160 research outputs found
Blood Banking in Living Droplets
- Author
- AMM Zadeoppe
- AW Rowe
- BI Whitaker
- BJ Luyet
- CF Hogman
- Christophe Egles
- DE Pegg
- DE Pegg
- Feng Xu
- GM Fahy
- H Xie
- Hasan Onur Keles
- HT Meryman
- HT Meryman
- HW Krijnen
- JD Bernardin
- JE Lovelock
- JH Pert
- JL Tullis
- Jordan Markel
- Josh Samot
- JR Hess
- KL Scott
- Laura Matloff
- Lei Shao
- NE Timmins
- P Mazur
- RA Malinauskas
- Sangjun Moon
- Utkan Demirci
- Xiaohui Zhang
- YoungSeok Song
- YS Song
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/11/2010
- Field of study
Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification has shown advantages over traditional cryopreservation techniques, it has not been incorporated into transfusion medicine mainly due to throughput challenges. Here, we present a scalable method that can vitrify red blood cells in microdroplets. This approach enables the vitrification of large volumes of blood in a short amount of time, and makes it a viable and scalable biotechnology tool for blood cryopreservation.National Institutes of Health (U.S.) (NIH R21 EB007707)Wallace H. Coulter FoundationUnited States. Army Medical Research and Materiel Command (Acquisition Activity Cooperative Agreement RO1 A1081534)Center for Integration of Medicine and Innovative TechnologyUnited States. Army Medical Research and Materiel Command (Acquisition Activity Cooperative Agreement R21 AI087107)United States. Army. Telemedicine & Advanced Technology Research Cente
Autism as a disorder of neural information processing: directions for research and targets for therapy
- Author
- A Klin
- A Klin
- A Peters
- A Pickles
- A Shah
- A Shah
- AL Beaudet
- AM Comi
- AM Connolly
- AY Hardan
- BF Sparks
- BK Lipska
- C Hughes
- C Hughes
- C Kemner
- C Kemner
- C Lord
- C Park
- CF Hohmann
- CJ Machado
- Cohen
- CT Ashley Jr
- D Tantam
- D Whitehouse
- DB Bailey Jr
- DH Geschwind
- DJ Laurie
- DJ Posey
- DL Braff
- DR Denney
- DW Smith
- E Courchesne
- E Courchesne
- E Courchesne
- E Courchesne
- E Courchesne
- E Courchesne
- E Courchesne
- E Fombonne
- E Fransen
- E Perry
- E Tierney
- EF Chang
- EH Aylward
- EH Aylward
- EH Cook Jr
- EH Cook Jr
- EM Ornitz
- EM Powell
- F Castelli
- F Graham
- F Happ
- F Kimura
- G Raymond
- GE Homanics
- GJ Blatt
- GM Anderson
- GM McAlonan
- GS Huh
- GS Tint
- GT Baranek
- H Kamiguchi
- H van Engeland
- HA Ring
- HD Critchley
- I Cohen
- I Krause
- I Lucki
- IJ Weiler
- IM Smith
- J Boucher
- J Caston
- J DeFelipe
- J Piven
- J Piven
- J Piven
- J Russell
- J Townsend
- J Townsend
- J Townsend
- J Veenstra-VanderWeele
- J.L. McCauley
- JA Burack
- JA Court
- JA Lamb
- JE Long
- JK Pritchard
- JL Ingram
- JLR Rubenstein
- JM Silverman
- JP Wisor
- K Ballaban-Gil
- K Hugdahl
- K Pierce
- K Pierce
- K Rubia
- KC Plaisted
- KG Plaisted
- KY Miyashiro
- L Jorde
- L Mottron
- L Shi
- LH Rolf
- LJ Miller
- LM Boulanger
- LM Marubio
- LR Cardon
- M Alkondon
- M Hallett
- M Kuwamura
- M Lauritsen
- M Lee
- M Pieretti
- M Toichi
- MA Geyer
- MA Geyer
- MA O'Riordan
- Martha R. Herbert
- MF Casanova
- MH Johnson
- MK Belmonte
- MK Belmonte
- MK Belmonte
- ML Bauman
- MR Picciotto
- MR Young
- MV Pletnikov
- N Akshoomoff
- N Risch
- NL Ward
- NR Mirza
- NR Swerdlow
- NR Swerdlow
- O Marin
- P Dalton
- P Tueting
- PH Patterson
- PI Yakovlev
- PK Todd
- PM Whitaker-Azmitia
- R DeLong
- R Galvez
- R Lalonde
- R-A Müller
- RA Carper
- RA Corriveau
- RC Belser
- RE Amir
- RI Kelley
- RJ Schain
- RM Carney
- RN Leaton
- RP Hobson
- RP Warren
- RP Warren
- RP Warren
- RT Schultz
- S Alcantara
- S Anderson
- S Baron-Cohen
- S Baron-Cohen
- S Baron-Cohen
