400 research outputs found
Impact of diastolic dysfunction severity on global left ventricular volumetric filling - assessment by automated segmentation of routine cine cardiovascular magnetic resonance
- Author
- Publication venue
- BioMed Central
- Publication date
- 01/01/2010
- Field of study
<p>Abstract</p> <p>Objectives</p> <p>To examine relationships between severity of echocardiography (echo) -evidenced diastolic dysfunction (DD) and volumetric filling by automated processing of routine cine cardiovascular magnetic resonance (CMR).</p> <p>Background</p> <p>Cine-CMR provides high-resolution assessment of left ventricular (LV) chamber volumes. Automated segmentation (LV-METRIC) yields LV filling curves by segmenting all short-axis images across all temporal phases. This study used cine-CMR to assess filling changes that occur with progressive DD.</p> <p>Methods</p> <p>115 post-MI patients underwent CMR and echo within 1 day. LV-METRIC yielded multiple diastolic indices - E:A ratio, peak filling rate (PFR), time to peak filling rate (TPFR), and diastolic volume recovery (DVR<sub>80 </sub>- proportion of diastole required to recover 80% stroke volume). Echo was the reference for DD.</p> <p>Results</p> <p>LV-METRIC successfully generated LV filling curves in all patients. CMR indices were reproducible (≤ 1% inter-reader differences) and required minimal processing time (175 ± 34 images/exam, 2:09 ± 0:51 minutes). CMR E:A ratio decreased with grade 1 and increased with grades 2-3 DD. Diastolic filling intervals, measured by DVR<sub>80 </sub>or TPFR, prolonged with grade 1 and shortened with grade 3 DD, paralleling echo deceleration time (p < 0.001). PFR by CMR increased with DD grade, similar to E/e' (p < 0.001). Prolonged DVR<sub>80 </sub>identified 71% of patients with echo-evidenced grade 1 but no patients with grade 3 DD, and stroke-volume adjusted PFR identified 67% with grade 3 but none with grade 1 DD (matched specificity = 83%). The combination of DVR<sub>80 </sub>and PFR identified 53% of patients with grade 2 DD. Prolonged DVR<sub>80 </sub>was associated with grade 1 (OR 2.79, CI 1.65-4.05, p = 0.001) with a similar trend for grade 2 (OR 1.35, CI 0.98-1.74, p = 0.06), whereas high PFR was associated with grade 3 (OR 1.14, CI 1.02-1.25, p = 0.02) DD.</p> <p>Conclusions</p> <p>Automated cine-CMR segmentation can discern LV filling changes that occur with increasing severity of echo-evidenced DD. Impaired relaxation is associated with prolonged filling intervals whereas restrictive filling is characterized by increased filling rates.</p
f(R) theories
- Author
- A Balcerzak
- A Balcerzak
- A Billyard
- A Borisov
- A Borzou
- A Codello
- A Cooray
- A Cruz-Dombriz de la
- A Cruz-Dombriz de la
- A Cruz-Dombriz de la
- A Dev
- A Einstein
- A Einstein
- A Felice De
- A Felice De
- A Felice De
- A Felice De
- A Felice De
- A Felice De
- A Felice De
- A Felice De
- A Felice De
- A Gruzinov
- A Hindawi
- A Hindawi
- A Iglesias
- A Linde
- A Lue
- A Macorra de la
- A Nicolis
- A Núñez
- A Palatini
- A Riazuelo
- A Shojai
- A Toporensky
- A Upadhye
- A Vilenkin
- AA Starobinsky
- AA Starobinsky
- AA Starobinsky
- AA Starobinsky
- AA Starobinsky
- AA Starobinsky
- AA Starobinsky
- AD Dolgov
- AD Linde
- AE Domínguez
- AF Zakharov
- AG Riess
- AG Riess
- AH Guth
- AI Vainshtein
- AJ Bustelo
- AK Sanyal
- AL Berkin
- AL Erickcek
- AO Barvinsky
- AR Liddle
- AR Liddle
- AR Liddle
- AV Frolov
- AW Brookfield
- B Bertotti
- B Boisseau
- B Jain
- B Li
- B Li
- B Li
- B Li
- B Li
