20 research outputs found
Mild and Ligand Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones
No full textMild and Ligand-Free Pd(II)-Catalyzed Conjugate Additions to Hindered γ-Substituted Cyclohexenones
No full textLigand-free cationic Pd(II) catalyst with NaNO<sub>3</sub> as an additive is a highly active catalytic system for conjugate additions to sterically hindered γ-substituted cyclohexenones. More challenging γγ- and βγ-substrates also react well to produce products with quaternary centers in good dr. The conjugate additions occur in a diastereoselective fashion under mild, practical and air-stable conditions, using readily available commercial reagents
Palladium-catalyzed direct C-H functionalization of benzoquinone
No full textA direct Pd-catalyzed C-H functionalization of benzoquinone (BQ) can be controlled to give either mono- or disubstituted BQ, including the installation of two different groups in a one-pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cyclo-alkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents.</p
Ligand and Base-free Pd(II)-Catalyzed Controlled Switching between Oxidative Heck and Conjugate Addition Reactions
No full textDivergent outcomes of gold(I)-catalyzed indole additions to 3,3-disubstituted cyclopropenes
No full textGold(I)-Catalyzed Addition of Thiols and Thioacids to 3,3-Disubstituted Cyclopropenes
No full textGoldÂ(I)-catalyzed reactions of thiols, thiophenols, and
thioacids
with 3,3-disubstituted cyclopropenes occur in a regioselective and
chemoselective manner to produce either vinyl thioethers or primary
allylic thioesters in good yields. A survey of commonly used goldÂ(I)
catalysts shows Echavarren’s cationic goldÂ(I) catalyst to be
most tolerant of deactivation by sulfur. A novel digold with bridging
thiolate complex is characterized by X-ray crystallography, shedding
light on a possible deactivation pathway
Gold(I)-Catalyzed Addition of Thiols and Thioacids to 3,3-Disubstituted Cyclopropenes
No full textGoldÂ(I)-catalyzed reactions of thiols, thiophenols, and
thioacids
with 3,3-disubstituted cyclopropenes occur in a regioselective and
chemoselective manner to produce either vinyl thioethers or primary
allylic thioesters in good yields. A survey of commonly used goldÂ(I)
catalysts shows Echavarren’s cationic goldÂ(I) catalyst to be
most tolerant of deactivation by sulfur. A novel digold with bridging
thiolate complex is characterized by X-ray crystallography, shedding
light on a possible deactivation pathway