- S Baron-Cohen
- S Baron-Cohen
- S Baron-Cohen
- S Bobee
- S Chakrabarti
- S Gupta
- S Jamain
- S Ozonoff
- S Stevens
- S Tordjman
- S Tordjman
- SA Irwin
- SA Irwin
- SB Powell
- SD Ugarte
- SE Folstein
- SE Folstein
- SH Fatemi
- SJ Kim
- SJ Rogers
- T Hashimoto
- T Rogers
- T Stühmer
- T Stühmer
- TA Comery
- TH Wassink
- TK Hensch
- TM DeLorey
- U Frith
- U Frith
- W Hirstein
- W Reik
- WT Greenough
- Y Yu
- YH Jiang
- YH Jiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 23/03/2004
- Field of study
The broad variation in phenotypes and severities within autism spectrum disorders suggests the involvement of multiple predisposing factors, interacting in complex ways with normal developmental courses and gradients. Identification of these factors, and the common developmental path into which theyfeed, is hampered bythe large degrees of convergence from causal factors to altered brain development, and divergence from abnormal brain development into altered cognition and behaviour. Genetic, neurochemical, neuroimaging and behavioural findings on autism, as well as studies of normal development and of genetic syndromes that share symptoms with autism, offer hypotheses as to the nature of causal factors and their possible effects on the structure and dynamics of neural systems. Such alterations in neural properties may in turn perturb activity-dependent development, giving rise to a complex behavioural syndrome many steps removed from the root causes. Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring these developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself
Biopsychosocial predictors of perceived life expectancy in a national sample of older men and women.
- Author
- A Arora
- A Steptoe
- A Steptoe
- A Wuebker
- A Zajacova
- AT Romm
- B Griffin
- B Griffin
- B Hesketh
- C von Wagner
- CA Roberto
- CE Ross
- CF Manski
- DS Hamermesh
- DW Russell
- E Diener
- E Grundy
- E Idler
- E Kahana
- E Kvaavik
- F Popham
- G Zou
- H Van Solinge
- J Adams
- J Adams
- J Adams
- J Mirowsky
- JF Hair Jr
- JN Boyd
- JP Ziegelmann
- K Rothman
- KL Whitaker
- KT Khaw
- LC Kobayashi
- LC Kobayashi
- Lindsay C. Kobayashi
- LL Carstensen
- LS Radloff
- M Hamer
- MD Hurd
- MD Hurd
- N Martin-Maria
- P Demakakos
- P Gellert
- R Wiggins
- Rebecca J. Beeken
- S Bridges
- SS McMillan
- Stephen D Ginsberg
- Susanne F. Meisel
- T Mann
- W Kuijpers
- Y Chida
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 14/12/2017
- Field of study
Perceived life expectancy (PLE) is predictive of mortality risk in older adults, but the factors that may contribute to mental conceptions of PLE are unknown. We aimed to describe the sociodemographic, biomedical, behavioral, and psychological predictors of self-reported PLE estimates among older English adults. Data were from 6662 adults aged 50-79 years in the population-based English Longitudinal Study of Ageing (cross-sectional sample from 2012/13). PLE was assessed in the face-to-face study interview ("What are the chances you will live to be age x or more?" where x = current age plus 10-15 years). Responses were categorized as 'low' (0-49%), 'medium' (50-74%), and 'high' (75-100%). Adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs) for low vs. high PLE were estimated using population-weighted modified Poisson regression with robust error variance. Overall, 1208/6662 (18%) participants reported a low PLE, 2806/6662 (42%) reported a medium PLE, and 2648/6662 (40%) reported a high PLE. The predictors of reporting a low PLE included older age (PR = 1.64; 95% CI: 1.50-1.76 per 10 years), male sex (PR = 1.14; 95% CI: 1.02-1.26), being a smoker (PR = 1.39; 95% CI: 1.22-1.59 vs. never/former smoker), and having a diagnosis of cancer or diabetes. A low sense of control over life was associated with low PLE, as was low satisfaction with life and worse self-rated health. Those with a higher perceived social standing were less likely to report a low PLE (PR = 0.90; 95% CI: 0.87-0.93 per 10-point increase, out of 100). This study provides novel insight into potential influences on older adults' expectations of their longevity, including aspects of psychological well-being. These results should be corroborated to better determine their implications for health-related decision-making, planning, and behavior among older adults
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Ackers M
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogan T
- Akesson TPA
- Akimoto G
- Akimov AV
- Alam MA
- Alam MS
- Albrand S
- Aleksa M
- Aleksandrov IN
- Aleppo M
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso J
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Andari N
- Andeen T
- Anders CF
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonelli S
- Antos J
- Anulli F
- Aoun S
- Apolle R
- Arabidze G
- Aracena I
- Arai Y
- Arce ATH
- Archambault JP
- Arfaoui S
- Arguin J-F
- Arik E
- Arik M
- Armbruster AJ
- Arms KE
- Armstrong SR
- Arnaez O
- Arnault C
- Artamonov A
- Artoni G
- Arutinov D
- Asai S
- Asfandiyarov R
- Ask S
- Asman B
- Asquith L
- Assamagan K
- Astbury A
- Astvatsatourov A
- Atoian G
- Aubert B
- Auerbach B
- Auge E
- Augsten K
- Aurousseau M
- Austin N
- Avramidou R
- Axen D
- Ay C
- Azuelos G
- Azuma Y
- Baak MA
- Baccaglioni G
- Bacci C
- Bach AM
- Bachacou H
- Bachas K
- Bachy G
- Backes M
- Badescu E
- Bagnaia P
- Bahinipati S
- Bai Y
- Bailey DC
- Bain T
- Baines JT
- Baker OK
- Baker S
- Banas E
- Banerjee P
- Banerjee S
- Banfi D
- Bangert A
- Bansal V
- Bansil HS
- Barak L
- Baranov SP
- Barashkou A
- Barber T
- Barberio EL
- Barberis D
- Barbero M
- Bardin DY
- Barillari T
- Barisonzi M
- Barklow T
- Barlow N
- Barnett BM
- Barnett RM
- Baroncelli A
- Barr AJ
- Barreiro F
- Barrera CO
- Barrillon P
- Bartoldus R
- Barton AE
- Bartsch D
- Bates RL
- Batkova L
- Batley JR
- Battaglia A
- Battistin M
- Battistoni G
- Bauer F
- Bawa HS
- Beare B
- Beau T
- Beauchemin PH
- Beccherle R
- Bechtle P
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- Beckingham M
- Becks KH
- Beddall A
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- Bednyakov VA
- Bee C
- Begel M
- Behera PK
- Beimforde M
- Belanger-Champagne C
- Belenguer MJ
- Belhorma B
- Bell PJ
- Bell WH
- Bella G
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- Bellina F
- Bellomo G
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- Belloni A
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- Beltramello O
- Ben Ami S
- Benary O
- Benchekroun D
- Benchouk C
- Bendel M
- Benedict BH
- Benekos N
- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
- Benslama K
- Bentvelsen S
- Berge D
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- Berghaus F
- Berglund E
- Beringer J
- Bernardet K
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- Bernhard R
- Bernius C
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- Bertin A
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- Borisov A
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- Borjanovic I
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- Calafiura P
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- Casadei D
- Casado MP
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- Caso C
- Castaneda-Miranda E
- Castanheira MTD
- Castillo Gimenez V
