177 research outputs found
Quenching phenomenon of singular parabolic problems with L1 initial data
We extend some previous existence results for quenching type parabolic problems involving a negative power of the unknown in the equation to the case of merely integrable initial data. We show that L1 Ω is the suitable framework to obtain the continuous dependence with respect to some norm of the initial datum; This way we answer to the question raised by several authors in the previous literature. We also show the complete quenching phenomena for such a L1-initial datum
A highly-ionized absorber as a new explanation for the spectral changes during dips from X-ray binaries
Until now, the spectral changes observed from persistent to dipping intervals
in dipping low-mass X-ray binaries were explained by invoking progressive and
partial covering of an extended emission region. Here, we propose a novel and
simpler way to explain these spectral changes, which does not require any
partial covering and hence any extended corona, and further has the advantage
of explaining self-consistently the spectral changes both in the continuum and
the narrow absorption lines that are now revealed by XMM-Newton. In 4U 1323-62,
we detect Fe XXV and Fe XXVI absorption lines and model them for the first time
by including a complete photo-ionized absorber model rather than individual
Gaussian profiles. We demonstrate that the spectral changes both in the
continuum and the lines can be simply modeled by variations in the properties
of the ionized absorber. From persistent to dipping the photo-ionization
parameter decreases while the equivalent hydrogen column density of the ionized
absorber increases. In a recent work (see Diaz Trigo et al. in these
proceedings), we show that our new approach can be successfully applied to all
the other dipping sources that have been observed by XMM-Newton.Comment: 5 pages, 5 figures, to appear in the proceedings of "The X-ray
Universe 2005", San Lorenzo de El Escorial (Spain), 26-30 September 200
Optimum sizing of launching nose of prestressed concrete bridges
El diseño del pico de lanzamiento de un puente lanzado determina su proceso constructivo y, por lo tanto, también sus dimensiones. La optimización del pico de lanzamiento puede plantearse como primer paso para la mejora del diseño de un puente lanzado. El procedimiento convencional de diseño del pico de lanzamiento se basa en emplear la técnica de prueba y error para reducir el momento flector sobre el apoyo frontal del tablero de hormigón pretensado durante el proceso de lanzamiento. Esta forma de trabajo en ningún caso garantiza alcanzar la mejor de entre todas las soluciones posibles, pues se basa en la experiencia e intuición del proyectista, además de limitarse necesariamente a escasos tanteos. Dado que los puentes lanzados constituyen una tipología constructiva importante, deben incorporar todas las capacidades disponibles de innovación del diseño, entre las que se encuentra la optimización matemática. Este trabajo propone una formulación objetiva y rigurosa para optimizar el pico de lanzamiento de un puente lanzado adaptada a los condicionantes reales que tienen en la práctica los proyectistas de puentes. Comparando los resultados obtenidos mediante procedimientos convencionales y con técnicas de optimización se puede comprobar el grado de validez de algunas afirmaciones, que se dan por supuestas en los métodos clásicos de diseño de picos de lanzamiento, pero que en realidad no se sustentan en fundamento teórico alguno, demostrándose la utilidad de la optimización matemática para la mejora del diseño.The design of the launching nose of an incrementally launched bridge determines its constructive process and, therefore, also its dimensions. The optimization of the launching nose can raise as a first step to improve the design of a launched bridge. The conventional design process of a launching nose is based on trial and error method to reduce bending moment of prestressed concrete deck at the foremost support during launch. In this way, there is no guarantee that the obtained solution is the best among all the possible solutions since they all depend on the experience and intuition of a designer, and they are also restricted by a limited number of possible iterations. Given that launched bridges constitute an important constructive typology, all the available capacities of design innovation should be incorporated, among which it can be found numerical optimization. This research work proposes an objective and rigorous formulation to optimize a launching nose of launched bridge under real constraints that a bridge designer can encounter in practice. Comparing the results obtained by conventional process and that by optimization techniques, it can be verified that some of the assumptions, considered in classical design methods of a launching nose, are not based on any theoretical foundation. This fact demonstrates the utility of numerical optimization to improve a design.Peer Reviewe
