12 research outputs found
Dopamine gating of glutamatergic sensorimotor and incentive motivational input signals to the striatum
Etude voltametrique des modifications du metabolisme de la dopamine dans le cortex prefrontal et le noyau accumbens intervenant lors de l'application de divers stimuli anxiogenes chez le rat
SIGLECNRS T Bordereau / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc
Effects of an electrolytic lesion of the prelimbic area on anxiety-related and cognitive tasks in the rat
Involvement of D2 dopaminergic receptors in the emotional and motivational responses induced by injection of CCK-8 in the posterior part of the rat nucleus accumbens
Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring
Involvement of Mesolimbic Dopamine Neurons in Sexual Behaviors: Implications for the Neurobiology of Motivation
Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus).
Dawirs RR, Teuchert-Noodt G, Czaniera R. Ontogeny of PFC-related behaviours is sensitive to a single non-invasive dose of methamphetamine in neonatal gerbils (Meriones unguiculatus). J Neural Transm. 1996;103(11):1235-1245.A single dose of methamphetamine (50 mg/kg; i.p.) was administered to neonatal male gerbils (Meriones unguiculatus) aged 14 days, and adult prefrontal cortex (PFC)-related behaviours were analysed and compared with saline-treated controls at the age of postnatal day 90. For that purpose, animals were tested for open-field activities and y-maze delayed alternation. This solitary and non-invasive drug challenge, which has recently been found to initiate serious restraint in maturation of the mesoprefrontal dopamine (DA)-system (Dawirs et al., 1994), induces a significant delayed alternation impairment as well as significant increases in open-field motor activity and emotionality. Since an undisturbed development of the prefrontal DA-innervation seems to be a precondition for the maturation of normal PFC-related behaviours, a single early methamphetamine impact may be a suitable animal model for further investigation of structural and functional aspects of non-invasively induced behavioural deficits in rodents. The present results are discussed with regard to the assumption that hypofunctional mesoprefrontal DA-systems might be basic to schizophrenic behaviours in man