Concert recording 2016-11-08

[Track 1]. Selve amiche / Antonio Caldara -- [Track 2]. Nuit d\u27étoiles / Claude Debussy -- [Track 3]. Silent noon / Ralph Vaughan Williams -- [Track 4]. Der Kuss / Ludwig van Beethoven -- [Track 5]. Dans un bois solitaire / Wolfgang Amadeus Mozart -- [Track 6]. Come ready and see me / Richard Hundley -- [Track 7]. Una donna a quindici anni from Cosi fan tutte / Mozart -- [Track 8]. Spring / Dominick Argento -- [Track 9]. O del mio amato ben / Stefano Donaudy -- [Track 10]. Quando me\u27n vo\u27 from La boheme / Giacomo Puccini -- [Track 11]. O quante volte from I Capuleti e i Montecchi / Vincenzo Bellini -- [Track 12]. Pierrot / Debussy -- [Track 13]. Frühlingstraum / Franz Schubert -- [Track 14]. The roadside fire / Vaughan Williams -- [Track 15]. Ich trage meine Minne / Richard Strauss -- [Track 16]. Fantoches / Debussy -- [Track 17]. Chanson triste / Henri Duparc -- [Track 18]. Auf dem See / Johannes Brahms -- [Track 19]. Abendempfindung / Mozart -- [Track 20]. Do not go, my love / Richard Hageman -- [Track 21]. Ah, love but a day / Amy Beach -- [Track 22]. Nixe binsefuss / Hugo Wolf -- [Track 23]. Der Engel / Richard Wagner -- [Track 24]. Dreaming / Lori Laitman

Concert recording 2016-11-08

[Track 1]. Selve amiche / Antonio Caldara -- [Track 2]. Nuit d\u27étoiles / Claude Debussy -- [Track 3]. Silent noon / Ralph Vaughan Williams -- [Track 4]. Der Kuss / Ludwig van Beethoven -- [Track 5]. Dans un bois solitaire / Wolfgang Amadeus Mozart -- [Track 6]. Come ready and see me / Richard Hundley -- [Track 7]. Una donna a quindici anni from Cosi fan tutte / Mozart -- [Track 8]. Spring / Dominick Argento -- [Track 9]. O del mio amato ben / Stefano Donaudy -- [Track 10]. Quando me\u27n vo\u27 from La boheme / Giacomo Puccini -- [Track 11]. O quante volte from I Capuleti e i Montecchi / Vincenzo Bellini -- [Track 12]. Pierrot / Debussy -- [Track 13]. Frühlingstraum / Franz Schubert -- [Track 14]. The roadside fire / Vaughan Williams -- [Track 15]. Ich trage meine Minne / Richard Strauss -- [Track 16]. Fantoches / Debussy -- [Track 17]. Chanson triste / Henri Duparc -- [Track 18]. Auf dem See / Johannes Brahms -- [Track 19]. Abendempfindung / Mozart -- [Track 20]. Do not go, my love / Richard Hageman -- [Track 21]. Ah, love but a day / Amy Beach -- [Track 22]. Nixe binsefuss / Hugo Wolf -- [Track 23]. Der Engel / Richard Wagner -- [Track 24]. Dreaming / Lori Laitman

Concert recording 2019-10-27

[Track 1]. Now sleeps the crimson petal / Roger Quilter -- [Track 2]. Ideale / Paolo Tosti -- [Track 3]. Intorno all\u27idol mio / Anthony Cesti -- [Track 4]. Chanson triste / Henri Duparc -- [Track 5]. Son tutta duolol / Alessandro Scarlatti -- [Track 6]. Aprile / P. Tosti -- [Track 7]. Ah, love, but a day! / Amy Beach -- [Track 8]. So shall the lute and harp awake from An Oratorio-Judas Maccebaeus / George Frideric Handel -- [Track 9]. Come again / John Dowland -- [Track 10]. Der kuss / Ludwig van Beethoven -- [Track 11]. An Chloe / W. A. Mozart -- [Track 12]. Auf dem Wasser zu singen / Franz Schubert --[Track 13]. Allerseelen / Richard Strauss -- [Track 14]. I never saw another butterfly. II. Yes, that\u27s the way things are ; [Track 15]. III. Birdsong / Lori Laitman -- [Track 16]. Je dis que rien m\u27epouvante from Carmen / Georges Bizet -- [Track 17]. Che gelinda manina from La Boheme / Giacomo Puccini -- [Track 18]. Kristine Mezines, piano Granada / Agustin Lara -- [Track 19]. My name from Eve-Song / Jake Heggie -- [Track 20]. Do not go, my love / Richard Hageman

Test–retest reliability of freesurfer measurements within and between sites: Effects of visual approval process

