36 research outputs found
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
- Antonelli M
- Antonello M
- Antonioli P
- Antusch S
- Anulli F
- Apolinario L
- Apollinari G
- Apollonio A
- Appeloe D
- Appleby RB
- Apyan A
- Apyan A
- Arbey A
- Arbuzov A
- Arduini G
- Ari V
- Arias S
- Armesto N
- Arnaldi R
- Arsenyev SA
- Arzeo M
- Asai S
- Aslanides E
- Assmann RW
- Astapovych D
- Atanasov M
- Atieh S
- Attie D
- Auchmann B
- Audurier A
- Aull S
- Aumon S
- Aune S
- Avino F
- Avrillaud G
- Aydin G
- Azatov A
- Azuelos G
- Azzi P
- Azzolini O
- Azzurri P
- Bacchetta N
- Bacchiocchi E
- Bachacou H
- Baek YW
- Baglin V
- Bai Y
- Baird S
- Baker MJ
- Baldwin MJ
- Ball AH
- Ballarino A
- Banerjee S
- Barber DP
- Barducci D
- Barjhoux P
- Barna D
- Barnafoldi GG
- Barnes MJ
- Barr A
- Barranco Garcia J
- Barreiro Guimaraes da Costa J
- Bartmann W
- Baryshevsky V
- Barzi E
- Bass SA
- Bastianin A
- Baudouy B
- Bauer F
- Bauer M
- Baumgartner T
- Bautista-Guzman I
- Bayindir C
- Beaudette F
- Bedeschi F
- Beguin M
- Bellafont I
- Bellagamba L
- Bellegarde N
- Belli E
- Bellingeri E
- Bellini F
- Bellomo G
- Belomestnykh S
- Bencivenni G
- Benedikt M
- Bernardi G
- Bernardi J
- Bernet C
- Bernhardt JM
- Bernini C
- Berriaud C
- Bertarelli A
- Bertolucci S
- Besana MI
- Besancon M
- Beznosov O
- Bhat C
- Bhat P
- Biagini ME
- Biarrotte J-L
- Bibet Chevalier A
- Bielert ER
- Biglietti M
- Bilei GM
- Bilki B
- Biscari C
- Bishara F
- Blanco-Garcia OR
- Blanquez FR
- Blekman F
- Blondel A
- Bluemlein J
- Boccali T
- Boels R
- Bogacz SA
- Bogomyagkov A
- Boine-Frankenheim O
- Boland MJ
- Bologna S
- Bolukbasi O
- Bomben M
- Bondarenko S
- Bonvini M
- Boos E
- Bordini B
- Bordry F
- Borghello G
- Borgonovi L
- Borowka S
- Bortoletto D
- Boscherini D
- Boscolo M
- Boselli S
- Bosley RR
- Bossu F
- Botta C
- Bottura L
- Boughezal R
- Boutin D
- Bovone G
- Bozbey A
- Bozovic Jelisavic I
- Bozzi C
- Bozzini D
- Braccini V
- Braibant-Giacomelli S
- Bramante J
- Braun-Munzinger P
- Briffa JA
- Britzger D
- Brodsky SJ
- Brooke JJ
- Bruce R
- Bruckman De Renstrom P
- Bruna E
- Bruning O
- Brunner K
- Brunner O
- Bruzzone P
- Buffat X
- Bulyak E
- Burkart F
- Burkhardt H
- Burnet J-P
- Butin F
- Buttazzo D
- Butterworth A
- Caccia M
- Cai Y
- Caiffi B
- Cairo V
- Cakir O
- Calaga R
- Calatroni S
- Calderini G
- Calderola G
- Caliskan A
- Calvet D
- Calviani M
- Camalich JM
- Camarri P
- Campanelli M
- Camporesi T
- Canbay AC
- Canepa A
- Cantergiani E
- Cantore-Cavalli D
- Capeans M
- Cardarelli R
- Cardella U
- Cardini A
- Carloni Calame CM
- Carra F
- Carra S
- Carvalho A
- Casalbuoni S
- Casas J
- Cascella M
- Castelnovo P
- Castorina G
- Catalano G
- Cavasinni V
- Cazzato E
- Cennini E
- Cerri A
- Cerutti F
- Cervantes J
- Chaikovska I
- Chakrabortty J
- Chala M
- Chamizo-Llatas M
- Chanal D
- Chanal H
- Chance A
- Chance S
- Charitos P
- Charles J
- Charles TK
- Chattopadhyay S
