Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory conditioning in adult Drosophila

Olfactory associative learning in Drosophila is mediated by synaptic plasticity between the Kenyon cells of the mushroom body and their output neurons. Both Kenyon cells and their inputs from projection neurons are cholinergic, yet little is known about the physiological function of muscarinic acetylcholine receptors in learning in adult flies. Here, we show that aversive olfactory learning in adult flies requires type A muscarinic acetylcholine receptors (mAChR-A), particularly in the gamma subtype of Kenyon cells. mAChR-A inhibits odor responses and is localized in Kenyon cell dendrites. Moreover, mAChR-A knockdown impairs the learning-associated depression of odor responses in a mushroom body output neuron. Our results suggest that mAChR-A function in Kenyon cell dendrites is required for synaptic plasticity between Kenyon cells and their output neurons

Spreading and localization of wavepackets in disordered wires in a magnetic field

We study the diffusive and localization properties of wavepackets in disordered wires in a magnetic field. In contrast to a recent supersymmetry approach our numerical results show that the decay rate of the steady state changes {\em smoothly} at the crossover from preserved to broken time-reversal symmetry. Scaling and fluctuation properties are also analyzed and a formula, which was derived analytically only in the pure symmetry cases is shown to describe also the steady state wavefunction at the crossover regime. Finally, we present a scaling for the variance of the packet which shows again a smooth transition due to the magnetic field.Comment: 4 pages, 4 figure

Distribution of local density of states in disordered metallic samples: logarithmically normal asymptotics

Asymptotical behavior of the distribution function of local density of states (LDOS) in disordered metallic samples is studied with making use of the supersymmetric $\sigma$--model approach, in combination with the saddle--point method. The LDOS distribution is found to have the logarithmically normal asymptotics for quasi--1D and 2D sample geometry. In the case of a quasi--1D sample, the result is confirmed by the exact solution. In 2D case a perfect agreement with an earlier renormalization group calculation is found. In 3D the found asymptotics is of somewhat different type: P(\rho)\sim \exp(-\mbox{const}\,|\ln^3\rho|).Comment: REVTEX, 14 pages, no figure

Activation Energy in a Quantum Hall Ferromagnet and Non-Hartree-Fock Skyrmions

The energy of Skyrmions is calculated with the help of a technique based on the excitonic representation: the basic set of one-exciton states is used for the perturbation-theory formalism instead of the basic set of one-particle states. We use the approach, at which a skyrmion-type excitation (at zero Lande factor) is considered as a smooth non-uniform rotation in the 3D spin space. The result within the framework of an excitonically diagonalized part of the Coulomb Hamiltonian can be obtained by any ratio $r_{\tiny C}=(e^2/\epsilon {}l_B)/\hbar \omega_c$ [where $e^2/\epsilon {}l_B$ is the typical Coulomb energy (${}l_B$ being the magnetic length); $\omega_c$ is the cyclotron frequency], and the Landau-level mixing is thereby taken into account. In parallel with this, the result is also found exactly, to second order in terms of the $r_{\tiny C}$ (if supposing $r_{\tiny C}$ to be small) with use of the total Hamiltonian. When extrapolated to the region $r_{\tiny C}\sim 1$, our calculations show that the skyrmion gap becomes substantially reduced in comparison with the Hartree-Fock calculations. This fact brings the theory essentially closer to the available experimental data.Comment: 14 pages, 1 figure. to appear in Phys. Rev. B, Vol. 65 (Numbers ~ 19-22), 200

Toward understanding covid-19 recovery: national institutes of health workshop on postacute covid-19

Over the past year, the SARS-CoV-2 pandemic has swept the globe, resulting in an enormous worldwide burden of infection and mortality. However, the additional toll resulting from long-term consequences of the pandemic has yet to be tallied. Heterogeneous disease manifestations and syndromes are now recognized among some persons after their initial recovery from SARS-CoV-2 infection, representing in the broadest sense a failure to return to a baseline state of health after acute SARS-CoV-2 infection. On 3 to 4 December 2020, the National Institute of Allergy and Infectious Diseases, in collaboration with other Institutes and Centers of the National Institutes of Health, convened a virtual workshop to summarize existing knowledge on postacute COVID-19 and to identify key knowledge gaps regarding this condition

