844 research outputs found
Dispersal and Management of Invasive Aquatic Plants in Mississippi Waterways
- Author
- Publication venue
- Scholars Junction
- Publication date
- 25/11/2013
- Field of study
To understand the flow of water as a factor that influences aquatic vegetation communities and aquatic plant dispersal, custom-made Global Positioning System (GPS) drones were used to monitor the movement of water in Aliceville Lake, Columbus Lake, and Ross Barnett Reservoir, MS. In each reservoir, the drones drifted in the wind-generated surface current. Analysis of wind speeds suggests that a certain wind speed may be necessary to overcome gradient flow. Wind direction and wind speed should be incorporated in future spatial simulation models for aquatic plant dispersal and distribution. An herbicide evaluation on Cuban bulrush (Oxycaryum cubenese) was conducted to determine what herbicides would effectively control the invasive species. Applications made prelowering were more successful than postlowering applications for all herbicides tested with glyphosate, 2,4-D, triclopyr, diquat, imazamox, and imazapyr resulting in 100% mean biomass reduction. For postlowering applications, glyphosate, triclopyr, and diquat are recommended
Vesicular monoamine transporter 2 (SLC18A2) regulates monoamine turnover and brain development in zebrafish
- Author
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Aim We aimed at identifying potential roles of vesicular monoamine transporter 2, also known as Solute Carrier protein 18 A2 (SLC18A2) (hereafter, Vmat2), in brain monoamine regulation, their turnover, behaviour and brain development using a novel zebrafish model. Methods A zebrafish strain lacking functional Vmat2 was generated with the CRISPR/Cas9 system. Larval behaviour and heart rate were monitored. Monoamines and their metabolites were analysed with high-pressure liquid chromatography. Amine synthesising and degrading enzymes, and genes essential for brain development, were analysed with quantitative PCR, in situ hybridisation and immunocytochemistry. Results The 5-bp deletion in exon 3 caused an early frameshift and was lethal within 2 weeks post-fertilisation. Homozygous mutants (hereafter, mutants) displayed normal low locomotor activity during night-time but aberrant response to illumination changes. In mutants dopamine, noradrenaline, 5-hydroxytryptamine and histamine levels were reduced, whereas levels of dopamine and 5-hydroxytryptamine metabolites were increased, implying elevated monoamine turnover. Consistently, there were fewer histamine, 5-hydroxytryptamine and dopamine immunoreactive cells. Cellular dopamine immunostaining, in wild-type larvae more prominent in tyrosine hydroxylase 1 (Th1)-expressing than in Th2-expressing neurons, was absent in mutants. Despite reduced dopamine levels, mutants presented upregulated dopamine-synthesising enzymes. Further, in mutants the number of histidine decarboxylase-expressing neurons was increased, notch1a and pax2a were downregulated in brain proliferative zones. Conclusion Lack of Vmat2 increases monoamine turnover and upregulates genes encoding amine-synthesising enzymes, including histidine decarboxylase. Notch1a and pax2a, genes implicated in stem cell development, are downregulated in mutants. The zebrafish vmat2 mutant strain may be a useful model to study how monoamine transport affects brain development and function, and for use in drug screening.Peer reviewe
Genome-wide associations for birth weight and correlations with adult disease
- Author
- Adair Linda S.
- Ahluwalia Tarunveer S.
- Appel Emil V. R.
- Atalay Mustafa
- Beaumont Robin N.
- Beilin Lawrence J.
- Bennett Amanda J.
- Bisgaard Hans
- Boh Eileen Tai Hui
- Bonàs-Guarch Sílvia
- Boomsma Dorret I.
- Borja Judith B.
- Bradfield Jonathan P.
- Bustamante Mariona
- Bønnelykke Klaus
- Campbell Harry
- Carstensen Lisbeth
- Cousminer Diana L.
- Davies Eleanor
- Day Felix R.
- De Geus Eco J. C. N.
- De Haan Hugoline G.
- Dedoussis George V.
- Diver Louise A.
- Eriksson Johan G.
- Evans David M.
- Feenstra Bjarke
- Felix Janine F.
- Fernandez-Tajes Juan
- Fonvig Cilius E.
- Frayling Timothy M.
- Freathy Rachel M.
- Ganesh Santhi K.
- Gaulton Kyle J.
- Geller Frank
- Grant Struan F. A.
- Grarup Niels
- Groves Christopher J.
- Hakonarson Hakon
- Hansen Torben
- Hattersley Andrew T.
- Have Christian T.
- Heinrich Joachim
- Hemani Gibran
- Hofman Albert
- Hollegaard Mads V.
- Holm Jens-Christian
- Horikoshi Momoko
- Hottenga Jouke-Jan
- Hougaard David M.
- Hyppönen Elina
- Jaddoe Vincent W. V.
- Jones Samuel E.
- Joro Raimo
- Joshi Peter K.