- Chehab R
- Chekanov SV
- Chen N
- Chernoded A
- Chetvertkova V
- Chevalier L
- Chiarelli G
- Chiarello G
- Chiesa M
- Chiggiato P
- Childers JT
- Chmielinska A
- Cholakian A
- Chomaz P
- Chorowski M
- Chou W
- Chrzaszcz M
- Chyhyrynets E
- Cibinetto G
- Ciftci AK
- Ciftci R
- Cimino R
- Ciuchini M
- Clark PJ
- Coadou Y
- Cobal M
- Coccaro A
- Cogan J
- Cogneras E
- Collamati F
- Colldelram C
- Collier P
- Collot J
- Contino R
- Conventi F
- Cook CTA
- Cooley L
- Corcella G
- Cornell AS
- Corral GH
- Correia-Rodrigues H
- Costa Pinto P
- Costanza F
- Couderc F
- Coupard J
- Craig N
- Crespo Garrido I
- Crivellin A
- Croteau JF
- Crouch M
- Cruz Alaniz E
- Cure B
- Curti J
- Curtin D
- Czech M
- D'Agnolo RT
- D'Aloia Schwartzentruber L
- D'Ambrosio G
- D'Auria S
- D'Auria V
- d'Enterria D
- D'Onofrio M
- da Silva W
- da Silveira GG
- Dachauer C
- Daibo M
- Dainese A
- Dalena B
- Daljevec A
- Dallapiazza W
- Dam M
- Das SP
- DasBakshi S
- David A
- Davidek T
- de Blas J
- De Curtis S
- De Filippis N
- de Florian D
- de Jong SJ
- De Lucia E
- de Rijk G
- De Roeck A
- de Vivie de Regie JB
- Deandrea A
- Debono CJ
- Deghaye S
- Del Bo C
- Del Duca V
- Delikaris D
- Deliot F
- Dell'Acqua A
- Delle Rose L
- Delmastro M
- Demarteau M
- Denegri D
- Deniau L
- Denisov D
- Denizli H
- Denner A
- Derue F
- Deschamps O
- Descotes-Genon S
- Dev PSB
- Dewanjee RK
- Di Ciaccio A
- Di Cicco A
- Di Micco B
- Di Nezza P
- Di Vita S
- Dillon BM
- Doblhammer A
- Dominjon A
- Dordei F
- Drago A
- Draper P
- Drasal Z
- Drewes M
- du Pree T
- Duarte L
- Dubovyk I
- Duda P
- Dudarev A
- Dudko L
- Duellmann D
- Dunser M
- Duran Yildiz H
- Durante M
- Dutta S
- Duval F
- Duval JM
- Dydyshka Y
- Dziewit B
- Eisenhardt S
- Eisterer M
- Ekelof T
- El Khechen D
- Ellis J
- Ellis SA
- Ellison JA
- Elsener K
- Elsing M
- Enari Y
- Englert C
- Eriksson H
- Eskola KJ
- Esposito LS
- Etisken O
- Etzion E
- Fabbricatore P
- Falkowski A
- Falou A
- Faltova J
- Fan J
- Fano L
- Farilla A
- Farinelli R
- Farinon S
- Faroughy DA
- Fartoukh SD
- Faus-Golfe A
- Fawcett WJ
- Felici G
- Felsberger L
- Ferdeghini C
- Fernandez Navarro AM
- Fernandez-Tellez A
- Ferradas Troitino J
- Ferrara G
- Ferrari R
- Ferreira da Silva P
- Ferreira L
- Ferrera G
- Ferro F
- Fiascaris M
- Fiorendi S
- Fiorio C
- Fischer E
- Fischer O
- Flieger W
- Florio M
- Fonnesu D
- Fontanesi E
- Foppiani N
- Foraz K
- Forkel-Wirth D
- Forte S
- Fouaidy M
- Fournier D
- Fowler T
- Fox J
- Francavilla P
- Franceschini R
- Franchino S
- Franco E
- Freitas A
- Fuks B
- Furukawa K
- Furuseth SV
- Gabrielli E
- Gaddi A
- Galanti M
- Gallo E
- Ganjour S
- Gao J
- Gao J
- Garcia Diaz V
- Garcia Perez M
- Garcia Tabares L
- Garion C
- Garzelli MV
- Garzia I
- Gascon-Shotkin SM
- Gaudio G
- Gay P
- Ge S-F
- Gehrmann T
- Genest MH
- Gerard R
- Gerigk F
- Gerwig H
- Giacomelli P
- Giagu S
- Gianfelice-Wendt E
- Gianotti F
- Giffoni F
- Gil Costa M
