161 research outputs found
Feeding Habits of the Invasive Weakfish (Cynoscion regalis) in the Gulf of Cadiz
- Author
- Publication venue
- Centro Oceanográfico de Cádiz
- Publication date
- 01/01/2022
- Field of study
Weakfish (Cynoscion regalis) has been present in Iberian waters since at least 2011, when it was first recorded in the Guadalquivir estuary. Little is known about the preferences and feeding
strategies of weakfish outside of its native range; therefore, in this work, we carried out a comprehensive study between March 2021 and September 2021 to elucidate these matters. In total, the stomach contents of 300 fish were examined. The fish were collected in spring and summer in the Gulf of Cadiz (Spain), with individuals caught ranging from 185 to 590 mm in total length. Due to the sampling period and size range of individuals, ontogenic and seasonal (spring–summer) variations in the diet were also explored. Overall, fish and crustaceans were the dominant groups consumed by weakfish. The European anchovy (Engraulis encrasicolus) and caramote prawn (Penaeus kerathurus) were the most abundant prey in each group. While no differences were found in the percentage of occurrence of fish in the non-empty stomachs analyzed in spring and summer (83%), a small increase was found in the percentage of occurrence of crustaceans from spring (20%) to summer (29%). In addition, the analysis of the results also suggested that weakfish of smaller sizes feed more on crustaceans, while bigger individuals feed mainly on fish. Our findings indicate that weakfish is a fully carnivorous species with a preference for fish. All this is in line with the diet and strategy that weakfish exhibits in its native area and with the first assessment made with the existing population in the Sado Estuary (Portugal). In recent years, due to the appearance of non-native species, there is increasing concern among local fishermen and the local authorities about the reduction in captures of certain species such as Penaeus kerathurus; therefore, this study could help researchers to understand the role of weakfish concerning this matter. The present study contributes to the ecological knowledge about this species in the Iberian Peninsula and the Gulf of Cadiz, helping the local authorities to establish, if needed, an appropriate management program to cope with this recently introduced species
Recruitment of the exotic weakfish at its southernmost limit in Europe: a preliminary assessment.
- Author
- Publication venue
- Centro Oceanográfico de Cádiz
- Publication date
- 01/01/2021
- Field of study
Since its first record in Europe as an exotic species back in 2009 at the Schelde estuary (Belgium), the weakfish Cynoscion regalis -native from North America East coast- has increased its presence in the Iberian Peninsula waters. Identified for the first time in the Guadalquivir River estuary (2011) and later in the Sado estuary (2014), C. regalis population is increasing in the Gulf of Cadiz and is becoming a fisheries resource. Its introduction into Europe probably occurred through maritime transatlantic trade. Morais et al (2017) suggested that weakfish could have been introduced through multiple independent ballast water release events. The Guadalquivir, Sado and Schelde estuaries show similar transoceanic ship traffic to upstream important commercial ports, supporting multiple direct or secondary transatlantic introductions among European ports. The first genetic studies suggest that C. regalis populations in southern European estuaries are connected and come from a single transoceanic commercial route. Currently, the Gulf of Cadiz maintains a well-established population with frequent catches by artisanal fishing, especially in coastal waters and the estuary, where it is sold in local markets of the surrounding cities.
The population in the area is constituted by mature specimens (ranging from 234 to 453 mm) that are using the estuary as a spawning area, where larvae and juvenile have also been found. In recent years, an increase in the abundance of larvae and juvenile has been observed through monthly samplings in the estuary, which indicates the culmination of the complete life cycle in the Gulf of Cadiz. These findings represent new evidence that the Guadalquivir estuary constitutes a remarkable nursery habitat for this species. This could have effects on native fauna and the ecosystem, which is why it is currently under study and evaluation (EcoInvadiz project) for helping the local Administration to establish, if needed, an appropriate management program
Embedded Software of the KM3NeT Central Logic Board
- Author
- Aiello S.
- Albert A.
- Aly Z.
- Ambrosone A.
- Ameli F.
- Andre M.
- Androutsou E.
- Anghinolfi M.
- Anguita M.
- Aphecetche L.
- Ardid M.
- Ardid S.
- Atmani H.
- Aublin J.
- Bagatelas C.
- Bailly-Salins L.
- Bardačová Z.
- Baret B.
- Becherini Y.
- Bendahman M.
- Benfenati F.
- Benhassi M.
- Benoit D. M.
- Berbee E.
- Bertin V.
- Biagi S.
- Boettcher M.
- Bojaddaini I. El
- Boumaaza J.
- Bouta M.
- Bouwhuis M.
- Bozza R. M.
- Bozzaa C.
- Bretaudeau F.
- Bruijn R.
- Brunner J.
- Bruno R.
- Brânzaşa H.
- Buisa E.
- Buompane R.
- Busto J.
- Caiffi B.
- Calvo D.
- Campion S.
- Capone A.
- Carenini F.
- Carretero V.
- Cartraud T.
- Castaldia P.
- Cecchini V.
- Celli S.
- Ceris L.
- Chabab M.
- Chadolia M.
- Chen A.
- Cherubini S.
- Chiarusi T.
- Chowdhury N. R. Khan
- Circella M.
- Clark M. Lindsey
- Cocimano R.
- Coelho J. A. B.
- Coleiro A.
- Coniglione R.
- Coyle P.
- Creusot A.
- Cruza A.
- Cuttone G.
- Dallier R.
- Darrasa Y.
- De Beneditti A.
- de Jong P.
- de Jongat M.
- De Martino B.
- de Sola F. Vazquez
- de Wolf E.
- Decoene V.
- Del Burgo R.
- Di Mauro L. S.
- Di Palma I.
- Diego-Tortosa D.
- Distefano C.
- Domia A.
- Donzaud C.
- Dornic D.
- Drakopoulou E.
- Drouhin D.
- Dvornický R.
- Díaz A. F.
- Dörra M.
- Eberla T.
- Eckerov\' E.
- Eddymaoui A.
- Effa M.
- Enzenhöfer A.
- Fearraigha B. Ó
- Ferrara G.
- Filipović M. D.
- Filippini F.
- Fusco L. A.
- Gabella O.
- Gabriela J.
- Gagliardini S.
- Gala T.
- Garre S. Alves
- Geißelbrecht N.
- Ghaddari H.
- Gialanella L.
- Gibson B. K.
- Giorgio E.
- Girardi A.
- Gomez E. J. Pastor
- González J. Palacios
- Goos I.
- Goupilliere D.
- Gozzinic S. R.
- Gracia R.
- Graf K.
- Greus F. Salesa
- Guidia C.
- Guillon B.
- Gutiérrez M.
- Hedri S. El
- Heijboer A.
- Hekalo A.
- Hennig L.
- Hernández-Rey J. J.
- Huang F.
- Ibnsalih W. Idrissi
- Illuminati G.
- Jamesa C. W.
- Jansweijer P.
- Jung B. J.
- Kalaczyński P.
- Kalekin O.
- Katz U. F.
- Khatun A.
- Kistauri G.
- Kopper C.
- Kouchner A.
- Kulikovskiy V.
- Kvatadzea R.
- Labalme M.
- Lahmann R.
- Larosa G.
- Lastoria C.
- Lazo A.
- Lehaut G.
