Simulation Study of Chic -> J/Psi + gamma Detection with J/Psi -> e+ e- in pp Collisions

We present Monte Carlo preliminary results about the feasibility to detect the Chic family in p-p collisions at 14 TeV in the ALICE Central Barrel at CERN LHC. The Chic1 and Chic2 were forced to decay in the channel J/Psi + gamma -> e+ e- + gamma and were merged with a proton-proton non-biased collision. After MonteCarlo transport and simulation of the detector response, the e+, e- and converted gamma were reconstructed and identified in the ALICE ITS, TPC and TRD detectors. Separate signals corresponding to gamma from Chic1 and from Chic2 were observed. The position and relative weight of the fit to gaussians agreed with the input values within the statistical limits. Similar studies will be done for Pb-Pb collisions

Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases

Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a protozoan etiology, high incidence, and prevalence in developing countries. As a result, economic factors constitute one of the main obstacles to their management. Endemic countries have high levels of poverty, deprivation and marginalization which affect patients and limit their access to proper medical care. As a matter of fact, statistics remain un- collected in some affected areas due to non-reporting cases. World Health Organization and other organizations proposed a plan for the eradication and control of the vector, although many of these plans were halted by the COVID-19 pandemic. Despite of the available drugs to treat these pathologies, it exists a lack of effectiveness against several parasite strains. Treatment protocols for diseases such as American trypanosomiasis (Chagas disease), leishmaniasis, and human African trypanosomiasis (HAT) have not achieved the desired results. Un- fortunately, these drugs present limitations such as side effects, toxicity, teratogenicity, renal, and hepatic impairment, as well as high costs that have hindered the control and eradication of these diseases. This review focuses on the analysis of a collection of scientific shreds of evidence with the aim of identifying novel chalcogen- derived molecules with biological activity against Chagas disease, leishmaniasis and HAT. Compounds illustrated in each figure share the distinction of containing at least one chalcogen element. Sulfur (S), selenium (Se), and tellurium (Te) have been grouped and analyzed in accordance with their design strategy, chemical synthesis process and biological activity. After an exhaustive revision of the related literature on S, Se, and Te compounds, 183 compounds presenting excellent biological performance were gathered against the different causative agents of CD, leishmaniasis and HAT

Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats

Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3?UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353CT polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in MurcianoGranadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.Le facteur de transcription de´nomme´ Sterol regulatory element binding transcription factor 1 (SREBF1) re´gule l’expression des ge`nes implique´s dans la biosynthe`se des acides gras et du choleste´rol. Dans cette e´tude, nous avons se´quence´ la quasi-totalite´ de la re´gion codante et une partie du la re´gion 3?UTR du ge`ne SREBF1 de la che`vre. Ce travail, nous a permis d’identifier un polymorphisme non-synonyme c.353CT causant la substitution d’une Proline en Leucine a` la position 118. L’e´tude d’association avec la composition du lait enregistre´e en che`vres Murciano-Granadina, a re´ve´le´ seulement une tendance statistique reliant SREBF1 ge´notype et l’acide gras ome´ga-3 du lait. L’absence d’associations significatives sugge`re que la substitution P118L n’implique pas un changement fonctionnel

Проверка эффективности вспомогательной системы для маневрирования в местах слияния автомобильных потоков в режиме реального вождения автомобиля

In the latest study conducted by the National Highway Traffic Safety Administration in 2018, it was published that human error is still considered the major factor in traffic accidents, 94 %, compared with other causes such as vehicles, environment and unknown critical reasons. Some driving scenarios are especially complex, such as highways merging lanes, where the driver obtains information from the environment while making decisions on how to proceed to perform the maneuver smoothly and safely. Ignorance of the intentions of the drivers around him leads to risky situations between them caused by misunderstandings or erroneous assumptions or perceptions. For this reason, Advanced Driver Assistance Systems could provide information to obtain safer maneuvers in these critical environments. In previous works, the behavior of the driver by means of a visual tracking system while merging in a highway was studied, observing a cognitive load in those instants due to the high attentional load that the maneuver requires. For this reason, a driver assistance system for merging situations is proposed. This system uses V2V communications technology and suggests to the driver how to modify his speed in order to perform the merging manoeuver in a safe way considering the available gap and the relative speeds between vehicles. The paper presents the results of the validation of this system for assisting in the merging maneuver. For this purpose, the interface previously designed and validated in terms of usability, has been integrated into an application for a mobile device, located inside the vehicle and tests has been carried out in real driving conditions.In the latest study conducted by the National Highway Traffic Safety Administration in 2018, it was published that human error is still considered the major factor in traffic accidents, 94 %, compared with other causes such as vehicles, environment and unknown critical reasons. Some driving scenarios are especially complex, such as highways merging lanes, where the driver obtains information from the environment while making decisions on how to proceed to perform the maneuver smoothly and safely. Ignorance of the intentions of the drivers around him leads to risky situations between them caused by misunderstandings or erroneous assumptions or perceptions. For this reason, Advanced Driver Assistance Systems could provide information to obtain safer maneuvers in these critical environments. In previous works, the behavior of the driver by means of a visual tracking system while merging in a highway was studied, observing a cognitive load in those instants due to the high attentional load that the maneuver requires. For this reason, a driver assistance system for merging situations is proposed. This system uses V2V communications technology and suggests to the driver how to modify his speed in order to perform the merging manoeuver in a safe way considering the available gap and the relative speeds between vehicles. The paper presents the results of the validation of this system for assisting in the merging maneuver. For this purpose, the interface previously designed and validated in terms of usability, has been integrated into an application for a mobile device, located inside the vehicle and tests has been carried out in real driving conditions

