Abundances for metal-poor stars with accurate parallaxes I. Basic data

We present element-to-element abundance ratios measured from high dispersion spectra for 150 field subdwarfs and early subgiants with accurate Hipparcos parallaxes (errors <20%). For 50 stars new spectra were obtained with the UVES on Kueyen (VLT UT2), the McDonald 2.7m telescope, and SARG at TNG. Additionally, literature equivalent widths were taken from the works by Nissen & Schuster, Fulbright, and Prochaska et al. to complement our data. The whole sample includes both thick disk and halo stars (and a few thin disk stars); most stars have metallicities in the range -2<[Fe/H]<-0.6. We found our data, that of Nissen & Schuster, and that of Prochaska to be of comparable quality; results from Fulbright scatter a bit more, but they are still of very good quality and are extremely useful due to the large size of his sample. The results of the present analysis will be used in forthcoming papers to discuss the chemical properties of the dissipational collapse and accretion components of our Galaxy.Comment: 43 pages, 8 encapsulated figures, 13 tables. Table 1 only available in electronic form at CDS or from first author. Accepted for publication in A&

Remarks on the forces generated by two-neutrino exchange

A brief up-to-date review of the long range forces generated by two neutrino exchange is presented. The potential due to exchange of a massive neutrino-antineutrino pair between particles carrying weak charge might be larger than expected if the neutrinos have not only masses but also magnetic moments close to the present experimental bounds. It still remains too small to be observable.Comment: 10 pages, 3 figures. One figure added. Accepted for publication in EPJ

A study protocol for the evaluation of occupational mutagenic/carcinogenic risks in subjects exposed to antineoplastic drugs: a multicentric project

<p>Abstract</p> <p>Background</p> <p>Some industrial hygiene studies have assessed occupational exposure to antineoplastic drugs; other epidemiological investigations have detected various toxicological effects in exposure groups labeled with the job title. In no research has the same population been studied both environmentally and epidemiologically. The protocol of the epidemiological study presented here uses an integrated environmental and biological monitoring approach. The aim is to assess in hospital nurses preparing and/or administering therapy to cancer patients the current level of occupational exposure to antineoplastic drugs, DNA and chromosome damage as cancer predictive effects, and the association between the two.</p> <p>Methods/Design</p> <p>About 80 healthy non-smoking female nurses, who job it is to prepare or handle antineoplastic drugs, and a reference group of about 80 healthy non-smoking female nurses not occupationally exposed to chemicals will be examined simultaneously in a cross-sectional study. All the workers will be recruited from five hospitals in northern and central Italy after their informed consent has been obtained.</p> <p>Evaluation of surface contamination and dermal exposure to antineoplastic drugs will be assessed by determining cyclophosphamide on selected surfaces (wipes) and on the exposed nurses' clothes (pads). The concentration of unmetabolized cyclophosphamide as a biomarker of internal dose will be measured in end-shift urine samples from exposed nurses.</p> <p>Biomarkers of effect and susceptibility will be assessed in exposed and unexposed nurses: urinary concentration of 8-hydroxy-2-deoxyguanosine; DNA damage detected using the single-cell microgel electrophoresis (comet) assay in peripheral white blood cells; micronuclei and chromosome aberrations in peripheral blood lymphocytes. Genetic polymorphisms for enzymes involved in metabolic detoxification (i.e. glutathione <it>S</it>-transferases) will also be analysed.</p> <p>Using standardized questionnaires, occupational exposure will be determined in exposed nurses only, whereas potential confounders (medicine consumption, lifestyle habits, diet and other non-occupational exposures) will be assessed in both groups of hospital workers.</p> <p>Statistical analysis will be performed to ascertain the association between occupational exposure to antineoplastic drugs and biomarkers of DNA and chromosome damage, after taking into account the effects of individual genetic susceptibility, and the presence of confounding exposures.</p> <p>Discussion</p> <p>The findings of the study will be useful in updating prevention procedures for handling antineoplastic drugs.</p

Stellar parameters of early-M dwarfs from ratios of spectral features at optical wavelengths