- B Li
- B Li
- B Modak
- B Ratra
- B Vakili
- B Vakili
- B Zwiebach
- BA Bassett
- BA Bassett
- BC Paul
- BM Gripaios
- BM Leith
- BN Breizman
- C Baccigalupi
- C Barragán
- C Brans
- C Cartier
- C Cherubini
- C Corda
- C Corda
- C Deffayet
- C Deffayet
- C Deffayet
- C Deffayet
- C Deffayet
- C Eling
- C Frigerio Martins
- C Lanczos
- C Porto Di
- C Rham de
- C Ringeval
- C Schimd
- C Wetterich
- C-G Shao
- C-P Ma
- CF Kolda
- CG Boehmer
- CG Boehmer
- CG Böhmer
- CSJ Pun
- CW Misner
- D Bazeia
- D Hilbert
- D Huterer
- D Kazanas
- D Kazanas
- D La
- D La
- D Lovelock
- D Polarski
- D Psaltis
- D Wands
- DA Easson
- DF Torres
- DH Lyth
- DJ Eisenstein
- DJ Gross
- DJ Gross
- DN Spergel
- DN Spergel
- DN Vollick
- DN Vollick
- E Babichev
- E Barausse
- E Barausse
- E Bertschinger
- E Dyer
- E Elizalde
- E Elizalde
- E Gunzig
- E Komatsu
- E Komatsu
- E Kretschmann
- E Rosenthal
- ED Stewart
- EJ Copeland
- EJ Copeland
- EJ Weinberg
- EV Linder
- EV Linder
- EW Kolb
- F Bernardeau
- F Briscese
- F Cooper
- F Perrotta
- F Perrotta
- F Schmidt
- F Schmidt
- F Schmidt
- FC Carvalho
- FP Silva
- FR Klinkhamer
- FSN Lobo
- FW Hehl
- G Allemandi
- G Allemandi
- G Allemandi
- G Allemandi
- G Calcagni
- G Calcagni
- G Chirco
- G Cognola
- G Cognola
- G Cognola
- G Dvali
- G Esposito-Farèse
- G Lambiase
- G Magnano
- G Marmo
- G Morandi
- G-B Zhao
- G-B Zhao
- GB Zhao
- GF Smoot
- GFR Ellis
- GFR Ellis
- GJ Olmo
- GJ Olmo
- GJ Olmo
- GJ Olmo
- GJ Olmo
- GJ Olmo
- GJ Olmo
- GJ Olmo
- GN Felder
- GR Dvali
- GR Dvali
- H Davoudiasl
- H Kodama
- H Mohseni Sadjadi
- H Motohashi
- H Oyaizu
- H Oyaizu
- H Sadjadi
- H Yajima
- H-J Schmidt
- HA Buchdahl
- HF Stabenau
- I Antoniadis
- I Laszlo
- I Navarro
- I Navarro
- I Sawicki
- I Thongkool
- I Thongkool
- I Zlatev
- IP Neupane
- IP Neupane
- J García-Bellido
- J Guzik
- J Khoury
- J Khoury
- J Klusoň
- J Klusoň
- J Martin
- J Moldenhauer
- J Novak
- J O’Hanlon
- J Saavedra
- J Santos
- J-C Hwang
- J-C Hwang
- J-C Hwang
- J-C Hwang
- J-C Hwang
- J-C Hwang
- J-M Gérard
- J-P Uzan
- J-Q Xia
- JAR Cembranos
- JC Hwang
- JCC Souza de
- JD Barrow
- JD Barrow
- JD Barrow
- JD Barrow
- JD Barrow
- JD Bekenstein
- JD Bekenstein
- JD Evans
- JF Navarro
- JH Traschen
- JM Bardeen
- JM Bardeen
- JM Bardeen
- JM Cline
- K Atazadeh
- K Atazadeh
- K Bamba
- K Bamba
- K Bamba
- K Bamba
- K Henttunen
- K Hinterbichler
- K Kainulainen
- K Kainulainen
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- K Koyama
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- K Sato
- K Uddin
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- K Yamamoto
- K-I Maeda
- K-I Maeda
- K-I Maeda
- KA Malik
- KN Ananda
- KS Stelle
- L Amendola
- L Amendola
- L Amendola
- L Amendola
- L Amendola
- L Amendola
- L Amendola
- L Amendola
- L Amendola
- L Amendola
- L Amendola
- L Hui
- L Iorio
- L Järv
- L Knox
- L Kofman
- L Kofman
- L Perivolaropoulos
- L Pogosian
- L Randall
- L Randall
- L Wang
- LA Kofman
- LH Ford
- LM Sokolowski
- M Abdelwahab
- M Akbar
- M Akbar
- M Akbar
- M Alimohammadi
- M Alimohammadi
- M Amarzguioui
- M Bartelmann
- M Borunda
- M Capone
- M Fairbairn
- M Fairbairn
- M Ferraris
- M Fierz
- M Fierz
- M Gasperini
- M Gasperini
- M Gasperini
- M Gasperini
- M Ishak
- M Ishak
- M Ishak
- M Kamionkowski
- M Kolanovic
- M Kolanović
- M Kowalski
- M Kunz
- M Libanov
- M Martinelli
- M Mohseni
- M Parry
- M Porrati
- M Salgado
- M Sami
- M Takada
- M Tegmark
- M Tegmark
- M Viel
- MA Luty
- MB Mijić
- MD Seifert
- ME Soussa
- MES Alves
- ML Ruggiero
