The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe

The preponderance of matter over antimatter in the early Universe, the dynamics of the supernova bursts that produced the heavy elements necessary for life and whether protons eventually decay --- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our Universe, its current state and its eventual fate. The Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed plan for a world-class experiment dedicated to addressing these questions. LBNE is conceived around three central components: (1) a new, high-intensity neutrino source generated from a megawatt-class proton accelerator at Fermi National Accelerator Laboratory, (2) a near neutrino detector just downstream of the source, and (3) a massive liquid argon time-projection chamber deployed as a far detector deep underground at the Sanford Underground Research Facility. This facility, located at the site of the former Homestake Mine in Lead, South Dakota, is approximately 1,300 km from the neutrino source at Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino charge-parity symmetry violation and mass ordering effects. This ambitious yet cost-effective design incorporates scalability and flexibility and can accommodate a variety of upgrades and contributions. With its exceptional combination of experimental configuration, technical capabilities, and potential for transformative discoveries, LBNE promises to be a vital facility for the field of particle physics worldwide, providing physicists from around the globe with opportunities to collaborate in a twenty to thirty year program of exciting science. In this document we provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess.Comment: Major update of previous version. This is the reference document for LBNE science program and current status. Chapters 1, 3, and 9 provide a comprehensive overview of LBNE's scientific objectives, its place in the landscape of neutrino physics worldwide, the technologies it will incorporate and the capabilities it will possess. 288 pages, 116 figure

Factor H-related proteins determine complement-activating surfaces.

Complement factor H-related proteins (FHRs) are strongly associated with different diseases involving complement dysregulation, which suggests a major role for these proteins regulating complement activation. Because FHRs are evolutionarily and structurally related to complement inhibitor factor H (FH), the initial assumption was that the FHRs are also negative complement regulators. Whereas weak complement inhibiting activities were originally reported for these molecules, recent developments indicate that FHRs may enhance complement activation, with important implications for the role of these proteins in health and disease. We review these findings here, and propose that FHRs represent a complex set of surface recognition molecules that, by competing with FH, provide improved discrimination of self and non-self surfaces and play a central role in determining appropriate activation of the complement pathway

Measurements of charge and CP asymmetries in b-hadron decays using top-quark events collected by the ATLAS detector in pp collisions at √s=8 TeV

Same- and opposite-sign charge asymmetries are measured in lepton+jets tt¯ events in which a b-hadron decays semileptonically to a soft muon, using data corresponding to an integrated luminosity of 20.3 fb−1 from proton-proton collisions at a centre-of-mass energy of √ s = 8 TeV collected with the ATLAS detector at the Large Hadron Collider at CERN. The charge asymmetries are based on the charge of the lepton from the top-quark decay and the charge of the soft muon from the semileptonic decay of a b-hadron and are measured in a fiducial region corresponding to the experimental acceptance. Four CP asymmetries (one mixing and three direct) are measured and are found to be compatible with zero and consistent with the Standard Model

Estudio molecular para la detección de Leptospira spp. en mamíferos silvestres y domésticos en la reserva ecológica Costanera Sur, CABA

