectroscopic Survey of SDSS-III
The Baryon Oscillation Spectroscopic Survey (BOSS) is designed to measure the
scale of baryon acoustic oscillations (BAO) in the clustering of matter over a
larger volume than the combined efforts of all previous spectroscopic surveys
of large scale structure. BOSS uses 1.5 million luminous galaxies as faint as
i=19.9 over 10,000 square degrees to measure BAO to redshifts z<0.7.
Observations of neutral hydrogen in the Lyman alpha forest in more than 150,000
quasar spectra (g<22) will constrain BAO over the redshift range 2.15<z<3.5.
Early results from BOSS include the first detection of the large-scale
three-dimensional clustering of the Lyman alpha forest and a strong detection
from the Data Release 9 data set of the BAO in the clustering of massive
galaxies at an effective redshift z = 0.57. We project that BOSS will yield
measurements of the angular diameter distance D_A to an accuracy of 1.0% at
redshifts z=0.3 and z=0.57 and measurements of H(z) to 1.8% and 1.7% at the
same redshifts. Forecasts for Lyman alpha forest constraints predict a
measurement of an overall dilation factor that scales the highly degenerate
D_A(z) and H^{-1}(z) parameters to an accuracy of 1.9% at z~2.5 when the survey
is complete. Here, we provide an overview of the selection of spectroscopic
targets, planning of observations, and analysis of data and data quality of
BOSS.Comment: 49 pages, 16 figures, accepted by A
T cell cytolytic capacity is independent of initial stimulation strength.
How cells respond to myriad stimuli with finite signaling machinery is central to immunology. In naive T cells, the inherent effect of ligand strength on activation pathways and endpoints has remained controversial, confounded by environmental fluctuations and intercellular variability within populations. Here we studied how ligand potency affected the activation of CD8+ T cells in vitro, through the use of genome-wide RNA, multi-dimensional protein and functional measurements in single cells. Our data revealed that strong ligands drove more efficient and uniform activation than did weak ligands, but all activated cells were fully cytolytic. Notably, activation followed the same transcriptional pathways regardless of ligand potency. Thus, stimulation strength did not intrinsically dictate the T cell-activation route or phenotype; instead, it controlled how rapidly and simultaneously the cells initiated activation, allowing limited machinery to elicit wide-ranging responses
Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology
In skeletal muscle fibers, tropomodulin 1 (Tmod1) can be compensated for, structurally but not functionally, by Tmod3 and -4
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