Survival Of Aids Patients In The Southeast And South Of Brazil: Analysis Of The 1998-1999 Cohort [sobrevida De Pacientes Com Aids Das Regiões Sudeste E Sul Do Brasil: Análise Da Coorte De 1998-1999]

The aim of this study was to evaluate survival time for AIDS patients 13 years and older in the South and Southeast regions of Brazil, according to socio-demographic, clinical, and epidemiological characteristics. The sample was selected from all cases diagnosed in 1998 and 1999 and notified to the Epidemiological Surveillance System of the National STD/AIDS Program. Use of a questionnaire allowed analyzing 2,091 patient charts. Based on the Kaplan-Meier method, estimated survival was at least 108 months after diagnosis in 59.5% of patients in the Southeast and 59.3% in the South. Cox regression models showed, in both regions, an increase in survival in patients on antiretroviral therapy, those classified as AIDS cases according to the CD4 T-cell criterion, females, and those with more schooling. Other factors associated with longer survival in the Southeast were: white skin color, no history of tuberculosis since the AIDS diagnosis, negative hepatitis B serology, and access to a multidisciplinary health team. 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Interpretação de dados e formulação de políticas de saúde no Brasil (2007) Cad Saúde Pública, 23, pp. 497-523Batista, L.E., (2002) Mulheres E Homens Negros: Saúde, Doença E Morte [Doctoral Dissertation], , Araraquara: Fa-culdade de Ciências e Letras, Universidade Estadual PaulistaFonseca, M.G.P., Lucena, F.F.A., Souza, A., Bastos, F.I., AIDS mortality, "race or color", and social inequality in a context of universal access to highly active antiretroviral therapy (HAART) in Brazil, 1999- 2004 (2007) Cad Saúde Pública, (23 SUPPL 3), pp. S445-S455Marins, J.R.P., (2004) Estudo De Sobrevida Dos Pacientes De AIDS Segundo Escolaridade, Co-infecção Hepatite C E Tuberculose. Coorte Brasileira 1995-1996 [Doctoral Dissertation], , Campinas: Faculdade de Ciências Médicas, Universidade Estadual de CampinasFerreira, M.S., Borges, A.S., Avanços no tratamento da hepatite pelo vírus B (2007) Rev Soc Bras Med Trop, 40, pp. 451-462Mussini, C., Manzardo, C., Johnson, M., Monforte, A., Uberti-Foppa, C., Antinori, A., Patients presenting with AIDS in the HAART era: A collaborative cohort analysis (2008) AIDS, 22, pp. 2461-2469Nemes, M.I.B., Alencar, T.M.D., (2008) Equipe Qualiaids. Avaliação Da Assistência Ambulatorial Aos Adultos Vivendo Com HIV/AIDS, , Qualiaids. Relatório 2007/2008. Brasília: Ministério da SaúdeMelchior, R., Nemes, M.I.B., Basso, C.R.B., Castanheira, E.R.L., Alves, M.T.S.B., Buchalla, C.M., Avaliação da estrutura organizacional assistência ambulatorial em HIV/AIDS no Brasil (2006) Rev Saúde Pública, 40, pp. 143-15

Survival of patients with AIDS and association with level of education level and race/skin color in South and Southeast Brazil: a cohort study, 1998-1999