- ML Ruggiero
- N Agarwal
- N Arkani-Hamed
- N Bartolo
- N Boulanger
- N Boulanger
- N Chow
- N Deruelle
- N Deruelle
- N Deruelle
- N Deruelle
- N Goheer
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- N Kaloper
- N Kaloper
- N Lanahan-Tremblay
- N Makino
- N Ohta
- ND Birrell
- NH Barth
- NJ Poplawski
- NW McLachlan
- O Bertolami
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- O Bertolami
- O Mena
- P Astier
- P Binétruy
- P Binétruy
- P Brax
- P Hořava
- P Kanti
- P McDonald
- P Teyssandier
- P Zhang
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- PD Mannheim
- PD Mannheim
- PF Machado
- PG Bergmann
- PG Ferreira
- PJ Steinhardt
- PJ Zhang
- PJE Peebles
- PJE Peebles
- PJE Peebles
- Q Exirifard
- R Bean
- R Brustein
- R Dick
- R Easther
- R Fakir
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- R Gannouji
- R Gannouji
- R Maartens
- R Saffari
- R-G Cai
- RC Souza de
- RC Souza de
- RE Smith
- RH Dicke
- RK Sheth
- RM Wald
- RM Wald
- RP Woodard
- RR Caldwell
- RR Metsaev
- S Alexeyev
- S Baghram
- S Baghram
- S Baghram
- S Capozziello
- S Capozziello
- S Capozziello
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- S Capozziello
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- S Capozziello
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- S Capozziello
- S Capozziello
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- S Capozziello
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- S Carloni
- S Carloni
- S Carloni
- S Dodelson
- S Fay
- S Fay
- S Kawai
- S Kawai
- S Lee
- S Mendoza
- S Mukohyama
- S Nesseris
- S Nesseris
- S Nojiri
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- S Nojiri
- S Nojiri
- S Nojiri
- S Nojiri
- S Perlmutter
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
- S Tsujikawa
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- S Weinberg
- S-F Wu
- S-F Wu
- S-Y Zhou
- SA Appleby
- SA Appleby
- SA Hayward
- SA Hayward
- SA Hayward
- SCC Ng
- SE Perez Bergliaffa
- SF Daniel
- SM Carroll
- SM Carroll
- SM Carroll
- SM Carroll
- SM Carroll
- SM Carroll
- SS Seahra
- SV Ketov
- SW Hawking
- SW Hawking
- SW Hawking
- SY Khlebnikov
- T Chiba
- T Chiba
- T Chiba
- T Chiba
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- T Clifton
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- T Damour
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- T Faulkner
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- T Jacobson
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- T Kobayashi
- T Kobayashi
- T Kobayashi
- T Koivisto
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- T Multamaki
- T Multamäki
- T Multamäki
- T Multamäki
- T Multamäki
- T Narikawa
- T Padmanabhan
- T Rador
- T Rador
- T Saidov
- T Shiromizu
- T Tamaki
- T Tatekawa
- TP Sotiriou
- TP Sotiriou
- TP Sotiriou
- TP Sotiriou
- TP Sotiriou
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- TP Sotiriou
- TP Sotiriou
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- TV Ruzmaikina
- U Alam
- U Alam
- U Alam
- U Günther
- U Günther
- V Acquaviva
- V Acquaviva
- V Faraoni
- V Faraoni
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- VF Mukhanov
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- VI Afonso
- W Hu
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- WJ Percival
- WL Freedman
- X Wu
- X-D Ji
- XH Meng
- XH Meng
- XH Meng
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- Y Ezawa
- Y Fujii
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- Y-S Song
- Y-S Song
- Y-S Song