- Castillo LRF
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- Cataneo F
- Catinaccio A
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- Cavalcanti TP
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- Cerutti F
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- Cetin SA
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- Chakraborty D
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- Chapleau B
- Chapman JD
- Chapman JW
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- Charlton DG
- Chavda V
- Cheatham S
- Chekanov S
- Chekulaev SV
- Chelkov GA
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- Cheong ALF
- Cheplakov A
- Chepurnov VF
- Cherkaoui El Moursli R
- Chernyatin V
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- Christidi IA
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- Chromek-Burckhart D
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- Comune G
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- Constantinescu S
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- Cooper BD
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- Correia AMH
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- Da Silva PVM
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- Dahlhoff A
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- Dallapiccola C
- Dallison SJ
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- Danielsson HO
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- de Renstrom PAB
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- Dedes G
- Dedovich DV
- Degenhardt J
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- Del Papa C
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- della Porta GZ
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- Delmastro M
- Delpierre P
- Delruelle N
- Delsart PA
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- Deviveiros PO
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- Dhullipudi R
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- Di Girolamo A
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- Di Luise S
- Di Mattia A
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- Di Simone A
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- Diehl EB
- Dietl H
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- Dietzsch TA
- Diglio S
- Dingfelder J
- Dionisi C
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- Dittus F
- Djama F
- Djilkibaev R
- Djobava T
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- Do Valle Wemans A
- Doan TKO
- Dobbs M
- Dobinson R
- Dobos D
- Dobson E
- Dobson M
- Dodd J
- Dogan OB
- Doglioni C
- Doherty T
- Dohmae T
- Doi Y
- Dolejsi J
- Dolenc I
- Dolezal Z
- Dolgoshein BA
- Donadelli M
- Donega M
- Donini J
- Donszelmann TC
- Dopke J
- Doria A
- Dos Anjos A
- Dos Santos DR
- Dosil M
- Dotti A
- Dova MT
- Dowell JD
- Doxiadis AD
- Doyle AT
- Drasal Z
- Drees J
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- Drevermann H
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- Duckeck G
- Dudarev A
- Dudziak F
- Duehrssen M
- Duerdoth IP
- Dueren M
- Duflot L
- Dufour M-A
- Dunford M
- Duxfield R
- Dwuznik M
- Dydak F
- Dzahini D
- Ebke J
- Eckert S
- Eckweiler S
- Edmonds K
- Edwards CA
- Efthymiopoulos I
- Ehrenfeld W
- Ehrich T
- Eifert T
- Eigen G
- Einsweiler K
- Eisenhandler E
- Ekelof T
- El Kacimi M
- Ellert M
- Elles S
- Ellinghaus F
- Ellis K
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- Elmsheuser J
- Elsing M
- Ely R
- Emeliyanov D
- Engelmann R
- Engl A
- Epp B
- Eppig A
- Erdmann J
- Ereditato A
- Eriksson D
- Ernst J
- Ernst M
- Ernwein J
- Errede D
- Errede S
- Ertel E
