92 research outputs found
Saynete nuevo Intitulado Don Chicho : para catorce personas
FernĂĄndez GĂłmez, Juan F. CatĂĄlogo de entremeses y sainetes del siglo XVIII, 688Arizpe, VĂctor. The "Teatro antiguo español" collection at Smith College Library : A descriptive catalogue, 286El autor es Gaspar Zavala y ZamoraAtribuido tambiĂ©n a RamĂłn de la CruzPrecede al tĂt.: "186.
Comedia. El sitio de Pultov por Carlos XII. Segunda parte / escrita por Don Gaspar Zavala y Zamora
Texto a 2 col.Aguilar Piñal, 4079En la port. sello de imprenta: "Se hallara en la Imprenta de Orga, calle de las Barcas, en Valencia, nÂș 13
Respuesta y satisfacion demonstratiua ... al dictamen ingenuo que ha manifestado ... Fr. Ioseph Franco, del Orden de Nuestra Señora de la Merced
Sign.: [A]-T2, [A]-D2Port. con orla tipSegunda obra con port. y paginaciĂłn propiasReclamos e inciales xil. decoradas en p. 3 y 1 de los dos docs.Contiene: Respuesta al segundo memorial sobre el repartimiento y contribuciĂłn de la Dezima, que sigue al Papel del Dictamen ingenuo del Reverendo ... Fr. Iosef Franco. - Fe de errata
Hacia el fomento de las TIC en el sector educativo en Colombia
El actual contexto tecnolĂłgico y la apertura de nuevos escenarios digitales de comunicaciĂłn y acceso al conocimiento ha generado cambios sustanciales en el sector educativo a nivel global. Los maestros y las instituciones educativas no pueden limitarse solo a proporcionar las clĂĄsicas estrategias de seguimiento y apoyo al aprendizaje del alumno; por el contrario, deben basarse en el fomento y promociĂłn de mecanismos mĂĄs sistemĂĄticos y continuados al momento de llevar a cabo dicha labor, con el fin de promover mayor autonomĂa en los procesos de enseñanza-aprendizaje que lideran. Precisamente, para conocer a fondo cĂłmo se encuentra el sector educativo en Colombia respecto a los retos que marcan las nuevas formas de enseñanza-aprendizaje en la sociedad del conocimiento, se presenta esta obra que contiene los resultados del proyecto MediciĂłn del impacto de las actividades orientadas al fomento de las TIC en el sector educativo en la regiĂłn Caribe Colombiana. Caso Barranquilla y Cartagena, ejecutado por el Observatorio de EducaciĂłn de la Uninorte, la Universidad TecnolĂłgica de BolĂvar y la CorporaciĂłn Colombia Digital, con el apoyo de asesores internacionales de la Universidad de Murcia y del Instituto Torre del Palau de España, y el financiamiento de COLCIENCIAS y el Ministerio de EducaciĂłn Nacional de Colombia. Los autores realizan una revisiĂłn crĂtica al actual escenario tecnolĂłgico del sector educativo en el paĂs y presentan una propuesta orientada al fortalecimiento del fomento de las TIC. Los resultados aquĂ compilados serĂĄn de gran utilidad para la generaciĂłn de nuevas medidas orientadas a optimizar el proceso de inclusiĂłn digital en Colombia y la replicaciĂłn de este propuesta en otros escenarios de AmĂ©rica Latina
A chemical survey of exoplanets with ARIEL
Thousands of exoplanets have now been discovered with a huge range of masses, sizes and orbits: from rocky Earth-like planets to large gas giants grazing the surface of their host star. However, the essential nature of these exoplanets remains largely mysterious: there is no known, discernible pattern linking the presence, size, or orbital parameters of a planet to the nature of its parent star. We have little idea whether the chemistry of a planet is linked to its formation environment, or whether the type of host star drives the physics and chemistry of the planetâs birth, and evolution. ARIEL was conceived to observe a large number (~1000) of transiting planets for statistical understanding, including gas giants, Neptunes, super-Earths and Earth-size planets around a range of host star types using transit spectroscopy in the 1.25â7.8 ÎŒm spectral range and multiple narrow-band photometry in the optical. ARIEL will focus on warm and hot planets to take advantage of their well-mixed atmospheres which should show minimal condensation and sequestration of high-Z materials compared to their colder Solar System siblings. Said warm and hot atmospheres are expected to be more representative of the planetary bulk composition. Observations of these warm/hot exoplanets, and in particular of their elemental composition (especially C, O, N, S, Si), will allow the understanding of the early stages of planetary and atmospheric formation during the nebular phase and the following few million years. ARIEL will thus provide a representative picture of the chemical nature of the exoplanets and relate this directly to the type and chemical environment of the host star. ARIEL is designed as a dedicated survey mission for combined-light spectroscopy, capable of observing a large and well-defined planet sample within its 4-year mission lifetime. Transit, eclipse and phase-curve spectroscopy methods, whereby the signal from the star and planet are differentiated using