Rupture de matériaux amorphes : cascades d'événements plastiques et hétérogénéités

Nous discuterons des résultats expérimentaux récents sur les hétérogénéités de l'écoulement plastique d'un matériau amorphe. Les zones d'écoulements plastiques s'organisent pour former une structure fluctuante de micro-bandes. Cette micro-structure de l'écoulement peut être décrite en considérant les interactions élastiques entre événements plastiques au sein du matériau. La transition entre cet écoulement plastique et la localisation finale de l'écoulement sera également discutée

Systems biology approaches applied to regenerative medicine

Systems biology is the creation of theoretical and mathematical models for the study of biological systems, as an engine for hypothesis generation and to provide context to experimental data. It is underpinned by the collection and analysis of complex datasets from different biological systems, including global gene, RNA, protein and metabolite profiles. Regenerative medicine seeks to replace or repair tissues with compromised function (for example, through injury, deficiency or pathology), in order to improve their functionality. In this paper, we will address the application of systems biology approaches to the study of regenerative medicine, with a particular focus on approaches to study modifications to the genome, transcripts and small RNAs, proteins and metabolites

Galactic bulge giants: probing stellar and galactic evolution I. Catalogue of Spitzer IRAC and MIPS sources

Aims: We aim at measuring mass-loss rates and the luminosities of a statistically large sample of Galactic bulge stars at several galactocentric radii. The sensitivity of previous infrared surveys of the bulge has been rather limited, thus fundamental questions for late stellar evolution, such as the stage at which substantial mass-loss begins on the red giant branch and its dependence on fundamental stellar properties, remain unanswered. We aim at providing evidence and answers to these questions. Methods: To this end, we observed seven 15 times 15 arcmin^2 fields in the nuclear bulge and its vicinity with unprecedented sensitivity using the IRAC and MIPS imaging instruments on-board the Spitzer Space Telescope. In each of the fields, tens of thousands of point sources were detected. Results: In the first paper based on this data set, we present the observations, data reduction, the final catalogue of sources, and a detailed comparison to previous mid-IR surveys of the Galactic bulge, as well as to theoretical isochrones. We find in general good agreement with other surveys and the isochrones, supporting the high quality of our catalogue.Comment: 21 pages, accepted for publication in A&A. A version with high-resolution figures, as well as the data catalogues (including cross-id with GLIMPSE and GALCEN) and image mosaics are available at the anonymous ftp://ftp.ster.kuleuven.be/dist/stefan/Spitzer

Functional Renormalization Group and the Field Theory of Disordered Elastic Systems

We study elastic systems such as interfaces or lattices, pinned by quenched disorder. To escape triviality as a result of ``dimensional reduction'', we use the functional renormalization group. Difficulties arise in the calculation of the renormalization group functions beyond 1-loop order. Even worse, observables such as the 2-point correlation function exhibit the same problem already at 1-loop order. These difficulties are due to the non-analyticity of the renormalized disorder correlator at zero temperature, which is inherent to the physics beyond the Larkin length, characterized by many metastable states. As a result, 2-loop diagrams, which involve derivatives of the disorder correlator at the non-analytic point, are naively "ambiguous''. We examine several routes out of this dilemma, which lead to a unique renormalizable field-theory at 2-loop order. It is also the only theory consistent with the potentiality of the problem. The beta-function differs from previous work and the one at depinning by novel "anomalous terms''. For interfaces and random bond disorder we find a roughness exponent zeta = 0.20829804 epsilon + 0.006858 epsilon^2, epsilon = 4-d. For random field disorder we find zeta = epsilon/3 and compute universal amplitudes to order epsilon^2. For periodic systems we evaluate the universal amplitude of the 2-point function. We also clarify the dependence of universal amplitudes on the boundary conditions at large scale. All predictions are in good agreement with numerical and exact results, and an improvement over one loop. Finally we calculate higher correlation functions, which turn out to be equivalent to those at depinning to leading order in epsilon.Comment: 42 pages, 41 figure

