64 research outputs found
Glucose variability: a new risk factor for cardiovascular disease
- Publication venue
- Publication date
- 01/10/2023
- Field of study
Aims and data synthesis: glucose variability (GV) is increasingly considered an additional index of glycemic control. Growing evidence indicates that GV is associated with diabetic vascular complications, thus being a relevant point to address in diabetes management. GV can be measured using various parameters, but to date, a gold standard has not been identified. This underscores the need for further studies in this field also to identify the optimal treatment. Conclusions: We reviewed the definition of GV, the pathogenetic mechanisms of atherosclerosis, and its relationship with diabetic complications
Angular momentum and mass evolution of contact binaries
- Author
- Ahn
- Awadalla
- Awadalla
- Baran
- Barnes
- Barone
- Bell
- Bilir
- Binnendijk
- Binnendijk
- Binnendijk
- Csák
- Demircan
- Duerbeck
- Eaton
- Eggen
- Eggleton
- Eker
- Gazeas
- Gazeas
- Gazeas
- Gazeas
- Gazeas
- Gimenez
- Goecking
- Goecking
- Hilditch
- Hilditch
- Hilditch
- Hilditch
- Hilditch
- Hrivnak
- Hrivnak
- K. Gazeas
- K. Stȩpień
- Kaluzny
- Kaluzny
- Khajavi
- Kim
- King
- Kreiner
- Kähler
- Kähler
- Lapasset
- Leung
- Lopez-Morales
- Lu
- Lu
- Lu
- Lucy
- Lucy
- Maceroni
- Maceroni
- Maceroni
- Maceroni
- Maciejewski
- Mancuso
- Martin
- McLean
- Metcalfe
- Milone
- Milone
- Mochnacki
- Nelson
- Nesci
- Niarchos
- Paczyński
- Pribulla
- Pribulla
- Pribulla
- Pribulla
- Qian
- Rainger
- Rainger
- Rasio
- Rovithis-Livaniou
- Rucinski
- Rucinski
- Rucinski
- Rucinski
- Rucinski
- Rucinski
- Rucinski
- Rucinski
- Russo
- Samec
- Schaller
- Sezer
- Stȩpień
- Stȩpień
- Stȩpień
- Stȩpień
- Stȩpień
- Vanko
- Vinkó
- Wang
- Wolf
- Wood
- Wood
- Yakut
- Yakut
- Yakut
- Yakut
- Yang
- Yang
- Yang
- Yang
- Zhang
- Zola
- Zola
- Zola
- Publication venue
- 'Wiley'
- Publication date
- 25/09/2008
- Field of study
Various scenarios of contact binary evolution have been proposed in the past,
giving hints of (sometimes contradictory) evolutionary sequence connecting
A-type and W-type systems. As the components of close detached binaries
approach each other and contact binaries are formed, following evolutionary
paths transform them into systems of two categories: A-type and W-type. The
systems evolve in a similar way but under slightly different circumstances. The
mass/energy transfer rate is different, leading to quite different evolutionary
results. An alternative scenario of evolution in contact is presented and
discussed, based on the observational data of over a hundred low-temperature
contact binaries. It results from the observed correlations among contact
binary physical and orbital parameters. Theoretical tracks are computed
assuming angular momentum loss from a system via stellar wind, accompanied by
mass transfer from an advanced evolutionary secondary to the main sequence
primary. Good agreement is seen between the tracks and the observed graphs.