- Leonora E.
- Lessing N.
- Levi G.
- Longhitano F.
- Losa A. Sánchez
- Majumdar J.
- Malerba L.
- Mamedov F.
- Manfred A.
- Marconi M.
- Margiott A.
- Marinelli A.
- Markou C.
- Martin L.
- Martínez S. Peña
- Martínez-Mora J. A.
- Marzaioli F.
- Mastrodicasa M.
- Mastroianni S.
- Mateo I. Mozun
- Mańczakc J.
- Melo I. Tosta e
- Miccichè S.
- Miele G.
- Migliozzi P.
- Migneco E.
- Minutoli S.
- Mitsou M. L.
- Mollo C. M.
- Morales-Gallegos L.
- Morley-Wonga C.
- Mosbruggera A.
- Moussa A.
- Muller R.
- Musone M. R.
- Musumeci M.
- Méndez J. García
- Nauta L.
- Navas S.
- Nayerhoda A.
- Nicola C. A.
- Nkosi B.
- Oliver C. Gatius
- Oliviero V.
- Orlando A.
- Oukach E.
- Papalashvilia G.
- Perrin-Terrind M.
- Perronnel J.
- Pestela V.
- Pestes R.
- Piattelli P.
- Poirè C.
- Popa V.
- Pradier T.
- Pree S. Basegmez du
- Pulvirenti S.
- Păun A. M.
- Păvălaş G. E.
- Quiroz C.
- Quéméner G.
- Rahaman U.
- Randazzo N.
- Razzaqueb S.
- Rea I. C.
- Real D.
- Reck S.
- Riccobene G.
- Robinson J.
- Romanova A.
- Saina A.
- Samtleben D. F. E.
- Sanguineti M.
- Santonastaso C.
- Santonocito D.
- Sapienza P.
- Scarpetta Y.
- Schnabel J.
- Schneider M. F.
- Schumann J.
- Schutte H. M.
- Seneca J.
- Setter B.
- Sgura I.
- Shanidze R.
- Shitov Y.
- Simonelli A.
- Sinopoulou A.
- Smirnov M. V.
- Soto A. Garcia
- Spisso B.
- Spurio M.
- Stavropoulos D.
- Stum S. Le
- Taiuti M.
- Tayalati Y.
- Tedjditi H.
- Thiersen H.
- Trocme B.
- Tsagkli S.
- Tsourapis V.
- Tzamariudaki E.
- Vacheret A.
- Valsecchi V.
- van Beveren V.
- van Eeden T.
- van Eijk D.
- van Haren H.
- Vannoye V. Van Elewyck G.
- Vasileiadisa G.
- Verilhac C.
- Veutro A.
- Viola S.
- Vivolo D.
- Warnhofer H.
- Wilmsb J.
- Yepes-Ramirez H.
- Zarpapis G.
- Zavatarelli S.
- Zegarelli A.
- Zito D.
- Zornoza J. D.
- Zywucka N.
- Zúñiga J.
- Šimkovic F.
- Štekl I.
- Publication venue
- Publication date
- 02/08/2023
- Field of study
The KM3NeT Collaboration is building and operating two deep sea neutrino
telescopes at the bottom of the Mediterranean Sea. The telescopes consist of
latices of photomultiplier tubes housed in pressure-resistant glass spheres,
called digital optical modules and arranged in vertical detection units. The
two main scientific goals are the determination of the neutrino mass ordering
and the discovery and observation of high-energy neutrino sources in the
Universe. Neutrinos are detected via the Cherenkov light, which is induced by
charged particles originated in neutrino interactions. The photomultiplier
tubes convert the Cherenkov light into electrical signals that are acquired and
timestamped by the acquisition electronics. Each optical module houses the
acquisition electronics for collecting and timestamping the photomultiplier
signals with one nanosecond accuracy. Once finished, the two telescopes will
have installed more than six thousand optical acquisition nodes, completing one
of the more complex networks in the world in terms of operation and
synchronization. The embedded software running in the acquisition nodes has
been designed to provide a framework that will operate with different hardware
versions and functionalities. The hardware will not be accessible once in
operation, which complicates the embedded software architecture. The embedded
software provides a set of tools to facilitate remote manageability of the
deployed hardware, including safe reconfiguration of the firmware. This paper
presents the architecture and the techniques, methods and implementation of the
embedded software running in the acquisition nodes of the KM3NeT neutrino
telescopes
Genome-wide analyses reveal a potential role for the MAPT, MOBP, and APOE loci in sporadic frontotemporal dementia
- Author
- Albani Diego
- Alvarez Ignacio
- Alvarez Victoria
- Andreassen Ole a.
- Angiolillo Antonella
- Arighi Andrea
- Baker Matt
- Bandres-Ciga Sara
- Benussi Luisa
- Bessi Valentina
- Binetti Giuliano
- Blackburn Daniel j.
- Boada Merce
- Boeve Bradley f.
- Borrego-Ecija Sergi
- Borroni Barbara
- Brooks William s.
- Bruni Amalia c.
- Bråthen Geir
- Caroppo Paola
- Clarimon Jordi
- Colao Rosanna
- Costa Beatrice
- Cruchaga Carlos
- Danek Adrian
- De boer Sterre cm.
- De rojas Itziar
- Di costanzo Alfonso
- Dickson Dennis w.
- Diehl-Schmid Janine
- Dobson-Stone Carol
- Dols-Icardo Oriol
- Donizetti Aldo
- Dopper Elise
- Durante Elisabetta
- Escott-Price Valentina
- Ferrari Camilla
- Ferrari Raffaele
- Forloni Gianluigi
- Frangipane Francesca
- Fratiglioni Laura
- Galimberti Daniela
- Gallucci Maurizio
- García-González Pablo
- Ghidoni Roberta
- Giaccone Giorgio
- Graff Caroline
- Graff-Radford Neill r.
- Grafman Jordan
- Halliday Glenda m.
- Hardy John
- Hernandez Dena g.
- Hjermind Lena e.
- Hodges John r.
- Holloway Guy
- Huey Edward d.
- Illán-Gala Ignacio
- Jabbari Edwin
- Josephs Keith a.
- Kia Demis a.
- Knopman David s.
- Kramberger Milica g.
- Kristiansen Mark
- Kwok John b.
- Leber Isabelle
- Leonard Hampton l.
- Leonenko Ganna
- Libri Ilenia
- Lleo Alberto
- Mackenzie Ian r.
- Madhan Gaganjit k.
- Maletta Raffaele
- Manzoni Claudia
- Marquié Marta
- Maver Ales
- Menendez-Gonzalez Manuel
- Milan Graziella
- Miller Bruce l.
- Momeni Parastoo
- Morris Christopher m.
- Morris Huw r.
- Nacmias Benedetta
- Nalls Mike a.
- Newton Judith
- Nielsen Jørgen e.
- Nilsson Christer
- Novelli Valeria
- Padovani Alessandro
- Pal Suvankar
- Pasquier Florence
- Pastor Pau
- Perneczky Robert
- Peterlin Borut
- Petersen Ronald c.
- Piguet Olivier
- Pijnenburg Yolande al.
- Puca Annibale a.
- Rademakers Rosa
- Rainero Innocenzo
- Reus Lianne m.