- Gilardoni SS
- Giovannetti M
- Giovannozzi M
- Giubellino P
- Giudice GF
- Giunta A
- Gladilin LK
- Glukhov S
- Gluza J
- Gobbi G
- Goddard B
- Goertz F
- Golling T
- Goncalo R
- Goncalves VP
- Gonzalez Gomez LA
- Gorgi Zadeh S
- Gorine G
- Gorini E
- Gourlay SA
- Gouskos L
- Grancagnolo F
- Grassellino A
- Grau A
- Graverini E
- Gray HM
- Greco M
- Greco M
- Grenard J-L
- Grimm O
- Grojean C
- Gromov VA
- Grosse-Oetringhaus JF
- Grudiev A
- Grzanka K
- Gu J
- Guadagnoli D
- Guidi V
- Guiducci S
- Guillermo Canton G
- Gunaydin YO
- Gupta R
- Gupta RS
- Gutierrez J
- Gutleber J
- Guyot C
- Guzey V
- Gwenlan C
- Haberstroh C
- Hacisahinoglu B
- Haerer B
- Hahn K
- Hahn T
- Hammad A
- Han C
- Hance M
- Hannah A
- Harris PC
- Hati C
- Haug S
- Hauptman J
- Haurylavets V
- He H-J
- Hegglin A
- Hegner B
- Heinemann K
- Heinemeyer S
- Helsens C
- Henriques A
- Henriques A
- Hernandez P
- Hernandez-Pinto RJ
- Hernandez-Sanchez J
- Herzig T
- Hiekkanen I
- Hillert W
- Hoehn T
- Hofer M
- Hofle W
- Holdener F
- Holleis S
- Holzer B
- Hong DK
- Honorato CG
- Hopkins SC
- Hrdinka J
- Hug F
- Humann B
- Humer H
- Hurth T
- Hutton A
- Iacobucci G
- Ibarrola N
- Iconomidou-Fayard L
- Ilyina-Brunner K
- Incandela J
- Infantino A
- Ippolito V
- Ishino M
- Islam R
- Ita H
- Ivanovs A
- Iwamoto S
- Iyer A
- Izquierdo Bermudez S
- Jadach S
- Jamin DO
- Janot P
- Jarry P
- Jeff A
- Jenny P
- Jensen E
- Jensen M
- Jiang X
- Jimenez JM
- Jones MA
- Jones OR
- Jowett JM
- Jung S
- Kaabi W
- Kado M
- Kahle K
- Kalinovskaya L
- Kalinowski J
- Kamenik JF
- Kannike K
- Kara SO
- Karadeniz H
- Karaventzas V
- Karpov I
- Kartal S
- Karyukhin A
- Kashikhin V
- Katharina Behr J
- Kaya U
- Keintzel J
- Keinz PA
- Keppel K
- Kersevan R
- Kershaw K
- Khanpour H
- Khatibi S
- Khatiri Yanehsari M
- Khoze VV
- Kieseler J
- Kilic A
- Kilpinen A
- Kim DW
- Kim Y-K
- Klein M
- Klein U
- Kling F
- Klinkenberg N
- Kloeppel S
- Klute M
- Klyukhin VI
- Knecht M
- Kniehl B
- Kocak F
- Koeberl C
- Kolano AM
- Kollegger A
- Kolodziej K
- Kolomiets AA
- Komppula J
- Koop I
- Koppenburg P
- Koratzinos M
- Kordiaczynska M
- Korjik M
- Kortner O
- Kostka P
- Kotlarski W
- Kotnig C
- Kottig T
- Kotwal AV
- Kovalenko AD
- Kowalski S
- Kozaczuk J
- Kozlov GA
- Kozub SS
- Kraemer M
- Krainer AM
- Kramer T
- Krammer M
- Krasnov AA
- Krauss F
- Kravalis K
- Kretzschmar L
- Kriske RM
- Kritscher H
- Krkotic P
- Kroha H
- Kucharczyk M
- Kuday S
- Kuendig A
- Kuhlmann G
- Kulesza A
- Kumar M
- Kumar M
- Kusina A
- Kuttimalai S
- Kuze M
- Kwon T
- La Francesca E
- La Mendola S
- Lackner F
- Lackner M
- Laine M
- Lamanna G
- Lancon E
- Landsberg G
- Langacker P
- Lange C
- Langner A
- Lankford AJ
- Lansberg JP
- Lari T
- Laycock PJ
- Le Guen P
- Lebrun P
- Lechner A
- Lee K
- Lee R
- Lee S
- Lefevre T
- Lehtinen T
- Leith SB
- Lenzi P
- Leogrande E
- Leon-Monzon I
- Leonidopoulos C
- Lerner G
- Leroy O
- Lesiak T