- Y-S Song
- YB Zel’dovich
- YS Song
- YS Song
- Z-K Guo
- Á Cruz-Dombriz de la
- ÉÉ Flanagan
- ÉÉ Flanagan
- ÉÉ Flanagan
- Publication venue
- 'Living Reviews'
- Publication date
- 01/06/2010
- Field of study
Over the past decade, f(R) theories have been extensively studied as one of
the simplest modifications to General Relativity. In this article we review
various applications of f(R) theories to cosmology and gravity - such as
inflation, dark energy, local gravity constraints, cosmological perturbations,
and spherically symmetric solutions in weak and strong gravitational
backgrounds. We present a number of ways to distinguish those theories from
General Relativity observationally and experimentally. We also discuss the
extension to other modified gravity theories such as Brans-Dicke theory and
Gauss-Bonnet gravity, and address models that can satisfy both cosmological and
local gravity constraints.Comment: 156 pages, 14 figures, Invited review article in Living Reviews in
Relativity, Published version, Comments are welcom
Geology and rural landscapes in central Spain (Guadalajara, Castilla—La Mancha)
- Author
- A García-Quintana
- A García-Quintana
- A. Garc�a-Quintana
- AE Godfrey
- AL Bloom
- CF Pain
- D Al Bakri
- DHK Fairbanks
- DL Linton
- DW Burbank
- F Guzzetti
- G Bertrand
- GE Host
- H. Est�vez
- J Gómezde Mendoza
- J Pedraza
- J. A. Gonz�lez-Mart�n
- J. F. Garc�a-Hidalgo
- J. F. Mart�n-Duque
- J. Pedraza
- JA Howard
- JG Estébanez Álvarez
- JM Omernik
- JW Powell
- M Laurie
- MR Moss
- NM Fenneman
- P Martínde Agar
- P. Herranz
- R. Rinc�n
- RG Bailey
- RL Wright
- TS Terkenli
- Y Aoki
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2005
- Field of study
Methods commonly used in regional geological analysis were employed to study the visual landscapes of the Sigüenza–Molina de Aragón area (Spain). Landscape data were compiled to produce a landscape map and a photograph
catalogue. Lithological composition, tectonic structure and recent erosive processes are the main factors controlling the visual landscapes. Territorial properties, such as colours and agricultural capacities, are controlled by these geological characteristics. The landscape map and the photographic catalogue is the main
contribution of this paper. The first level of landscape classification distinguishes zones with dominance of either flat, concave or convex areas. Other parts of the territory are, however, composed of concave and convex combinations that originate hybrid orographic structures. In a second level of classification, several subdivisions for each of these types are established
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
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- Abdesselam A
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- Ackers M
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- Aleksandrov IN
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- Alessandria F
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- Arguin J-F
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- Bahinipati S
- Bai Y
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- Bednyakov VA
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- Benhammou Y
- Benjamin DP
- Benoit M
- Bensinger JR
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- Bernhard R
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- Bethke S
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- Biebel O
- Biesiada J
- Biglietti M
- Bilokon H
- Bindi M
- Bingul A
- Bini C