Context. Low-mass stars have been recognised as promising targets in the search for rocky, small planets with the potential of supporting life. As a consequence, Doppler search programmes using high-resolution spectrographs like HARPS or HARPS-N are providing huge quantities of optical spectra of M dwarfs. However, determining the stellar parameters of M dwarfs using optical spectra has proven to be challenging. Aims: We aim to calibrate empirical relationships to determine accurate stellar parameters for early-M dwarfs (spectral types M0-M4.5) using the same spectra as those that are used for radial velocity determinations, without the necessity of acquiring IR spectra or relying on atmospheric models and/or photometric calibrations. Methods: Our methodology consists of using ratios of pseudo-equivalent widths of spectral features as a temperature diagnostic, a technique frequently used in solar-type stars. Stars with effective temperatures obtained from interferometric estimates of their radii are used as calibrators. Empirical calibrations for the spectral type are also provided. Combinations of features and ratios of features are used to derive calibrations for the stellar metallicity. Our methods are then applied to a large sample of M dwarfs that are currently being observed in the framework of the HARPS GTO search for extrasolar planets. The derived temperatures and metallicities are used together with photometric estimates of mass, radius, and surface gravity to calibrate empirical relationships for these parameters. Results: A long list of spectral features in the optical spectra of early-M dwarfs was identified. This list shows that the pseudo-equivalent width of roughly 43% of the features is strongly anticorrelated with the effective temperature. The correlation with the stellar metallicity is weaker. A total of 112 temperature sensitive ratios were identified and calibrated over the range 3100-3950 K, providing effective temperatures with typical uncertainties of about 70 K. Eighty-two ratios of pseudo-equivalent widths of features were calibrated to derive spectral types within 0.5 subtypes for stars with spectral types between K7V and M4.5V. We calibrated 696 combinations of the pseudo-equivalent widths of individual features and temperature-sensitive ratios for the stellar metallicity over a metallicity range from -0.54 to +0.24 dex, with estimated uncertainties in the range of 0.07-0.10 dex. We provide our own empirical calibrations for stellar mass, radius, and surface gravity. These parameters depend on the stellar metallicity. For a given effective temperature, lower metallicities predict lower masses and radii as well as higher gravities. Based on data products from observations made with ESO Telescopes at the La Silla Paranal Observatory under programmes ID 072.C-0488(E), 082.C-0718(B), 085.C-0019(A), 180.C-0886(A), 183.C-0437(A), and 191.C-0505(A), as well as data from the Italian Telescopio Nazionale Galileo (TNG) Archive (programmes ID CAT-147, and A27CAT_83).Our computational codes including the full version of Tables 2, 4, and 6 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/577/A132Appendix A is available in electronic form at http://www.aanda.org</A

Impact of gastrointestinal side effects on patients’ reported quality of life trajectories after radiotherapy for prostate cancer: Data from the prospective, observational pros-it CNR study

Radiotherapy (RT) represents an important therapeutic option for the treatment of localized prostate cancer. The aim of the current study is to examine trajectories in patients’ reported quality of life (QoL) aspects related to bowel function and bother, considering data from the PROState cancer monitoring in ITaly from the National Research Council (Pros-IT CNR) study, analyzed with growth mixture models. Data for patients who underwent RT, either associated or not associated with androgen deprivation therapy, were considered. QoL outcomes were assessed over a 2-year period from the diagnosis, using the Italian version of the University of California Los Angeles-Prostate Cancer Index (Italian-UCLA-PCI). Three trajectories were identified for the bowel function; having three or more comorbidities and the use of 3D-CRT technique for RT were associated with the worst trajectory (OR = 3.80, 95% CI 2.04–7.08; OR = 2.17, 95% CI 1.22–3.87, respectively). Two trajectories were identified for the bowel bother scores; diabetes and the non-Image guided RT method were associated with being in the worst bowel bother trajectory group (OR = 1.69, 95% CI 1.06–2.67; OR = 2.57, 95% CI 1.70–3.86, respectively). The findings from this study suggest that the absence of comorbidities and the use of intensity modulated RT techniques with image guidance are related with a better tolerance to RT in terms of bowel side effects

VizieR Online Data Catalog: TrES-4b RV and Ic curves (Sozzetti+, 2015)

The TrES-4 system was observed with HARPS-N on 17 individual epochs between March 2013 and July 2014. We carried out Ic-band precision photometric observations of two complete transit events of TrES-4 b with the CAHA 1.23-m on UT 2013 July 6 and UT 2014 June 30. (2 data files)

Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients: The Pros-IT CNR study

Background: The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. Methods: One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). Results: At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. Conclusions: Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care

Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV

Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for stop and higgsino production using diphoton Higgs boson decays

Results are presented of a search for a "natural" supersymmetry scenario with gauge mediated symmetry breaking. It is assumed that only the supersymmetric partners of the top-quark (stop) and the Higgs boson (higgsino) are accessible. Events are examined in which there are two photons forming a Higgs boson candidate, and at least two b-quark jets. In 19.7 inverse femtobarns of proton-proton collision data at sqrt(s) = 8 TeV, recorded in the CMS experiment, no evidence of a signal is found and lower limits at the 95% confidence level are set, excluding the stop mass below 360 to 410 GeV, depending on the higgsino mass