- Richardson Anna mt.
- Riemenschneider Matthias
- Rogaeva Ekaterina
- Rogelj Boris
- Rollinson Sara
- Rosen Howard
- Rossi Giacomina
- Rowe James b.
- Rubino Elisa
- Ruiz Agustin
- Saba Valentina
- Salvi Erika
- Sanchez-Valle Raquel
- Sando Sigrid botne
- Santillo Alexander f.
- Saxon Jennifer a.
- Schlachetzki Johannes cm.
- Scholz Sonja w.
- Seelaar Harro
- Seeley William w.
- Serpente Maria
- Singleton Andrew b.
- Sorbi Sandro
- Sordon Sabrina
- St george-Hyslop Peter
- Tagliavini Fabrizio
- Tan Manuela mx.
- Thompson Jennifer c.
- Van broeckhoven Christine
- Van deerlin Vivianna m.
- Van der lee Sven j.
- Van der zee Julie
- Van swieten John
- Veronesi Arianna
- Vitale Emilia
- Waldo Maria landqvist
- Yokoyama Jennifer s.
- Publication venue
- Publication date
- 17/06/2024
- Field of study
Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found a cluster of variants at the MAPT (rs199443; p = 2.5 × 10−12, OR = 1.27) and APOE (rs6857; p = 1.31 × 10−12, OR = 1.27) loci and a candidate locus on chromosome 3 (rs1009966; p = 2.41 × 10−8, OR = 1.16) in the intergenic region between RPSA and MOBP, contributing to increased risk for sFTD through effects on expression and/or splicing in brain cortex of functionally relevant in-cis genes at the MAPT and RPSA-MOBP loci. The association with the MAPT (H1c clade) and RPSA-MOBP loci may suggest common genetic pleiotropy across FTD and progressive supranuclear palsy (PSP) (MAPT and RPSA-MOBP loci) and across FTD, AD, Parkinson disease (PD), and cortico-basal degeneration (CBD) (MAPT locus). Our data also suggest population specificity of the risk signals, with MAPT and APOE loci associations mainly driven by Central/Nordic and Mediterranean Europeans, respectively. This study lays the foundations for future work aimed at further characterizing population-specific features of potential FTD-discriminant APOE haplotype(s) and the functional involvement and contribution of the MAPT H1c haplotype and RPSA-MOBP loci to pathogenesis of sporadic forms of FTD in brain cortex
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
- Author
- Aarsland D
- Abramzon Y
- Adams DJ
- Adeleye A
- Aguilar M
- Ahmed S
- Al-Chalabi A
- Al-Sarraj S
- Al-Sarraj S
- Alba C
- Alba C
- Albani D
- Albert MS
- Altschuler S
- Alvarez I
- Amar K
- Ambrose JC
- Archibald N
- Arcila-Londono X
- Arepalli S
- Aronica E
- Arumugam P
- Asress S
- Atassi N
- Attems J
- Auluck P
- Baas F
- Baas F
- Babu S
- Bacikova D
- Bacikova D
- Baloh RH
- Baloh RH
- Bandmann O
- Baple EL
- Barrett MJ
- Beach TG
- Bekris LM
- Bennett DA
- Benussi L
- Berry JD
- Bertolin C
- Besser LM
- Bigio EH
- Binetti G
- Black SE
- Blair IP
- Bleda M
- Boada M
- Boardman-Pretty F
- Boeve BF
- Bohannan RC
- Boissiere JM
- Borroni B
- Boustred CR
- Bowser R
- Bowser R
- Boylan KB
- Brady CB
- Brett F
- Brice A
- Brice A
- Brittain H
- Broach J
- Broach JR
- Broce I
- Brown RH
- Brunetti M
- Bruni A
- Butovsky O
- Calini D
- Calvo A
- Camu W
- Canosa A
- Capps E
- Caraway CA
- Caroppo P
- Castellotti B
- Caulfield MJ
- Cereda C
- Ceroni M
- Chan GC
- Chandran S
- Chia R
- Chiang H-H
- Chiò A
- Chiò A
- Church A
- Clarimon J
- Clarimon J
- Coebergh J
- Colombrita C
- Comi GP
- Cooper-Knock J
- Corcia P
- Corrado L
- Corti S
- Costantini A
- Cox GA
- Craig CEH
- Crary J
- Critchley P
- Dalgard CL
- Danek A
- Danielson EW
- Dardiotis E
- Daugherty LC
- De Belleroche J
- De Burca A
- Del Bo R
- Devereau A
- Dewan R
- Dickson D
- Diehl-Schimd J
- Diekstra FP
- Diez-Fairen M
- Diez-Fairen M
- Ding J
- Dols-Icardo O
- Drepper C
- Drory V
- Drory VE
- Dubnau J
- Duga S
- Dunckley TL
- Duyckaerts C
- D’Alfonso S
- Elgar G
- Esteban-Pérez J
- Faber K
- Faghri F
- Fallini C
- Farren J
- Feldman E
- Ferman T
- Ferrari R
- Ferrucci L
- Finkbeiner S
- Flanagan ME
- Floeter MK
- Floris G
- Foroud TM
- Fortea J
- Foulger RE
- Fowler T
- Fraenkel E
- Fratta P
- Fratta P
- Furió-Tarí P
- Gagliardi S
- Galimberti D
- Gan-Or Z
- García-Redondo A
- Gellera C
- Gentleman S
- Gerhard G
- Ghetti B
- Ghidoni R
- Ghosh BCP
- Gibbs JR
- Gibbs JR
- Gibson SB
- Gkazi AS
- Glass JD
- Goate A
- Goldstein D
- González-Aramburu I
- Gotkine M
- Goutman SA
- Graff C
- Graff-Radford NR
- Hackett JM
- Halai D
- Hamblin A
- Hammell MG
- Hardiman O
- Hardy JA
- Harms M
- Harms MB
- Harris B
- Heiman-Patterson T
- Heiman-Patterson TD
- Henderson S
- Hernandez DG
- Hernández I
- Hickman RA
- Hjermind LE
- Hodges AK
- Holman JE
- Hoover B
- Hornstein E
- Hu H-C
- Hu MTM
- Hubbard TJP
- Hupalo D
- Hupalo DN
- Ibáñez K
- Illán-Gala I
- Infante J
- Iranzo A
- Jabbari E
- Jackson R
- Jansson L
- Johansson PM
- Jones LJ
- Kaiser SM
- Kamel F
- Kasperaviciute D
- Kaufmann H
- Kayikci M
- Keagle P
- Keith J
- Kenna KP
- Khoshnood B
- Kim RC
- King A
- Kirby J
- Klein G
- Kobylecki C
- Kost J
- Kowal N
- Kowall NW
- Krüger R
- Kukull W
- Kuzma A
- Kwan J
- Laaksovirta H
- Lage C
- Lahnstein L
- Landers JE
- Landi F
- Lange DJ
- Lauria G
- Lawson K
- Le Ber I
- Leblond-Manry C
- Lee EB
- Leigh PN
- Leigh SEA
- Leong IUS
- Lesage S
- Leverenz JB
- Lewis EA
- Lleó A
- Lleó A
- Logroscino G
- Lopez G
- Lopez JF
- Love S
- Lumbroso S
- MacGowan DJ
- MacGowan DJL
- Malaspina A
- Maleady-Crowe F
- Mann C
- Mao Q
- Maragakis NJ
- Marti MJ
- Martinez EM
- Martinez-McGrath E
- Masellis M
- Masliah E
- Mason J
- Massey LA
- May P
- Mazzini L
- McDonagh EM
- McKeith I
- McKenna-Yasek D
- McLaughlin RL
- McMillan C
- Menon V
