363 research outputs found
Secondary pulmonary alveolar proteinosis treated by lung transplant: A case report.
Pulmonary alveolar proteinosis (PAP) is a pulmonary disease characterized by disruption of surfactant homeostasis resulting in its accumulation in the alveoli. PAP is classically classified into three categories (Table 1): 1/primary (or autoimmune) with antibodies targeting the GM-CSF pathway, 2/secondary to another disease, typically a hematologic malignancy, and 3/genetic.
A 30 year-old woman received an allogenic hematopoietic stem cell transplantation (HSCT) after treatment for acute myeloid leukemia (AML). Within the first 6 months post HSCT, she developed an ocular, oral, digestive and hepatic graft-versus-host disease associated with a mixed ventilatory defect with a very severe obstructive syndrome and a severe CO diffusion impairment. High resolution computed tomography showed a classical "crazy paving" pattern. Aspect and differential cell count of BAL were normal. All microbiological samples remained culture negative. Histo-pathological analysis of transbronchial biopsies was unremarkable. Because of the severity of the respiratory insufficiency, open-lung biopsy (OBL) could not be performed. Despite multiple immunosuppressive therapies, lung function deteriorated rapidly; the patient also developed an excavated fungal lesion unresponsive to treatment. She underwent a bilateral lung transplant 48 months after HSCT. Histo-pathological analysis of explanted lungs showed obliterative bronchiolitis (OB), diffuse PAP and invasive cavitary pulmonary aspergillosis.
This case illustrates the simultaneous occurrence of OB, PAP and a fungal infection in a 30-year old female patient who underwent HSCT for acute myeloid leukemia (AML). To our knowledge this is the only documented case of PAP associated with OB treated by lung transplantation
Science to Solutions Dialogue 3 - Everyone eating well within environmental limits
EAT and the World Business Council for Sustainable Development (WBCSD) convened through FReSH a Science to Solutions Dialogue (SSD) on Everyone Eating Well within Environmental Limits. This third dialogue took place from 4-7 December 2018 in Texcoco, Mexico, and brought together business, science and civil society to explore how to feed almost 10 billion people with sustainable and healthy diets. The summary of the discussion sets out three mutually supportive narratives to focus business action and the key solutions
Observation of semileptonic decays with CMD-2 detector
The decay has been observed by the CMD-2 detector at
the e^+e^- collider VEPP-2M at Novosibirsk. Of 6 million produced
pairs, events of the decay were selected. The
corresponding branching ratio is . This result is consistent with the evaluation of from the semileptonic rate and lifetime
assuming .Comment: 7 pages, 6 figures, LaTex2e. Submitted to Phys.Lett.
Radiological findings of complications after lung transplantation.
Complications following lung transplantation may impede allograft function and threaten patient survival. The five main complications after lung transplantation are primary graft dysfunction, post-surgical complications, alloimmune responses, infections, and malignancy. Primary graft dysfunction, a transient ischemic/reperfusion injury, appears as a pulmonary edema in almost every patient during the first three days post-surgery. Post-surgical dysfunction could be depicted on computed tomography (CT), such as bronchial anastomosis dehiscence, bronchial stenosis and bronchomalacia, pulmonary artery stenosis, and size mismatch. Alloimmune responses represent acute rejection or chronic lung allograft dysfunction (CLAD). CLAD has three different forms (bronchiolitis obliterans syndrome, restrictive allograft syndrome, acute fibrinoid organizing pneumonia) that could be differentiated on CT. Infections are different depending on their time of occurrence. The first post-operative month is mostly associated with bacterial and fungal pathogens. From the second to sixth months, viral pneumonias and fungal and parasitic opportunistic infections are more frequent. Different patterns according to the type of infection exist on CT. Malignancy should be depicted and corresponded principally to post-transplantation lymphoproliferative disease (PTLD). In this review, we describe specific CT signs of these five main lung transplantation complications and their time of occurrence to improve diagnosis, follow-up, medical management, and to correlate these findings with pathology results. KEY POINTS: • The five main complications are primary graft dysfunction, surgical, alloimmune, infectious, and malignancy complications. • CT identifies anomalies in the setting of unspecific symptoms of lung transplantation complications. • Knowledge of the specific CT signs can allow a prompt diagnosis. • CT signs maximize the yield of bronchoscopy, transbronchial biopsy, and bronchoalveolar lavage. • Radiopathological correlation helps to understand CT signs after lung transplantation complications
Heavy-quark mass dependence in global PDF analyses and 3- and 4-flavour parton distributions
We study the sensitivity of our recent MSTW 2008 NLO and NNLO PDF analyses to
the values of the charm- and bottom-quark masses, and we provide additional
public PDF sets for a wide range of these heavy-quark masses. We quantify the
impact of varying m_c and m_b on the cross sections for W, Z and Higgs
production at the Tevatron and the LHC. We generate 3- and 4-flavour versions
of the (5-flavour) MSTW 2008 PDFs by evolving the input PDFs and alpha_S
determined from fits in the 5-flavour scheme, including the eigenvector PDF
sets necessary for calculation of PDF uncertainties. As an example of their
use, we study the difference in the Z total cross sections at the Tevatron and
LHC in the 4- and 5-flavour schemes. Significant differences are found,
illustrating the need to resum large logarithms in Q^2/m_b^2 by using the
5-flavour scheme. The 4-flavour scheme is still necessary, however, if cuts are
imposed on associated (massive) b-quarks, as is the case for the experimental
measurement of Z b bbar production and similar processes.Comment: 40 pages, 11 figures. Grids can be found at
http://projects.hepforge.org/mstwpdf/ and in LHAPDF V5.8.4. v2: version
published in EPJ
The S-wave from the decay
Using data from FOCUS (E831) experiment at Fermilab, we present a model
independent partial-wave analysis of the S-wave amplitude from the
decay . The S-wave is a generic complex function to be
determined directly from the data fit. The P- and D-waves are parameterized by
a sum of Breit-Wigner amplitudes. The measurement of the S-wave amplitude
covers the whole elastic range of the system.Comment: 13 pages, 9 figures, submitted to Physics Letters
Counterexamples to the maximal p-norm multiplicativity conjecture for all p > 1
For all p > 1, we demonstrate the existence of quantum channels with
non-multiplicative maximal output p-norms. Equivalently, for all p >1, the
minimum output Renyi entropy of order p of a quantum channel is not additive.