Critical Currents of Ideal Quantum Hall Superfluids

Filling factor $\nu=1$ bilayer electron systems in the quantum Hall regime have an excitonic-condensate superfluid ground state when the layer separation $d$ is less than a critical value $d_c$. On a quantum Hall plateau current injected and removed through one of the two layers drives a dissipationless edge current that carries parallel currents, and a dissipationless bulk supercurrent that carries opposing currents in the two layers. In this paper we discuss the theory of finite supercurrent bilayer states, both in the presence and in the absence of symmetry breaking inter-layer hybridization. Solutions to the microscopic mean-field equations exist at all condensate phase winding rates for zero and sufficiently weak hybridization strengths. We find, however, that collective instabilities occur when the supercurrent exceeds a critical value determined primarily by a competition between direct and exchange inter-layer Coulomb interactions. The critical current is estimated using a local stability criterion and varies as $(d_c-d)^{1/2}$ when $d$ approaches $d_c$ from below. For large inter-layer hybridization, we find that the critical current is limited by a soliton instability of microscopic origin.Comment: 18 RevTeX pgs, 21 eps figure

The Problem of Patent Thickets in Convergent Technologies

Patent thickets are unintentionally dense webs of overlapping intellectual property rights owned by different companies that can retard progress. This article begins with a review of existing research on patent thickets, focusing in particular on the problem of patent thickets in nanotechnology, or nanothickets. After presenting visual evidence of the presence of nanothickets using a network analytic technique, it discusses potential organizational responses to patent thickets. It then reviews the existing research on patent pools and discusses pool formation in the shadow of antitrust enforcement. Based on recent research on patent pool formation, it examines the divergent fate of two recent pools and discusses the prospects for the future formation of nanotechnology patent pools, or nanopools.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72678/1/annals.1382.014.pd

Search for dark matter produced in association with a hadronically decaying vector boson in pp collisions at sqrt (s) = 13 TeV with the ATLAS detector

A search is presented for dark matter produced in association with a hadronically decaying W or Z boson using 3.2 fb−1 of pp collisions at View the MathML sources=13 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with a hadronic jet compatible with a W or Z boson and with large missing transverse momentum are analysed. The data are consistent with the Standard Model predictions and are interpreted in terms of both an effective field theory and a simplified model containing dark matter

Measurement of the View the tt production cross-section using eμ events with b-tagged jets in pp collisions at √s = 13 TeV with the ATLAS detector

This paper describes a measurement of the inclusive top quark pair production cross-section (σtt¯) with a data sample of 3.2 fb−1 of proton–proton collisions at a centre-of-mass energy of √s = 13 TeV, collected in 2015 by the ATLAS detector at the LHC. This measurement uses events with an opposite-charge electron–muon pair in the final state. Jets containing b-quarks are tagged using an algorithm based on track impact parameters and reconstructed secondary vertices. The numbers of events with exactly one and exactly two b-tagged jets are counted and used to determine simultaneously σtt¯ and the efficiency to reconstruct and b-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section is measured to be: σtt¯ = 818 ± 8 (stat) ± 27 (syst) ± 19 (lumi) ± 12 (beam) pb, where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, the integrated luminosity and the LHC beam energy, giving a total relative uncertainty of 4.4%. The result is consistent with theoretical QCD calculations at next-to-next-to-leading order. A fiducial measurement corresponding to the experimental acceptance of the leptons is also presented

The performance of the jet trigger for the ATLAS detector during 2011 data taking

The performance of the jet trigger for the ATLAS detector at the LHC during the 2011 data taking period is described. During 2011 the LHC provided proton–proton collisions with a centre-of-mass energy of 7 TeV and heavy ion collisions with a 2.76 TeV per nucleon–nucleon collision energy. The ATLAS trigger is a three level system designed to reduce the rate of events from the 40 MHz nominal maximum bunch crossing rate to the approximate 400 Hz which can be written to offline storage. The ATLAS jet trigger is the primary means for the online selection of events containing jets. Events are accepted by the trigger if they contain one or more jets above some transverse energy threshold. During 2011 data taking the jet trigger was fully efficient for jets with transverse energy above 25 GeV for triggers seeded randomly at Level 1. For triggers which require a jet to be identified at each of the three trigger levels, full efficiency is reached for offline jets with transverse energy above 60 GeV. Jets reconstructed in the final trigger level and corresponding to offline jets with transverse energy greater than 60 GeV, are reconstructed with a resolution in transverse energy with respect to offline jets, of better than 4 % in the central region and better than 2.5 % in the forward direction