3,137 research outputs found
Concentric Characterization and Classification of Complex Network Nodes: Theory and Application to Institutional Collaboration
Differently from theoretical scale-free networks, most of real networks
present multi-scale behavior with nodes structured in different types of
functional groups and communities. While the majority of approaches for
classification of nodes in a complex network has relied on local measurements
of the topology/connectivity around each node, valuable information about node
functionality can be obtained by Concentric (or Hierarchical) Measurements. In
this paper we explore the possibility of using a set of Concentric Measurements
and agglomerative clustering methods in order to obtain a set of functional
groups of nodes. Concentric clustering coefficient and convergence ratio are
chosen as segregation parameters for the analysis of a institutional
collaboration network including various known communities (departments of the
University of S\~ao Paulo). A dendogram is obtained and the results are
analyzed and discussed. Among the interesting obtained findings, we emphasize
the scale-free nature of the obtained network, as well as the identification of
different patterns of authorship emerging from different areas (e.g. human and
exact sciences). Another interesting result concerns the relatively uniform
distribution of hubs along the concentric levels, contrariwise to the
non-uniform pattern found in theoretical scale free networks such as the BA
model.Comment: 15 pages, 13 figure
Hierarchical characterization of complex networks
While the majority of approaches to the characterization of complex networks
has relied on measurements considering only the immediate neighborhood of each
network node, valuable information about the network topological properties can
be obtained by considering further neighborhoods. The current work discusses on
how the concepts of hierarchical node degree and hierarchical clustering
coefficient (introduced in cond-mat/0408076), complemented by new hierarchical
measurements, can be used in order to obtain a powerful set of topological
features of complex networks. The interpretation of such measurements is
discussed, including an analytical study of the hierarchical node degree for
random networks, and the potential of the suggested measurements for the
characterization of complex networks is illustrated with respect to simulations
of random, scale-free and regular network models as well as real data
(airports, proteins and word associations). The enhanced characterization of
the connectivity provided by the set of hierarchical measurements also allows
the use of agglomerative clustering methods in order to obtain taxonomies of
relationships between nodes in a network, a possibility which is also
illustrated in the current article.Comment: 19 pages, 23 figure
Quantifying the interdisciplinarity of scientific journals and fields
There is an overall perception of increased interdisciplinarity in science,
but this is difficult to confirm quantitatively owing to the lack of adequate
methods to evaluate subjective phenomena. This is no different from the
difficulties in establishing quantitative relationships in human and social
sciences. In this paper we quantified the interdisciplinarity of scientific
journals and science fields by using an entropy measurement based on the
diversity of the subject categories of journals citing a specific journal. The
methodology consisted in building citation networks using the Journal Citation
Reports database, in which the nodes were journals and edges were established
based on citations among journals. The overall network for the 11-year period
(1999-2009) studied was small-world and scale free with regard to the
in-strength. Upon visualizing the network topology an overall structure of the
various science fields could be inferred, especially their interconnections. We
confirmed quantitatively that science fields are becoming increasingly
interdisciplinary, with the degree of interdisplinarity (i.e. entropy)
correlating strongly with the in-strength of journals and with the impact
factor.Comment: 23 pages, 6 figure
ANN-based energy reconstruction procedure for TACTIC gamma-ray telescope and its comparison with other conventional methods
The energy estimation procedures employed by different groups, for
determining the energy of the primary -ray using a single atmospheric
Cherenkov imaging telescope, include methods like polynomial fitting in SIZE
and DISTANCE, general least square fitting and look-up table based
interpolation. A novel energy reconstruction procedure, based on the
utilization of Artificial Neural Network (ANN), has been developed for the
TACTIC atmospheric Cherenkov imaging telescope. The procedure uses a 3:30:1 ANN
configuration with resilient backpropagation algorithm to estimate the energy
of a -ray like event on the basis of its image SIZE, DISTANCE and
zenith angle. The new ANN-based energy reconstruction method, apart from
yielding an energy resolution of 26%, which is comparable to that of
other single imaging telescopes, has the added advantage that it considers
zenith angle dependence as well. Details of the ANN-based energy estimation
procedure along with its comparative performance with other conventional energy
reconstruction methods are presented in the paper and the results indicate that
amongst all the methods considered in this work, ANN method yields the best
results. The performance of the ANN-based energy reconstruction has also been
validated by determining the energy spectrum of the Crab Nebula in the energy
range 1-16 TeV, as measured by the TACTIC telescope.Comment: 23pages, 9 figures Accepted for publication in NIM
Gene identification and analysis of transcripts differentially regulated in fracture healing by EST sequencing in the domestic sheep
BACKGROUND: The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural importance of the sheep, relatively little research has been performed into sheep genetics, and DNA sequences are available for only a small number of sheep genes. RESULTS: In this work we have sequenced over 47 thousand expressed sequence tags (ESTs) from libraries developed from healing bone in a sheep model of fracture healing. These ESTs were clustered with the previously available 10 thousand sheep ESTs to a total of 19087 contigs with an average length of 603 nucleotides. We used the newly identified sequences to develop RT-PCR assays for 78 sheep genes and measured differential expression during the course of fracture healing between days 7 and 42 postfracture. All genes showed significant shifts at one or more time points. 23 of the genes were differentially expressed between postfracture days 7 and 10, which could reflect an important role for these genes for the initiation of osteogenesis. CONCLUSION: The sequences we have identified in this work are a valuable resource for future studies on musculoskeletal healing and regeneration using sheep and represent an important head-start for genomic sequencing projects for Ovis aries, with partial or complete sequences being made available for over 5,800 previously unsequenced sheep genes
Airborne chemical sensing with mobile robots
Airborne chemical sensing with mobile robots has been an active research areasince the beginning of the 1990s. This article presents a review of research work in this field,including gas distribution mapping, trail guidance, and the different subtasks of gas sourcelocalisation. Due to the difficulty of modelling gas distribution in a real world environmentwith currently available simulation techniques, we focus largely on experimental work and donot consider publications that are purely based on simulations
Automatic Network Fingerprinting through Single-Node Motifs
Complex networks have been characterised by their specific connectivity
patterns (network motifs), but their building blocks can also be identified and
described by node-motifs---a combination of local network features. One
technique to identify single node-motifs has been presented by Costa et al. (L.