Independently of details of the evolution in contact and a relation between
A-type and W-type systems, the ultimate fate of contact binaries involves the
coalescence of both components into a single fast rotating star.Comment: 11 pages, 5 figures, a short paragraph added on p. 6, MNRAS, in pres
Mutations in GDP-mannose pyrophosphorylase b cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan
- Author
- A. Reghan Foley
- Abramoff
- Akanchha Kesari
- Alexander Hoischen
- Barone
- Beltrán-Valero de Bernabé
- Bouchet
- Brockington
- Buysse
- Carla M. Grosmann
- Caroline Sewry
- Carsten G. Bönnemann
- Chiba
- Cirak
- Clement
- Daniel G. MacArthur
- Davis
- Denton
- Derek L. Stemple
- Dirk J. Lefeber
- Dubowitz
- Duclos
- Durbeej
- Durbeej
- Elizabeth Stevens
- Elizabeth Wraige
- Endo
- Enrico Bertini
- Eric Hoffman
- Ervasti
- Francesco Muntoni
- Godfrey
- Hans van Bokhoven
- Hara
- Helen K. Young
- Herzog
- Holt
- Ibraghimov-Beskrovnaya
- Inamori
- Jae
- Jaya Punetha
- Jiang
- Jose E. Abdenur
- Kathryn N. North
- Keller
- Keren J. Carss
- Kevin P. Campbell
- Kobayashi
- Langheinrich
- Lefeber
- Lefeber
- Leigh B. Waddell
- Li
- Lin
- Lina Brodd
- Liu
- Longman
- Lucy Feng
- Maeda
- Manzini
- Manzini
- Matthew E. Hurles
- McKenna
- McLaren
- Mercuri
- Messina
- Michele
- Michele
- Moniek Riemersma
- Monique van Scherpenzeel
- Mostacciuolo
- Nilsson
- Ning
- Parsons
- Qin
- Rafiq
- Ros Quinlivan
- Roscioli
- Schuler
- Sebahattin Cirak
- Sharma
- Shu Yau
- Silvia Torelli
- Sonia Messina
- Stalnaker
- Stevens
- Steven A. Moore
- Timal
- Tobias Willer
- van Reeuwijk
- Warit
- Wheeler
- Willer
- Wright
- Yoshida
- Yoshida-Moriguchi
- Yung-Yao Lin
- Zhang
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Congenital muscular dystrophies with hypoglycosylation of α-dystroglycan (α-DG) are a heterogeneous group of disorders often associated with brain and eye defects in addition to muscular dystrophy. Causative variants in 14 genes thought to be involved in the glycosylation of α-DG have been identified thus far. Allelic mutations in these genes might also cause milder limb-girdle muscular dystrophy phenotypes. Using a combination of exome and Sanger sequencing in eight unrelated individuals, we present evidence that mutations in guanosine diphosphate mannose (GDP-mannose) pyrophosphorylase B (GMPPB) can result in muscular dystrophy variants with hypoglycosylated α-DG. GMPPB catalyzes the formation of GDP-mannose from GTP and mannose-1-phosphate. GDP-mannose is required for O-mannosylation of proteins, including α-DG, and it is the substrate of cytosolic mannosyltransferases. We found reduced α-DG glycosylation in the muscle biopsies of affected individuals and in available fibroblasts. Overexpression of wild-type GMPPB in fibroblasts from an affected individual partially restored glycosylation of α-DG. Whereas wild-type GMPPB localized to the cytoplasm, five of the identified missense mutations caused formation of aggregates in the cytoplasm or near membrane protrusions. Additionally, knockdown of the GMPPB ortholog in zebrafish caused structural muscle defects with decreased motility, eye abnormalities, and reduced glycosylation of α-DG. Together, these data indicate that GMPPB mutations are responsible for congenital and limb-girdle muscular dystrophies with hypoglycosylation of α-DG. © 2013 The American Society of Human Genetics.Funding for UK10K was provided by the Wellcome Trust under award WT091310
Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera
- Author
- Albalawi Wejdan
- Alex Beatrice
- Alshehri Abdullateef
- Andrikopoulos Petros
- Bach Benjamin
- Baillie J. Kenneth
- Baltazar Murielle
- Barclay Wendy S.
- Barone Francesco G.
- Bogaert Debby
- Carson Gail
- Chand Meera
- Chechi Kanta
- Clohisey Sara
- Connor Marie
- Cooke Graham S.
- da Silva Filipe Ana
- Dalton Jo
- de Silva Thushan
- Dobson Susan
- Docherty Annemarie B.
- Donegan Cara
- Donohue Chloe
- dos Santos Correia Gonçalo
- Drake Thomas M.
- Dumas Marc Emmanuel
- Dunning Jake
- Fairfield Cameron J.
- Fletcher Tom
- Gamble Carrol
- Girvan Michelle
- Grammatikopoulos Tassos
- Green Christoper A.
- Greenhalf William
- Griffin Julian L.
- Griffiths Fiona
- Gupta Rishi K.
- Halpin Sophie
- Hardwick Hayley
- Harrison Ewen M.
- Harrison Janet
- Hendry Ross
- Ho Antonia Ying Wai
- Ho Antonia Ying Wai
- Horby Peter W.
