La superpoblación relativa en Argentina actual: un ejercicio de medición

Este ejercicio constituye una primera aproximación a definir quiénes constituyen la población que ocupa la posición de sobrante para las necesidades inmediatas del capital o superpoblación relativa en la Argentina actual y un intento por medir su tamaño. Ese volumen de población, que aparece en su manifestación más evidente como desocupación y subocupación pero que incluye a trabajadores ocupados considerados sobrantes por el capital más concentrado, tiene momentos de crecimiento y decrecimiento, pero la tendencia es a un incremento independiente de las fluctuaciones del ciclo industrial y que se da simultáneamente con un crecimiento de la producción y la productividad del trabajo.This exercise is the first step in the attempt to define who are part of the surplus population in Argentina today. Unemployment and underemployment are the most evident forms of this surplus population, which also includes occupied workers that are considered redundant by the highly concentrated capital. The size of this surplus population increases and diminishes according to the economic cycles, but its general long term tendency is to grow simultaneously with the increase of production and labour productivity.Fil: Iñigo Carrera, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto de Historia Argentina y Americana "dr. Emilio Ravignani". Universidad de Buenos Aires. Facultad de Filosofía y Letras. Instituto de Historia Argentina y Americana "dr. Emilio Ravignani"; ArgentinaFil: Cavalleri, Stella Maris.Fil: Murruni, Marina Laura

Heparin Strongly Enhances the Formation of β2-Microglobulin Amyloid Fibrils in the Presence of Type I Collagen

The tissue specificity of fibrillar deposition in dialysis-related amyloidosis is most likely associated with the peculiar interaction of beta2-microglobulin (beta2-m) with collagen fibers. However, other co-factors such as glycosaminoglycans might facilitate amyloid formation. In this study we have investigated the role of heparin in the process of collagen-driven amyloidogenesis. In fact, heparin is a well known positive effector of fibrillogenesis, and the elucidation of its potential effect in this type of amyloidosis is particularly relevant because heparin is regularly given to patients subject to hemodialysis to prevent blood clotting. We have monitored by atomic force microscopy the formation of beta2-m amyloid fibrils in the presence of collagen fibers, and we have discovered that heparin strongly accelerates amyloid deposition. The mechanism of this effect is still largely unexplained. Using dynamic light scattering, we have found that heparin promotes beta2-m aggregation in solution at pH 6.4. Morphology and structure of fibrils obtained in the presence of collagen and heparin are highly similar to those of natural fibrils. The fibril surface topology, investigated by limited proteolysis, suggests that the general assembly of amyloid fibrils grown under these conditions and in vitro at low pH is similar. The exposure of these fibrils to trypsin generates a cleavage at the C-terminal of lysine 6 and creates the 7-99 truncated form of beta2-m (DeltaN6beta2-m) that is a ubiquitous constituent of the natural beta2-m fibrils. The formation of this beta2-m species, which has a strong propensity to aggregate, might play an important role in the acceleration of local amyloid deposition

Ruptured hepatoblastoma: A case report and literature review

n/

Constitución de familias como sujetos políticos: primera aproximación a las organizaciones conformadas a partir de la vulneración de derechos

El presente trabajo se propone compartir parte del proceso de investigación en el marco del Proyecto denominado Políticas Sociales, Trabajo Social y constitución de las familias como sujetos políticos. El mismo integra un conjunto de producciones del equipo que van demarcando los avances de la tarea investigativa. En este caso, el texto procura comunicar algunas de las actividades que estamos desarrollando en este momento, vinculadas al relevamiento de información empírica a partir de las entrevistas a organizaciones que componen el universo en estudio. Para ello, presentamos inicialmente, y de modo sumamente sintético, algunas coordenadas que orientan el proceso analítico en curso. Posteriormente los objetivos de la investigación y la propuesta metodológica, detallando las organizaciones seleccionadas para esta etapa.Eje 4: Balances y perspectivas sobre las políticas públicas en la región. Sus impactos en la desigualdad, la construcción de derechos y constitución de sujetos.Facultad de Trabajo Socia

Ropinirole and pramipexole promote structural plasticity in human iPSC- derived dopaminergic neurons via BDNF and mTOR signaling

