The experience of Internet freedom among African users

This article examines African Internet users’ experience of online freedom to assess levels of trust and mistrust of the Internet in Africa. Internet users’ perception of the protection or denial of their rights online—such as freedom of expression, privacy, and safety and security—in selected African countries is examined here as an outcome of constraining or enabling Internet policy and regulatory frameworks. Demand-side survey data collected via nationally representative ICT access and use surveys in 2017 is analyzed within the context of the Internet ecosystem as it plays out at the national level in three sub-Saharan African countries: Nigeria, Rwanda, and South Africa. Findings are contextualized within the framework of the Sustainable Development Goals, emphasizing the role that the Internet plays in contributing to the growth of a country when relevant policies are formulated in a way that addresses users’ needs while safeguarding their rights

Media, Art and Stories: A Case for Funding Research into Community-based Creative Arts Practices in Western Sydney

This brief provides practical recommendations for how universities and community-based organisations can join forces to implement creative arts projects with CALD groups with evaluative research components, with the aim of enriching the lives of the people of Western Sydney

Vegetation root biomechanics and its role in river ecomorphodynamics

Successful establishment of riparian vegetation on riverbanks and bedforms depends on river hydrology and related flow and sediment erosion processes. Extreme flow-induced erosion events can uproot vegetation, leading in some cases to failure of bank protection and river restoration schemes. This thesis uses experimental, analytical, and numerical approaches to examine key aspects of the mechanisms of vegetation uprooting by flow. First, the ability of riparian vegetation to respond to different water table regimes is investigated in terms of root growth and resistance. To this purpose, small-scale Salix cuttings were allowed to grow under different water level regimes. At the end of the growing period, extracted samples, obtained through pullout tests, were analysed in terms of root biomass distribution and resistance to external forces. The results demonstrate the driving influence of water and oxygen availability on the vertical configuration of below-ground biomass and thence on uprooting resistance. Second, a free-body model is derived to predict the critical rooting length – a key parameter that determines the probability of flow-induced uprooting of flexible plants at different erosion stages. Model validation is achieved using laboratory and field-scale data. Third, the dynamics of mobilization of stranded living wood logs from alluvial bedforms is investigated experimentally. Pullout test results are used to assess the root resistance of small-scale wood logs at several stages of growth. Trends in below- and above-ground biomass, together with the free-body model, enable detection of ‘biological time windows’ within which re-mobilization becomes possible. The results illustrate that uprooting occurs within two time-lapses, which coincide with particular growth stages of the plant. Finally, a combined analytical and numerical model is derived. This model uses the probability of flow-induced plant uprooting as a proxy to study how perturbations to the natural flow regime may drive riparian ecosystem dynamics towards new and potentially irreversible statistical equilibrium states. The model is applied to an actual case study, in which dam impoundment of a reach of the Maggia River, Switzerland, has led to intense riparian vegetation encroachment with consequent river narrowing. The output of the model sheds light on the type of irreversibility that may arise in riverine ecosystems of severely impounded river basins. The theoretical and experimental results presented in the thesis should be useful to river engineers and managers responsible for river restoration projects, natural flood management schemes, and optimal dam regulation strategies

Titanium Dioxide, NM-100, NM-101, NM-102, NM-103, NM-104, NM-105: Characterisation and Physico-Chemical Properties

The European Commission's Joint Research Centre (JRC) provides scientific support to European Union policy including nanotechnology. Within this context, the JRC launched, in February 2011, a repository for Representative Test Materials (RTMs), based on preparatory work started in 2008. It supports both EU and international research projects, and especially the OECD Working Party on Manufactured Nanomaterials (WPMN). The WPMN leads an exploratory testing programme "Testing a Representative set of Manufactured Nanomaterials" for the development and collection of data on characterisation, toxicological and ecotoxicological properties, as well as risk assessment and safety evaluation of nanomaterials. The purpose is to understand the applicability of the OECD Test Guidelines for the testing of nanomaterials as well as end-points relevant for such materials. The Repository responds to a need for nanosafety research purposes: availability of nanomaterial from a single production batch to enhance the comparability of results between different research laboratories and projects. The availability of representative nanomaterials to the international scientific community furthermore enhances and enables development of safe materials and products. The present report presents the physico-chemical characterisation of the Titanium dioxide series from the JRC repository: NM-100, NM-101, NM-102, NM-103, NM-104 and NM-105. NM-105 was selected as principal material for the OECD test programme "Testing a representative set of manufactured nanomaterials". NM-100 is included in the series as a bulk comparator. Each of these NMs originates from one batch of commercially manufactured TiO2. The TiO2 NMs may be used as representative material in the measurement and testing with regard to hazard identification, risk and exposure assessment studies. The results for more than 15 endpoints are addressed in the present report, including physico-chemical properties, such as size and size distribution, crystallite size and electron microscopy images. Sample and test item preparation procedures are addressed. The results are based on studies by several European laboratories participating to the NANOGENOTOX Joint Action, as well as by the JRC.JRC.I.4-Nanobioscience

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts, which occur far more frequently, are a major source of disability and social and economic burden. Both have substantial genetic etiology, which is partially shared and partially distinct from that of related psychiatric disorders. Methods We conducted a genome-wide association study (GWAS) of 29,782 suicide attempt (SA) cases and 519,961 controls in the International Suicide Genetics Consortium (ISGC). The GWAS of SA was conditioned on psychiatric disorders using GWAS summary statistics via multitrait-based conditional and joint analysis, to remove genetic effects on SA mediated by psychiatric disorders. We investigated the shared and divergent genetic architectures of SA, psychiatric disorders, and other known risk factors. Results Two loci reached genome-wide significance for SA: the major histocompatibility complex and an intergenic locus on chromosome 7, the latter of which remained associated with SA after conditioning on psychiatric disorders and replicated in an independent cohort from the Million Veteran Program. This locus has been implicated in risk-taking behavior, smoking, and insomnia. SA showed strong genetic correlation with psychiatric disorders, particularly major depression, and also with smoking, pain, risk-taking behavior, sleep disturbances, lower educational attainment, reproductive traits, lower socioeconomic status, and poorer general health. After conditioning on psychiatric disorders, the genetic correlations between SA and psychiatric disorders decreased, whereas those with nonpsychiatric traits remained largely unchanged. Conclusions Our results identify a risk locus that contributes more strongly to SA than other phenotypes and suggest a shared underlying biology between SA and known risk factors that is not mediated by psychiatric disorders.Peer reviewe

Art, development and peace working with adolescents living in internally displaced people's camps in Mindanao

Within a framework of Communication for Development in Peacebuilding, this article sheds light on the use of art forms such as puppetry and photography as communication channels among youth affected by conflict and displacement. The study presented here evaluates UNICEF Art for Development programme, which was carried out with adolescents living in transitory sites in the city of Zamboanga in 2015. Rather than focusing on the therapeutic effect of the activities, this investigation looks at their ability to provide adolescents living in the context of community-based conflict—such as that of a displaced people’s camp—with a safe space to participate and collaborate in art and media production to express themselves and communicate with one another