- Biscarat C
- Bischof R
- Bitenc U
- Black KM
- Blair RE
- Blanchard J-B
- Blanchot G
- Blocker C
- Blocki J
- Blondel A
- Blum W
- Blumenschein U
- Boaretto C
- Bobbink GJ
- Bobrovnikov VB
- Bocci A
- Bock R
- Boddy CR
- Boehler M
- Boek J
- Boelaert N
- Boeser S
- Bogaerts JA
- Bogdanchikov A
- Bogouch A
- Bohm C
- Boisvert V
- Bold T
- Boldea V
- Bona M
- Boonekamp M
- Boorman G
- Booth CN
- Booth JRA
- Booth P
- Bordoni S
- Borer C
- Borisov A
- Borissov G
- Borjanovic I
- Borroni S
- Bos K
- Boscherini D
- Bosman M
- Boterenbrood H
- Botterill D
- Bouchami J
- Boudreau J
- Bouhova-Thacker EV
- Boulahouache C
- Bourdarios C
- Bousson N
- Boveia A
- Boyd J
- Boyko IR
- Bozhko NI
- Bozovic-Jelisavcic I
- Braccini S
- Bracinik J
- Braem A
- Brambilla E
- Branchini P
- Branco MDO
- Brandenburg GW
- Brandt A
- Brandt G
- Brandt O
- Bratzler U
- Brau B
- Brau JE
- Braun HM
- Brelier B
- Bremer J
- Brenner R
- Bressler S
- Breton D
- Brett ND
- Bright-Thomas PG
- Britton D
- Brochu FM
- Brock I
- Brock R
- Brodbeck TJ
- Brodet E
- Broggi F
- Bromberg C
- Brooijmans G
- Brooks WK
- Brown G
- Brubaker E
- Bruncko D
- Bruneliere R
- Brunet S
- Bruni A
- Bruni G
- Bruschi M
- Buanes T
- Bucci F
- Buchanan J
- Buchanan NJ
- Buchholz P
- Buckingham RM
- Buckley AG
- Buda SI
- Budagov IA
- Budick B
- Buescher V
- Bueso XP
- Bugge L
- Buira-Clark D
- Buis EJ
- Bulekov O
- Bunse M
- Buran T
- Burckhart H
- Burdin S
- Burgess T
- Burke S
- Busato E
- Bussey P
- Buszello CP
- Butin F
- Butler B
- Butler JM
- Buttar CM
- Butterworth JM
- Buttinger W
- Byatt T
- Cabrera Urban S
- Caccia M
- Caforio D
- Cakir IT
- Cakir O
- Calafiura P
- Calderini G
- Calfayan P
- Calkins R
- Caloba LP
- Caloi R
- Calvet D
- Calvet S
- Camard A
- Camarri P
- Cambiaghi M
- Cameron D
- Camillocci ES
- Cammin J
- Campana S
- Campanelli M
- Canale V
- Canelli F
- Canepa A
- Cantero J
- Capasso L
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- Zhemchugov A
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- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdel Khalek S
- Abdelalim AA
- Abdinov O
- Aben R
- Abi B
- Abolins M
- Abouzeid OS
- Abramowicz H
- Abreu H
- Acharya BS
- Adamczyk L
- Adams DL
- Addy TN
- Adelman J
- Adomeit S
- Adragna P
- Adye T
- Aefsky S
- Aguilar-Saavedra JA
- Agustoni M
- Ahlen SP
- Ahles F
- Ahmad A
- Ahsan M
- Aielli G
- Akesson TP
- Akimoto G
- Akimov AV
- Alam MA
- Albert J
- Albrand S
- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
- Alexander G
- Alexandre G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Allbrooke BM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almond J
- Aloisio A
- Alon R
- Alonso A
- Alonso F
- Altheimer A
- Alvarez Gonzalez B
- Alviggi MG
- Amako K
- Amelung C
- Ammosov VV
- Amor Dos Santos SP
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- Publication venue
- American Physical Society
- Publication date
- 01/01/2012
- Field of study
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Measurement of the cross-section of high transverse momentum vector bosons reconstructed as single jets and studies of jet substructure in pp collisions at √s = 7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdinov O
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- Zhemchugov A
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- Zimmermann C
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- Zitoun R
- Zobernig G
- Zoccoli A
- Zurzolo G
- Zutshi V
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2014
- Field of study
