900 research outputs found
In vitro influence of stem surface finish and mantle conformity on pressure generation in cemented hip arthroplasty
Background and purpose Under physiological loads, debonded cemented femoral stems have been shown to move within their cement mantle and generate a fluid pump that may facilitate peri-prosthetic osteolysis by pressurizing fluid and circulating wear debris. The long-term physiological loading of rough and polished tapered stems in vitro has shown differences in performance, with greater interface pressures generated by the rough stems. In this study we investigated the individual effects of stem surface finish, degree of mantle wear, and mode of loading on the stem pump mechanism
The Dosimetric Outcome of a Rotational Planning Target Volume in Patients With Oropharyngeal Cancers
An isotropic expanded Planning Target Volume (PTV) neglects patient's off-axis rotation. This study designs a rotational PTV that is used instead of the standard 3-mm Clinical Target Volume (CTV) expanded PTV in oropharyngeal cancers with the goal to reduce pharyngeal constrictor muscle (PCM) mean dose. 10 patients were retrospectively evaluated. For off-axis rotation, the image was rotated around the longitudinal axis (cervical spinal canal)â±â5 degrees. These new CTVs were combined to form the rotational PTV. The standard and rotational treatment plans were designed with the goal to keep the superior and middle PCM-CTV70 mean dose to less than 50 Gy. There were a 355 cGy reduction in the superior PCM mean dose (form 5332 to 4977 cGy) and a 506 cGy reduction in middle PCM mean dose (from 4185 to 3679 cGy). 60% of patients may have at least a 20% reduction in dysphagia probability based on a Normal Tissue Complication Probability (NTCP) formula. The superior and middle PCM mean dose were reduced to less than 50 Gy in 40 and 20% of cases. There was an association between superior PCM mean dose and overlap volume of PTV70 and superior PCM in both standard (râ=â0.92, pâ=â0.001) and rotational (râ=â0.84, pâ=â0.002) plans. This association was present for middle PCM and PTV70 (râ=â0.52, pâ=â0.02 and râ=â0.62, pâ=â0.006). Rotational PTV can lower the mean dose to superior and middle PCMs, ultimately leading to lower dysphagia rates
In vitro comparison of the effects of rough and polished stem surface finish on pressure generation in cemented hip arthroplasty
Background and purpose High pressures around implants can cause bone lysis and loosening. We investigated how pressures are generated around cemented femoral stems
Toward physical realizations of thermodynamic resource theories
Conventional statistical mechanics describes large systems and averages over
many particles or over many trials. But work, heat, and entropy impact the
small scales that experimentalists can increasingly control, e.g., in
single-molecule experiments. The statistical mechanics of small scales has been
quantified with two toolkits developed in quantum information theory: resource
theories and one-shot information theory. The field has boomed recently, but
the theorems amassed have hardly impacted experiments. Can thermodynamic
resource theories be realized experimentally? Via what steps can we shift the
theory toward physical realizations? Should we care? I present eleven
opportunities in physically realizing thermodynamic resource theories.Comment: Publication information added. Cosmetic change
Patient selection for neonatal extracorporeal membrane oxygenation: beyond severity of illness
Markovian Dynamics on Complex Reaction Networks
Complex networks, comprised of individual elements that interact with each
other through reaction channels, are ubiquitous across many scientific and
engineering disciplines. Examples include biochemical, pharmacokinetic,
epidemiological, ecological, social, neural, and multi-agent networks. A common
approach to modeling such networks is by a master equation that governs the
dynamic evolution of the joint probability mass function of the underling
population process and naturally leads to Markovian dynamics for such process.
Due however to the nonlinear nature of most reactions, the computation and
analysis of the resulting stochastic population dynamics is a difficult task.
This review article provides a coherent and comprehensive coverage of recently
developed approaches and methods to tackle this problem. After reviewing a
general framework for modeling Markovian reaction networks and giving specific
examples, the authors present numerical and computational techniques capable of
evaluating or approximating the solution of the master equation, discuss a
recently developed approach for studying the stationary behavior of Markovian
reaction networks using a potential energy landscape perspective, and provide
an introduction to the emerging theory of thermodynamic analysis of such
networks. Three representative problems of opinion formation, transcription
regulation, and neural network dynamics are used as illustrative examples.Comment: 52 pages, 11 figures, for freely available MATLAB software, see
http://www.cis.jhu.edu/~goutsias/CSS%20lab/software.htm
Electrodeposited lead dioxide coatings
Lead dioxide coatings on inert substrates such as titanium and carbon now offer new opportunities for a material known for 150 years. It is now recognised that electrodeposition allows the preparation of stable coatings with different phase structures and a wide range of surface morphologies. In addition, substantial modification to the physical properties and catalytic activities of the coatings are possible through doping and the fabrication of nanostructured deposits or composites. In addition to applications as a cheap anode material in electrochemical technology, lead dioxide coatings provide unique possibilities for probing the dependence of catalytic activity on layer composition and structure (critical review, 256 references)
Random-phase approximation and its applications in computational chemistry and materials science
The random-phase approximation (RPA) as an approach for computing the
electronic correlation energy is reviewed. After a brief account of its basic
concept and historical development, the paper is devoted to the theoretical
formulations of RPA, and its applications to realistic systems. With several
illustrating applications, we discuss the implications of RPA for computational
chemistry and materials science. The computational cost of RPA is also
addressed which is critical for its widespread use in future applications. In
addition, current correction schemes going beyond RPA and directions of further
development will be discussed.Comment: 25 pages, 11 figures, published online in J. Mater. Sci. (2012
Quantum computation based on d-level cluster states
The concept of qudit (a d-level system) cluster state is proposed by
generalizing the qubit cluster state (Phys. Rev. Lett. \textbf{86}, 910 (2001))
according to the finite dimensional representations of quantum plane algebra.
We demonstrate their quantum correlations and prove a theorem which guarantees
the availability of the qudit cluster states in quantum computation. We
explicitly construct the network to show the universality of the one-way
computer based on the defined qudit cluster states and single-qudit
measurement. And the corresponding protocol of implementing one-way quantum
computer can be suggested with the high dimensional "Ising" model which can be
found in many magnetic systems.Comment: Revtex4, 15 pages, 3 eps figure
The evolution of tooth wear indices
Tooth wearâattrition, erosion and abrasionâis perceived internationally as an ever-increasing problem. Clinical and epidemiological studies, however, are difficult to interpret and compare due to differences in terminology and the large number of indices that have been developed for diagnosing, grading and monitoring dental hard tissue loss. These indices have been designed to identify increasing severity and are usually numerical. Some record lesions on an aetiological basis (e.g. erosion indices), others record lesions irrespective of aetiology (tooth wear indices); none have universal acceptance, complicating the evaluation of the true increase in prevalence reported. This article considers the ideal requirements for an erosion index. It reviews the literature to consider how current indices have evolved and discusses if these indices meet the clinical and research needs of the dental profession
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