In the last decade, many studies have used automated processes to analyze magnetic resonance imaging (MRI) data such as cortical thickness, which is one indicator of neuronal health. Due to the convenience of image processing software (e.g., FreeSurfer), standard practice is to rely on automated results without performing visual inspection of intermediate processing. In this work, structural MRIs of 40 healthy controls who were scanned twice were used to determine the test–retest reliability of FreeSurfer‐derived cortical measures in four groups of subjects—those 25 that passed visual inspection (approved), those 15 that failed visual inspection (disapproved), a combined group, and a subset of 10 subjects (Travel) whose test and retest scans occurred at different sites. Test–retest correlation (TRC), intraclass correlation coefficient (ICC), and percent difference (PD) were used to measure the reliability in the Destrieux and Desikan–Killiany (DK) atlases. In the approved subjects, reliability of cortical thickness/surface area/volume (DK atlas only) were: TRC (0.82/0.88/0.88), ICC (0.81/0.87/0.88), PD (0.86/1.19/1.39), which represent a significant improvement over these measures when disapproved subjects are included. Travel subjects’ results show that cortical thickness reliability is more sensitive to site differences than the cortical surface area and volume. To determine the effect of visual inspection on sample size required for studies of MRI‐derived cortical thickness, the number of subjects required to show group differences was calculated. Significant differences observed across imaging sites, between visually approved/disapproved subjects, and across regions with different sizes suggest that these measures should be used with caution. Hum Brain Mapp 36:3472–3485, 2015. © 2015 Wiley Periodicals, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/113142/1/hbm22856.pd

Bacteroides dorei dominates gut microbiome prior to autoimmunity in Finnish children at high risk for type 1 diabetes

The incidence of the autoimmune disease, type 1 diabetes (T1D), has increased dramatically over the last half century in many developed countries and is particularly high in Finland and other Nordic countries. Along with genetic predisposition, environmental factors are thought to play a critical role in this increase. As with other autoimmune diseases, the gut microbiome is thought to play a potential role in controlling progression to T1D in children with high genetic risk, but we know little about how the gut microbiome develops in children with high genetic risk for T1D. In this study, the early development of the gut microbiomes of 76 children at high genetic risk for T1D was determined using high-throughput 16S rRNA gene sequencing. Stool samples from children born in the same hospital in Turku, Finland were collected at monthly intervals beginning at 4-6 months after birth until 2.2 years of age. Of those 76 children, 29 seroconverted to T1D-related autoimmunity (cases) including 22 who later developed T1D, the remaining 47 subjects remained healthy (controls). While several significant compositional differences in low abundant species prior to seroconversion were found, one highly abundant group composed of two closely related species, Bacteroides dorei and Bacteroides vulgatus, was significantly higher in cases compared to controls prior to seroconversion. Metagenomic sequencing of samples high in the abundance of the B. dorei/vulgatus group before seroconversion, as well as longer 16S rRNA sequencing identified this group as Bacteroides dorei. The abundance of B. dorei peaked at 7.6 months in cases, over 8 months prior to the appearance of the first islet autoantibody, suggesting that early changes in the microbiome may be useful for predicting T1D autoimmunity in genetically susceptible infants. The cause of increased B. dorei abundance in cases is not known but its timing appears to coincide with the introduction of solid food.</p

Bacteroides dorei dominates gut microbiome prior to autoimnnunity in Finnish children at high risk for type 1 diabetes

Peer reviewe

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015 : a systematic analysis for the Global Burden of Disease Study 2015