- Ijaz Samreen
- Jackson Clare
- Keating Seán
- Khoo Saye
- Klenerman Paul
- Knight Stephen R.
- Knight Susan
- Law Andrew
- Lee James
- Leeming Gary
- Lewis Matthew R.
- Liggi Sonia
- Lim Wei Shen
- Maddocks Emily
- Marsh Laura
- Maslen Lynn
- McDonald Sarah E.
- Mclean Kenneth A.
- Mentzer Alexander J.
- Merson Laura
- Meynert Alison M.
- Moore Shona C.
- Murphy Derek
- Norman Lisa
- Norris Lucy
- Noursadeghi Mahdad
- Olanipekun Michael
- Oosthuyzen Wilna
- Openshaw Peter J.M.
- Osagie Anthonia
- Palmarini Massimo
- Palmieri Carlo
- Paxton William A.
- Pius Riinu
- Plotkin Daniel
- Pollakis Georgios
- Price Nicholas
- Rambaut Andrew
- Roberts Stephanie
- Robertson David L.
- Roper Kelly J.
- Russell Clark D.
- Sancho-Shimizu Vanessa
- Sands Caroline J.
- Saviciute Egle
- Scott Janet T.
- Scott-Brown James
- Semple Malcolm G.
- Shaw Catherine A.
- Shaw Victoria
- Sigfrid Louise
- Solomon Tom
- Spencer Rebecca G.
- Sriskandan Shiranee
- Stuart David
- Summers Charlotte
- Swann Olivia V.
- Tait Sarah
- Takats Zoltan
- Takis Panteleimon
- Tedder Richard S.
- Thomas Jordan
- Thompson A.A. Roger
- Thomson Emma C.
- Thwaites Ryan S.
- Turtle Lance
- Wham Murray
- Zambon Maria
- Publication venue
- Publication date
- 01/12/2023
- Field of study
The ongoing SARS-CoV-2 pandemic was initially managed by non-pharmaceutical interventions such as diagnostic testing, isolation of positive cases, physical distancing and lockdowns. The advent of vaccines has provided crucial protection against SARS-CoV-2. Neutralising antibody (nAb) responses are a key correlate of protection, and therefore measuring nAb responses is essential for monitoring vaccine efficacy. Fingerstick dried blood spots (DBS) are ideal for use in large-scale sero-surveillance because they are inexpensive, offer the option of self-collection and can be transported and stored at ambient temperatures. Such advantages also make DBS appealing to use in resource-limited settings and in potential future pandemics. In this study, nAb responses in sera, venous blood and fingerstick blood stored on filter paper were measured. Samples were collected from SARS-CoV-2 acutely infected individuals, SARS-CoV-2 convalescent individuals and SARS-CoV-2 vaccinated individuals. Good agreement was observed between the nAb responses measured in eluted DBS and paired sera. Stability of nAb responses was also observed in sera stored on filter paper at room temperature for 28 days. Overall, this study provides support for the use of filter paper as a viable sample collection method to study nAb responses.</p
Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
- Author
- Abdulkader Rita
- Abozaid Hanan S.
- Adab Peymané
- Adizie Tochukwu
- Adshead Rebecca
- Ahmad Yasmeen
- Ahmed Azeem A.
- Akil Mohammed
- Alavi Azita
- Alcorn Desmond
- Alexander Yvonne
- Alexander Yvonne
- Alexander Yvonne
- Allen Maggie
- Amarasena Roshan
- Amarasena Roshan I.
- Ambler Nick
- Amft Nicole
- Amft Nicole
- Amissah-Arthur Maame
- Amos Nicholson
- Anderson David
- Andres Mariano
- Andrews Jacqueline
- Arthur Catherine
- Ashton Simon
- Axford John
- Ayalew Yezenash
- Baburaj Krishnan
- Bacon Paul A.
- Baguley Elaine
- Ball Elisabeth
- Banik Snehashish
- Bari Syed F.
- Barone Francesca
- Barone Francesca
- Barton Anne
- Barton Anne
- Basu Neil
- Bateman James
- Bavakunji Riaz
- Bayley Rachel
- Beasley Marcus
- Bell Aubrey
- Bell Aubrey L.
- Birnbaum Julius
- Bombardieri M.
- Bombardieri Michele
- Bombardieri Michele
- Bombardieri Michele
- Bond Christine
- Bond Ursula
- Borg Frances
- Borg Frances A.