- Levai P
- Leveratto A
- Levichev E
- Li G
- Li R
- Li S
- Liberati D
- Liepe M
- Lissauer DA
- Liu Z
- Lobko A
- Locci E
- Logothetis Agaliotis E
- Lombardo MP
- Long AJ
- Lorin C
- Losito R
- Louzguiti A
- Low I
- Lucchesi D
- Lucchini MT
- Luciani A
- Lueckhof M
- Lunt AJG
- Luzum M
- Lyubimtsev DA
- Maggiora M
- Magnin N
- Mahmoud MA
- Mahmoudi F
- Maitre J
- Makarenko V
- Malagoli A
- Malcles J
- Malgeri L
- Mallon PJ
- Maltoni F
- Malvezzi S
- Malyshev OB
- Mancinelli G
- Mandrik P
- Manfrinetti P
- Mangano M
- Manil P
- Mannelli M
- Marchiori G
- Marhauser F
- Mariani V
- Marinozzi V
- Mariotto S
- Marquard P
- Marquet C
- Marriott-Dodington T
- Martin Camalich J
- Martin O
- Martin R
- Martinez Bruzual H
- Martinez T
- Martinez-Hernandez MI
- Martins DE
- Marzani S
- Marzocca D
- Marzola L
- Masciocchi S
- Masina I
- Massimiliano A
- Massironi A
- Masubuchi T
- Matveev VA
- Mazzoni MA
- McCullough M
- McIntosh PA
- Meade P
- Medina L
- Meier A
- Meignan J
- Mele B
- Mendes Saraiva JG
- Menez F
- Mentink M
- Meoni E
- Meridiani P
- Merk M
- Mermod P
- Mertens V
- Mether L
- Metral E
- Migliorati M
- Milanese A
- Milardi C
- Milhano G
- Militsyn BL
- Millet F
- Minashvili I
- Minervini JV
- Miralles LS
- Mirarchi D
- Mishima S
- Missiaen DP
- Mitselmakher G
- Mitshuhashi T
- Mnich J
- Mohammadi Najafabadi M
- Mohapatra RN
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- Molson JG
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- Moortgat F
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- Moreno Llacer M
- Moretti M
- Moretti S
- Morley AK
- Moros A
- Morozov I
- Morretta V
- Morrone M
- Mostacci A
- Muanza S
- Muchnoi N
- Mueller A-S
- Mueller F
- Muhlegger M
- Mulder M
- Mulders M
- Muller B
- Munilla J
- Murray MJ
- Muttoni Y
- Myers S
- Mylona M
- Nachtman J
- Nakamoto T
- Nardecchia M
- Nardini G
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- Nergiz Z
- Nesterenko AV
- Netto JA
- Nettstraeter A
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- Neundorf J
- Niccoli F
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- Nie Y
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- Niedziela J
- Niemi A
- Nikitin SA
- Nisati A
- No JM
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- Nosochkov Y
- Novak M
- Novokhatski A
- O'Callaghan JM
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- Ogur S
- Ohmi K
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- Okorokov VA
- Okumura Y
- Oleari C
- Olness FI
- Onel Y
- Ortino M
- Osborne J
- Osland P
- Otto T
- Oyulmaz KY
- Ozansoy A
- Ozcan V
- Ozdemir K
- Pagliarone CE
- Pais da Silva HF
- Palmieri E
- Palumbo L
- Pampaloni A
- Pan R-Q
- Panareo M
- Panella O
- Panico G
- Panizzo G
- Pankov AA
- Pantsyrny V
- Papadopoulos CG
- Papaefstathiou A
- Papaphilippou Y
- Parker MA
- Parma V
- Pasquali M
- Patra SK
- Patterson R
- Paukkunen H
- Pauss F
- Peggs S
- Penttinen J-P