Analisar a sobrevida de pessoas com aids e sua associação com escolaridade e raça/cor da pele. Coorte de diagnosticados entre 1998 e 1999, nas regiões Sul e Sudeste do Brasil, com análise de sobrevida (método de Kaplan--Meier), estratificada por escolaridade e raça/cor da pele; a análise multivariada foi realizada mediante regressão de Cox. Foram incluídas 2.091 pessoas com sobrevida em 60 meses, a percentuais de 65% entre brancos e 62% entre pretos/pardos; o uso irregular de antirretrovirais (HR=11,2 - IC95%8,8;14,2) e a idade ≥60 anos (HR=2,5 - IC95%1,4;4,4) foram relacionados com menor sobrevida; escolaridade >8 anos (HR=0,4 - IC95%0,3;0,6) e sexo feminino (HR=0,6 - IC95%0,5;0,8) relacionaram-se positivamente com sobrevida; os menos escolarizados tiveram sobrevida menor. Menor escolaridade sobrepôs-se às diferenças de raça/cor da pele, quando relacionada à sobrevida; tais desigualdades explicaram as diferenças observadas, mesmo com políticas de acesso universal aos antirretrovirais. Síndrome da Imunodeficiência Adquirida; Sobrevivência (Saúde Pública); Análise de Sobrevida; Escolaridade; Origem Étnica e Saúde281To analyze the survival of people with AIDS and association with schooling and race/skin color. METHODS: this was a retrospective cohort study of people diagnosed with AIDS between 1998 and 1999, in the South and Southeast regions of Brazil. We used survival analysis (Kaplan-Meier method), stratified by schooling and race/skin color and multivariate analysis was performed using Cox regression. RESULTS: the study included 2,091 people who had survived at 60 months, with 65% survival among White participants and 62% among Black/brown participants. Irregular use of antiretroviral (HR=11.2 - 95%CI8.8;14.2), and age ≥60 years (HR=2.5 - 95%CI1.4;4.4) were related to lower survival; schooling >8 years (HR=0.4 - 95%CI0.3;0.6) and being female (HR=0.6 - 95%CI0.5;0.8) were positively related to survival; those with less schooling had lower survival. CONCLUSION: lower schooling levels overlap race/skin color differences in relation to survival; these inequalities explain the differences found, despite the policies on universal access to antiretroviral.OBJETIVO: analisar a sobrevida de pessoas com aids e sua associação com escolaridade e raça/cor da pele. MÉTODOS: coorte de diagnosticados entre 1998 e 1999, nas regiões Sul e Sudeste do Brasil, com análise de sobrevida (método de Kaplan--Meier), estratificada por escolaridade e raça/cor da pele; a análise multivariada foi realizada mediante regressão de Cox. RESULTADOS: foram incluídas 2.091 pessoas com sobrevida em 60 meses, a percentuais de 65% entre brancos e 62% entre pretos/pardos; o uso irregular de antirretrovirais (HR=11,2 - IC95%8,8;14,2) e a idade ≥60 anos (HR=2,5 - IC95%1,4;4,4) foram relacionados com menor sobrevida; escolaridade >8 anos (HR=0,4 - IC95%0,3;0,6) e sexo feminino (HR=0,6 - IC95%0,5;0,8) relacionaram-se positivamente com sobrevida; os menos escolarizados tiveram sobrevida menor. CONCLUSÃO: menor escolaridade sobrepôs-se às diferenças de raça/cor da pele, quando relacionada à sobrevida; tais desigualdades explicaram as diferenças observadas, mesmo com políticas de acesso universal aos antirretrovirais.OBJETIVO: analizar la sobrevida de personas con sida y su asociación con escolaridad y raza/color de la piel. MÉTODOS: cohorte de diagnosticados entre 1998 y 1999, en las regiones Sur y Sudeste de Brasil, con análisis de supervivencia (Kaplan-Meier), estratificados por educación y raza/color de la piel; el análisis multivariante se realizó con regresión de Cox. RESULTADOS: fueron incluidas 2.091 personas con sobrevida de 60 meses, a porcentuales de 65% entre blancos y 62% entre negros/pardos; el uso irregular de antirretrovirales (HR=11,2 - IC95%8,8;14,2) y la edad ≥60 años (HR=2,5 - IC95%1,4;4,4) se relacionaron con una menor sobrevida; escolaridad >8 años (HR=0,4 - IC95%0,3;0,6) y sexo femenino (HR=0,6 - IC95%0,5;0,8) se relacionaron positivamente con sobrevida; los menos escolarizados tuvieron sobrevida menor. CONCLUSIÓN: menor escolaridad se superpuso a las diferencias de raza/color de la piel referida, cuando relacionada a la supervivencia; tales desigualdades explicaron las diferencias observadas, aún con políticas de acceso universal a antirretrovirales