Influence of cirrhosis on outcomes of patients with advanced intrahepatic cholangiocarcinoma receiving chemotherapy

International audienceBackground: Cirrhosis is a risk factor for intrahepatic cholangiocarcinoma (iCC). However, its exact prevalence is uncertain and its impact on the management of advanced disease is not established.Methods: Retrospective analysis of patients treated with systemic chemotherapy for advanced iCC in the 1st-line setting at 2 tertiary cancer referral centres. Cirrhosis was diagnosed based on at least one element prior to any treatment: pathological diagnosis, baseline platelets <150 × 109/L, portal hypertension and/or dysmorphic liver on imaging.Results: In the cohort of patients (n = 287), 82 (28.6%) had cirrhosis (45 based on pathological diagnosis). Patients with cirrhosis experienced more grade 3/4 haematologic toxicity (44% vs 22%, respectively, P = 0.001), and more grade 3/4 non-haematologic toxicity (34% vs 14%, respectively, P = 0.001) than those without. The overall survival (OS) was significantly shorter in patients with cirrhosis: median 9.1 vs 13.1 months for those without (HR = 1.56 [95% CI: 1.19-2.05]); P = 0.002), confirmed on multivariable analysis (HR = 1.48 [95% CI: 1.04-2.60]; P = 0.028).Conclusion: Cirrhosis was relatively common in patients with advanced iCC and was associated with increased chemotherapy-induced toxicity and shorter OS. Formal assessment and consideration of cirrhosis in therapeutic management is recommended

VLT/NACO near-infrared imaging and spectroscopy of N88A in the SMC

We present near-infrared imaging and spectroscopic high spatial resolution observations of the SMC region N88 containing the bright, excited, extincted and compact H II region N88A of size ~ 1 pc. To investigate its stellar content and reddening, N88 was observed using spectroscopy and imagery in the JHKs- and L'-band at a spatial resolution of ~ 0.1-0.3", using the VLT UT4 equipped with the NAOS adaptive optics system. In order to attempt to establish if the origin of the infra-red (IR) excess is due to bright nebulosity, circumstellar material and/or local dust, we used Ks vs J-K colour-magnitude (CM) and JHK colour-colour (CC) diagrams, as well as L' imagery.Our IR-data reveal in the N88 area an IR-excess fraction of geq 30 per cent of the detected stars,as well as an unprecedently detailed morphology of N88A. It consists of an embedded cluster of ~3.5" (~ 1 pc) in diameter, of at least thirteen resolved stars superposed with an unusual bright continuum centered on a very bright star. The four brightest stars in this cluster lie red-ward of H-K geq 0.45 mag, and could be classified as young stellar object (YSO) candidates. Four other probable YSO candidates are also detected in N88 along a south-north bow-shaped thin H2 filament at ~ 7" east of the young central bright star. At 0.2" east of this star, a heavily embedded core is detected that could be a massive class I protostar candidate. The 2.12 mu H2 image of N88A resembles a shell of diameter ~ 3" ~ 0.9 pc) centered on the bright star. The line ratios of H2 2-1 S(1) and 1-0 S(0) relative to 1-0 S(1), as well as the presence of high v lines, are indicative of photodissociation regions, rather than shocks.Comment: 15 pages, 14 figures, accepted by Astronomy and Astrophysics, uses pdflatex, aa.cl

Grain Dynamics in a Two-dimensional Granular Flow

We have used particle tracking methods to study the dynamics of individual balls comprising a granular flow in a small-angle two-dimensional funnel. We statistically analyze many ball trajectories to examine the mechanisms of shock propagation. In particular, we study the creation of, and interactions between, shock waves. We also investigate the role of granular temperature and draw parallels to traffic flow dynamics.Comment: 17 pages, 24 figures. To appear in Phys.Rev.E. High res./color figures etc. on http://www.nbi.dk/CATS/Granular/GrainDyn.htm