- Mesulam M-M
- Miller JW
- Miller TM
- Molina-Porcel L
- Monuki ES
- Mora G
- Moreno-Grau S
- Morris CM
- Morris CM
- Morris HR
- Morris HR
- Morrison KE
- Moutsianas L
- Mouzat K
- Mueller M
- Murugaesu N
- Muñoz-Blanco JL
- Myllykangas L
- Nacmias B
- Nalls MA
- Nath A
- Nath U
- Need AC
- Newell KL
- Nicholson GA
- Nielsen JE
- Nilsson CF
- Norcliffe-Kaufmann L
- Novelli V
- Odhams CA
- Orrell RW
- Ostrow LW
- Ostrow LW
- Padovani A
- Paganoni S
- Pal S
- Pall H
- Palma J-A
- Palmer L
- Pamphlett R
- Pastor P
- Pastor P
- Patch C
- Patsopoulos NA
- Pavese N
- Paviour D
- Pensato V
- Perez-Gil D
- Perkins M
- Perneczky R
- Phatnani H
- Phillips-Cremins J
- Pickering-Brown S
- Pioro E
- Pletnikova O
- Polak M
- Pollard HB
- Polychronopoulos D
- Portley MK
- Poss M
- Puca AA
- Pullinger J
- Pulst SM
- Querin G
- Rademakers R
- Rahim T
- Raj T
- Ratti A
- Ravits J
- Ravits JM
- Rendon A
- Renton AE
- Renton AE
- Resnick SM
- Reynolds RH
- Riesgo-Ferreiro P
- Robberecht W
- Robey I
- Rodríguez-Rodríguez E
- Rogaeva E
- Rogaeva E
- Rogaeva E
- Rogers T
- Rohrer JD
- Ross OA
- Rossi G
- Rossi M
- Rothstein JD
- Rouleau GA
- Rowe JB
- Ruiz A
- Ryten M
- Sabir MS
- Sanchez-Juan P
- Sapp PC
- Sareen D
- Savage K
- Sawant K
- Scarpini E
- Scherzer CR
- Schlachetzki JC
- Scholz SW
- Scott RH
- Scotter EL
- Sendtner M
- Serpente M
- Serrano GE
- Shakkottai V
- Shalem O
- Shankaracharya FNU
- Sharma J
- Shaw CE
- Shaw PJ
- Shaw PJ
- Shneider NA
- Siddiq A
- Sidle KC
- Sidransky E
- Sieghart A
- Silani V
- Simmons Z
- Simmons Z
- Singleton AB
- Smedley D
- Smith BN
- Smith C
- Smith KR
- Soltis AR
- Sorarù G
- Sorbi S
- Sosinsky A
- Spooner W
- Stefanis L
- Stein TD
- Stevens HE
- Stevic Z
- Stone DJ
- Stuckey A
- Sukumar G
- Sultana R
- Tagliavini F
- Talbot K
- Tanaka T
- Taroni F
- Tayebi N
- Ten Asbroek ALMA
- Thomas AJ
- Thomas ERA
- Thompson LM
- Thompson SR
- Ticozzi N
- Tienari PJ
- Tilley BS
- Tiloca C
- Topp SD
- Torkamani A
- Traynor BJ
- Tregidgo C
- Troakes C
- Troakes C
- Trojanowski JQ
- Troncoso JC
- Troncoso JC
- Tucci A
- Tuck M
- Turner MR
- Valori M
- Van Blitterswijk M
- Van Damme P
- Van Deerlin V
- Van den Berg LH
- Van Den Bosch L
- Van Rheenen W
- Vance C
- Vaughan J
- Veldink JH
- Viollet C
- Vonsattel JP
- Waldo ML
- Walsh E
- Walton RL
- Watters SA
- Welland MJ
- Wilkerson MD
- Williams E
- Williams KL
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- Woltjer R
- Wood SM
- Wszolek ZK
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- Xiromerisiou G
- Zaitlen N
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- Zecca C
- Zhang B
- Zhang X
- Zinman L
- Öijerstedt L
- Publication venue
- Neuron
- Publication date
- 01/01/2020
- Field of study
We examined the role of repeat expansions in the pathogenesis of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) by analyzing whole-genome sequence data from 2,442 FTD/ALS patients, 2,599 Lewy body dementia (LBD) patients, and 3,158 neurologically healthy subjects. Pathogenic expansions (range, 40-64 CAG repeats) in the huntingtin (HTT) gene were found in three (0.12%) patients diagnosed with pure FTD/ALS syndromes but were not present in the LBD or healthy cohorts. We replicated our findings in an independent collection of 3,674 FTD/ALS patients. Postmortem evaluations of two patients revealed the classical TDP-43 pathology of FTD/ALS, as well as huntingtin-positive, ubiquitin-positive aggregates in the frontal cortex. The neostriatal atrophy that pathologically defines Huntington's disease was absent in both cases. Our findings reveal an etiological relationship between HTT repeat expansions and FTD/ALS syndromes and indicate that genetic screening of FTD/ALS patients for HTT repeat expansions should be considered
Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic
- Author
- 14 | COVIDSurg COllabOratIVe Tzovaras G. (General University Hospital of Larissa)
- Aawsaj Y.
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- Alma Mater Studiorum University of Bologna)
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- COVIDSurg COllabOratIVe | 15 Violante T. (IRCCS Azienda Ospedaliero – Universitaria di Bologna
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- Universiti Sains Malaysia)
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- Valbuena Jabares V. (Marqués de Valdecilla University Hospital)
- Valdes- Hernandez J. (Hospital Universitario Virgen Macarena)
- Valero Soriano M. (Hospital General Reina Sofía)
- Valle Rubio A. (Getafe University Hospital)
- Valverde S. (Hospital Clinic Barcelona)
- Van den Eynde J.
- Van den Eynde R. (Uz Leuven). Bulgaria: Sokolov M. (University Hospital Alexandrovska). Canada: Boutros M.
- Varma M. (University of California
- Vasljević J.
- Vassiliu P. (Attikon University General Hospital)
- Vaz Pereira R.
- Vaz S. (Centro Hospitalar e Universitário de São João)
- Velchuru V.
- Velickovic D. (Clinic for Digestive Surgery
- Velidedeoglu M.
- Venn M. (Royal London Hospital)
- Venskutonis D. (Lithuanian University of Health Sciences Kaunas Clinical Hospital). Madagascar: Rasoaherinomenjanahary F.
- Vera Mansilla C. (Hospital Universitario Principe de Asturias)
- Verberne C. (John Radcliffe Hospital)
- Vergari R. (Ospedali Riuniti di Ancona)
- Vernon L. (Cork University Hospital)
- Vervoort D.
- Vescio G. (University ‘Magna Graecia’ of Catanzaro)
- Vezakis A. (Aretaieion Hospital)
- Videira J. F. (IPO Porto). Réunion: Kassir R.
