Civic Attitude and Activity of Loma Linda University Dental Graduates

Introduction: Dentistry is regarded as a profession and granted certain privileges, such as self-regulation. Associated with this status are stated and implied responsibilities which are widely debated. In recent years, dental professionalism seems to be on the decline. Evidence cited includes access-to-care issues and decreased public trust in dentists. In response, academia and professional organizations have developed curricula and statements intended to bolster professionalism. Meanwhile little is known about practicing dentists’ attitudes or participation in health-related civic matters. Objectives: This study seeks to examine the importance Loma Linda University (LLU) dental graduates place on public roles, their reported participation in public activities and the factors related to their responses. Methods: Four hundred and fifty-six LLU dental graduates were surveyed. Civic-mindedness was ascertained from respondents’ reported attitudes regarding community participation, political involvement and collective advocacy. Civic activity was determined from reported civic participation during the last three years. Additional responses were gathered on a number of health-related issues to assess the respondents’ level of social concern beyond the immediate dental care needs of their patients. Findings from this study were compared with those of a similar study of physicians from the US.1 Results: Overall, three quarters of LLU respondents were considered civic-minded and 91% participated in civic activities. Attitudes regarding civic obligations were very similar to the US physician group. 1 The LLU dental graduates, however, reported a higher level of civic action than did the US physicians1 (91% vs. 65%). Regression analysis for civic-mindedness determined female gender and the specialties of pediatric dentistry and orthodontics were salient factors. Regression analysis for civic activity determined civic-mindedness, pediatric dentistry, and professional age greater than 20 years were related factors. The majority of LLU respondents, unlike US physicians, 1 deemed broader concerns not obviously tied to the health of their patients as important. The implications of these results as well as directions for future research were discussed

Intended Mathematics Curriculum as Represented in State-Level Curriculum Standards: Consensus or Confusion?

Full Report published by: Information Age Publishers. http://www.infoagepub.comThis report represents the first detailed analysis of the grade placement of particular learning goals across all state-level curriculum documents published and current as of May 2005. The report documents the current situation regarding grade-level mathematics curriculum specification in the U.S. and highlights a general lack of consensus across states. As states continue to work to improve learning opportunities for all students, we hope this report will serve as a useful summary to inform future curriculum decisions.This report is based on the work of the Center for the Study of Mathematics Curriculum, supported by the National Science Foundation under Grant No. ESI-0333879. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation

Human Metapneumovirus, Peru

We retrospectively studied 420 pharyngeal swab specimens collected from Peruvian and Argentinean patients with influenzalike illness in 2002 and 2003 for evidence of human metapneumovirus (HMPV). Twelve specimens (2.3%) were positive by multiple assays. Six specimens yielded HMPV isolates. Four of the 6 isolates were of the uncommon B1 genotype

Bilingual Learning for Second and Third Generation Children

Throughout the English-speaking world, children from bilingual backgrounds are being educated in mainstream classrooms where they have little or no opportunity to use their mother tongue. Second and third generation children, in particular, are assumed to be learning sufficiently through English only. This study investigated how British Bangladeshi children, learning Bengali in after-school classes but mostly more fluent in English than in their mother tongue, responded when able to use their full language repertoire within the mainstream curriculum. Through action research with mainstream and community language class teachers, bilingual literacy and numeracy tasks were devised and carried out with pupils aged seven to eleven in two East London primary schools. The bilingual activities were videorecorded and analysed qualitatively to identify the strategies used. The following cognitive and cultural benefits of bilingual learning discovered by researchers in other contexts were also found to apply in this particular setting: conceptual transfer, enriched understanding through translation, metalinguistic awareness, bicultural knowledge and building bilingual learner identities. The findings suggest that second and third generation children should be enabled to learn bilingually, and appropriate strategies are put forward for use in the mainstream classroom

Authigenic carbonates from the Cascadia subduction zone and their relation to gas hydrate stability

Authigenic carbonates are intercalated with massive gas hydrates in sediments of the Cascadia margin. The deposits were recovered from the uppermost 50 cm of sediments on the southern summit of the Hydrate Ridge during the RV Sonne cruise SO110. Two carbonate lithologies that differ in chemistry, mineralogy, and fabric make up these deposits. Microcrystalline high-magnesium calcite (14 to 19 mol% MgCO3) and aragonite are present in both semiconsolidated sediments and carbonate-cemented clasts. Aragonite occurs also as a pure phase without sediment impurities. It is formed by precipitation in cavities as botryoidal and isopachous aggregates within pure white, massive gas hydrate. Variations in oxygen isotope values of the carbonates reflect the mineralogical composition and define two end members: a Mg-calcite with δ18O =4.86‰ PDB and an aragonite with δ18O =3.68‰ PDB. On the basis of the ambient bottom-water temperature and accepted equations for oxygen isotope fractionation, we show that the aragonite phase formed in equilibrium with its pore-water environment, and that the Mg-calcite appears to have precipitated from pore fluids enriched in 18O. Oxygen isotope enrichment probably originates from hydrate water released during gas-hydrate destabilization