- Escalier M
- Eschrich IG
- Escobar C
- Espinal Curull X
- Esposito B
- Etienne F
- Etienvre AI
- Etzion E
- Evangelakou D
- Evans H
- Fabbri L
- Fabre C
- Facius K
- Fajardo LSG
- Fakhrutdinov RM
- Falciano S
- Falou AC
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- Zhemchugov A
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- Zieminska D
- Zilka B
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- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
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- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
- Abramowicz H
- Abreu H
- Acerbi E
- Acharya BS
- Adams DL
- Addy TN
- Adelman J
- Aderholz M
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Aharrouche M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akdogana T
- Akesson TPA
- Akimoto G
- Akimov AV
- Akiyama A
- Aktas A
- Alam MA
- Alam MS
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Aliyev M
- Allport PP
- Allwood-Spiers SE
- Almenar CC
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alviggi MG
- Amako K
- Amaral P
- Amelung C
- Ammosov VV
- Amorim A
- Amoros G
- Amram N
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders CF
- Anders G
- Anderson KJ
- Andreazza A
- Andrei V
- Andrieux M-L
- Anduaga XS
- Angerami A
- Anghinolfi F
- Anh TV
- Anjos N
- Annovi A
- Antonaki A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
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- Wickens FJ
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- Yamada M
- Yamaguchi H
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- Yamanaka T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
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- Yildizb HD
- Yilmaz M
- Yoosootiniya R
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- Yurkewicz A
- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zeitnitz C
- Zeller M
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
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- Zhang H
- Zhang J
- Zhang Q
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- Zhang Z
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- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
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- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Zinonos Z
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of √s = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pT≥20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60≤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2≤{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Recommended from our members
Preface paper to the Semi-Arid Land-Surface-Atmosphere (SALSA) Program special issue
- Author
- ARİAS HY
- Avissar R.
- Begue A.
- Bonnefond J.-M.
- Boulet G.
- Branan B.
- Brunel J.P.
- Carlos R.
- CAYROL PL
- CHEHBOUNİ AL
- Chen L.C.
- CLARKE TH
- Cooper D.I.
- Davis M.R.
- DEBRUİN HE
- Dedieu G.
- Eichinger W.E.
- ELGUERO EF
- Everitt J.
- Garatuza-Payan J.
- Gempko V.L.
- GOFF BR
- Goodrich D.C.
- Gupta H.
- Harlow C.
- HARTOGENSİS OL
- HELFERT ML
- Hipps L.H.
- HOLİFİELD CF
- HYMER DL
- JONES BL
- Kahle A.
- Keefer T.
- KEPNER WR
- Kerr Y.H.
- KİRKLAND MN
- Krishnamoorthy S.
- Lagouarde J.-P.
- Lhomme J.-P.
- Lo Seen D.
- Luquet D.
- MACNİSH BR
- MADDOCK TOM
- MARSETT RG
- Monteny B.
- MORAN SUSAN
- Nİ WE
- Nouvellon Y.
- PETERS CG
- PİNKER RL
- POOL DF
- Qİ JK
- RAMBAL SE
- Rodriguez J.
- Sano E.
- SANTİAGO FG
- Schaeffer S.M.
- SCHİELDGE JR
- Schulte M.
- SCOTT RE
- Shao X.
- Shuttleworth W.J.
- Snyder K.A.
- Sorooshian S.
- Unkrich C.L.
- WATTS CHRİS
- WHİTAKER MK
- Williams D.G.
