1,144 research outputs found
Simulation Study of Chic -> J/Psi + gamma Detection with J/Psi -> e+ e- in pp Collisions
We present Monte Carlo preliminary results about the feasibility to detect
the Chic family in p-p collisions at 14 TeV in the ALICE Central Barrel at CERN
LHC. The Chic1 and Chic2 were forced to decay in the channel J/Psi + gamma ->
e+ e- + gamma and were merged with a proton-proton non-biased collision. After
MonteCarlo transport and simulation of the detector response, the e+, e- and
converted gamma were reconstructed and identified in the ALICE ITS, TPC and TRD
detectors. Separate signals corresponding to gamma from Chic1 and from Chic2
were observed. The position and relative weight of the fit to gaussians agreed
with the input values within the statistical limits. Similar studies will be
done for Pb-Pb collisions
Small molecules containing chalcogen elements (S, Se, Te) as new warhead to fight neglected tropical diseases
Neglected tropical diseases (NTDs) encompass a group of infectious diseases with a protozoan etiology, high
incidence, and prevalence in developing countries. As a result, economic factors constitute one of the main
obstacles to their management. Endemic countries have high levels of poverty, deprivation and marginalization
which affect patients and limit their access to proper medical care. As a matter of fact, statistics remain un-
collected in some affected areas due to non-reporting cases. World Health Organization and other organizations
proposed a plan for the eradication and control of the vector, although many of these plans were halted by the
COVID-19 pandemic. Despite of the available drugs to treat these pathologies, it exists a lack of effectiveness
against several parasite strains. Treatment protocols for diseases such as American trypanosomiasis (Chagas
disease), leishmaniasis, and human African trypanosomiasis (HAT) have not achieved the desired results. Un-
fortunately, these drugs present limitations such as side effects, toxicity, teratogenicity, renal, and hepatic
impairment, as well as high costs that have hindered the control and eradication of these diseases. This review
focuses on the analysis of a collection of scientific shreds of evidence with the aim of identifying novel chalcogen-
derived molecules with biological activity against Chagas disease, leishmaniasis and HAT. Compounds illustrated
in each figure share the distinction of containing at least one chalcogen element. Sulfur (S), selenium (Se), and
tellurium (Te) have been grouped and analyzed in accordance with their design strategy, chemical synthesis
process and biological activity. After an exhaustive revision of the related literature on S, Se, and Te compounds,
183 compounds presenting excellent biological performance were gathered against the different causative agents
of CD, leishmaniasis and HAT
Short communication: An association analysis between one missense polymorphism at the SREBF1 gene and milk yield and composition traits in goats
Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in
the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of
the 3?UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353CT polymorphism causing a proline
to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in MurcianoGranadina
goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The
lack of significant associations suggests that the P118L substitution does not involve a functional change.Le facteur de transcription de´nomme´ Sterol regulatory element binding transcription factor 1 (SREBF1)
re´gule l’expression des ge`nes implique´s dans la biosynthe`se des acides gras et du choleste´rol. Dans cette e´tude, nous avons
se´quence´ la quasi-totalite´ de la re´gion codante et une partie du la re´gion 3?UTR du ge`ne SREBF1 de la che`vre. Ce travail,
nous a permis d’identifier un polymorphisme non-synonyme c.353CT causant la substitution d’une Proline en Leucine a`
la position 118. L’e´tude d’association avec la composition du lait enregistre´e en che`vres Murciano-Granadina, a re´ve´le´
seulement une tendance statistique reliant SREBF1 ge´notype et l’acide gras ome´ga-3 du lait. L’absence d’associations
significatives sugge`re que la substitution P118L n’implique pas un changement fonctionnel
Проверка эффективности вспомогательной системы для маневрирования в местах слияния автомобильных потоков в режиме реального вождения автомобиля
In the latest study conducted by the National Highway Traffic Safety Administration in 2018, it was published that human error is still considered the major factor in traffic accidents, 94 %, compared with other causes such as vehicles, environment and unknown critical reasons. Some driving scenarios are especially complex, such as highways merging lanes, where the driver obtains information from the environment while making decisions on how to proceed to perform the maneuver smoothly and safely. Ignorance of the intentions of the drivers around him leads to risky situations between them caused by misunderstandings or erroneous assumptions or perceptions. For this reason, Advanced Driver Assistance Systems could provide information to obtain safer maneuvers in these critical environments. In previous works, the behavior of the driver by means of a visual tracking system while merging in a highway was studied, observing a cognitive load in those instants due to the high attentional load that the maneuver requires. For