- Peon G
- Perepelkin EE
- Perez Codina E
- Perez Morales J
- Perez E
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- Perez JC
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- Peruzzi M
- Pes C
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- Petracca S
- Petriello F
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- Pfeiffer S
- Piccinini F
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- Pierini M
- Pikhartova H
- Pikurs G
- Pilicer E
- Piminov P
- Pira C
- Pittau R
- Placzek W
- Plagge M
- Plehn T
- Pleier M-A
- Ploskon M
- Podeur M
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- Podzorny T
- Poggioli L
- Poiron A
- Polesello G
- Poli Lener M
- Polini A
- Polinski J
- Polozov SM
- Ponce L
- Pont M
- Pontecorvo L
- Portaluri T
- Potamianos K
- Prasse C
- Prausa M
- Preinerstorfer A
- Premat E
- Price T
- Primavera M
- Prino F
- Prioli M
- Proudfoot J
- Provino A
- Pugnat T
- Pukhaeva N
- Pulawski S
- Pulikowski D
- Punzi G
- Putti M
- Pyarelal A
- Quack H
- Quispe M
- Racioppi A
- Rafique H
- Raginel V
- Raidal M
- Ramirez-Uribe NS
- Ramsey-Musolf MJ
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- Redaelli S
- Renner E
- Renteria-Olivo AE
- Rescigno M
- Reuter J
- Ribon A
- Ricci AM
- Riegler W
- Riemann B
- Riemann S
- Riemann T
- Rifflet JM
- Rimmer RA
- Rinaldesi R
- Rinolfi L
- Rios Rubiras O
- Risselada T
- Rivetti A
- Rivkin L
- Rizzo T
- Robens T
- Robert F
- Robson AJ
- Rochepault E
- Roda C
- Rodrigo G
- Rodriguez-Cahuantzi M
- Rogan C
- Roig M
- Rojas-Torres S
- Rojo J
- Rolandi G
- Rolando G
- Roloff P
- Romanenko A
- Romanov A
- Roncarolo F
- Rosado Sanchez A
- Rosaz G
- Rossi A
- Rossi L
- Rossmanith R
- Rousset B
- Royon C
- Ruan X
- Ruehl I
- Ruhlmann-Kleider V
- Ruiz R
- Rumyantsev L
- Ruprecht R
- Ryazanov AI
- Saba A
- Sadykov R
- Saez de Jauregui D
- Sahin M
- Sailer B
- Saito M
- Sala F
- Salam GP
- Salfeld-Nebgen J
- Salgado CA
- Salini S
- Sallese JM
- Salmi T
- Salzburger A
- Sampayo OA
- Sanfilippo S
- Santiago J
- Santopinto E
- Santoro R
- Sanz Ull A
- Sarasola X
- Sarpun IH
- Sauvain M
- Savelyeva S
- Sawada R
- Sborlini GFR
- Schaffer A
- Schaumann M
- Schenk M
- Scheuerlein C
- Schienbein I
- Schlenga K
- Schmickler H
- Schmidt R
- Schoerling D
- Schoerner-Sadenius T
- Schoning A
- Schott M
- Schulte D
- Schwaller P
- Schwanenberger C
- Schwemling P
- Schwerg N
- Scibile L
- Sciuto A
- Scomparin E
- Sebastiani C
- Seeber B
- Segreti M
- Selva P
- Selvaggi M
- Senatore C
- Senol A
- Serin L
- Serluca M
- Serra N
- Seryi A
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- Sfyrla A
- Shaposhnikov M
- Shaposhnikova E
- Sharkov BY
- Shatilov D
- Shelton J
- Shiltsev V
- Shipsey IP
- Shirkov GD
- Shivaji A
- Shwartz D
- Sian T
- Sidorov S
- Siemko A
- Silvestrini L
- Simand N
- Simon F
- Singh BK
- Siodmok A
- Sirois Y
- Sirtori E
- Sirvinskaite R
- Sitar B
- Sjostrand T
- Skands P
- Skordis E