- Yücel İsmail
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2000
- Field of study
The Semi-Arid Land-Surface-Atmosphere Program (SALSA) is a multi-agency, multi-national research effort that seeks to evaluate the consequences of natural and human-induced environmental change in semi-arid regions. The ultimate goal of SALSA is to advance scientific understanding of the semi-arid portion of the hydrosphere–biosphere interface in order to provide reliable information for environmental decision making. SALSA approaches this goal through a program of long-term, integrated observations, process research, modeling, assessment, and information management that is sustained by cooperation among scientists and information users. In this preface to the SALSA special issue, general program background information and the critical nature of semi-arid regions is presented. A brief description of the Upper San Pedro River Basin, the initial location for focused SALSA research follows. Several overarching research objectives under which much of the interdisciplinary research contained in the special issue was undertaken are discussed. Principal methods, primary research sites and data collection used by numerous investigators during 1997–1999 are then presented. Scientists from about 20 US, five European (four French and one Dutch), and three Mexican agencies and institutions have collaborated closely to make the research leading to this special issue a reality. The SALSA Program has served as a model of interagency cooperation by breaking new ground in the approach to large scale interdisciplinary science with relatively limited resources
Eag and HERG potassium channels as novel therapeutic targets in cancer
- Author
- A Arcangeli
- A Arcangeli
- A Bruggemann
- A Catsch
- A Cherubini
- A Darszon
- A Jemal
- A Masi
- AE Dubin
- AM Farrelly
- Anish Bali
- AP Hegle
- AS Bender
- AS Borowiec
- B Ganetzky
- B Ganetzky
- B Hemmerlein
- B Nilius
- B Rosati
- B Rouzaire-Dubois
- B Rouzaire-Dubois
- BR Downie
- C Toral
- C Weber
- CF Wu
- CK Bauer
- CK Bauer
- D Gomez-Varela
- DJ Blackiston
- E Lastraioli
- F Furlan
- F Gullo
- F Lang
- F Mello de Queiroz
- G Hofmann
- G Yellen
- GA Smith
- GL Semenza
- H Sontheimer
- H Wang
- Heidi Sowter
- J Camacho
- J Colomer
- J Ludwig
- J Ludwig
- J Ousingsawat
- J Warmke
- J Zhao
- JA Bertout
- JE Brayden
- JH Morais Cabral
- JL Fiske
- JL Overholt
- JR Agarwal
- JW Warmke
- KJ Swartz
- L Bianchi
- L Diaz
- LA Pardo
- LA Pardo
- LA Pardo
- LA Pardo
- LM Farias
- M Conti
- M Jenke
- M Whitaker
- MC Sanguinetti
- ME Curran
- MJ Perrin
- NJ Abbott
- O Crociani
- O Gavrilova-Ruch
- O Gavrilova-Ruch
- P Bijlenga
- R Brugada
- R Meyer
- R Meyer
- Raheela Khan
- RE Garcia-Ferreiro
- Robert Shaw
- S Bergquist
- S Frings
- S Martin
- S Patt
- S Pillozzi
- S Wadhwa
- SA Titus
- T Occhiodoro
- T Suzuki
- Viren Asher
- W Stuhmer
- WD Kaplan
- XD Shao
- XD Shao
- XW Ding
- XW Ding
- XX Sun
- XX Sun
- Z Xia
- Publication venue
- BioMed Central
- Publication date
- 01/12/2010
- Field of study
Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. Inhibition of these channels has been shown to reduce proliferation both in vitro and vivo studies identifying potassium channel modulators as putative inhibitors of tumour progression. Eag channels in view of their restricted expression in normal tissue may emerge as novel tumour biomarkers
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
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- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
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- Coloma G
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- Coman S
- Commerford P
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- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
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- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
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- Craig W
- Crandall L
- Crawford G
- Crea F
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- Crocamo A
- Cromer M
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- Cruz M
- Csala L
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- Zineldine A.