The violations found are large; in all cases, the minimum output Renyi entropy
of order p for a product channel need not be significantly greater than the
minimum output entropy of its individual factors. Since p=1 corresponds to the
von Neumann entropy, these counterexamples demonstrate that if the additivity
conjecture of quantum information theory is true, it cannot be proved as a
consequence of any channel-independent guarantee of maximal p-norm
multiplicativity. We also show that a class of channels previously studied in
the context of approximate encryption lead to counterexamples for all p > 2.Comment: Merger of arXiv:0707.0402 and arXiv:0707.3291 containing new and
improved analysis of counterexamples. 17 page
Theory and phenomenology of two-Higgs-doublet models
We discuss theoretical and phenomenological aspects of two-Higgs-doublet
extensions of the Standard Model. In general, these extensions have scalar
mediated flavour changing neutral currents which are strongly constrained by
experiment. Various strategies are discussed to control these flavour changing
scalar currents and their phenomenological consequences are analysed. In
particular, scenarios with natural flavour conservation are investigated,
including the so-called type I and type II models as well as lepton-specific
and inert models. Type III models are then discussed, where scalar flavour
changing neutral currents are present at tree level, but are suppressed by
either specific ansatze for the Yukawa couplings or by the introduction of
family symmetries. We also consider the phenomenology of charged scalars in
these models. Next we turn to the role of symmetries in the scalar sector. We
discuss the six symmetry-constrained scalar potentials and their extension into
the fermion sector. The vacuum structure of the scalar potential is analysed,
including a study of the vacuum stability conditions on the potential and its
renormalization-group improvement. The stability of the tree level minimum of
the scalar potential in connection with electric charge conservation and its
behaviour under CP is analysed. The question of CP violation is addressed in
detail, including the cases of explicit CP violation and spontaneous CP
violation. We present a detailed study of weak basis invariants which are odd
under CP. A careful study of spontaneous CP violation is presented, including
an analysis of the conditions which have to be satisfied in order for a vacuum
to violate CP. We present minimal models of CP violation where the vacuum phase
is sufficient to generate a complex CKM matrix, which is at present a
requirement for any realistic model of spontaneous CP violation.Comment: v3: 180 pages, 506 references, new chapter 7 with recent LHC results;
referee comments taken into account; submitted to Physics Report
Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation
The current status of electric dipole moments of diamagnetic atoms which
involves the synergy between atomic experiments and three different theoretical
areas -- particle, nuclear and atomic is reviewed. Various models of particle
physics that predict CP violation, which is necessary for the existence of such
electric dipole moments, are presented. These include the standard model of
particle physics and various extensions of it. Effective hadron level combined
charge conjugation (C) and parity (P) symmetry violating interactions are
derived taking into consideration different ways in which a nucleon interacts
with other nucleons as well as with electrons. Nuclear structure calculations
of the CP-odd nuclear Schiff moment are discussed using the shell model and
other theoretical approaches. Results of the calculations of atomic electric
dipole moments due to the interaction of the nuclear Schiff moment with the
electrons and the P and time-reversal (T) symmetry violating
tensor-pseudotensor electron-nucleus are elucidated using different
relativistic many-body theories. The principles of the measurement of the
electric dipole moments of diamagnetic atoms are outlined. Upper limits for the
nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained
combining the results of atomic experiments and relativistic many-body
theories. The coefficients for the different sources of CP violation have been
estimated at the elementary particle level for all the diamagnetic atoms of
current experimental interest and their implications for physics beyond the
standard model is discussed. Possible improvements of the current results of
the measurements as well as quantum chromodynamics, nuclear and atomic
calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for
EPJ
Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events
The - oscillation frequency has been measured with a sample of
23 million \B\bar B pairs collected with the BABAR detector at the PEP-II
asymmetric B Factory at SLAC. In this sample, we select events in which both B
mesons decay semileptonically and use the charge of the leptons to identify the
flavor of each B meson. A simultaneous fit to the decay time difference
distributions for opposite- and same-sign dilepton events gives ps.Comment: 7 pages, 1 figure, submitted to Physical Review Letter
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