- Bosworth Ailsa
- Boulton John
- Bowman Simon
- Bowness Paul
- Bowness Paul
- Bowness Paul
- Braude Simon
- Brooksby Alan
- Brophy Sinead
- Brown Deborah
- Brown Nina
- Brown Sue J.
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Buckley Chris
- Buckley Chris
- Buckley Chris
- Buckley Chris D.
- Bukhari Marwan
- Bukhari Marwan
- Bukhari Marwan
- Bullock Craig
- Bunn Diane
- Bunn Diane
- Bunning Rowena
- Bunning Rowena A. D.
- Bunning Rowena D.
- Calnan Michael
- Cardy Caroline M.
- Casey Matthew
- Caswell Richard
- Ceeraz Sabrina
- Chan Antoni
- Chana Jasroop K.
- Chapman Victoria
- Chen Liye
- Cheng K. K.
- Chitale Sarang
- Chitale Sarang
- Chiverton Neil
- Chiverton Neil
- Choy Ernest
- Choy Ernest H.
- Christidis Dimitrios
- Cloake Tom
- Cloake Tom
- Clunie Gavin
- Coady David
- Coady David
- Coady David
- Colaco Bernard
- Cole Zoe A.
- Coles Mark
- Collins Fraser
- Cooksey Roxanne
- Cooper Annie
- Cooper Cyrus
- Cooper Cyrus
- Cooper Nicola
- Cope Andrew
- Cordingley Lis
- Corrigall Valerie
- Coward Lucy
- Crawford Aileen
- Crilly Anne
- Cross Alison
- Cross Alison K.
- Crouch Carina
- Crozier Sarah R.
- Cumming Jo
- Curtis Elizabeth M.
- D'Cruz David
- Danda Debashish
- Daniel Priya
- Daniels Jodie
- Darroch James
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Davies Charlotte
- Davies David
- Davies Rebecca
- Davies Ursula M.
- Dent Caroline
- Devanny Ian
- Dey Ida D.
- Dhanjal Mandish
- Dhillon Veena
- DiCicco Maria
- Dixey Josh
- Dixey Josh
- Doherty Teresa
- Donnelly Simon P.
- Driscoll Paul C.
- Duncan G.
- Duncan Rosie
- Dunn Sara
- Dures Emma
- Edgar Suzanne
- Edmonds Sally
- Edwards Christopher J.
- Edwards Christopher J.
- Edwards Steven W.
- Ellis Benjamin
- Ellis Corrinne
- Else Sara
- Emery Paul
- Ennis H.
- Estrach Cristina
- Estrach Cristina
- Evans Bronwen
- Evans Hayley G.
- Evans Laura
- Eyre Tracey
- Fang Hong
- Farrow Luke
- Fattah Zozik
- Ferrell William R.
- Field Max
- Finlay Ron
- Fisher Roman
- Fleming S.
- Fletcher Debbie
- Fluess Elisa
- Foggo Heather
- Fortune F.
- Fu Bo
- Gainsborough Nicola
- Galloway James
- Galloway James
- Garner Rozeena
- Garza-Garcia Acely
- Gathany Tim
- Gayed Mary
- Gayed Mary
- Georgia Ntani
- Giles Ian
- Giles Ian
- Giles Ian
- Giles Joanna L.
- Godfrey Keith M.
- Goff Iain
- Golor G.
- Goodson Nicola J.
- Goodson Nicola J.
- Goodson Nicola J.
- Gordon Caroline
- Gordon Caroline
- Gordon Caroline
- Gorman Claire L.
- Greenbank Cathi
- Griffiths Bridget
- Griffiths Bridget
- Gullick Nicola J.
- Gullick Nicola J.
- Gupta Monica
- Haddock Gail
- Haddock Gail
- Hakim Alan J.
- Halsey John
- Han Chenglong
- Hands Rebecca
- Harper Lorraine
- Harris Claire L.
- Harta N.
- Harvey Nicholas C.
- Hashmi Tahir M.
- Hassan Ahmed I.
- Hassell Andrew
- Hayes Fiona
- Hayes Fiona
- Heaney Jonathan
- Heathfield Sarah
- Heron Louise
- Herrick Ariane
- Hewlett Sarah
- Hewlett Sarah
- Hickling M.
- Horan Michael
- Hsia Elizabeth
- Hughes Michael
- Hui Michelle
- Hull Richard
- Hull Richard G.