- Vieira B. (Centro Hospitalar de Trás-Os-Montes e Alto Douro
- Vieira Caroço T. (IPO Coimbra)
- Vieira Paiva Lopes A. C. (Hospital de Torres Vedras – Centro Hospitalar do Oeste)
- Vignali A. (San Raffaele Scientific Institute
- Vigorita V. (Álvaro Cunqueiro Hospital)
- Vijayan D. (Queen Elizabeth Hospital Birmingham)
- Villalabeitia Ateca I. (Hospital Universitario Cruces)
- Vimalachandran D. (Countess of Chester Hospital)
- Viswanath Y. K. S. (James Cook University Hospital)
- Vitali A. (Ospedale San Giovanni di Dio)
- Vitone L. (Royal Blackburn Hospital)
- Vives R. V. (Bellvitge University Hospital)
- Vo U. G. (Fiona Stanley Hospital)
- Von Papen M.
- Vovola F. (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia)
- Vucic N.
- Vázquez Fernández A. (Hospital Clínico Universitario de Valladolid)
- Wadham B. (The University Hospital of South Manchester)
- Walkes K. (Queen Elizabeth Hospital). Belgium: Flamey N.
- Wani R. (Sher-I-Kashmir Institute of Medical Sciences)
- Waqar S. H. (Pakistan Institute of Medical Sciences). Poland: Major P. (Jagiellonian University Medical College). Portugal: Azevedo C.
- Warren O. (Chelsea and Westminster Hospital)
- Watson L. J. (Sunderland Royal Hospital)
- Watson N. (King’s Mill Hospital)
- Weitz J.
- Welsch T. (Carl-Gustav-Carus University Hospital
- Werner J. (LMU Klinikum Campus Innenstadt)
- Westwood E. (James Paget University NHS Foundation Trust Hospital)
- Whelan M. (Tallaght University Hospital)
- Whitmore H. (Torbay and South Devon NHS Trust)
- Wilkin R. J. W. (South Warwickshire NHS Foundation Trust)
- Wilkins A. (Hull University Teaching Hospitals NHS Trust)
- Williams G. (Royal Gwent Hospital)
- Williams K. (St George’s Hospital)
- Wilson M. (Forth Valley Royal Hospital)
- Wimmer A. (Paracelsus Medical University Salzburg). Barbados: Barker D.
- Wong M.
- Worku D. (Queens Medical Centre)
- Wullschleger M. (Gold Coast University Hospital)
- Xavier R. G.
- Xenaki S.
- Xynos E. (University Hospital of Heraklion Crete and Interclinic Hospital of Crete). Hong Kong: Futaba K.
- Yang W.
- Yassin N. (Royal Wolverhampton NHS Trust)
- Ye G.
- Yesantharao P.
- Yetkin S. G. (Sisli Hamidiye Etfal Training and Research Hospital)
- Yeşilyurt D. (University of Health Sciences Tepecik Training and Research Hospital)
- Yiallourou A. (Nicosia General Hospital). Czechia: Martinek L.
- Yıldırım A.
- Yildiz A. (Yildirim Beyazit University Yenimahalle Training and Research Hospital). Uganda: Lule H.
- Young R. (York Teaching Hospitals NHS Trust)
- Yousof E. A. (Assiut University Hospital)
- Youssef M. (Norfolk and Norwich University Hospital)
- Yurttas C. (University Hospital Tuebingen)
- Yánez C. (Royo Villanova)
- Yüksel E. (Kocaeli University Teaching Hospital)
- Zafar S. N. (University of Wisconsin)
- Zakaria A. D.
- Zakaria Z. (School of Medical Sciences and Hospital
- Zambon M. (Policlinico Umberto I Sapienza University of Rome)
- Zanus G. (Ca’ Foncello Treviso – DISCOG – Università di Padova)
- Zegarac M. (Institute for Oncology and Radiology of Serbia)
- Zelić M. (University Hospital Center Rijeka)
- Zengin A. K. (Istanbul Universty – Cerrahpaşa Medical Faculty)
- Zerbib P. (CHU Lille)
- Zervas K.
- Zese M. (Santa Maria degli Angeli Hospital ULSS 5 – Adria)
- Zhang H. (Concord Repatriation General Hospital)
- Zizzo M. (Azienda Unità Sanitaria Locale – IRCCS di Reggio Emilia)
- Zografos C. (Laiko University Hospital)
- Zorrilla Ortúzar J. (Hospital General Universitario Gregorio Marañón)
- Zourntou S. (General Hospital of Larissa ‘Koutlimpaneio and Triantafylleio’)
- Zubaidi A. M. (King Saud University). Serbia: Aleksić L.
- Ângelo M.
- Çelebi F.
- Çolak E.
- Öfner D. (Medical University of Innsbruck)
- Öhlberger L.
- Özçelık M. F.
- Öğücü H.
- Überrück L.
- Ćoza I.
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic
Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adzic Petar
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behera Prafulla Kumar
- Behnamian Hadi
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benelli Gabriele
- Beni Noemi
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhopatkar Vallary
- Bhowmik Sandeep
- Bi Ran
- Bialkowska Helena
- Bian Jian-Guo
- Bianchini Lorenzo
- Bianco Stefano
- Bierwagen Katharina
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bin Anuar Afiq Aizuddin
- Bisello Dario
- Bitioukov Sergei
- Blekman Freya
- Blinov Vladimir
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Boccali Tommaso
- Bocci Andrea
- Bodek Arie
- Boimska Bożena
- Boletti Alessio
- Bolla Gino
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Boos Edouard
- Boren Samuel
- Bornheim Adolf
- Borras Kerstin
- Bortignon Pierluigi
- Borzou Ahmad
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bowen James
- Bradmiller-Feld John
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breto Guillermo
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brinson Jessica
- Brito Lucas
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brodski Michael
- Brom Jean-Marie
- Brondolin Erica
- Brooke James John
- Brown Robert M
- Brun Hugues
- Bruner Christopher
- Bruno Giacomo
- Buchmuller Oliver
- Bucinskaite Inga
- Bundock Aaron
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burkett Kevin
- Burns Douglas
- Burns Dustin
- Burt Kira
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H
- Buttignol Michael
- Butz Erik
- Bylinkin Alexander
- Bylsma Ben
- Byszuk Adrian
- Bäni Lukas
- Cabrera Andrés
- Cabrillo Iban Jose
- Cadamuro Luca
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Call Kenneth
- Calligaris Luigi
- Calpas Betty
- Calvelli Valerio
- Calvert Brian
- Calvo Enrique
- Caminada Lea
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Cankocak Kerem
- Capiluppi Paolo
- Caputo Claudio
- Carlin Roberto
- Carnes Andrew
- Carpinteyro Severiano
- Carrera Jarrin Edgar
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Antunes De Oliveira Alexandra
- Carvalho Wagner
- Carver Matthew
- Casal Bruno
- Casarsa Massimo
- Casasso Stefano
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castiñeiras De Saa Juan Ramon
- Castle James
- Castro Andrea
- Caudron Adrien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Celik Ali
- Centis Vignali Matteo
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chadeeva Marina
- Chamizo Llatas Maria
- Chang Paoti
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Chapon Emilien
- Charaf Otman
- Charlot Claude
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Shubhanshu
- Chauhan Sushil
- Chaves Jorge
- Chawla Ridhi
- Chen Geng
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Mingshui
- Chen Po-Hsun
- Chen Ye
- Chen Yi
- Chen Zhenyu
- Chenarani Shirin
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chiorboli Massimiliano
- Chistov Ruslan
- Chlebana Frank
- Cho Sungwoong
- Choi Minkyoo
- Choi Suyong
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Chtchipounov Leonid