knowledge of the planetary ephemerides, allow us to measure atmospheric signals from the planet at levels of 10â100 part per million (ppm) relative to the star and, given the bright nature of targets, also allows more sophisticated techniques, such as eclipse mapping, to give a deeper insight into the nature of the atmosphere. These types of observations require a stable payload and satellite platform with broad, instantaneous wavelength coverage to detect many molecular species, probe the thermal structure, identify clouds and monitor the stellar activity. The wavelength range proposed covers all the expected major atmospheric gases from e.g. H2O, CO2, CH4 NH3, HCN, H2S through to the more exotic metallic compounds, such as TiO, VO, and condensed species. Simulations of ARIEL performance in conducting exoplanet surveys have been performed â using conservative estimates of mission performance and a full model of all significant noise sources in the measurement â using a list of potential ARIEL targets that incorporates the latest available exoplanet statistics. The conclusion at the end of the Phase A study, is that ARIEL â in line with the stated mission objectives â will be able to observe about 1000 exoplanets depending on the details of the adopted survey strategy, thus confirming the feasibility of the main science objectives.Peer reviewedFinal Published versio
Epidemiological trends of HIV/HCV coinfection in Spain, 2015-2019
Altres ajuts: Spanish AIDS Research Network; European Funding for Regional Development (FEDER).Objectives: We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015-2018. Methods: The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results: The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions: In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
Measurement of Ï production in pp collisions at âs = 2.76 TeV
The production of Ï(1S), Ï(2S) and Ï(3S)
mesons decaying into the dimuon final state is studied with
the LHCb detector using a data sample corresponding to an
integrated luminosity of 3.3 pbâ1 collected in protonâproton
collisions at a centre-of-mass energy of âs = 2.76 TeV. The
differential production cross-sections times dimuon branching
fractions are measured as functions of the Ï transverse
momentum and rapidity, over the ranges pT < 15 GeV/c
and 2.0 < y < 4.5. The total cross-sections in this kinematic
region, assuming unpolarised production, are measured to be
Ï (pp â Ï(1S)X) Ă B
Ï(1S)âÎŒ+ÎŒâ
= 1.111 ± 0.043 ± 0.044 nb,
Ï (pp â Ï(2S)X) Ă B
Ï(2S)âÎŒ+ÎŒâ
= 0.264 ± 0.023 ± 0.011 nb,
Ï (pp â Ï(3S)X) Ă B
Ï(3S)âÎŒ+ÎŒâ
= 0.159 ± 0.020 ± 0.007 nb,
where the first uncertainty is statistical and the second systematic
The epidemiology of renal replacement therapy in two different parts of the worldThe Latin American Dialysis and Transplant Registry versus the European Renal Association-European Dialysis and Transplant Association Registry
Publisher Copyright: © 2018 Pan American Health Organization. All rights reserved.Objective: To compare the epidemiology of renal replacement therapy (RRT) for end-stage renal disease (ESRD) in Latin America and Europe, as well as to study differences in macro-economic indicators, demographic and clinical patient characteristics, mortality rates, and causes of death between these two populations. Methods: We used data from 20 Latin American and 49 European national and subnational renal registries that had provided data to the Latin American Dialysis and Renal Transplant Registry (RLADTR) and the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, respectively. The incidence and prevalence of RRT in 2013 were calculated per million population (pmp), overall and by subcategories of age, sex, primary renal disease, and treatment modality. The correlation between gross domestic product and the prevalence of RRT was analyzed using linear regression. Trends in the prevalence of RRT between 2004 and 2013 were assessed using Joinpoint regression analysis. Results: In 2013, the overall incidence at day 91 after the onset of RRT was 181 pmp for Latin American countries and 130 pmp for European countries. The overall prevalence was 660 pmp for Latin America and 782 pmp for Europe. In the Latin American countries, the annual increase in the prevalence averaged 4.0% (95% confdence interval (CI): 2.5%-5.6%) from 2004 to 2013, while the European countries showed an average annual increase of 2.2% (95% CI: 2.0%-2.4%) for the same time period. The crude mortality rate was higher in Latin America than in Europe (112 versus 100 deaths per 1 000 patient-years), and cardiovascular disease was the main cause of death in both of those regions. Conclusions. There are considerable differences between Latin America and Europe in the epidemiology of RRT for ESRD. Further research is needed to explore the reasons for these differences.Peer reviewe
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