πΞ\pi\Xi phase shifts and CP Violation in Ω→πΞ{\Omega\to\pi\Xi} Decay

In the study of CP violation signals in {\O}\to\pi\Xi nonleptonic decays, the strong $J$=3/2 $P$ and $D$ phase shifts for the $\pi\Xi$ final-state interactions are needed. These phases are calculated using an effective Lagrangian model, including $\Xi$, $\Xi^*$(1530), $\rho$ and the $\sigma$-term, in the intermediate states. The $\sigma$-term is calculated in terms of the scalar form factor of the baryon.Comment: 6 pages, 2 figure

Screening polymeric ionic liquids for chromatography-based purification of bacteriophage M13

M13 bacteriophage is a key instrument in phage display applications, as well as a possible antibacterial therapeutic agent due to its highly restrictive bacterial pathogenesis, and other applications. The traditional phage purification process is usually achieved by gradient ultracentrifugation or a combination of precipitation, centrifugation and microfiltration. These approaches easily lead to long process times, high operational costs, phage aggregation and consequent product loss (approximately 60%). This work is thus focused on an alternative potential large-scale process to achieve high yield and purity while minimizing the operational costs. Electrostatic-based separation processes are also common biomolecules purification techniques. Although anion exchange chromatography has been used before to purify several viral particles, this technique has been poorly reported for the purification of M13 phage. In a recent work, our group has demonstrated the use of a predominant anion exchange process, where a polymeric ionic liquid (PIL) was used as an alternative separation matrix for M13 bacteriophage. In this work, a variety of system parameters was studied, including chemical structure of the cation and the anion, the crosslinker nature and its concentration, either in batch adsorption/elution or chromatographic operation mode. The PIL-based chromatographic operation mode revealed to be a suitable separation process for M13 from directly filtered E. coli supernatant, reaching over 70% M13 recovery and 4.6 purification factor in a single step. To our knowledge, this is the first time that PILs have been reported as separation agents for bioproducts from complex mixtures.publishe

Altered glucose homeostasis and hepatic function in obese mice deficient for both kinin receptor genes

The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and promote their effects by binding to two different receptors, the kinin B2 and B1 receptors, respectively. To understand the influence of the KKS on the pathophysiology of obesity and type 2 diabetes (T2DM), we generated an animal model deficient for both kinin receptor genes and leptin (obB1B2KO). Six-month-old obB1B2KO mice showed increased blood glucose levels. Isolated islets of the transgenic animals were more responsive to glucose stimulation releasing greater amounts of insulin, mainly in 3-month-old mice, which was corroborated by elevated serum C-peptide concentrations. Furthermore, they presented hepatomegaly, pronounced steatosis, and increased levels of circulating transaminases. This mouse also demonstrated exacerbated gluconeogenesis during the pyruvate challenge test. The hepatic abnormalities were accompanied by changes in the gene expression of factors linked to glucose and lipid metabolisms in the liver. Thus, we conclude that kinin receptors are important for modulation of insulin secretion and for the preservation of normal glucose levels and hepatic functions in obese mice, suggesting a protective role of the KKS regarding complications associated with obesity and T2DM

Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}=2.76 TeV

The elliptic, $v_2$, triangular, $v_3$, and quadrangular, $v_4$, azimuthal anisotropic flow coefficients are measured for unidentified charged particles, pions and (anti-)protons in Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV with the ALICE detector at the Large Hadron Collider. Results obtained with the event plane and four-particle cumulant methods are reported for the pseudo-rapidity range $|\eta|<0.8$ at different collision centralities and as a function of transverse momentum, $p_{\rm T}$, out to $p_{\rm T}=20$ GeV/$c$. The observed non-zero elliptic and triangular flow depends only weakly on transverse momentum for $p_{\rm T}>8$ GeV/$c$. The small $p_{\rm T}$ dependence of the difference between elliptic flow results obtained from the event plane and four-particle cumulant methods suggests a common origin of flow fluctuations up to $p_{\rm T}=8$ GeV/$c$. The magnitude of the (anti-)proton elliptic and triangular flow is larger than that of pions out to at least $p_{\rm T}=8$ GeV/$c$ indicating that the particle type dependence persists out to high $p_{\rm T}$.Comment: 16 pages, 5 captioned figures, authors from page 11, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186