741 research outputs found

    MAPPING THE ANKLE JOINTS PASSIVE MOTION AND MEASURING THE EFFECT OF INJURY ON LIGAMENT CONSTRAINT AT THE ANKLE JOINT

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    Lateral ankle sprain is one of the most common sports injuries, and having a better understanding of how ligament constraint changes after injury can assist in accurately diagnosing ankle laxity, prevention, and recovery. The objective was to map out the range of motion of the ankle under constant torque loading, and to examine the effect of a lateral ankle sprain level 2 and 3. Nine cadaveric ankles were run through a range of motion where a 6 degree of freedom load cell was used to collect force and torque loads and an Optotrak scanner collected the position of the tibia, talus, and calcaneus. The ankle saw more motion in abduction and inversion than adduction and eversion in the talocrural joint, and the ankle joint complex. The subtalar joint saw no change in inversion or eversion, or adduction, but there was less than four degrees of motion in adduction while the foot was plantarflexed. In general the foot was insensitive to varying torque levels with or without injury except in the talocrural joint where inversion and eversion saw a three to four degree difference after a sprain level 3. It was observed that when ABAD torques were applied the ankle was free to move in INEV, but when INEV torques were applied there was a constraint that limited the motion of the ankle in the ABAD direction. The results from this study show the range of motion of the ankle intact, and with a level 2 and level 3 sprain in the subtalar joint, the talocrural joint, and the ankle joint complex. With knowledge of the ankle's envelope of motion and quantitative assessment of the Taylor tilt test could be created, as well during a total ankle replacement different mid-flexion assessments could be made to create better outcomes for patients

    BMPR2 expression is suppressed by signaling through the estrogen receptor

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    <p>Abstract</p> <p>Background</p> <p>Studies in multiple organ systems have shown cross-talk between signaling through the bone morphogenetic protein receptor type 2 (BMPR2) and estrogen pathways. In humans, pulmonary arterial hypertension (PAH) has a female predominance, and is associated with decreased BMPR2 expression. The goal of this study was to determine if estrogens suppress BMPR2 expression.</p> <p>Methods</p> <p>A variety of techniques were utilized across several model platforms to evaluate the relationship between estrogens and BMPR2 gene expression. We used quantitative RT-PCR, gel mobility shift, and luciferase activity assays in human samples, live mice, and cell culture.</p> <p>Results</p> <p>BMPR2 expression is reduced in lymphocytes from female patients compared with male patients, and in whole lungs from female mice compared with male mice. There is an evolutionarily conserved estrogen receptor binding site in the BMPR2 promoter, which binds estrogen receptor by gel-shift assay. Increased exogenous estrogen decreases BMPR2 expression in cell culture, particularly when induced to proliferate. Transfection of increasing quantities of estrogen receptor alpha correlates strongly with decreasing expression of BMPR2.</p> <p>Conclusions</p> <p>BMPR2 gene expression is reduced in females compared to males in live humans and in mice, likely through direct estrogen receptor alpha binding to the BMPR2 promoter. This reduced BMPR2 expression may contribute to the increased prevalence of PAH in females.</p

    Search for narrow resonances in dilepton mass spectra in proton-proton collisions at root s=13 TeV and combination with 8 TeV data

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    Measurement of ZZ production in leptonic final states at {\surd}s of 1.96 TeV at CDF

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    In this paper we present a precise measurement of the total ZZ production cross section in pp collisions at {\surd}s= 1.96 TeV, using data collected with the CDF II detector corresponding to an integrated luminosity of approximately 6 fb-1. The result is obtained by combining separate measurements in the four-charged (lll'l'), and two-charged-lepton and two-neutral-lepton (llvv) decay modes of the Z. The combined measured cross section for pp {\to} ZZ is 1.64^(+0.44)_(-0.38) pb. This is the most precise measurement of the ZZ production cross section in 1.96 TeV pp collisions to date.Comment: submitted to Phys. Rev. Let

    Search for heavy gauge W ' bosons in events with an energetic lepton and large missing transverse momentum at root s=13TeV

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    Search for R-parity violating supersymmetry with displaced vertices in proton-proton collisions at root s=8 TeV

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    Search for new physics with dijet angular distributions in proton-proton collisions at root S = 13 TeV

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    Cross section measurement of t-channel single top quark production in pp collisions at root s=13 TeV

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    Search for single production of vector-like quarks decaying into a b quark and a W boson in proton-proton collisions at root s=13 TeV

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    Search for light bosons in decays of the 125 GeV Higgs boson in proton-proton collisions at root s=8 TeV

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