Under "One Health" concept, the health problem is approached from a holistic view linking human, animal and environmental health. Multiple pathogens circulating among animal and human populations, which can be a threatto both human and animal health. Leptospira spp. has been reported to cause infection in almost all species of mammals. In this work the human-animal-environment interface was analyzed by studying Leptospira spp. infection model in wild and domestic species in the Costanera Sur Ecological Reserve. Data were obtained through a transects, stratified stages and proportionate sampling. Urine and renal tissue were taken as appropriate and PCR diagnostic was performed. The present work has the objective to study the occurrence of leptospirosis by molecular techniques(PCR), in populations of domestic and wild animals of the RECS. At the same time, contribute to the knowledge of the impact of the contact of these populations and their potential role as reservoirs and transmitters of Leptospira spp. Which inhabit protected natural areas, modified by increasing urbanization processes, such as the RECS.A total of 140 animals belonging to 10 different species were caught:6 species of rodents, 3 species of marsupials, 1 cingulate and a total of 30canines. All analyzed samples were negative. The eco-environmental conditions of the study area posed an enabling environment for development of Leptospira spp. But we could presume that the dispersion of the populations of host (and therefore their potential reservoirs)condition the environmental burden of bacteria in different habitats, may establish a detection limit below the level of sampling and diagnostic techniques used in this research. This study is considered an approach of the knowledge of the eco epidemiology and infection risk of diseases in the human- animal - environment interface in CABA, considering Leptospira spp. as zoonotic infectious disease model, in which proposals to deepen these studies are performed.Fil: Berra, Yanina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Veterinaria en Salud Pública; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arocena, Gastón Maximiliano. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Artuso, María Carolina. Ministerio de Agricultura, Ganadería, Pesca y Alimento. Servicio Nacional de Sanidad y Calidad Agroalimentaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ercolini, Carina. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; ArgentinaFil: Bruno, Antonela. Gobierno de la Ciudad Autónoma de Buenos Aires. Ministerio de Salud. Instituto de Zoonosis Luis Pasteur; ArgentinaFil: Orozco, Maria Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Degregorio, Osvaldo Jorge. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Veterinaria en Salud Pública; Argentin

High level expression of bioactive recombinant human growth hormone in the milk of a cloned transgenic cow

Transgenic farm animals have been proposed as an alternative to current bioreactors for large scale production of biopharmaceuticals. However, the efficiency of both methods in the production of the same protein has not yet been established. Here we report the production of recombinant human growth hormone (hGH) in the milk of a cloned transgenic cow at levels of up to 5 g l(-1). The hormone is identical to that currently produced by expression in E. coli. In addition, the hematological and somatometric parameters of the cloned transgenic cow are within the normal range for the breed and it is fertile and capable of producing normal offspring. These results demonstrate that transgenic cattle can be used as a cost-effective alternative for the production of this hormone.Fil: Salamone, Daniel Felipe. Universidad de Buenos Aires. Facultad de Agronomía; Argentina. Biosidus ; ArgentinaFil: Barañao, Jose Lino Salvador. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Santos, Claudio. Biosidus ; ArgentinaFil: Bussmann, Leonardo Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Artuso, Jorge. Biosidus; ArgentinaFil: Werning, Carlos. Biosidus; ArgentinaFil: Prync, Aida. Biosidus; ArgentinaFil: Carbonetto, Cesar. Biosidus; ArgentinaFil: Dabsys, Susana. Biosidus; ArgentinaFil: Munar, Carlos. Munar y Asociados; ArgentinaFil: Salaberry R. Biosidus; ArgentinaFil: Berra, Guillermo. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Berra, Ignacio. Instituto Nacional de Tecnología Agropecuaria; ArgentinaFil: Fernández, Nahuel. Biosidus ; ArgentinaFil: Papouchado, Mariana. Biosidus; ArgentinaFil: Foti, Marcelo. Biosidus; ArgentinaFil: Judewicz, Norberto. Biosidus; ArgentinaFil: Mujica, Ignacio. Munar y Asociados; ArgentinaFil: Muñoz, Luciana. Biosidus; ArgentinaFil: Fernandez Alvarez, Silvina. Biosidus; ArgentinaFil: González, Eliseo. Centro de Diagnóstico Molecular; ArgentinaFil: Zimmermann, Juan. Biosidus; ArgentinaFil: Criscuolo, Marcelo. Biosidus; ArgentinaFil: Melo, Carlos. Biosidus; Argentin

Search for Bc+→π+μ+μ−B_c^+\to\pi^+\mu^+\mu^- decays and measurement of the branching fraction ratio B(Bc+→ψ(2S)π+)/B(Bc+→J/ψπ+){\cal B}(B_c^+\to\psi(2S)\pi^+)/{\cal B}(B_c^+\to J/\psi \pi^+)

