Transport Dynamics of Broad Resonances

The propagation of short life time particles with consequently broad mass width are discussed in the context of transport descriptions. In the first part some known properties of finite life time particles such as resonances are reviewed and discussed at the example of the $\rho$-meson. Grave deficiencies in some of the transport treatment of broad resonances are disclosed and quantified. The second part addresses the derivation of transport equations which permit to account for the damping width of the particles. Baym's $\Phi$-derivable method is used to derive a self-consistent and conserving scheme, which fulfils detailed balance relations even in the case of particles with broad mass distributions. For this scheme a conserved energy-momentum tensor can be constructed. Furthermore, a kinetic entropy can be derived which besides the standard quasi-particle part also includes contributions from fluctuations.Comment: Talk presented on the Erice School on Nuclear Physics, Erice, Italy, Sept. 17 - 25, 1998 to be published in Progress in Particle and Nuclear Physics, Vol. 42 (10 pages, 5 eps-figures

Continuous Decoupling of Dynamically Expanding Systems

The question of decoupling and freeze-out is reinvestigated and analysed in terms of transparent semi-classical decoupling formulae, which provide a smooth decoupling in time both, for single and two particle inclusive spectra. They generalise frequently employed instantaneous freeze-out procedures and provide simple relations between the damping width and the duration of the decoupling process. The implications on physical phenomena arising from the expansion and decay dynamics of the highly compressed hadronic matter generated in high energy nuclear collisions are discussed.Comment: The paper is significantly revised concentrating on the physics discussion, thereby including material that appeared during the revision stage. The formal derivations are deferred to a forthcoming paper. 20 pages, 2 Figures, Nucl. Phys. A in pres

Trust-Based Protection of Software Component Users and Designers

Abstract. Software component technology supports the cost-effective design of applications suited to the particular needs of the application owners. This design method, however, causes two new security risks. At first, a malicious component may attack the application incorporating it. At second, an application owner may incriminate a component designer falsely for any damage in his application which in reality was caused by somebody else. The first risk is addressed by security wrappers control-ling the behavior at the component interface at runtime and enforcing certain security policies in order to protect the other components of the application against attacks from the monitored component. Moreover, we use trust management to reduce the significant performance overhead of the security wrappers. Here, the kind and intensity of monitoring a com-ponent is adjusted according to the experience of other users with this component. Therefore a so-called trust information service collects posi-tive and negative experience reports of the component from various users

Delays Associated with Elementary Processes in Nuclear Reaction Simulations

Scatterings, particularly those involving resonances, and other elementary processes do not happen instantaneously. In the context of semiclassical nuclear reaction simulations, we consider delays associated with an interaction for incident quantum wave-packets. As a consequence, we express delays associated with elementary processes in terms of elements of the scattering matrix and phase shifts for elastic scattering. We show that, to within the second order in density, the simulation must account for delays in scattering consistently with the mean field in order to properly model thermodynamic properties such as pressure and free-energy density. The delays associated with nucleon-nucleon and pion-nucleon scattering in free space are analysed with their nontrivial energy dependence. Finally, an example of s-channel scattering of massless partons is studied, and scattering schemes in nuclear reaction simulations are investigated in the context of scattering delays.Comment: 45 pages, 5 uuencoded Postscript figure

A Phase II Trial of AZD6244 (Selumetinib, ARRY-142886), an Oral MEK1/2 Inhibitor, in Relapsed/Refractory Multiple Myeloma

AZD6244 is a MEK1/2 inhibitor with significant preclinical activity in multiple myeloma (MM) cells. This phase 2 study used a two-stage Simon design to determine the AZD6244 response rate in patients with relapsed or refractory MM

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

Developing a collaborative agenda for humanities and social scientific research on laboratory animal science and welfare.