- Humby Frances
- Humphreys Jennifer
- Hunter John
- Hunter John
- Husain Muhammad J.
- Hutchinson David
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Ibrahim
- Inskip Hazel M.
- Ioannou John
- Ioannou Yiannis
- Iqbal Itrat
- Irvine Elizabeth
- Isaacs John
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Ismajli Mediola
- Jani Meghna
- Jani Meghna
- Jayaraj David M.
- Jayne David
- Jenkins Jessica
- Jennens Hannah
- Jiang C. Q.
- John Elizabeth
- Johnson Phil
- Jones Gareth T.
- Jones Gareth T.
- Jones Simon A.
- Jullion A.
- Kallankara Sathish
- Kate I.
- Kay Lesley
- Keeley Philip
- Keidel Sarah
- Kelly Sara
- Kelly Stephen
- Kendall David
- Kenu Ernest
- Kessler Benedikt M.
- Khamashta Munther
- Khattak Fazlihakim
- Kiely Patrick D.
- Kindness Kathy
- Kollnberger Simon
- Kollnberger Simon
- Kollnberger Simon
- Kretsos K.
- Kumar Kanta
- Kumar Namita
- Kuvikova Inna
- Lam T. H.
- Lane Peter
- Lanyon Peter
- Lanyon Peter
- Lanyon Peter
- Lawton Sally
- Le Maitre Christine
- Le Maitre Christine L.
- Le Maitre Christine L.
- Ledingham Jo
- Lendrem Dennis
- Leung Jansen
- Lewis Cathryn M.
- Lim Ken
- Ling Stephanie
- Lip Stefanie
- Little Jayne
- Littlewood Alison
- Lockhart John
- Loke Yoon
- Lovell Karina
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lutalo Pamela M.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Matthew V.
- MacGregor Alex
- MacGregor Alex
- MacGregor Alex
- Mackie Sarah L.
- Macphie Elizabeth
- Mahadik Younis
- Mahendranath K. M.
- Main Wong Way
- Malaviya Anshuman P.
- Marks Jonathan
- Marroquin Osiris
- Mason Justin
- Mc Laughlin Maeve
- McBeth John
- McBeth John
- McBurney H.
- McHugh Kirsty
- McHugh Kirsty
- McHugh Neil
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Ian
- McKenna Frank
- McKeogh John
- Mckew Jennifer R.
- McLaren John
- McLoughlin Yokemei
- Mehta Puja
- Mehta Puja
- Meldrum Gillian
- Mercer Louise
- Middleton Jim
- Millar Auleen M.
- Misra Ramnath
- Mitchell Adam
- Mitchell Sheryl
- Mobasheri Ali
- Moots Robert J.
- Moots Robert J.
- Moots Robert J.
- Morgan Anne
- Morgan Matthew
- Morris Marianne
- Mugford Miranda
- Mulvey Matthew
- Mulvey Matthew R.
- Murfitt Lucy
- Murphy Helen
- Murray-Brown William
- Mérida Angeles Acosta
- Nayar Saba
- Nayar Saba
- Nazeer Moideen Abdul
- Nelson-Piercy Catherine
- Newman W.
- Ng Nora
- Ng Wan-Fai
- Nicholl Karl
- Nikiphorou Elena
- Nikiphorou Elena
- Nowell Mari A.
- O'Connor Mortimer B.
- O'Neill Terence
- Ogunbambi Olabambo
- Oldroyd Alexander G.
- Oomatia Amin
- Oreffo Richard O.
- Osei-Bordom Daniel-Clement
- Osgood Louise
- Ostor Andrew J.
- Owens Martina
- Palmer Helen
- Parker Ben
- Parker Ben
- Parker Ben
- Patel Dipti
- Patel Yusuf
- Patil Pravin
- Paudyal Priya
- Paul Morgan B.
- Pauling John D.
- Payeli Sravan
- Pearce Fiona
- Pease Colin T.
- Pease Colin T.
- Pendleton Neil
- Pericleous Charis
- Pericleous Charis
- Perry Liz
- Petri Michelle
- Phelan Mark J.
- Phillips Ceri J.
- Phillips E.
- Phillips Kate L. E.
- Picarelli G.
- Pierangeli Silvia
- Pierangeli Silvia S.
- Pilling Claire
- Pitzalis C.