This paper presents a measurement of the cross-section for high transverse momentum W and Z bosons produced in pp collisions and decaying to all-hadronic final states. The data used in the analysis were recorded by the ATLAS detector at the CERN Large Hadron Collider at a centre-of-mass energy of √s = 7 TeV;{\rm Te}{\rm V}andcorrespondtoanintegratedluminosityof4.6\;{\rm f}{{{\rm b}}^{-1}}.ThemeasurementisperformedbyreconstructingtheboostedWorZbosonsinsinglejets.ThereconstructedjetmassisusedtoidentifytheWandZbosons,andajetsubstructuremethodbasedonenergyclusterinformationinthejetcentre−of−massframeisusedtosuppressthelargemulti−jetbackground.Thecross−sectionforeventswithahadronicallydecayingWorZboson,withtransversemomentum{{p}_{{\rm T}}}\gt 320\;{\rm Ge}{\rm V}andpseudorapidity|\eta |\lt 1.9,ismeasuredtobe{{\sigma }_{W+Z}}=8.5\pm 1.7$ pb and is compared to next-to-leading-order calculations. The selected events are further used to study jet grooming techniques
Search for R-parity-violating supersymmetry in events with four or more leptons in sqrt(s) =7 TeV pp collisions with the ATLAS detector
- Author
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- von der Schmitt H
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- Anh TV
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- Vukotic I
- Wagner W
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- Wijeratne PA
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- Winkelmann S
- Winklmeier F
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- Yamamoto S
- Yamamura T
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- Yamazaki T
- Yamazaki Y
- Yan Z
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- Yanush S
- Yao L
- Yao Y
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- Smit GVY
- Ye J
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- Yilmaz M
- Yoosoofmiya R
- Yorita K
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- Yoshihara K
- Young C
- Young CJ
- Youssef S
- Yu D
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- Yu J
- Yuan L
- Yurkewicz A
- Zabinski B
- Zaidan R
- Zaitsev AM
- Zajacova Z
- Zanello L
- Zanzi D
- Zaytsev A
- Zeitnitz C
- Zeman M
- Zemla A
- Zendler C
- Zenin O
- Zenis T
- Zinonos Z
- Zerwas D
- della Porta GZ
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zibell A
- Zieminska D
- Zimin NI
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Collaboration ATLAS
- Publication venue
- Springer Verlag
- Publication date
- 01/01/2008
- Field of study
A search for new phenomena in final states with four or more leptons (electrons or muons) is presented. The analysis is based on 4.7 fb−1 of s=7TeV proton-proton collisions delivered by the Large Hadron Collider and recorded with the ATLAS detector. Observations are consistent with Standard Model expectations in two signal regions: one that requires moderate values of missing transverse momentum and another that requires large effective mass. The results are interpreted in a simplified model of R-parity-violating supersymmetry in which a 95% CL exclusion region is set for charged wino masses up to 540 GeV. In an R-parity-violating MSUGRA/CMSSM model, values of m 1/2 up to 820 GeV are excluded for 10 < tan β < 40
Septation of Infectious Hyphae Is Critical for Appressoria Formation and Virulence in the Smut Fungus Ustilago Maydis
- Author
- A Bottin
- A Brachmann
- A Brachmann
- A Hlubek
- A Mendoza-Mendoza
- A Schirenbeck
- A Yonetani
- B Sandrock
- B Schulz
- Björn Sandrock
- Brett Tyler
- C Bechinger