Improving laboratory animal science and welfare requires both new scientific research and insights from enquiry in the humanities and social sciences. Whilst scientific research provides evidence to replace, reduce and refine procedures involving laboratory animals (the ‘3Rs’), work in the humanities and social sciences can help understand the social, economic and cultural processes that enhance or impede humane ways of knowing and working with laboratory animals. However, communication across these disciplinary perspectives is currently limited, and they frame questions, generate results, engage users, and seek to influence policy in different ways. To facilitate dialogue and future research at this interface, we convened an interdisciplinary group of 45 life scientists, social scientists, humanities scholars, non-governmental organisations and policy-makers to generate a collaborative research agenda. This drew on other agenda-setting exercises in science policy, using a collaborative and deliberative approach for the identification of research priorities. Participants were recruited from across the community, invited to submit research questions and vote on their priorities. They then met at an interactive workshop in the UK, discussed all 136 questions submitted, and collectively defined the 30 most important issues for the group. The output is a collaborative future agenda for research in the humanities and social sciences on laboratory animal science and welfare. The questions indicate a demand for new research in the humanities and social sciences to inform emerging discussions and priorities on the governance and practice of laboratory animal research, including around: international harmonisation, openness and public engagement, ‘cultures of care’, harm-benefit analysis and the future of the 3Rs. The process underlines the value of interdisciplinary exchange for improving mutual understanding of different research cultures and identifies ways of enhancing the effectiveness of future research at the interface between the humanities, social sciences, science and science policy

The Planetary Nebula System of M33

We report the results of a photometric and spectroscopic survey for planetary nebulae (PNe) in the Local Group spiral galaxy M33. We use our sample of 152 PNe to derive an [O III] planetary nebula luminosity function (PNLF) distance of (m-M)_0 = 24.86^+0.07-0.11 (0.94^+0.03-0.05 Mpc). Although this value is ~ 15% larger than the galaxy's Cepheid distance, the discrepancy likely arises from differing assumptions about the system's internal extinction. Our photometry (which extends >3 mag down the PNLF), also reveals that the faint-end of M33's PN luminosity function is non-monotonic, with an inflection point ~2 mag below the PNLF cutoff. We argue that this feature is due to the galaxy's large population of high core-mass planetaries, and that its amplitude may eventually be useful as a diagnostic for studies of stellar populations. Fiber-coupled spectroscopy of 140 of the PN candidates confirms that M33's PN population rotates along with the old disk, with a small asymmetric drift of \~ 10km/s. Remarkably, the population's line-of-sight velocity dispersion varies little over ~4 optical disk scale lengths, with sigma_{rad}~20km/s. We show that this is due to a combination of factors, including a decline in the radial component of the velocity ellipsoid at small galactocentric radii, and a gradient in the ratio of the vertical to radial velocity dispersion. We use our data to show that the mass scale length of M33's disk is ~2.3 times larger than that of the system's IR luminosity and that the disk's V-band mass-to-light ratio changes from M/L_V ~0.3 in the galaxy's inner regions to M/L_V ~2.0 at ~9 kpc. Models in which the dark matter is distributed in the plane of the galaxy are excluded by our data. (abridged)Comment: 45 pages, including 12 figures (some with reduced resolution); accepted for publication in the Astrophysical Journa

In vitro models of medulloblastoma: choosing the right tool for the job

The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice. This review seeks to build a more comprehensive picture of the in vitro systems available for modelling medulloblastoma. The subtype classification and molecular characterisation for over 40 medulloblastoma cell-lines has been compiled, making it possible to identify the strengths and weaknesses in current model systems. Less than half (18/44) of established medulloblastoma cell-lines have been subgrouped. The majority of the subgrouped cell-lines (11/18) are Group 3 with MYC-amplification. SHH cell-lines are the next most common (4/18), half of which exhibit TP53 mutation. WNT and Group 4 subgroups, accounting for 50% of patients, remain underrepresented with 1 and 2 cell-lines respectively. In vitro modelling relies not only on incorporating appropriate tumour cells, but also on using systems with the relevant tissue architecture and phenotype as well as normal tissues. Novel ways of improving the clinical relevance of in vitro models are reviewed, focusing on 3D cell culture, extracellular matrix, co-cultures with normal cells and organotypic slices. This paper champions the establishment of a collaborative online-database and linked cell-bank to catalyse preclinical medulloblastoma research