- Pitzalis Costantino
- Pitzalis Costantino
- Pitzalis Costantino
- Plant Darren
- Plant Darren
- Platt Philip N.
- Plevin Robin
- Pope Denise
- Popham Maria
- Price Elizabeth
- Price Elizabeth
- Price-Forbes Alec
- Priori R.
- Pushpakom S.
- Rahman Anisur
- Rahman Anisur
- Rahman Anisur
- Rankin Elizabeth
- Rao Chandini
- Ray David W.
- Raza Karim
- Rees Frances
- Regan Marian
- Regan Marian
- Reid David M.
- Renner Christoph
- Reynolds John A.
- Reynolds Piero
- Rhys-Dillon Brian
- Ridley Anna
- Robertson Calum
- Robinson Frances
- Robinson Sandra
- Robinson Siân M.
- Rooke Royston
- Rooney Madeleine
- Roskell S.
- Roussou Thalia
- Roussou Thalia
- Rump-Goodrich Lisa
- Russell M.
- Rutherford Michelle
- Ryan Sarah
- Rysnik Oliwia J.
- Sanderson Tessa
- Sayer Avan A.
- Scott David L.
- Scott Ian C.
- Segeda Iuliia
- Selvan Shilpa
- Semenova Olga
- Sensky T.
- Seoudi N.
- Severn Andrew
- Shah Preeti
- Sharp Charlotte A.
- Shastri Nilabh
- Shaw Jackie
- Shaw Jacqueline
- Shaw S.
- Sheldon Jo
- Shevchuk Sergii
- Siebert Stefan
- Siebert Stefan
- Simpson John
- Sivakumar Rajappa
- Skeoch Sarah
- Sofat Nidhi
- Solymossy Csilla
- Spandley A.
- Spector Tim
- Spencer Jo
- Srikanth Asha
- Steer Sophia
- Stewart Kirsty
- Stockton Marie
- Stone Michael
- Strand V.
- Sutcliffe Nurhan
- Sutton Emily J.
- Swan Joan
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Taams Leonie S.
- Tahir Hasan
- Tan Shaun
- Tandon Neeta
- Tappuni T.
- Tarelli Edward
- Taylor P.
- Taylor Peter
- Taylor Peter
- Teh Lee-Suan
- Thapper Muryum
- Thapper Muryum
- Thomas Huw B.
- Thompson Helen
- Timoshanko J.
- Tugnet Nicola
- Tysoe Carolyn
- Vadivelu Saravanan
- Valesini G.
- Vartoukian S.
- Varughese Sneha
- Venning Michael
- Verstappen Suzanne M.
- Viatte Sebastien
- Vincent Tonia
- Walker David
- Walker-Bone Karen
- Walker-Bone Karen
- Walsh David A.
- Wang Edward
- Watson Kath
- Watson Kath D.
- Watts Richard
- Weaver Dan
- West Louise
- West Lucy
- Wilkinson Mark
- Williams Anwen S.
- Williams Anwen S.
- Williams Emma L.
- Williams Frances M.
- Williams Mark
- Williams Mark R.
- Wilson Anthony
- Wilson Gillian
- Wilson Jo
- Win Maw Win
- Woby Steve
- Wong-Baeza Isabel
- Wood Elizabeth F.
- Worthington J.
- Worthington Jane
- Wright Helen L.
- Wright Stephen A.
- Yates Max
- Yee Chee-Seng
- Young Adam
- Young Adam
- Young Stephen
- Young Stephen P.