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Measurement of the cross-section for b-jets produced in association with a Z boson at root s=7 TeV with the ATLAS detector ATLAS Collaboration
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
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- Abreu H
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- Aharrouche M
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- Swedish S
- Sykora I
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- Vilucchi E
- Vincter MG
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- Vorobiev AP
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- Yamaguchi H
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- Yamanaka T
- Yamaoka J
- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yang Y
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- Yang Z
- Yanush S
- Yao Y
- Yasu Y
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- Ye S
- Yildizb HD
- Yilmaz M
- Yoosoofmiya R
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- Zaets VG
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
- Zeitnitz C
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- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
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- Zhang X
- Zhang Z
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- Zhemchugov A
- Zheng S
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- Zhou B
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- Zieminska D
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- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
A measurement is presented of the inclusive cross-section for b-jet production in association with a Z boson in pp collisions at a centre-of-mass energy of root s = 7 TeV. The analysis uses the data sample collected by the ATLAS experiment in 2010, corresponding to an integrated luminosity of approximately 36 pb(-1). The event selection requires a Z boson decaying into high P-T electrons or muons, and at least one b-jet, identified by its displaced vertex, with transverse momentum p(T) > 25 GeV and rapidity vertical bar y vertical bar < 2.1. After subtraction of background processes, the yield is extracted from the vertex mass distribution of the candidate b-jets. The ratio of this cross-section to the inclusive Z cross-section (the average number of b-jets per Z event) is also measured. Both results are found to be in good agreement with perturbative QCD predictions at next-to-leading order
Metopic synostosis
- Author
- A Mehner
- AK Oh
- AM Sadove
- AO Wilkie
- AO Wilkie
- B Kallen
- B Say
- BD Kuper
- BL Eppley
- BM Greenberg
- BW Alderman
- C Azimi
- C Davis
- C DiRocco
- C Sargent
- CF Kweldam
- CG Lauritzen
- CM Barone
- D Marchac
- D Marchac
- D Renier
- D Renier
- DB Matic
- DD Matson
- DE Hilling
- DF Jimenez
- DJ David
- DT Gault
- E Lajeunie
- EJ Sidoti Jr
- F Rocco Di
- F Rocco Di
- FJ Ramos Fuentes
- FM Anderson
- FM Anderson
- FM Anderson
- FS Jehee
- G Maltese
- G Tamburrini
- GF Tuite
- GJ Murad
- H Collmann
- H Friede
- H Welcker
- HE Aryan
- HH Ardinger
- HJ Hoffman
- HL Vu
- IM Heer de
- J Hinojosa
- J Hinojosa
- J Hinojosa
- J Meulen van der
- J Meulen van der
- J Selber
- J Selber
- J Shillito Jr
- J Weinzweig
- JA Fearon
- JA Persing
- Jacques van der Meulen
- JB Delashaw
- JC Kolar
- JC Posnick
- JG McCarthy
- JG McCarthy
- JJ Meulen van der
- JJ Meulen van der
- JL Huret
- JL Marsh
- JL Penfold
- JM Graham Jr
- JM Smartt Jr
- K Aldridge
- K Aldridge
- K Webster
- KA Kapp-Simon
- KA Kapp-Simon
- KA Kapp-Simon
- L Bottero
- L Genitori
- LA Whitaker
- M Cohen
- M Frydman
- M Strickler
- MG Obregon
- ML Moss
- MP Zumpano
- O Alfi
- P Dhellemmes
- P Tessier
- PA Riemenschneider
- PK Eide
- R Dominguez
- R Virchow
- RC Hennekam
- RE Albin
- RE Johnsonbaugh
- RJ Havlik
- S Oi
- S Warschausky
- SA Rasmussen
- SA Temtamy
- SL Boulet
- SN Siddiqi
- SR Cohen
- T Haaf
- T Inagaki
- T Shimoji
- W Kress
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Premature closure of the metopic suture results in a growth restriction of the frontal bones, which leads to a skull malformation known as trigonocephaly. Over the course of recent decades, its incidence has been rising, currently making it the second most common type of craniosynostosis. Treatment consists of a cranioplasty, usually preformed before the age of 1 year. Metopic synostosis is linked with an increased level of neurodevelopmental delays. Theories on the etiology of these delays range from a reduced volume of the anterior cranial fossa to intrinsic malformations of the brain. This paper aims to provide an overview of this entity by giving an update on the epidemiology, etiology, evolution of treatment, follow-up, and neurodevelopment of metopic synostosis
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