- Chu Jennifer
- Chudasama Ruchi
- Chwalek Thorsten
- Ciangottini Diego
- Cieri Davide
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cipriani Marco
- Cirkovic Predrag
- Citron Matthew
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clarke Christopher
- Clement Emyr
- Clerbaux Barbara
- Cockerill David JA
- Cocoros Alice
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Colombo Fabio
- Connor Patrick
- Contardo Didier
- Conte Eric
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cooperstein Stephane
- Cornelis Tom
- Corpe Louie
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costanza Francesco
- Coubez Xavier
- Couderc Fabrice
- Coughlan John A
- Courbon Benoit
- Cousins Robert
- Covarelli Roberto
- Cowden Christopher
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremonesi Matteo
- Cristella Leonardo
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Curras Esteban
- Curry David
- Cussans David
- Custódio Analu
- Cutts David
- Czellar Sandor
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Enterria David
- D'Hondt Jorgen
- D'imperio Giulia
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Daci Nadir
- Dalchenko Mykhailo
- Dall'Osso Martino
- Dallavalle Gaetano-Marco
- Damarseckin Serdal
- Damgov Jordan
- Danilov Mikhail
- Daponte Vincenzo
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Dauncey Paul
- David Tinoco Mendes Andre
- Davies Gavin
- Davignon Olivier
- de Barbaro Pawel
- De Boer Wim
- De Bruyn Isabelle
- De Castro Manzano Pablo
- De Cosa Annapaola
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Nardo Guglielmo
- De Oliveira Martins Carley
- De Palma Mauro
- De Remigis Paolo
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
- De Wit Adinda
- De Wolf Eddi A
- Degano Alessandro
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delannoy Hugo
- Delcourt Martin
- Delgado Peris Antonio
- Delgado Andrea
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demiragli Zeynep
- Demiroglu Zuhal Seyma
- Denegri Daniel
- Depasse Pierre
- Derdzinski Mark
- Dermenev Alexander
- Deroover Kevin
- Dev Nabarun
- Devetak Damir
- Dewanjee Ram Krishna
- Dey Sourav
- Di Francesco Agostino
- Di Guida Salvatore
- Di Marco Emanuele
- Di Maria Riccardo
- Di Matteo Leonardo
- Di Mattia Alessandro
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dildick Sven
- Dilsiz Kamuran
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dini Paolo
- Dishaw Adam
- Dissertori Günther
- Dittmann Jay
- Dittmar Michael
- Dittmer Susan
- Doan Thi Hien
- Dobson Marc
- Dobur Didar
- Dodd Laura
- Dogra Sunil
- Dolen James
- Dolinska Ganna
- Dominguez Aaron
- Donato Silvio
- Donegà Mauro
- Dordevic Milos
- Dorigo Tommaso
- Dorney Brian
- Doroba Krzysztof
- Dosselli Umberto
- Dozen Candan
- Draeger Arne-Rasmus
- Dragicevic Marko
- Dragoiu Cosmin
- Dremin Igor
- Dreyer Torben
- Driga Olga
- Du Pree Tristan
- Duarte Javier
- Dube Sourabh
- Dubinin Mikhail
- Duchardt Deborah
- Dudenas Vytautas
- Dudero Phillip Russell
- Dudko Lev
- Dugad Shashikant
- Duggan Daniel
- Duh Yi-ting
- Dumanoglu Isa
- Dunne Patrick
- Dupont Niels
- Durgut Süleyman
- Duric Senka
- Durkin Lloyd Stanley
- Dutt Suneel
- Dutta Dipanwita
- Dutta Suchandra
- Dutta Valentina
- Dünser Marc
- Eckerlin Guenter
- Ecklund Karl Matthew
- Eckstein Doris
- Eerola Paula
- El Mamouni Houmani
- Elliott-Peisert Anna
- Ellison John Anthony
- Ellithi Kamel Ali
- Elmer Peter
- Elumakhov Dmitry
- Elvira Victor Daniel
- Elwood Adam
- Eminizer Nicholas
- Endres Matthias
- Eno Sarah Catherine
- Epshteyn Vladimir
- Erbacher Robin
- Erdmann Martin
- Erdmann Wolfram
- Erdweg Sören
- Eren Engin
- Ershov Alexander
- Erö Janos
- Escalante Del Valle Alberto
- Esch Thomas
- Eskandari Tadavani Esmaeel
- Esposito Marco
- Etesami Seyed Mohsen
- Eusebi Ricardo
- Evangelou Ioannis
- Evans Andrew
- Evdokimov Olga
- Everaerts Pieter
- Fabbri Fabrizio
- Fabbri Franco
- Fabbro Bernard
- Fabozzi Francesco
- Faccioli Pietro
- Fagot Alexis
- Fahim Ali
- Fan Jiawei
- Fanfani Alessandra
- Fang Wenxing
- Fangmeier Caleb
- Fanò Livio
- Fartoukh Stephane
- Fasanella Daniele
- Fasanella Giuseppe
- Faulkner James
- Faure Jean-Louis
- Favaro Carlotta
- Favart Laurent
- Fay Jean
- Fedi Giacomo
- Fehling David
- Felcini Marta
- Feld Lutz
- Feng Lei
- Ferbel Thomas
- Ferencek Dinko
- Ferguson Thomas
- Fernandez Bedoya Cristina
- Fernandez Menendez Javier
- Fernandez Marcos
- Fernández Ramos Juan Pablo
- Ferraioli Charles
- Ferreira Parracho Pedro Guilherme
- Ferri Federico
- Ferro Fabrizio
- Field Richard D
- Filipovic Nicolas
- Finco Linda
- Finger Jr Michael
- Finger Miroslav
- Fink Simon
- Finkel Alexey
- Fiore Luigi
- Fiorendi Sara
- Fiori Francesco
- Fischer Robert
- Fisk Ian
- Flacher Henning
- Flechl Martin
- Flix Jose
- Florent Alice
- Flores Chad
- Florez Carlos
- Flouris Giannis
- Flowers Kristen
- Flowers Sean
- Flügge Günter
- Focardi Ettore
- Foerster Mark
- Folgueras Santiago
- Fonseca De Souza Sandro
- Fontaine Jean-Charles
- Ford William T
- Forthomme Laurent
- Foudas Costas
- Fouz Maria Cruz
- Francis Brian
- Franco Sevilla Manuel
- Francois Brieuc
- Franzoni Giovanni
- Freeman Jim
- Friedl Markus
- Friese Raphael
- Frueboes Tomasz
- Fruehwirth Rudolf
- Fulcher Jonathan
- Funk Garrett
- Funk Wolfgang
- Furic Ivan-Kresimir
- Futyan David
- Gadrat Sébastien
- Galanti Mario
- Gallinaro Michele
- Gallo Elisabetta
- Galloni Camilla
- Gandrajula Reddy Pratap
- Ganguly Sanmay
- Ganjour Serguei
- Garabedian Alex
- Garay Garcia Jasone
- Garcia Guillaume
- Garcia-Abia Pablo
- Garcia-Bellido Aran
- Garcia-Ferrero Juan
- Gardner Michael
- Garg Rocky Bala
- Garutti Erika
- Gary J William
- Gascon Susan
- Gastler Daniel
- Gauthier Lucie
- Gavrilov Vladimir
- Geffert Paul
- Geiser Achim
- Gelli Simone
- Gelé Denis
- Gennai Simone
- George Christopher
- George Jimin
- Geralis Theodoros
- Gerber Cecilia Elena
- Gerosa Raffaele
- Gershtein Yuri
- Geurts Frank JM
- Ghete Vasile Mihai
- Ghezzi Alessio
- Ghiasi Shirazi Seyyed Mohammad Amin
- Ghosh Saranya
- Ghosh Shamik
- Giacomelli Paolo
- Giakoumopoulou Viktoria Athina
- Giammanco Andrea
- Giassi Alessandro
- Giffels Manuel
- Gigi Dominique
- Gilbert Andrew
- Gill Karl
- Gilmore Jason
- Giordano Ferdinando
- Girgis Semiray
- Girone Maria
- Givernaud Alain
- Gizhko Andrii
- Glege Frank
- Glushkov Ivan
- Gninenko Sergei
- Go Yeonju
- Godinovic Nikola
- Godshalk Andrew
- Goerlach Ulrich
- Goh Junghwan
- Gokbulut Gul
- Goldenzweig Pablo
- Goldouzian Reza
- Goldstein Joel
- Golf Frank
- Golovtsov Victor
- Golubev Nikolai
- Golunov Alexander
- Golutvin Igor
- Gomber Bhawna
- Gomez Ceballos Guillelmo
- Gomez Gervasio
- Gomez Jaime
- Gomez Juan Pablo
- Goncharov Maxim
- Gonzalez Caballero Isidro
- Gonzalez Lopez Oscar
- Gonzalez Suarez Rebeca
- Gonzalez Daniel
- González Fernández Juan Rodrigo
- González Hernández Carlos Felipe
- Goodell Joseph
- Gorbounov Nikolai
- Gori Valentina
- Gottschalk Erik
- Gouskos Loukas
- Gouzevitch Maxime