Infrared properties of the SDSS-maxBCG galaxy clusters

The physics of galaxy clusters has proven to be influenced by several processes connected with their galactic component which pollutes the ICM with metals, stars and dust. However, it is not clear whether the presence of diffuse dust can play a role in clusters physics since a characterisation of the IR properties of galaxy clusters is yet to be completely achieved. We focus on the recent work of Giard et al. (2008) who performed a stacking analysis of the IRAS data in the direction of several thousands of galaxy clusters, providing a statistical characterisation of their IR luminosity and redshift evolution. We model the IR properties of the galactic population of the SDSS-maxBCG clusters (0.1<z<0.3) in order to check if it accounts for the entire observed signal and to constrain the possible presence of other components, like dust in the ICM. Starting from the optical properties of the galaxy members, we estimate their emission in the 60 and 100 micron IRAS bands making use of modeled SEDs of different spectral types (E/S0, Sa, Sb, Sc and starburst). We also consider the evolution of the galactic population/luminosity with redshift. Our results indicate that the galactic emission, which is dominated by the contribution of star-forming galaxies, is consistent with the observed signal. In fact, our model slightly overestimates the observed fluxes, with the excess being concentrated in low-redshift clusters (z <~ 0.17). This indicates that, if present, the IR emission from intracluster dust must be very small. We obtain an upper limit on the dust-to-gas mass ratio in the ICM of Z_d <~ 5 10^-5. The excess in luminosity obtained at low redshift constitutes an indication that the cluster environment is driving a process of star-formation quenching in its galaxy members.Comment: 12 pages, 6 figures, 2 tables. Accepted for publication in A&

Management Effects on Greenhouse Gas Dynamics in Fen Ditches

Globally, large areas of peatland have been drained through the digging of ditches, generally to increase agricultural production. By lowering the water table it is often assumed that drainage reduces landscape-scale emissions of methane (CH4) into the atmosphere to negligible levels. However, drainage ditches themselves are known to be sources of CH4 and other greenhouse gases (GHGs), but emissions data are scarce, particularly for carbon dioxide (CO2) and nitrous oxide (N2O), and show high spatial and temporal variability. Here, we report dissolved GHGs and diffusive fluxes of CH4 and CO2 from ditches at three UK lowland fens under different management; semi-natural fen, cropland, and cropland restored to low-intensity grassland. Ditches at all three fens emitted GHGs to the atmosphere, but both fluxes and dissolved GHGs showed extensive variation both seasonally and within-site. CH4 fluxes were particularly large, with medians peaking at all three sites in August at 120-230 mg m-2 d-1. Significant between site differences were detected between the cropland and the other two sites for CO2 flux and all three dissolved GHGs, suggested that intensive agriculture has major effects on ditch biogeochemistry. Multiple regression models using environmental and water chemistry data were able to explain 29-59% of observed variation in dissolved GHGs. Annual CH4 fluxes from the ditches were 37.8, 18.3 and 27.2 g CH4 m-2 yr-1 for the semi-natural, grassland and cropland, and annual CO2 fluxes were similar (1100 to 1440 g CO2 m-2 yr-1) among sites. We suggest that fen ditches are important contributors to landscape-scale GHG emissions, particularly for CH4. Ditch emissions should be included in GHG budgets of human modified fens, particularly where drainage has removed the original terrestrial CH4 source, e.g. agricultural peatlands

About the lithospheric structure of central Tibet based on seismic data from the INDEPTH III profile

Signals from 11 shots and 8 earthquakes, and numerous teleseismic events were recorded along the 400-km seismic line INDEPTH III in central Tibet and interpreted together with previous seismic and tectonic data. The abnormal behavior of various mantle phases reveals a complex Moho-transition zone, especially in the northern part of the line, in the Changtang Block, where the lower crust and the mantle show unusually low velocities, a shingled appearance of Pn and no low-velocity layer in the upper crust. The strong east-west anisotropy in the Changtang Block is related to an easterly escape movement of the whole lithosphere, facilitated by the warm and weak layers in the lower crust and the upper mantle, bounded apparently by two prominent west-east running fault zones