The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081

The human enteropathogen, Yersinia enterocolitica, is a significant link in the range of Yersinia pathologies extending from mild gastroenteritis to bubonic plague. Comparison at the genomic level is a key step in our understanding of the genetic basis for this pathogenicity spectrum. Here we report the genome of Y. enterocolitica strain 8081 (serotype 0:8; biotype 1B) and extensive microarray data relating to the genetic diversity of the Y. enterocolitica species. Our analysis reveals that the genome of Y. enterocolitica strain 8081 is a patchwork of horizontally acquired genetic loci, including a plasticity zone of 199 kb containing an extraordinarily high density of virulence genes. Microarray analysis has provided insights into species-specific Y. enterocolitica gene functions and the intraspecies differences between the high, low, and nonpathogenic Y. enterocolitica biotypes. Through comparative genome sequence analysis we provide new information on the evolution of the Yersinia. We identify numerous loci that represent ancestral clusters of genes potentially important in enteric survival and pathogenesis, which have been lost or are in the process of being lost, in the other sequenced Yersinia lineages. Our analysis also highlights large metabolic operons in Y. enterocolitica that are absent in the related enteropathogen, Yersinia pseudotuberculosis, indicating major differences in niche and nutrients used within the mammalian gut. These include clusters directing, the production of hydrogenases, tetrathionate respiration, cobalamin synthesis, and propanediol utilisation. Along with ancestral gene clusters, the genome of Y. enterocolitica has revealed species-specific and enteropathogen-specific loci. This has provided important insights into the pathology of this bacterium and, more broadly, into the evolution of the genus. Moreover, wider investigations looking at the patterns of gene loss and gain in the Yersinia have highlighted common themes in the genome evolution of other human enteropathogens

A Conflict Model for Strategists and Managers

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67210/2/10.1177_000276427201500604.pd

Ozone in the Pacific tropical troposphere from ozonesonde observations

Ozone vertical profile measurements obtained from ozonesondes flown at Fiji, Samoa, Tahiti, and the Galapagos are used to characterize ozone in the troposphere over the tropical Pacific. There is a significant seasonal variation at each of these sites. At sites in both the eastern and western Pacific, ozone mixing ratios are greatest at almost all levels in the troposphere during the September‐November season and smallest during March‐May. The vertical profile has a relative maximum at all of the sites in the midtroposphere throughout the year (the largest amounts are usually found near the tropopause). This maximum is particularly pronounced during the September‐November season. On average, throughout the troposphere, the Galapagos has larger ozone amounts than the western Pacific sites. A trajectory climatology is used to identify the major flow regimes that are associated with the characteristic ozone behavior at various altitudes and seasons. The enhanced ozone seen in the midtroposphere during September‐November is associated with flow from the continents. In the western Pacific this flow is usually from southern Africa (although 10‐day trajectories do not always reach the continent) but also may come from Australia and Indonesia. In the Galapagos the ozone peak in the midtroposphere is seen in flow from the South American continent and particularly from northern Brazil. High ozone concentrations within potential source regions and flow characteristics associated with the ozone mixing ratio peaks seen in both the western and eastern Pacific suggest that these enhanced ozone mixing ratios result from biomass burning. In the upper troposphere, low ozone amounts are seen with flow that originates in the convective western Pacific

Upper limits on the strength of periodic gravitational waves from PSR J1939+2134

The first science run of the LIGO and GEO gravitational wave detectors presented the opportunity to test methods of searching for gravitational waves from known pulsars. Here we present new direct upper limits on the strength of waves from the pulsar PSR J1939+2134 using two independent analysis methods, one in the frequency domain using frequentist statistics and one in the time domain using Bayesian inference. Both methods show that the strain amplitude at Earth from this pulsar is less than a few times $10^{-22}$.Comment: 7 pages, 1 figure, to appear in the Proceedings of the 5th Edoardo Amaldi Conference on Gravitational Waves, Tirrenia, Pisa, Italy, 6-11 July 200

Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer

The myotonic dystrophy-related Cdc42-binding kinases MRCKα and MRCKβ contribute to the regulation of actin-myosin cytoskeleton organization and dynamics, acting in concert with the Rho-associated coiled-coil kinases ROCK1 and ROCK2. The absence of highly potent and selective MRCK inhibitors has resulted in relatively little knowledge of the potential roles of these kinases in cancer. Here we report the discovery of the azaindole compounds BDP8900 and BDP9066 as potent and selective MRCK inhibitors that reduce substrate phosphorylation, leading to morphological changes in cancer cells along with inhibition of their motility and invasive character. In over 750 human cancer cell lines tested, BDP8900 and BDP9066 displayed consistent anti-proliferative effects with greatest activity in hematological cancer cells. Mass spectrometry identified MRCKα S1003 as an autophosphorylation site, enabling development of a phosphorylation-sensitive antibody tool to report on MRCKα status in tumor specimens. In a two-stage chemical carcinogenesis model of murine squamous cell carcinoma, topical treatments reduced MRCKα S1003 autophosphorylation and skin papilloma outgrowth. In parallel work, we validated a phospho-selective antibody with the capability to monitor drug pharmacodynamics. Taken together, our findings establish an important oncogenic role for MRCK in cancer, and they offer an initial preclinical proof of concept for MRCK inhibition as a valid therapeutic strategy