this reason, a driver assistance system for merging situations is proposed. This system uses V2V communications technology and suggests to the driver how to modify his speed in order to perform the merging manoeuver in a safe way considering the available gap and the relative speeds between vehicles. The paper presents the results of the validation of this system for assisting in the merging maneuver. For this purpose, the interface previously designed and validated in terms of usability, has been integrated into an application for a mobile device, located inside the vehicle and tests has been carried out in real driving conditions.In the latest study conducted by the National Highway Traffic Safety Administration in 2018, it was published that human error is still considered the major factor in traffic accidents, 94 %, compared with other causes such as vehicles, environment and unknown critical reasons. Some driving scenarios are especially complex, such as highways merging lanes, where the driver obtains information from the environment while making decisions on how to proceed to perform the maneuver smoothly and safely. Ignorance of the intentions of the drivers around him leads to risky situations between them caused by misunderstandings or erroneous assumptions or perceptions. For this reason, Advanced Driver Assistance Systems could provide information to obtain safer maneuvers in these critical environments. In previous works, the behavior of the driver by means of a visual tracking system while merging in a highway was studied, observing a cognitive load in those instants due to the high attentional load that the maneuver requires. For this reason, a driver assistance system for merging situations is proposed. This system uses V2V communications technology and suggests to the driver how to modify his speed in order to perform the merging manoeuver in a safe way considering the available gap and the relative speeds between vehicles. The paper presents the results of the validation of this system for assisting in the merging maneuver. For this purpose, the interface previously designed and validated in terms of usability, has been integrated into an application for a mobile device, located inside the vehicle and tests has been carried out in real driving conditions
Nanoindentation of Bridgman YBCO samples
In this study, the mechanical properties of YBa2Cu3O7−x, obtained by the Bridgman technique, were examined using a Berkovich tip indenter on the basal plane (0 0 1). Intrinsic hardness was measured by nanoindentation tests and corrected using the Nix and Gao model for this material. Furthermore, Vickers hardness tests were performed, in order to determine the possible size effect on these measurements. The results showed an underestimation of the hardness value when the tests were performed with large loads. Moreover, the elastic modulus of the Bridgman samples was 128 ± 5 GPa. Different residual imprints were visualised by atomic force microscopy and a focused ion beam, in order to observe superficial and internal fracturing. Mechanical properties presented a considerable reduction at the interface. This effect could be attributed to internal stress generated during the texturing process. In order to corroborate this hypothesis, an observation using transmission electron microscopy was performed
Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at = 5.02 TeV
Two-particle angular correlations between unidentified charged trigger and
associated particles are measured by the ALICE detector in p-Pb collisions at a
nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum
range 0.7 5.0 GeV/ is examined,
to include correlations induced by jets originating from low
momen\-tum-transfer scatterings (minijets). The correlations expressed as
associated yield per trigger particle are obtained in the pseudorapidity range
. The near-side long-range pseudorapidity correlations observed in
high-multiplicity p-Pb collisions are subtracted from both near-side
short-range and away-side correlations in order to remove the non-jet-like
components. The yields in the jet-like peaks are found to be invariant with
event multiplicity with the exception of events with low multiplicity. This
invariance is consistent with the particles being produced via the incoherent
fragmentation of multiple parton--parton scatterings, while the yield related
to the previously observed ridge structures is not jet-related. The number of
uncorrelated sources of particle production is found to increase linearly with
multiplicity, suggesting no saturation of the number of multi-parton
interactions even in the highest multiplicity p-Pb collisions. Further, the
number scales in the intermediate multiplicity region with the number of binary
nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/161
Multi-particle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider
Measurements of multi-particle azimuthal correlations (cumulants) for charged
particles in p-Pb and Pb-Pb collisions are presented. They help address the
question of whether there is evidence for global, flow-like, azimuthal
correlations in the p-Pb system. Comparisons are made to measurements from the
larger Pb-Pb system, where such evidence is established. In particular, the
second harmonic two-particle cumulants are found to decrease with multiplicity,
characteristic of a dominance of few-particle correlations in p-Pb collisions.