International audienceThe first search for nonresonant $B_c^+\to\pi^+\mu^+\mu^-$ decays is reported. The analysis uses proton-proton collision data collected with the LHCb detector between 2011 and 2018, corresponding to an integrated luminosity of 9 fb$^{-1}$. No evidence for an excess of signal events over background is observed and an upper limit is set on the branching fraction ratio ${\cal B}(B_c^+\to\pi^+\mu^+\mu^-)/{\cal B}(B_c^+\to J/\psi \pi^+) < 2.1\times 10^{-4}$ at $90\%$ confidence level. Additionally, an updated measurement of the ratio of the $B_c^+\to\psi(2S)\pi^+$ and $B_c^+\to J/\psi \pi^+$ branching fractions is reported. The ratio ${\cal B}(B_c^+\to\psi(2S)\pi^+)/{\cal B}(B_c^+\to J/\psi \pi^+)$ is measured to be $0.254\pm 0.018 \pm 0.003 \pm 0.005$, where the first uncertainty is statistical, the second systematic, and the third is due to the uncertainties on the branching fractions of the leptonic $J/\psi$ and $\psi(2S)$ decays. This measurement is the most precise to date and is consistent with previous LHCb results

A model-independent measurement of the CKM angle γ\gamma in partially reconstructed B±→D∗h±B^{\pm} \to D^{*} h^{\pm} decays with D→KS0h+h−D \to K_{S}^{0} h^{+}h^{-}(h=π,K)(h=\pi, K)

International audienceA measurement of $C\!P$-violating observables in $B^{\pm} \to D^{*} K^{\pm}$ and $B^{\pm} \to D^{*} \pi^{\pm}$ decays is made where the photon or neutral pion from the $D^{*} \to D\gamma$ or $D^{*} \to D\pi^{0}$ decay is not reconstructed. The $D$ meson is reconstructed in the self-conjugate decay modes, $D \to K_{S}^{0} \pi^{+} \pi^{-}$ or $D \to K_{S}^{0} K^{+} K^{-}$. The distribution of signal yields in the $D$ decay phase space is analysed in a model-independent way. The measurement uses a data sample collected in proton-proton collisions at centre-of-mass energies of 7, 8, and 13 TeV, corresponding to a total integrated luminosity of approximately 9 fb$^{-1}$. The $B^{\pm} \to D^{*} K^{\pm}$ and $B^{\pm} \to D^{*} \pi^{\pm}$$C\!P$-violating observables are interpreted in terms of hadronic parameters and the CKM angle $\gamma$, resulting in a measurement of $\gamma = (92^{+21}_{-17})^{\circ}$. The total uncertainty includes the statistical and systematic uncertainties, and the uncertainty due to external strong-phase inputs

Observation of strangeness enhancement with charmed mesons in high-multiplicity pPbp\mathrm{Pb} collisions at sNN=8.16 \sqrt {s_{\mathrm{NN}}}=8.16\,TeV

International audienceThe production of prompt $D^+_{s}$ and $D^+$ mesons is measured by the LHCb experiment in proton-lead ($p\mathrm{Pb}$) collisions in both the forward ($1.5<y^*<4.0$) and backward ($-5.0<y^*<-2.5$) rapidity regions at a nucleon-nucleon center-of-mass energy of $\sqrt {s_{\mathrm{NN}}}=8.16\,$TeV. The nuclear modification factors of both $D^+_{s}$ and $D^+$ mesons are determined as a function of transverse momentum, $p_{\mathrm{T}}$, and rapidity. In addition, the $D^+_{s}$ to $D^+$ cross-section ratio is measured as a function of the charged particle multiplicity in the event. An enhanced $D^+_{s}$ to $D^+$ production in high-multiplicity events is observed for the whole measured $p_{\mathrm{T}}$ range, in particular at low $p_{\mathrm{T}}$ and backward rapidity, where the significance exceeds six standard deviations. This constitutes the first observation of strangeness enhancement in charm quark hadronization in high-multiplicity $p\mathrm{Pb}$ collisions. The results are also qualitatively consistent with the presence of quark coalescence as an additional charm quark hadronization mechanism in high-multiplicity proton-lead collisions