Background Improving survival and extending the longevity of life for all populations requires timely, robust evidence on local mortality levels and trends. The Global Burden of Disease 2015 Study (GBD 2015) provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015. These results informed an in-depth investigation of observed and expected mortality patterns based on sociodemographic measures. Methods We estimated all-cause mortality by age, sex, geography, and year using an improved analytical approach originally developed for GBD 2013 and GBD 2010. Improvements included refinements to the estimation of child and adult mortality and corresponding uncertainty, parameter selection for under-5 mortality synthesis by spatiotemporal Gaussian process regression, and sibling history data processing. We also expanded the database of vital registration, survey, and census data to 14 294 geography-year datapoints. For GBD 2015, eight causes, including Ebola virus disease, were added to the previous GBD cause list for mortality. We used six modelling approaches to assess cause-specific mortality, with the Cause of Death Ensemble Model (CODEm) generating estimates for most causes. We used a series of novel analyses to systematically quantify the drivers of trends in mortality across geographies. First, we assessed observed and expected levels and trends of cause-specific mortality as they relate to the Socio-demographic Index (SDI), a summary indicator derived from measures of income per capita, educational attainment, and fertility. Second, we examined factors affecting total mortality patterns through a series of counterfactual scenarios, testing the magnitude by which population growth, population age structures, and epidemiological changes contributed to shifts in mortality. Finally, we attributed changes in life expectancy to changes in cause of death. We documented each step of the GBD 2015 estimation processes, as well as data sources, in accordance with Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Findings Globally, life expectancy from birth increased from 61.7 years (95% uncertainty interval 61.4-61.9) in 1980 to 71.8 years (71.5-72.2) in 2015. Several countries in sub-Saharan Africa had very large gains in life expectancy from 2005 to 2015, rebounding from an era of exceedingly high loss of life due to HIV/AIDS. At the same time, many geographies saw life expectancy stagnate or decline, particularly for men and in countries with rising mortality from war or interpersonal violence. From 2005 to 2015, male life expectancy in Syria dropped by 11.3 years (3.7-17.4), to 62.6 years (56.5-70.2). Total deaths increased by 4.1% (2.6-5.6) from 2005 to 2015, rising to 55.8 million (54.9 million to 56.6 million) in 2015, but age-standardised death rates fell by 17.0% (15.8-18.1) during this time, underscoring changes in population growth and shifts in global age structures. The result was similar for non-communicable diseases (NCDs), with total deaths from these causes increasing by 14.1% (12.6-16.0) to 39.8 million (39.2 million to 40.5 million) in 2015, whereas age-standardised rates decreased by 13.1% (11.9-14.3). Globally, this mortality pattern emerged for several NCDs, including several types of cancer, ischaemic heart disease, cirrhosis, and Alzheimer's disease and other dementias. By contrast, both total deaths and age-standardised death rates due to communicable, maternal, neonatal, and nutritional conditions significantly declined from 2005 to 2015, gains largely attributable to decreases in mortality rates due to HIV/AIDS (42.1%, 39.1-44.6), malaria (43.1%, 34.7-51.8), neonatal preterm birth complications (29.8%, 24.8-34.9), and maternal disorders (29.1%, 19.3-37.1). Progress was slower for several causes, such as lower respiratory infections and nutritional deficiencies, whereas deaths increased for others, including dengue and drug use disorders. Age-standardised death rates due to injuries significantly declined from 2005 to 2015, yet interpersonal violence and war claimed increasingly more lives in some regions, particularly in the Middle East. In 2015, rotaviral enteritis (rotavirus) was the leading cause of under-5 deaths due to diarrhoea (146 000 deaths, 118 000-183 000) and pneumococcal pneumonia was the leading cause of under-5 deaths due to lower respiratory infections (393 000 deaths, 228 000-532 000), although pathogen-specific mortality varied by region. Globally, the effects of population growth, ageing, and changes in age-standardised death rates substantially differed by cause. Our analyses on the expected associations between cause-specific mortality and SDI show the regular shifts in cause of death composition and population age structure with rising SDI. Country patterns of premature mortality (measured as years of life lost [YLLs]) and how they differ from the level expected on the basis of SDI alone revealed distinct but highly heterogeneous patterns by region and country or territory. Ischaemic heart disease, stroke, and diabetes were among the leading causes of YLLs in most regions, but in many cases, intraregional results sharply diverged for ratios of observed and expected YLLs based on SDI. Communicable, maternal, neonatal, and nutritional diseases caused the most YLLs throughout sub-Saharan Africa, with observed YLLs far exceeding expected YLLs for countries in which malaria or HIV/AIDS remained the leading causes of early death. Interpretation At the global scale, age-specific mortality has steadily improved over the past 35 years; this pattern of general progress continued in the past decade. Progress has been faster in most countries than expected on the basis of development measured by the SDI. Against this background of progress, some countries have seen falls in life expectancy, and age-standardised death rates for some causes are increasing. Despite progress in reducing age-standardised death rates, population growth and ageing mean that the number of deaths from most non-communicable causes are increasing in most countries, putting increased demands on health systems. Copyright (C) The Author(s). Published by Elsevier Ltd.Peer reviewe

SIGN Fracture Care - Negative Pressure Wound Therapy System

Negative pressure wound therapy (NPWT) is a method of healing wounds by applying continuous suction to the affected area. Existing NPWT devices are often too expensive and electrically dependent to be used in low-resource settings of developing countries. The UP capstone team designed and developed an easily assembled, mechanical device to increase accessibility to NPWT in developing countries at a more affordable price.https://pilotscholars.up.edu/egr_project/1036/thumbnail.jp

Unconventional Monetary Policy

The Federal Reserve has significant control over several factors in the economy including their ability to indirectly affect certain targets through their actions and policies. The Federal Reserve has also developed many new strategies to affect certain targets, popularly known as unconventional monetary policy tools. Our research involves analyzing these different tools that the Federal Reserve has implemented since the recession of 2008. In particular, how these tools were actually used by comparing the actions that proceeded the recession with actions that followed it. This will build an understanding of how these tools affected the economy and how we are measuring their effectiveness. The unconventional monetary policy tools that we analyze include Interest on Reserves, Quantitative Easing, Balance Sheet Normalization, Margin Requirements, Forward Guidance, Open Market Operations, etc. We take an in-depth look at these tools to extend our understating of why they had a significant impact over other tools and why we continue to use some of them today. We also cover tools that were created but ultimately discontinued such as the Money Market Investor Funding Facility (MMIF), Commercial Paper Funding Facility (CPPF), and Primary Dealer Credit Facility. These tools are included in the study to specifically shed light on the ineffectiveness of these tools and to avoid any similar errors in the future, if any. The overall goal is to differentiate between why some of these tools were more effective than others in their efficiency to affect markets and the economy as a whole. Once that is established, a policy can be created for developing countries on what tools they can implement in order to boost their own economies. The usefulness of all these tools on the banking and investment side of business appeals to a wide audience. The study improves our understanding of how the actions of the Fed affect the economy in which we live in. It will also enhance greater economic literacy and an ability to better examine economic policy within the democracy that we live in