- Skovpen K
- Skrzypek M
- Slade E
- Slavich P
- Slovak R
- Smaluk V
- Smirnov V
- Snoeys W
- Soffi L
- Sollander P
- Solovyanov O
- Soltveit HK
- Song H
- Sopicki P
- Sorbi M
- Spallino L
- Spannowsky M
- Spataro B
- Sphicas P
- Spiesberger H
- Spiller P
- Spira M
- Srivastava T
- Stachel J
- Stakia A
- Stanyard JL
- Starchenko E
- Starikov AY
- Stasto AM
- Statera M
- Steerenberg R
- Steggemann J
- Stenvall A
- Stivanello F
- Stoeckinger D
- Stoeger-Pollach M
- Stoel LS
- Strauss B
- Stuart M
- Stupakov G
- Su S
- Sublet A
- Sugita K
- Sulak L
- Sullivan MK
- Sultansoy S
- Sumida T
- Suzuki K
- Sylva G
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- Taborelli M
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- Tal Hod E
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- The FCC Collaboration
- Thomas S
- Tiirakari MT
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- Yang G
- Yang HJ
- Yao W-M
- Yazgan E
- Yermolchik V
- Yilmaz A
- Yilmaz A
- Yoo H-D
- Yost SA
- You T
- Young C
- Yu F
- Yu T-T
- Zaborowska A
- Zadeh SG
- Zahnd M
- Zanetti M
- Zanotto L
- Zawiejski L
- Zeiler P
- Zerlauth M
- Zernov SM
- Zevi Dell Porta G
- Zhang C
- Zhang H
- Zhang Y
- Zhang Z
- Zhao Z
- Zhong Y-M
- Zhou D
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- Zhuang P
- Zick G
- Zimmermann F
- Zinn-Justin J
- Zivkovic L
- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agaliotis EL
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alexahin Y
- Alia RG
- Alioli S
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
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- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
- Antinori F
- Antipov SA
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- Appleby RB
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- Ari V
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- Assmann RW
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- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/06/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with todayâs technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
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- Aguilera-Verdugo JJ
- Ahnen JV
- Aiba M
- Aichinger I
- Aielli G
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- Akhundov A
- Aksakal H
- Alaniz EC
- Albacete JL
- Albergo S
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- Alexahin Y
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- Publication venue
- 'Springer Fachmedien Wiesbaden GmbH'
- Publication date
- 01/06/2019
- Field of study
We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics
FCC-ee: The Lepton Collider â Future Circular Collider Conceptual Design Report Volume 2
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- AlĂa R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
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- Anulli F.