D. F. Costa, F. A. Rodrigues, C. C. Hilgetag, and M. Kaiser, Europhys. Lett.,
87, 1, 2009). Here, we first suggest improvements to the method including how
its parameters can be determined automatically. Such automatic routines make
high-throughput studies of many networks feasible. Second, the new routines are
validated in different network-series. Third, we provide an example of how the
method can be used to analyse network time-series. In conclusion, we provide a
robust method for systematically discovering and classifying characteristic
nodes of a network. In contrast to classical motif analysis, our approach can
identify individual components (here: nodes) that are specific to a network.
Such special nodes, as hubs before, might be found to play critical roles in
real-world networks.Comment: 16 pages (4 figures) plus supporting information 8 pages (5 figures
Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension
Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or those with lesion activity on imaging. We sought to assess whether natalizumab slows disease progression in secondary progressive multiple sclerosis, independent of relapses. Methods: ASCEND was a phase 3, randomised, double-blind, placebo-controlled trial (part 1) with an optional 2 year open-label extension (part 2). Enrolled patients aged 18–58 years were natalizumab-naive and had secondary progressive multiple sclerosis for 2 years or more, disability progression unrelated to relapses in the previous year, and Expanded Disability Status Scale (EDSS) scores of 3·0–6·5. In part 1, patients from 163 sites in 17 countries were randomly assigned (1:1) to receive 300 mg intravenous natalizumab or placebo every 4 weeks for 2 years. Patients were stratified by site and by EDSS score (3·0–5·5 vs 6·0–6·5). Patients completing part 1 could enrol in part 2, in which all patients received natalizumab every 4 weeks until the end of the study. Throughout both parts, patients and staff were masked to the treatment received in part 1. The primary outcome in part 1 was the proportion of patients with sustained disability progression, assessed by one or more of three measures: the EDSS, Timed 25-Foot Walk (T25FW), and 9-Hole Peg Test (9HPT). The primary outcome in part 2 was the incidence of adverse events and serious adverse events. Efficacy and safety analyses were done in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01416181. Findings: Between Sept 13, 2011, and July 16, 2015, 889 patients were randomly assigned (n=440 to the natalizumab group, n=449 to the placebo group). In part 1, 195 (44%) of 439 natalizumab-treated patients and 214 (48%) of 448 placebo-treated patients had confirmed disability progression (odds ratio [OR] 0·86; 95% CI 0·66–1·13; p=0·287). No treatment effect was observed on the EDSS (OR 1·06, 95% CI 0·74–1·53; nominal p=0·753) or the T25FW (0·98, 0·74–1·30; nominal p=0·914) components of the primary outcome. However, natalizumab treatment reduced 9HPT progression (OR 0·56, 95% CI 0·40–0·80; nominal p=0·001). In part 1, 100 (22%) placebo-treated and 90 (20%) natalizumab-treated patients had serious adverse events. In part 2, 291 natalizumab-continuing patients and 274 natalizumab-naive patients received natalizumab (median follow-up 160 weeks [range 108–221]). Serious adverse events occurred in 39 (13%) patients continuing natalizumab and in 24 (9%) patients initiating natalizumab. Two deaths occurred in part 1, neither of which was considered related to study treatment. No progressive multifocal leukoencephalopathy occurred. Interpretation: Natalizumab treatment for secondary progressive multiple sclerosis did not reduce progression on the primary multicomponent disability endpoint in part 1, but it did reduce progression on its upper-limb component. Longer-term trials are needed to assess whether treatment of secondary progressive multiple sclerosis might produce benefits on additional disability components. Funding: Biogen
Measurement of the cross-section and charge asymmetry of bosons produced in proton-proton collisions at TeV with the ATLAS detector
This paper presents measurements of the and cross-sections and the associated charge asymmetry as a
function of the absolute pseudorapidity of the decay muon. The data were
collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with
the ATLAS experiment at the LHC and correspond to a total integrated luminosity
of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements
varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the
1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured
with an uncertainty between 0.002 and 0.003. The results are compared with
predictions based on next-to-next-to-leading-order calculations with various
parton distribution functions and have the sensitivity to discriminate between
them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables,
submitted to EPJC. All figures including auxiliary figures are available at
https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13
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