- Govoni Pietro
- Goy Lopez Silvia
- Gozzelino Andrea
- Grab Christoph
- Grados Luyando Juan Manuel
- Gran Jason
- Grandi Claudio
- Granier de Cassagnac Raphael
- Gras Philippe
- Gray Lindsey
- Grebenyuk Anastasia
- Green Dan
- Greene Senta
- Grenier Gérald
- Gribushin Andrey
- Grimes Mark
- Grippo Maria Teresa
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- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Sunan Kalijaga State Islamic University
- Publication date
- 01/01/2012
- Field of study
Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis
Search for supersymmetry in events with one lepton and multiple jets in proton-proton collisions at root s=13 TeV
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Jordon Rowe
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexakhin Vadim
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Ian
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
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- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
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- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baumgartel Darin
- Baus Colin
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- Bean Alice
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- Beaudette Florian
- Beck Lana
- Beernaert Kelly
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- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Bellato Marco
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benato Lisa
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- Bendavid Joshua
- Benelli Gabriele
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- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
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- Braghieri Alessandro
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- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Breedon Richard
- Breto Guillermo
- Brew Christopher
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- Brom Jean-Marie
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- Chadeeva Marina
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- Choudhary Brajesh C
- Choudhury Somnath
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- de Barbaro Pawel
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- De Bruyn Isabelle
- De Castro Manzano Pablo
- De Cosa Annapaola
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- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
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- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Nardo Guglielmo
- De Oliveira Martins Carley
- De Palma Mauro
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
- De Wit Adinda
- De Wolf Eddi A
- Degano Alessandro
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delannoy Hugo
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- Delgado Andrea
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- Yang Yong
- Yang Yu Chul
- Yates Brent
- Yazgan Efe
- Yelton John
- Yetkin Elif Asli
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yonamine Ryo
- Yoo Hwi Dong
- Yoo Jaehyeok
- You Can
- Yu Geum Bong
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yusli Mohd Nizam
- Zabel James
- Zabi Alexandre
- Zaganidis Nicolas
- Zagoździńska Agnieszka
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenoni Florian
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zevi Della Porta Giovanni
- Zeyrek Mehmet
- Zghiche Amina
- Zhang Fengwangdong
- Zhang Huaqiao
- Zhang Jingyu
- Zhao Jingzhou
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zientek Margaret
- Zolkapli Zukhaimira
- Zorbakir Ibrahim Soner
- Zorbilmez Caglar
- Zotto Pierluigi
- Zou David
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Search for anomalous couplings in boosted WW/WZ -> l nu q(q)over-bar production in proton-proton collisions at root s=8TeV
- Author
- Aarrestad Thea Klaeboe
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Abercrombie Daniel
- Abu Zeid Shimaa
- Ackert Andrew
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adzic Petar
- Afanasiev Serguei
- Agapitos Antonis
- Aggleton Robin
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmad Muhammad
- Ahmed Ijaz
- Ahuja Sudha
- Akbiyik Melike
- Akchurin Nural
- Akgun Bora
- Al-bataineh Ayman
- Albergo Sebastiano
- Albert Andreas
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Allen Brandon
- Almond John
- Alunni Solestizi Luisa
- Alverson George
- Alves Fábio Lúcio
- Alves Gilvan
- Alyari Maral
- Amapane Nicola
- Amin Nick
- Amsler Claude
- Anagnostou Georgios
- Anderson Dustin
- Anderson Jacob
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Michael Benjamin
- Androsov Konstantin
- Anelli Christopher
- Antonelli Louis
- Antropov Iurii
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Apresyan Artur
- Apyan Aram
- Arcaro Daniel
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arndt Till
- Arneodo Michele
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Askew Andrew
- Ather Mohsan Waseem
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Aushev Tagir
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Aşılar Ece
- Baarmand Marc M
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahinipati Seema
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ball Fionn
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Bargassa Pedrame
- Baringer Philip
- Barker Anthony
- Barnes Virgil E
- Barney David
- Baron Owen
- Barone Luciano
- Barria Patrizia
- Barrio Luna Mar
- Bartek Rachel
- Barth Christian
- Bartosik Nazar
- Bartók Márton
- Baskakov Alexey
- Battilana Carlo
- Baty Austin
- Bauerdick Lothar AT
- Baur Sebastian
- Baus Colin
- Bayshev Igor
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beck Lana
- Beernaert Kelly
- Behera Prafulla Kumar
- Behnke Olaf
- Behrens Ulf
- Bein Samuel
- Beirão Da Cruz E Silva Cristóvão
- Belchior Batista Das Chagas Ewerton
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Ken W
- Bellan Riccardo
- Belloni Alberto
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benato Lisa
- Bencze Gyorgy
- Bendavid Joshua
- Benelli Gabriele
- Beni Noemi
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
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- Bernardini Jacopo
- Bernet Colin
- Berry Douglas
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Betts Russell Richard
- Bhandari Rohan
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Rajarshi
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhawandeep Bhawandeep
- Bhopatkar Vallary
- Bhowmik Sandeep
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- Bornheim Adolf
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- Bortignon Pierluigi
- Borzou Ahmad
- Bose Tulika
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Bouvier Elvire
- Bowen James
- Bradmiller-Feld John
- Braghieri Alessandro
- Braibant-Giacomelli Sylvie