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- Yilmaz A.
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- Zurita J.
- Ăzcan V.
- Ăzdemir K.
- Publication venue
- Springer Verlag
- Publication date
- 14/11/2019
- Field of study
HE-LHC: The High-Energy Large Hadron Collider â Future Circular Collider Conceptual Design Report Volume 4
- Author
- Abada A.
- Abbrescia M.
- AbdusSalam S. S.
- Abdyukhanov I.
- Abelleira Fernandez J.
- Abramov A.
- Aburaia M.
- Acar A. O.
- Adzic P. R.
- Agrawal P.
- Aguilar-Saavedra J. A.
- Aguilera-Verdugo J. J.
- Ahnen J. von
- Aiba M.
- Aichinger I.
- Aielli G.
- Akay A.
- Akhundov A.
- Aksakal H.
- Albacete J. L.
- Albergo S.
- Alekou A.
- Aleksa M.
- Aleksan R.
- Alemany Fernandez R. M.
- Alexahin Y.
- Alioli S.
- Alipour Tehrani N.
- Allanach B. C.
- Allport P. P.
- Altınlı M.
- Altmannshofer W.
- AlĂa R. G.
- Ambrosio G.
- Amorim D.
- Amstutz O.
- Anderlini L.
- Andreazza A.
- Andreini M.
- Andriatis A.
- Andris C.
- Andronic A.
- Angelucci M.
- Antinori F.
- Antipov S. A.
- Antonelli M.
- Antonello M.
- Antonioli P.
- Antusch S.
- Anulli F.
- ApolinĂĄrio L.
- Apollinari G.
- Apollonio A.
- Appelö D.
- Appleby R. B.
- Apyan A.
- Apyan A.
- Arbey A.
- Arbuzov A.
- Arduini G.
- Arı V.
- Arias S.
- Armesto N.
- Arnaldi R.
- Arsenyev S. A.
- Arzeo M.
- Asai S.
- Aslanides E.
- Astapovych D.
- Atanasov M.
- Atieh S.
- Attié D.
- Auchmann B.
- Audurier A.
- Aull S.
- Aumon S.
- Aune S.
- Avino F.
- Avrillaud G.
- Aydın G.
- Azatov A.
- Azuelos G.
- Azzi P.
- Azzolini O.
- Azzurri P.
- AĂmann R. W.
- Bacchetta N.
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- Publication venue
- Springer Verlag
- Publication date
- 09/02/2021
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
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- Aguilera-Verdugo JJ
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- Aichinger I
- Aielli G
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- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
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- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
HE-LHC: The High-Energy Large Hadron Collider
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
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- Acar AO
- Adzic PR
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 18/12/2018
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
FCC-hh: The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- Author
- Abada A
- Abbrescia M
- AbdusSalam SS
- Abdyukhanov I
- Abelleira Fernandez J
- Abramov A
- Aburaia M
- Acar AO
- Adzic PR
- Agrawal P
- Aguilar-Saavedra JA
- Aguilera-Verdugo JJ
- Aiba M
- Aichinger I
- Aielli G
- Akay A
- Akhundov A
- Aksakal H
- Albacete JL
- Albergo S
- Alekou A
- Aleksa M
- Aleksan R
- Alemany Fernandez RM
- Alexahin Y
- Alia RG
- Alioli S
- Alipour Tehrani N
- Allanach BC
- Allport PP
- Altinli M
- Altmannshofer W
- Ambrosio G
- Amorim D
- Amstutz O
- Anderlini L
- Andreazza A
- Andreini M
- Andriatis A
- Andris C
- Andronic A
- Angelucci M
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- Antipov SA
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- Thomas S
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- Yilmaz A
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- Zlobin AV
- Zobov M
- Zupan J
- Zurita J
- Publication venue
- SPRINGER HEIDELBERG
- Publication date
- 01/07/2019
- Field of study
In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries
Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer.