- Zaki Awal
- Zeef Leo
- Zoma Asad
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
Studies of jet mass in dijet and W/Z plus jet events
- Author
- A Abdesselam
- A Banfi
- A Hornig
- A Hornig
- A. A. Ocampo Rios
- A. Abdulsalam
- A. Adair
- A. Adiguzel
- A. Anastassov
- A. Apresyan
- A. Apyan
- A. Askew
- A. Attikis
- A. Avetisyan
- A. B. Meyer
- A. Baden
- A. Barker
- A. Bean
- A. Belyaev
- A. Belyaev
- A. Benaglia
- A. Beretvas
- A. Bethani
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- W. Dominik
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- WH Richardson
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- Y Vardi
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- Y. J. Lu
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- Y. Kim
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- Y. Lu
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- Y. Ma
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- Y. Musienko
- Y. O. Günaydin
- Y. Onel
- Y. Pakhotin
- Y. Roh
- Y. S. Chung
- Y. Sirois
- Y. Tschudi
- Y. Tu
- Y. W. Chang
- Y. Weng
- Y. Yang
- Y. Yilmaz
- Y. Zheng
- Y.-J. Lee
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- Yu. Andreev
- Z. Antunovic
- Z. C. Yang
- Z. Demiragli
- Z. Hatherell
- Z. Hu
- Z. L. Trocsanyi
- Z. Szillasi
- Z. Tsamalaidze
- Z. Wan
- Z. Wang
- Z. Zhang
- Zero J. Kim
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
This is the pre-print version of the final published paper that is available from the link below.Invariant mass spectra for jets reconstructed using the anti-kT and Cambridge-Aachen algorithms are studied for different jet “grooming” techniques in data corresponding to an integrated luminosity of 5 fb-1, recorded with the CMS detector in proton-proton collisions at the LHC at a center-of-mass energy of 7TeV. Leading-order QCD predictions for inclusive dijet and W/Z+jet production combined with parton-shower Monte Carlo models are found to agree overall with the data, and the agreement improves with the implementation of jet grooming methods used to distinguish merged jets of large transverse momentum from softer QCD gluon radiation
Inflammation-induced formation of fat-associated lymphoid clusters
- Author
- A Fütterer
- Adam F Cunningham
- Adriana Flores-Langarica
- AE Price
- AF Ochsenbein
- Alistair McIntosh
- Andrei A Kruglov
- Andrew N J McKenzie
- C Bénézech
- C Gil-Cruz
- C Platell
- Cécile Bénézech
- D Bouskra
- D Kontoyiannis
- DA Carlow
- David R Withers
- DR Neill
- F Martin
- Francesca Barone
- George Kollias
- GJ Silverman
- Gurdyal Besra
- H Hamada
- H Spits
- HS Schipper
- J Rangel-Moreno
- JB Foote
- Jennifer A Walker
- Jennifer Marshall
- JL Marshall
- JL Marshall
- Jorge H Caamaño
- Judith E Allen
- K Moro
- Kai Michael Toellner
- Katherine Miles
- KM Ansel
- KM Ansel
- KM Haas
- KR Alugupalli
- Kyoko Nakamura
- L Lynch
- L Wu
- Lucy H Jones
- M Boes
- M Cascalho
- M Gil-Ortega
- M Matsumoto
- Marc Veldhoen
- MD Muzumdar
- Mohini Gray
- N Baumgarth
- N Kamada
- Nguyet-Thin Luu
- NH Ruddle
- Nick D Jones
- NJ Krautler
- O Pabst
- P De Togni
- PA Koni
- PJ Brennan
- R Roozendaal
- S Casola
- S Fukuyama
- SA Ha
- Saba Nayar
- Sergei A Nedospasov
- SI Grivennikov
- SJ Jenkins
- TD Randall
- VN Ngo
- Y Ji
- Y Ji
- Y Yang
- Y Yang
- Yang Zhang
- YH Elewa
- Yunhua Loo
- YX Fu
- Z Sun
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/06/2015
- Field of study
Fat-associated lymphoid clusters (FALCs) are a type of lymphoid tissue associated with visceral fat. Here we found that the distribution of FALCs was heterogeneous, with the pericardium containing large numbers of these clusters. FALCs contributed to the retention of B-1 cells in the peritoneal cavity through high expression of the chemokine CXCL13, and they supported B cell proliferation and germinal center differentiation during peritoneal immunological challenges. FALC formation was induced by inflammation, which triggered the recruitment of myeloid cells that expressed tumor-necrosis factor (TNF) necessary for signaling via the TNF receptors in stromal cells. Natural killer T cells (NKT cells) restricted by the antigen-presenting molecule CD1d were likewise required for the inducible formation of FALCs. Thus, FALCs supported and coordinated the activation of innate B cells and T cells during serosal immune responses
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
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- Arif Shaikh Md
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- Armato Federico
- Arnaud Nicolas
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- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
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- Babak Stanislav
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- Yan T.
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- Yang Fengwei
- Yang Kate Z.
- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
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- Barber J.
- Barish B. C.
- Barker D.
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- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
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- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
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- Bedakihale V. M.
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- Benedetto V.
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- Berger Beverly
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- Bertolini A.
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- Beveridge Damon
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- Capote E.
