On the functional overlap between complement and anti-microbial peptides

Intriguingly, activated complement and anti-microbial peptides share certain functionalities; lytic, phagocytic, and chemo-attractant activities and each may, in addition, exert cell instructive roles. Each has been shown to have distinct LPS detoxifying activity and may play a role in the development of endotoxin tolerance. In search of the origin of complement, a functional homolog of complement C₃ involved in opsonization has been identified in horseshoe crabs. Horseshoe crabs possess anti-microbial peptides able to bind to acyl chains or phosphate groups/saccharides of endotoxin, LPS. Complement activity as a whole is detectable in marine invertebrates. These are also a source of anti-microbial peptides with potential pharmaceutical applicability. Investigating the locality for the production of complement pathway proteins and their role in modulating cellular immune responses are emerging fields. The significance of local synthesis of complement components is becoming clearer from in vivo studies of parenchymatous disease involving specifically generated, complement-deficient mouse lines. Complement C₃ is a central component of complement activation. Its provision by cells of the myeloid lineage varies. Their effector functions in turn are increased in the presence of anti-microbial peptides. This may point to a potentiating range of activities, which should serve the maintenance of health but may also cause disease. Because of the therapeutic implications, this review will consider closely studies dealing with complement activation and anti-microbial peptide activity in acute inflammation (e.g., dialysis-related peritonitis, appendicitis, and ischemia)

Exile

Byron rehearsed going into exile in 1809, when he was twenty-one years old. Before setting sail for Lisbon, he wrote, “I leave England without regret, I shall return to it without pleasure. – I am like Adam the first convict sentenced to transportation, but I have no Eve, and have eaten no apple but what was sour as a crab and thus ends my first Chapter” (BLJ 1: 211). Byron’s sardonic perception of himself as a biblical exile foreshadowed the allusive character of his second longer-term exile at the age of twenty-eight, when his carefully staged exit required an audience (some of the same friends and servants), expensive props (a replica of Napoleon’s carriage) and a literary precursor. On his last evening in England, Byron visited the burial place of the satirist Charles Churchill, and lay down on his grave. It was a performance of immense weariness with life and solidarity with an embittered outcast.Postprin

The Lake Poets

“If Southey had not been comparatively good,” writes Herbert F. Tucker, “he would never have drawn out Byron’s best in those satirical volleys that were undertaken, at bottom, in order to reprehend not the want of talent but its wastage.” And if Wordsworth and Coleridge had not been dangerously talented, Byron might have spared them some of his stinging sallies. In Table Talk Coleridge proclaimed the conclusion of the “intellectual war” Byron threatened in Don Juan (XI. 62: 496), declaring Wordsworth the poet who “will wear the crown,” triumphing over Byron and his ilk for the poetic laurels of the Romantic period. But Byron was not simply an opponent of his contemporaries. His responses to the Lake poets, particularly to Wordsworth, ran the gamut from “reverence” (HVSV, 129) then “nausea” (Medwin, 237) to Don Juan’s comical though cutting disdain, in under a decade. Focusing on Byron’s relationship with Wordsworth and Coleridge, I will show how Byron’s poetry and drama reveal the range and complexity of his dialogue with his older peers, where, even at their most apparently divergent, the conversation between the poets reveals the depth of the engagement across their works