Acción del análogo tumoral de PTH (PTHrP) en la regulación de factores asociados al fenotipo invasivo y a la angiogénesis en células de cáncer de colon humano
El péptido relacionado con la hormona paratiroidea (PTHrP) está implicado en varios cánceres humanos, entre los que se encuentra el cáncer colorrectal (CCR). Esta patología implica varios procesos, como mayor supervivencia celular, proliferación, migración, invasión, transición epitelio-mesenquimática (TEM) y angiogénesis. Previamente encontramos que PTHrP induce la proliferación, supervivencia y migración de células Caco-2 y HCT116, dos líneas celulares de tumores de colon humano. La invasión celular durante la progresión del cáncer se ha asociado a la pérdida de características epiteliales, la remodelación de la matriz extracelular, y el desarrollo de vascularización, por lo que abordar estos procesos es de relevancia para entender el rol de PTHrP en la enfermedad y constituye el objetivo de este trabajo. Se observó que el tratamiento con PTHrP 10-8 M en estas células aumenta los niveles de ARNm de la metaloproteinasa de la matriz 7 (MMP-7) y la expresión proteica de la proteína ácida y rica en cisteína SPARC, dos proteínas que participan en la reestructuración del estroma y que están fuertemente implicadas en la invasión tumoral. Además el tratamiento con PTHrP disminuyó los niveles proteicos de citoqueratina-18 (CK-18) un marcador epitelial asociado con TEM mediante Western blot e Inmunocitoquímica. Los niveles del factor de crecimiento endotelial vascular (VEGF), del factor inducible por hipoxia 1α (HIF-1α) y de la metaloproteinasa de la matriz 9 (MMP-9) por RT-qPCR mostraron que PTHrP aumenta la transcripción de estos factores implicados en la angiogénesis tumoral. Estos resultados sugieren un nuevo rol de PTHrP en la regulación de fenómenos asociados a un fenotipo más agresivo de células derivadas de cáncer colorrectalFil: Carriere, P.. Universidad Nacional del Sur.Fil: Riquelme, A.N.. Universidad Nacional del Sur.Fil: Novoa Díaz, M.B.. Universidad Nacional del Sur.Fil: Calvo, N. . Universidad Nacional del Sur.Fil: Gentili, C.. Universidad Nacional del Sur
Self-similar community structure in organisations
The formal chart of an organisation is designed to handle routine and easily
anticipated problems, but unexpected situations arise which require the
formation of new ties so that the corresponding extra tasks can be properly
accomplished. The characterisation of the structure of such informal networks
behind the formal chart is a key element for successful management. We analyse
the complex e-mail network of a real organisation with about 1,700 employees
and determine its community structure. Our results reveal the emergence of
self-similar properties that suggest that some universal mechanism could be the
underlying driving force in the formation and evolution of informal networks in
organisations, as happens in other self-organised complex systems
Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at TeV
The elliptic, , triangular, , and quadrangular, , azimuthal
anisotropic flow coefficients are measured for unidentified charged particles,
pions and (anti-)protons in Pb-Pb collisions at TeV
with the ALICE detector at the Large Hadron Collider. Results obtained with the
event plane and four-particle cumulant methods are reported for the
pseudo-rapidity range at different collision centralities and as a
function of transverse momentum, , out to GeV/.
The observed non-zero elliptic and triangular flow depends only weakly on
transverse momentum for GeV/. The small dependence
of the difference between elliptic flow results obtained from the event plane
and four-particle cumulant methods suggests a common origin of flow
fluctuations up to GeV/. The magnitude of the (anti-)proton
elliptic and triangular flow is larger than that of pions out to at least
GeV/ indicating that the particle type dependence persists out
to high .Comment: 16 pages, 5 captioned figures, authors from page 11, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186
Centrality dependence of charged particle production at large transverse momentum in Pb-Pb collisions at TeV
The inclusive transverse momentum () distributions of primary
charged particles are measured in the pseudo-rapidity range as a
function of event centrality in Pb-Pb collisions at
TeV with ALICE at the LHC. The data are presented in the range
GeV/ for nine centrality intervals from 70-80% to 0-5%.