- Author
- A Grothey
- A Sadanandam
- A Sparmann
- AA Samatar
- AG Gilmartin
- Alexis De Haven Brandon
- Alistair G. Rust
- Anguraj Sadanandam
- Annette Self
- AT Boutin
- B Ancrile
- BB Ancrile
- C Berthon
- C Sun
- Cancer Genome Atlas N.
- Caterina Mancusi
- Clare M. Isacke
- CM Emery
- David Cunningham
- DM Knight
- DS Shouval
- E Cerami
- E Cutsem Van
- E Cutsem Van
- E Manchado
- E Nicodeme
- Floriana Manodoro
- G Vlachogiannis
- Gary Box
- Georgios Vlachogiannis
- H Clevers
- H Hurwitz
- HG Golay
- Ioannis Assiotis
- J Barretina
- J Blagg
- J Gao
- J TerziÄ
- JD Brown
- JE Delmore
- Jeremy Lewin
- JR Infante
- JS Zawistowski
- K Sakamoto
- Kate Eason
- Khurum Khan
- KT Flaherty
- LD Wood
- Liam Jenkins
- M Nagarkatti
- M Romano
- M Wislez
- Melanie Valenti
- Naureen Starling
- Nicola Valeri
- Nik Matthews
- P Filippakopoulos
- P Lito
- P Workman
- Penny Robinson
- Ritika Chauhan
- SI Grivennikov
- SM Crusz
- SR Whittaker
- SR Whittaker
- Steve Wagner
- Steven R. Whittaker
- T Hickish
- T Jamieson
- T Raedt De
- TI Roumeliotis
- V Gelfo
- Vladimir Kirkin
- W Luo
- Y Ma
- Z Zou
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2019
- Field of study
Despite showing clinical activity in BRAF-mutant melanoma, the MEK inhibitor (MEKi) trametinib has failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify mechanisms of resistance to MEKi, we employed a pharmacogenomic analysis of MEKi-sensitive versus MEKi-resistant colorectal cancer cell lines. Strikingly, interferon- and inflammatory-related gene sets were enriched in cell lines exhibiting intrinsic and acquired resistance to MEK inhibition. The bromodomain inhibitor JQ1 suppressed interferon-stimulated gene (ISG) expression and in combination with MEK inhibitors displayed synergistic effects and induced apoptosis in MEKi-resistant colorectal cancer cell lines. ISG expression was confirmed in patient-derived organoid models, which displayed resistance to trametinib and were resensitized by JQ1 co-treatment. In in vivo models of colorectal cancer, combination treatment significantly suppressed tumor growth. Our findings provide a novel explanation for the limited response to MEK inhibitors in KRAS-mutant colorectal cancer, known for its inflammatory nature. Moreover, the high expression of ISGs was associated with significantly reduced survival of colorectal cancer patients. Excitingly, we have identified novel therapeutic opportunities to overcome intrinsic and acquired resistance to MEK inhibition in colorectal cancer
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
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- de la Fuente Carmen
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- Ebenezer R
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- Gordon Anthony C.
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- Hall Alistair S
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- Hornsby James
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- Horvat Christopher M.
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- Krishnamurthy Vinodh
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- Wright Kim
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- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 nonâcritically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (nâ=â257), ARB (nâ=â248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; nâ=â10), or no RAS inhibitor (control; nâ=â264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ supportâfree days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ supportâfree days among critically ill patients was 10 (â1 to 16) in the ACE inhibitor group (nâ=â231), 8 (â1 to 17) in the ARB group (nâ=â217), and 12 (0 to 17) in the control group (nâ=â231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ supportâfree days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570