- Brandstetter Johannes
- Brandt Stephanie
- Branson James G
- Bravo Cameron
- Breedon Richard
- Brew Christopher
- Brianza Luca
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Brito Lucas
- Brivio Francesco
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brodski Michael
- Brom Jean-Marie
- Brondolin Erica
- Brooke James John
- Brown Robert M
- Brun Hugues
- Bruno Giacomo
- Buccilli Andrew
- Buchanan James
- Buchmuller Oliver
- Bucinskaite Inga
- Bundock Aaron
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- Bunn Julian
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- Burkett Kevin
- Burns Douglas
- Burns Dustin
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- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H
- Buttignol Michael
- Butz Erik
- Bylinkin Alexander
- Bylsma Ben
- Byszuk Adrian
- Bäni Lukas
- Cabrera Andrés
- Cabrillo Iban Jose
- Cadamuro Luca
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
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- Call Kenneth
- Calligaris Luigi
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- Caputo Claudio
- Carlin Roberto
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- Carpinteyro Severiano
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- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Cartiglia Nicolo
- Carvalho Antunes De Oliveira Alexandra
- Carvalho Wagner
- Carver Matthew
- Casal Bruno
- Casarsa Massimo
- Casasso Stefano
- Caspart René
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castle James
- Castro Andrea
- Caudron Adrien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Celik Ali
- Cenna Francesca
- Centis Vignali Matteo
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerminara Gianluca
- Cerrada Marcos
- Chabert Eric Christian
- Chadeeva Marina
- Chamizo Llatas Maria
- Chang Paoti
- Chang You-Hao
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Chapon Emilien
- Charaf Otman
- Charlot Claude
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Shubhanshu
- Chauhan Sushil
- Chaves Jorge
- Chawla Ridhi
- Checchia Paolo
- Chen Geng
- Chen Guo-Ming
- Chen He-Sheng
- Chen Kai-Feng
- Chen Mingshui
- Chen Po-Hsun
- Chen Ye
- Chen Yi
- Chen Zhenyu
- Chenarani Shirin
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chlebana Frank
- Cho Sungwoong
- Choi Minkyoo
- Choi Suyong
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Chtchipounov Leonid
- Chu Jennifer
- Chudasama Ruchi
- Chwalek Thorsten
- Ciangottini Diego
- Cieri Davide
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cipriani Marco
- Ciriolo Vincenzo
- Cirkovic Predrag
- Citron Matthew
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clarke Christopher
- Clement Emyr
- Clerbaux Barbara
- CMS Collaboration
- Cockerill David JA
- Cocoros Alice
- Codispoti Giuseppe
- Colafranceschi Stefano
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- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Colombo Fabio
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- Contardo Didier
- Conte Eric
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- Conway John
- Conway Rylan
- Cooper Seth
- Cooperstein Stephane
- Cornelis Tom
- Corpe Louie
- Cossutti Fabio
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- Costa Salvatore
- Costanza Francesco
- Coubez Xavier
- Couderc Fabrice
- Coughlan John A
- Courbon Benoit
- Cousins Robert
- Covarelli Roberto
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremonesi Matteo
- Cristella Leonardo
- Cuevas Javier
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- Hatakeyama Kenichi
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- Hoorani Hafeez R
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- Northup Michael
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- Novaes Sergio F
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- O'Dell Vivian
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- Zucchetta Alberto
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- Zykunov Vladimir
- Publication venue
- Publication date
- 01/01/2017
- Field of study
Peer reviewe
Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
- Author
- Alcolea D.
- Barthélemy N.R.
- Bateman R.J.
- Bertram L.
- Beschorner R.
- Biernat J.
- Brandt M.
- Brockmann K.
- Brosseron F.
- Bähr M.
- Bürger K.
- Carbayo Á
- Chatterjee M.
- Cosma N.C.
- Dinter E.
- Dols-Icardo O.
- Doğdu C.
- Düzel E.
- Falkenburger B.
- Fliessbach K.
- Flöel A.
- Fortea J.
- Fritz C.
- Frommann I.
- Gasser T.
- Glanz W.
- Goerss D.
- Guenther R.
- Halle A.
- Hansen N.
- Heneka M.T.
- Hermann A.
- Herms J.
- Heutink P.
- Hoffmann D.C.
- Hopfner F.
- Höglinger G.
- Illán-Gala I.
- Incesoy E.
- Janowitz D.
- Kilimann I.
- Kimmich O.
- Kleineidam L.
- Klockgether T.
- Krause P.
- Kühn A.A.
- Levin J.
- Lleó A.
- Mandelkow E.
- McCormick C.
- Mengel D.
- Miklitz C.
- Möbius W.
- Nestor P.J.
- Neumann M.
- Perneczky R.
- Peters O.
- Priller J.
- Prudlo J.
- Ramirez A.
- Rauchmann B.S.
- Rizzu P.
- Roeske S.
- Rojas-García R.
- Rubio-Guerra S.
- Santos-Santos M.A.
- Schmid M.
- Schneider A.
- Schneider L.-S.
- Selma-González J.
- Spottke A.
- Spruth E.
- Synofzik M.
- Teipel S.
- Turon-Sans J.
- Vogt I.R.
- Wagemann O.
- Wagner M.
- Wang X.
- Weydt P.
- Wilke C.
- Wiltfang J.
- Zerr I.
- Zimmermann M.
- Özdemir S.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/06/2024
- Field of study
Minimally invasive biomarkers are urgently needed to detect molecular pathology in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Here, we show that plasma extracellular vesicles (EVs) contain quantifiable amounts of TDP-43 and full-length tau, which allow the quantification of 3-repeat (3R) and 4-repeat (4R) tau isoforms. Plasma EV TDP-43 levels and EV 3R/4R tau ratios were determined in a cohort of 704 patients, including 37 genetically and 31 neuropathologically proven cases. Diagnostic groups comprised patients with TDP-43 proteinopathy ALS, 4R tauopathy progressive supranuclear palsy, behavior variant FTD (bvFTD) as a group with either tau or TDP-43 pathology, and healthy controls. EV tau ratios were low in progressive supranuclear palsy and high in bvFTD with tau pathology. EV TDP-43 levels were high in ALS and in bvFTD with TDP-43 pathology. Both markers discriminated between the diagnostic groups with area under the curve values >0.9, and between TDP-43 and tau pathology in bvFTD. Both markers strongly correlated with neurodegeneration, and clinical and neuropsychological markers of disease severity. Findings were replicated in an independent validation cohort of 292 patients including 34 genetically confirmed cases. Taken together, the combination of EV TDP-43 levels and EV 3R/4R tau ratios may aid the molecular diagnosis of FTD, FTD spectrum disorders and ALS, providing a potential biomarker to monitor disease progression and target engagement in clinical trials
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