The antiparkinsonian ropinirole and pramipexole are D3 receptor- (D3R-) preferring dopaminergic (DA) agonists used as adjunctive therapeutics for the treatment resistant depression (TRD). While the exact antidepressant mechanism of action remains uncertain, a role for D3R in the restoration of impaired neuroplasticity occurring in TRD has been proposed. Since D3R agonists are highly expressed on DA neurons in humans, we studied the effect of ropinirole and pramipexole on structural plasticity using a translational model of human-inducible pluripotent stem cells (hiPSCs). Two hiPSC clones from healthy donors were differentiated into midbrain DA neurons. Ropinirole and pramipexole produced dose-dependent increases of dendritic arborization and soma size after 3 days of culture, effects antagonized by the selective D3R antagonists SB277011-A and S33084 and by the mTOR pathway kinase inhibitors LY294002 and rapamycin. All treatments were also effective in attenuating the D3R-dependent increase of p70S6-kinase phosphorylation. Immunoneutralisation of BDNF, inhibition of TrkB receptors, and blockade of MEK-ERK signaling likewise prevented ropinirole-induced structural plasticity, suggesting a critical interaction between BDNF and D3R signaling pathways. The highly similar profiles of data acquired with DA neurons derived from two hiPSC clones underpin their reliability for characterization of pharmacological agents acting via dopaminergic mechanisms

Constitución de familias como sujetos políticos: primera aproximación a las organizaciones conformadas a partir de la vulneración de derechos

El presente trabajo se propone compartir parte del proceso de investigación en el marco del Proyecto denominado Políticas Sociales, Trabajo Social y constitución de las familias como sujetos políticos. El mismo integra un conjunto de producciones del equipo que van demarcando los avances de la tarea investigativa. En este caso, el texto procura comunicar algunas de las actividades que estamos desarrollando en este momento, vinculadas al relevamiento de información empírica a partir de las entrevistas a organizaciones que componen el universo en estudio. Para ello, presentamos inicialmente, y de modo sumamente sintético, algunas coordenadas que orientan el proceso analítico en curso. Posteriormente los objetivos de la investigación y la propuesta metodológica, detallando las organizaciones seleccionadas para esta etapa.Eje 4: Balances y perspectivas sobre las políticas públicas en la región. Sus impactos en la desigualdad, la construcción de derechos y constitución de sujetos.Facultad de Trabajo Socia

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Measurements of Higgs boson production and couplings in diboson final states with the ATLAS detector at the LHC

Measurements are presented of production properties and couplings of the recently discovered Higgs boson using the decays into boson pairs, H →γ γ, H → Z Z∗ →4l and H →W W∗ →lνlν. The results are based on the complete pp collision data sample recorded by the ATLAS experiment at the CERN Large Hadron Collider at centre-of-mass energies of √s = 7 TeV and √s = 8 TeV, corresponding to an integrated luminosity of about 25 fb−1. Evidence for Higgs boson production through vector-boson fusion is reported. Results of combined fits probing Higgs boson couplings to fermions and bosons, as well as anomalous contributions to loop-induced production and decay modes, are presented. All measurements are consistent with expectations for the Standard Model Higgs boson

Measurement of the top quark-pair production cross section with ATLAS in pp collisions at \sqrt{s}=7\TeV

A measurement of the production cross-section for top quark pairs(\ttbar) in $pp$ collisions at \sqrt{s}=7 \TeV is presented using data recorded with the ATLAS detector at the Large Hadron Collider. Events are selected in two different topologies: single lepton (electron $e$ or muon $\mu$) with large missing transverse energy and at least four jets, and dilepton ($ee$, $\mu\mu$ or $e\mu$) with large missing transverse energy and at least two jets. In a data sample of 2.9 pb-1, 37 candidate events are observed in the single-lepton topology and 9 events in the dilepton topology. The corresponding expected backgrounds from non-\ttbar Standard Model processes are estimated using data-driven methods and determined to be $12.2 \pm 3.9$ events and $2.5 \pm 0.6$ events, respectively. The kinematic properties of the selected events are consistent with SM \ttbar production. The inclusive top quark pair production cross-section is measured to be \sigmattbar=145 \pm 31 ^{+42}_{-27} pb where the first uncertainty is statistical and the second systematic. The measurement agrees with perturbative QCD calculations.Comment: 30 pages plus author list (50 pages total), 9 figures, 11 tables, CERN-PH number and final journal adde

Measurement of the top quark pair cross section with ATLAS in pp collisions at √s=7 TeV using final states with an electron or a muon and a hadronically decaying τ lepton

A measurement of the cross section of top quark pair production in proton-proton collisions recorded with the ATLAS detector at the Large Hadron Collider at a centre-of-mass energy of 7 TeV is reported. The data sample used corresponds to an integrated luminosity of 2.05 fb -1. Events with an isolated electron or muon and a τ lepton decaying hadronically are used. In addition, a large missing transverse momentum and two or more energetic jets are required. At least one of the jets must be identified as originating from a b quark. The measured cross section, σtt-=186±13(stat.)±20(syst.)±7(lumi.) pb, is in good agreement with the Standard Model prediction