Nanoindentation of Bridgman YBCO samples

In this study, the mechanical properties of YBa2Cu3O7−x, obtained by the Bridgman technique, were examined using a Berkovich tip indenter on the basal plane (0 0 1). Intrinsic hardness was measured by nanoindentation tests and corrected using the Nix and Gao model for this material. Furthermore, Vickers hardness tests were performed, in order to determine the possible size effect on these measurements. The results showed an underestimation of the hardness value when the tests were performed with large loads. Moreover, the elastic modulus of the Bridgman samples was 128 ± 5 GPa. Different residual imprints were visualised by atomic force microscopy and a focused ion beam, in order to observe superficial and internal fracturing. Mechanical properties presented a considerable reduction at the interface. This effect could be attributed to internal stress generated during the texturing process. In order to corroborate this hypothesis, an observation using transmission electron microscopy was performed

Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at sNN\sqrt{s_{NN}} = 5.02 TeV

Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7 $< p_{\rm{T}, assoc} < p_{\rm{T}, trig} <$ 5.0 GeV/$c$ is examined, to include correlations induced by jets originating from low momen\-tum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range $|\eta|<0.9$. The near-side long-range pseudorapidity correlations observed in high-multiplicity p-Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the non-jet-like components. The yields in the jet-like peaks are found to be invariant with event multiplicity with the exception of events with low multiplicity. This invariance is consistent with the particles being produced via the incoherent fragmentation of multiple parton--parton scatterings, while the yield related to the previously observed ridge structures is not jet-related. The number of uncorrelated sources of particle production is found to increase linearly with multiplicity, suggesting no saturation of the number of multi-parton interactions even in the highest multiplicity p-Pb collisions. Further, the number scales in the intermediate multiplicity region with the number of binary nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/161

Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider

Measurements of multi-particle azimuthal correlations (cumulants) for charged particles in p-Pb and Pb-Pb collisions are presented. They help address the question of whether there is evidence for global, flow-like, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is established. In particular, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of few-particle correlations in p-Pb collisions. However, when a $|\Delta \eta|$ gap is placed to suppress such correlations, the two-particle cumulants begin to rise at high-multiplicity, indicating the presence of global azimuthal correlations. The Pb-Pb values are higher than the p-Pb values at similar multiplicities. In both systems, the second harmonic four-particle cumulants exhibit a transition from positive to negative values when the multiplicity increases. The negative values allow for a measurement of $v_{2}\{4\}$ to be made, which is found to be higher in Pb-Pb collisions at similar multiplicities. The second harmonic six-particle cumulants are also found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find $v_{2}\{4\} \simeq v_{2}\{6\}\neq 0$ which is indicative of a Bessel-Gaussian function for the $v_{2}$ distribution. For very high-multiplicity Pb-Pb collisions, we observe that the four- and six-particle cumulants become consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and Pb-Pb are measured. These are found to be similar for overlapping multiplicities, when a $|\Delta\eta| > 1.4$ gap is placed.Comment: 25 pages, 11 captioned figures, 3 tables, authors from page 20, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/87

Charge separation relative to the reaction plane in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}= 2.76 TeV

Measurements of charge dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudo-rapidity range $|\eta| < 0.8$ are presented as a function of the collision centrality, particle separation in pseudo-rapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge dependent azimuthal correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286

A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE

In this small note we are concerned with the solution of Forward-Backward Stochastic Differential Equations (FBSDE) with drivers that grow quadratically in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem is a comparison result that allows comparing componentwise the signs of the control processes of two different qgFBSDE. As a byproduct one obtains conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio

Analyse d’association entre un polymorphisme non synonyme dans le gène SREBF1 et la production et la composition laitières chez les chèvres.

[EN]: Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3′UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353C>T polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in Murciano-Granadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.[FR]: Le facteur de transcription dénommé Sterol regulatory element binding transcription factor 1 (SREBF1) régule l'expression des gènes impliqués dans la biosynthèse des acides gras et du cholestérol. Dans cette étude, nous avons séquencé la quasi-totalité de la région codante et une partie du la région 3′UTR du gène SREBF1 de la chèvre. Ce travail, nous a permis d'identifier un polymorphisme non-synonyme c.353C> T causant la substitution d'une Proline en Leucine à la position 118. L’étude d'association avec la composition du lait enregistrée en chèvres Murciano-Granadina, a révélé seulement une tendance statistique reliant SREBF1 génotype et l'acide gras oméga-3 du lait. L'absence d'associations significatives suggère que la substitution P118L n'implique pas un changement fonctionnel.This research was funded by projects AGL2007-66161-C02-01 and AGL2007-66161-C02-02. A. Zidi received fellowships of the Spanish Agency of International Cooperation and Development and of the Centre for Research in Agrigenomics (CRAG). Arianna Manunza received a postdoctoral fellowship from the Centre for Research in Agrigenomics (CRAG).Peer reviewe