The Pb-Pb spectra are presented in terms of the nuclear modification factor
using a pp reference spectrum measured at the same collision
energy. We observe that the suppression of high- particles strongly
depends on event centrality. In central collisions (0-5%) the yield is most
suppressed with at -7 GeV/. Above
GeV/, there is a significant rise in the nuclear modification
factor, which reaches for GeV/. In
peripheral collisions (70-80%), the suppression is weaker with almost independently of . The measured nuclear
modification factors are compared to other measurements and model calculations.Comment: 17 pages, 4 captioned figures, 2 tables, authors from page 12,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/284
Measurement of charm production at central rapidity in proton-proton collisions at TeV
The -differential production cross sections of the prompt (B
feed-down subtracted) charmed mesons D, D, and D in the rapidity
range , and for transverse momentum GeV/, were
measured in proton-proton collisions at TeV with the ALICE
detector at the Large Hadron Collider. The analysis exploited the hadronic
decays DK, DK, DD, and their charge conjugates, and was performed on a
nb event sample collected in 2011 with a
minimum-bias trigger. The total charm production cross section at TeV and at 7 TeV was evaluated by extrapolating to the full phase space
the -differential production cross sections at TeV
and our previous measurements at TeV. The results were compared
to existing measurements and to perturbative-QCD calculations. The fraction of
cdbar D mesons produced in a vector state was also determined.Comment: 20 pages, 5 captioned figures, 4 tables, authors from page 15,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/307
Inequalities in the use of secondary prevention of cardiovascular disease by socioeconomic status: evidence from the PURE observational study
Background: There is little evidence on the use of secondary prevention medicines for cardiovascular disease by socioeconomic groups in countries at different levels of economic development. Methods: We assessed use of antiplatelet, cholesterol, and blood-pressure-lowering drugs in 8492 individuals with self-reported cardiovascular disease from 21 countries enrolled in the Prospective Urban Rural Epidemiology (PURE) study. Defining one or more drugs as a minimal level of secondary prevention, wealth-related inequality was measured using the Wagstaff concentration index, scaled from −1 (pro-poor) to 1 (pro-rich), standardised by age and sex. Correlations between inequalities and national health-related indicators were estimated. Findings: The proportion of patients with cardiovascular disease on three medications ranged from 0% in South Africa (95% CI 0–1·7), Tanzania (0–3·6), and Zimbabwe (0–5·1), to 49·3% in Canada (44·4–54·3). Proportions receiving at least one drug varied from 2·0% (95% CI 0·5–6·9) in Tanzania to 91·4% (86·6–94·6) in Sweden. There was significant (p<0·05) pro-rich inequality in Saudi Arabia, China, Colombia, India, Pakistan, and Zimbabwe. Pro-poor distributions were observed in Sweden, Brazil, Chile, Poland, and the occupied Palestinian territory. The strongest predictors of inequality were public expenditure on health and overall use of secondary prevention medicines. Interpretation: Use of medication for secondary prevention of cardiovascular disease is alarmingly low. In many countries with the lowest use, pro-rich inequality is greatest. Policies associated with an equal or pro-poor distribution include free medications and community health programmes to support adherence to medications. Funding: Full funding sources listed at the end of the paper (see Acknowledgments)
Profiling of antioxidant potential and phytoconstituents of Plantago coronopus
The halophyte species Plantago coronopus has several described ethnomedicinal uses, but few reported biological activities. This work carried out for the first time a comparative analysis of P. coronopus organs in terms of phenolic composition and antioxidant activity of organic and water extracts from roots, leaves and flowers. The leaves contents in selected nutrients, namely amino acids and minerals, are also described. Roots (ethyl acetate and methanol extracts) had the highest radical scavenging activity (RSA) towards 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radicals, while leaves (hexane extract) had higher RSA on nitric oxide radical and iron chelating ability. High performance liquid chromatography (HPLC) analysis identified eighteen phenolics from which salicylic acid and epicatechin are here firstly described in Plantago species. Leaves had mineral levels similar to those of most vegetables, proving to be a good source for elements like calcium, sodium, iron and magnesium, and also for several of the essential amino acids justifying it use as food. Our results, especially those regarding the phenolics composition, can explain the main traditional uses given to this plantain and, altogether, emphasize the potential of P. coronopus as a source of bioactive molecules particularly useful for the prevention of oxidative stress-related diseases
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