However, when a gap is placed to suppress such correlations,
the two-particle cumulants begin to rise at high-multiplicity, indicating the
presence of global azimuthal correlations. The Pb-Pb values are higher than the
p-Pb values at similar multiplicities. In both systems, the second harmonic
four-particle cumulants exhibit a transition from positive to negative values
when the multiplicity increases. The negative values allow for a measurement of
to be made, which is found to be higher in Pb-Pb collisions at
similar multiplicities. The second harmonic six-particle cumulants are also
found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find
which is indicative of a Bessel-Gaussian
function for the distribution. For very high-multiplicity Pb-Pb
collisions, we observe that the four- and six-particle cumulants become
consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and
Pb-Pb are measured. These are found to be similar for overlapping
multiplicities, when a gap is placed.Comment: 25 pages, 11 captioned figures, 3 tables, authors from page 20,
published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/87
Charge separation relative to the reaction plane in Pb-Pb collisions at TeV
Measurements of charge dependent azimuthal correlations with the ALICE
detector at the LHC are reported for Pb-Pb collisions at TeV. Two- and three-particle charge-dependent azimuthal correlations in
the pseudo-rapidity range are presented as a function of the
collision centrality, particle separation in pseudo-rapidity, and transverse
momentum. A clear signal compatible with a charge-dependent separation relative
to the reaction plane is observed, which shows little or no collision energy
dependence when compared to measurements at RHIC energies. This provides a new
insight for understanding the nature of the charge dependent azimuthal
correlations observed at RHIC and LHC energies.Comment: 12 pages, 3 captioned figures, authors from page 2 to 6, published
version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/286
A note on comonotonicity and positivity of the control components of decoupled quadratic FBSDE
In this small note we are concerned with the solution of Forward-Backward
Stochastic Differential Equations (FBSDE) with drivers that grow quadratically
in the control component (quadratic growth FBSDE or qgFBSDE). The main theorem
is a comparison result that allows comparing componentwise the signs of the
control processes of two different qgFBSDE. As a byproduct one obtains
conditions that allow establishing the positivity of the control process.Comment: accepted for publicatio
Analyse d’association entre un polymorphisme non synonyme dans le gène SREBF1 et la production et la composition laitières chez les chèvres.
[EN]: Sterol regulatory element binding transcription factor 1 (SREBF1) regulates the expression of genes involved in the biosynthesis of fatty acids and cholesterol. Herewith, we have sequenced the near-complete coding region and part of the 3′UTR of the goat SREBF1 gene. In doing so, we have detected a missense c.353C>T polymorphism causing a proline to leucine substitution at position 118 (P118L). An association analysis with milk composition traits recorded in Murciano-Granadina goats only revealed a statistical tendency linking SREBF1 genotype and milk omega-3 fatty acid content. The lack of significant associations suggests that the P118L substitution does not involve a functional change.[FR]: Le facteur de transcription dénommé Sterol regulatory element binding transcription factor 1 (SREBF1) régule l'expression des gènes impliqués dans la biosynthèse des acides gras et du cholestérol. Dans cette étude, nous avons séquencé la quasi-totalité de la région codante et une partie du la région 3′UTR du gène SREBF1 de la chèvre. Ce travail, nous a permis d'identifier un polymorphisme non-synonyme c.353C> T causant la substitution d'une Proline en Leucine à la position 118. L’étude d'association avec la composition du lait enregistrée en chèvres Murciano-Granadina, a révélé seulement une tendance statistique reliant SREBF1 génotype et l'acide gras oméga-3 du lait. L'absence d'associations significatives suggère que la substitution P118L n'implique pas un changement fonctionnel.This research was funded by projects AGL2007-66161-C02-01 and AGL2007-66161-C02-02. A. Zidi received fellowships of the Spanish Agency of International Cooperation and Development and of the Centre for Research in Agrigenomics (CRAG). Arianna Manunza received a postdoctoral fellowship from the Centre for Research in Agrigenomics (CRAG).Peer reviewe
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