- C Böhmer
- C Böhmer
- C Veneault-Fourrey
- CA Kumamoto
- CF Robinow
- Christian Böhmer
- CT Ingold
- D Chalkia
- D Lanver
- D Pruyne
- D Pruyne
- Daniel Lanver
- DG Saunders
- DH Castrillon
- DR Kovar
- F Banuett
- F Banuett
- F Chang
- F Chang
- F Li
- G Döhlemann
- G Loubradou
- G Steinberg
- G Weinzierl
- H Imamura
- HN Higgs
- HP Schmitz
- I Alvarez-Tabares
- I Sagot
- J Kämper
- J Kämper
- J Schirawski
- JC de Jong
- JJ Christensen
- Johannes Freitag
- K Heimel
- Kay Oliver Schink
- KM Snetselaar
- KP Dixon
- M Bathe
- M Böhmer
- M Bölker
- M Evangelista
- M Evangelista
- M Evangelista
- M Kikyo
- M Mahlert
- M Scherer
- MF Olson
- Michael Bölker
- MJ Kershaw
- P Wadsworth
- PR Day
- R Kahmann
- RA Wilson
- RW Emmett
- S Oliferenko
- SL Tucker
- T Garcia-Muse
- T Kamei
- T Spellig
- W Choi
- W Liu
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Differentiation of hyphae into specialized infection structures, known as appressoria, is a common feature of plant pathogenic fungi that penetrate the plant cuticle. Appressorium formation in U. maydis is triggered by environmental signals but the molecular mechanism of this hyphal differentiation is largely unknown. Infectious hyphae grow on the leaf surface by inserting regularly spaced retraction septa at the distal end of the tip cell leaving empty sections of collapsed hyphae behind. Here we show that formation of retraction septa is critical for appressorium formation and virulence in U. maydis. We demonstrate that the diaphanous-related formin Drf1 is necessary for actomyosin ring formation during septation of infectious hyphae. Drf1 acts as an effector of a Cdc42 GTPase signaling module, which also consists of the Cdc42-specific guanine nucleotide exchange factor Don1 and the Ste20-like kinase Don3. Deletion of drf1, don1 or don3 abolished formation of retraction septa resulting in reduced virulence. Appressorium formation in these mutants was not completely blocked but infection structures were found only at the tip of short filaments indicating that retraction septa are necessary for appressorium formation in extended infectious hyphae. In addition, appressoria of drf1 mutants penetrated the plant tissue less frequently
Public Sector Reform and Governance for Adaptation: Implications of New Public Management for Adaptive Capacity in Mexico and Norway
- Author
- B Smit
- C Hood
- C Pollitt
- Cecilie Øyen
- CF Øyen
- Comisión Nacional
- D Arellano-Gault
- D Armitage
- D Nelson
- DE Klingner
- E Cabrero-Mendoza
- E Tompkins
- E Tompkins
- F Berkes
- G Cedujo
- G Davis
- G Yohe
- H Eakin
- H Eakin
- H Eakin
- H Eakin
- Hallie Eakin
- I Hanssen-Bauer
- J Ivey
- LD Terry
- LO Næss
- M Painter
- M Wilder
- MC Lemos
- Ministry of Consumer Affairs and Administration
- Ministry of Government Administration and Reform
- MP Cohen
- N Engle
- P Dunleavy
- P Self
- P Weller
- Per-Ove Eikeland
- PY Groisman
- R Box
- R Few
- R Plummer
- RAW Rhodes
- RE Benestad
- S Eriksen
- Siri Eriksen
- T Christensen
- T Christensen
- T Christensen
- V Bogdanor
- WN Adger
- WN Adger
- WN Adger