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- Carpinelli Massimo
- Carter Jonathan
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- Casentini C.
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- Cavaglia Marco
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- Cella Giancarlo
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- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
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- Christensen Nelson
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- Ciani Giacomo
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- Cieślar Marek
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- Ciolfi Riccardo
- Clara F.
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- Clearwater P.
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- Corsi Alessandra
- Cortese Stefano
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- Countryman S. T.
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- Cumming Alan
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- Cusinato Marco
- D'Angelo Beatrice
- D'Antonio S.
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- Dal Canton Tito
- DALL'OSSO Simone
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- de rossi camilla
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- Degallaix Jerome
- Del Pozzo W.
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- Dell'Aquila Daniele
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- Demos N.
- Dent Thomas
- Depasse Antoine
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- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
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- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
- Diamond P. Z.
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- Doravari Suresh
- Dorosh O.
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- Duval Hannah
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- Eichholz Johannes
- Einsle H.
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- Elizabeth Ramirez Guevara Karla
- Engelby E.
- Engl A. J.
- Erasmo Peña Arellano Fabián
- Errico L.
- error error
- error error
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans C. R.
- Evans Matthew J.
- Evans T. M.
- Evstafyeva T.
- Ewing B. E.
- Fabrizi Federica
- Faedi F.
- Fafone Viviana
- Fair H.
- Fairhurst Stephen
- Fan Pinchen
- Farah Amanda M.
- Farr Ben
- Farr Will M.
- Fauchon-Jones E. J.
- Favaro Giulio
- Favata Marc
- Fays Maxime
- Feicht J.
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- Fenyvesi Edit
- Ferguson Deborah
- Ferrante Isidoro
- Ferreira T. A.
- Fidecaro Francesco
- Fiori Alessio
- Fiori Irene
- Fishbach Maya
- Fisher R. P.
- Fittipaldi R.
- Fiumara V.
- Flaminio R.
- Fleischer Svenja
- Fleming L. S.
- Floden E.
- Fong H.
- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Francisco Nuño Siles José
- Franke A.
- Frasca S.
- Frasconi Franco
- Frei Zsolt
- Freise Andreas
- Freitas Osvaldo
- Frey Raymond
- Frischhertz W.
- Fritschel P.
- Frolov V. V.
- Fujii S.
- Fukunaga I.
- Fulda P.
- Fung Wong Chun
- Fyffe M.
- Gabella William
- Gadre Bhooshan
- Gaetano Fronzé Gabriele
- Gair Jonathan
- Gais J.
- Galaudage S.
- Gallardo S.
- Gamba Rossella
- Ganapathy Dhruva
- Ganguly Apratim
- Gaonkar S. G.
- Garaventa Barbara
- Garcia-Bellido Juan
- García Quirós Cecilio
- García-Núñez C.
- Gardner James W.
- Gardner K. A.
- Gargiulo J.
- Garufi Fabio
- Gasbarra Claudio
- Gateley B.
- Gayathri V.
- Gemme Gianluca
- Gennai Alberto
- George J.
- Gerberding Oliver
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- Goetz Evan
- Goetz Ryan
- Golomb J.
- Goncharov Boris
- Gonzalez Gabriela
- Goodwin-Jones Aaron W.
- Gosselin M.
- Gouaty Romain
- Gould D. W.
- Goyal Srashti
- Grace B.
- Grado Aniello
- Graef Rollins Jameson
- Graham V.
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- GRANATA VERONICA.
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- Griggs Hannah
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- guetta dafne
- Guidi Gianluca
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- Gunny A. M.
- Guo Huaike
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- Helmling-Cornell Adrian
- Hemming Gary
- Hendry Martin
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- hennes eric
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- Henshaw Chad
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- Iess Alberto
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- Irwin Jessica
- Isi Maximiliano
- Itoh Yousuke
- Iwaya M.
- Jaberian Hamedan Vahid
- Jacqmin Thibaut
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- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
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- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
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- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
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- Bagui E.
- Bai Y.
- Baier Jeremy
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- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
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- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
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- Bassiri Riccardo
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- Bejger Michał
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- Bentley Joe
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- Bergamin Fabio
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- Bernuzzi Sebastiano
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- Betzwieser Joseph
- Beveridge Damon
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- Bhaumik Shubhagata
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- Bitossi Massimiliano
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
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- Zhu Zong-Hong
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
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