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Although many governments are assuming the responsibility of initiating adaptation policy in relation to climate change, the compatibility of “governance-for-adaptation” with the current paradigms of public administration has generally been overlooked. Over the last several decades, countries around the globe have embraced variants of the philosophy of administration broadly called “New Public Management” (NPM) in an effort to improve administrative efficiencies and the provision of public services. Using evidence from a case study of reforms in the building sector in Norway, and a case study of water and flood risk management in central Mexico, we analyze the implications of the adoption of the tenets of NPM for adaptive capacity. Our cases illustrate that some of the key attributes associated with governance for adaptation—namely, technical and financial capacities; institutional memory, learning and knowledge; and participation and accountability—have been eroded by NPM reforms. Despite improvements in specific operational tasks of the public sector in each case, we show that the success of NPM reforms presumes the existence of core elements of governance that have often been found lacking, including solid institutional frameworks and accountability. Our analysis illustrates the importance of considering both longer-term adaptive capacities and short-term efficiency goals in public sector administration reform
Liver Cancer-Derived Hepatitis C Virus Core Proteins Shift TGF-Beta Responses from Tumor Suppression to Epithelial-Mesenchymal Transition
- Author
- A Kaimori
- A Moustakas
- A Moustakas
- A Nishihara
- A Rullier
- AB Roberts
- AB Roberts
- AH Chou
- Anna Linda Zignego
- Azeddine Atfi
- B Baum
- B Schmierer
- C Giannini
- C Giannini
- CF Kao
- Christian Bréchot
- D Wotton
- Didier Samuel
- DK Lee
- G Giannelli
- H Nakabayashi
- J McLauchlan
- JA Mendoza
- JF Alcorn
- JM Pawlotsky
- JP Thiery
- K Pardali
- L Levy
- L Pichard
- L Yu
- M Levrero
- M McIntyre
- M Zeisberg
- Marie-Françoise Bourgeade
- Mauricio Rojas
- MM Lai
- N Delhem
- N Pavio
- N Schrantz
- N Zhu
- Nassima Benzoubir
- NJ Laping
- NM Meindl-Beinker
- OA Gressner
- Pierre Charneau
- PL Cheng
- R Derynck
- R Derynck
- R Serra
- R Sobesky
- SA Mani
- Serena Battaglia
- Soizic Nobilet
- SR Seo
- T Horikawa
- W He
- W Rossmanith
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
International audienceBACKGROUND: Chronic hepatitis C virus (HCV) infection and associated liver cirrhosis represent a major risk factor for hepatocellular carcinoma (HCC) development. TGF-beta is an important driver of liver fibrogenesis and cancer; however, its actual impact in human cancer progression is still poorly known. The aim of this study was to investigate the role of HCC-derived HCV core natural variants on cancer progression through their impact on TGF-beta signaling. PRINCIPAL FINDINGS: We provide evidence that HCC-derived core protein expression in primary human or mouse hepatocyte alleviates TGF-beta responses in terms or growth inhibition or apoptosis. Instead, in these hepatocytes TGF-beta was still able to induce an epithelial to mesenchymal transition (EMT), a process that contributes to the promotion of cell invasion and metastasis. Moreover, we demonstrate that different thresholds of Smad3 activation dictate the TGF-beta responses in hepatic cells and that HCV core protein, by decreasing Smad3 activation, may switch TGF-beta growth inhibitory effects to tumor promoting responses. CONCLUSION/SIGNIFICANCE: Our data illustrate the capacity of hepatocytes to develop EMT and plasticity under TGF-beta, emphasize the role of HCV core protein in the dynamic of these effects and provide evidence for a paradigm whereby a viral protein implicated in oncogenesis is capable to shift TGF-beta responses from cytostatic effects to EMT development
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