- Järvelin Marjo-Riitta
- Kadarmideen Haja N.
- Kiess Wieland
- Kooijman Marjolein N.
- Kovacs Peter
- Kreiner Eskil
- Kutalik Zoltán
- Kähönen Mika
- Körner Antje
- Lagou Vasiliki
- Lakka Timo A.
- Langenberg Claudia
- Lawlor Debbie A.
- Lehtimäki Terho
- Li-Gao Ruifang
- Lindi Virpi
- Loh Po-Ru
- Lowe William L.
- Luan Jian'An
- Lyytikaïnen Leo-Pekka
- Ma Ronald C. W.
- MacKenzie Scott M.
- Mahajan Anubha
- Marques-Vidal Pedro
- McCarthy Mark I.
- McMahon George
- Medina-Gomez Carolina
- Melbye Mads
- Mentch Frank D.
- Mercader Josep M.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Morris Andrew P.
- Murcia Mario
- Newnham John P.
- Niinikoski Harri
- Nodzenski Michael
- Ntalla Ioanna
- Nyholt Dale R.
- Ong Ken K.
- Pahkala Katja
- Panoutsopoulou Kalliope
- Paternoster Lavinia
- Pedersen Oluf
- Pennell Craig E.
- Perry John R. B.
- Pisinger Charlotta
- Pitkänen Niina
- Power Christine
- Prokopenko Inga
- Rahmioglu Nilufer
- Raitakari Olli T.
- Reynolds Rebecca M.
- Ring Susan M.
- Rivadeneira Fernando
- Robertson Neil R.
- Rosendaal Frits R.
- Rueedi Rico
- Ruth Katherine S.
- Saw Seang-Mei
- Scholtens Denise M.
- Schraut Katharina E.
- Scott Robert A.
- Sebert Sylvain
- Smith George Davey
- Standl Marie
- Strachan David P.
- Stumvoll Michael
- Sánchez Friman
- Sørensen Thorkild I. A.
- Tam Claudia H. T.
- Tam Wing Hung
- Teo Yik-Ying
- Thiering Elisabeth
- Tiesler Carla M. T.
- Timpson Nicholas J.
- Torrents David
- Trier Caecilie
- Tuke Marcus A.
- Tyrrell Jessica
- Tönjes Anke
- Uitterlinden André G.
- Vaag Allan A.
- Van Beijsterveldt Catharina E. M.
- Van Duijn Cornelia M.
- Van Leeuwen Elisabeth M.
- Van Rooij Frank J. A.
- Van Zuydam Natalie R.
- Viikari Jorma S.
- Vilor-Tejedor Natalia
- Vollenweider Peter
- Vrijheid Martine
- Waage Johannes
- Walker Brian R.
- Wang Carol A.
- Wang Xu
- Wareham Nicholas J.
- Warrington Nicole M.
- Widén Elisabeth
- Willems Sara M.
- Willemsen Gonneke
- Wilson James F.
- Wood Andrew R.
- Wu Ying
- Yaghootkar Hanieh
- Zeggini Eleftheria
- Zhao Jing Hua
- Zondervan Krina T.
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Birth weight (BW) is influenced by both foetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease1. These lifecourse associations have often been attributed to the impact of an adverse early life environment. We performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where foetal genotype was associated with BW (P <5x10-8). Overall, ˜15% of variance in BW could be captured by assays of foetal genetic variation. Using genetic association alone, we found strong inverse genetic correlations between BW and systolic blood pressure (rg-0.22, P =5.5x10-13), T2D (rg-0.27, P =1.1x10-6) and coronary artery disease (rg-0.30, P =6.5x10-9) and, in large cohort data sets, demonstrated that genetic factors were the major contributor to the negative covariance between BW and future cardiometabolic risk. Pathway analyses indicated that the protein products of genes within BW-associated regions were enriched for diverse processes including insulin signalling, glucose homeostasis, glycogen biosynthesis and chromatin remodelling. There was also enrichment of associations with BW in known imprinted regions (P =1.9x10-4). We have demonstrated that lifecourse associations between early growth phenotypes and adult cardiometabolic disease are in part the result of shared genetic effects and have highlighted some of the pathways through which these causal genetic effects are mediated
Genome-wide associations for birth weight and correlations with adult disease
- Author
- A Mishra
- AE Locke
- AL Price
- Albert Hofman
- Allan A. Vaag
- Amanda J. Bennett
- Andrew P. Morris
- Andrew R. Wood
- Andrew T. Hattersley
- André G. Uitterlinden
- Anke Tönjes
- Antje Körner
- Anubha Mahajan
- AP Morris
- AP Morris
- AR Wood
- AS Dimas
- AT Hattersley
- AT Hattersley
- AV Segrè
- B Bulik-Sullivan
- B Devlin
- B Howie
- BE Stranger
- Bjarke Feenstra
- BK Bulik-Sullivan
- BP Fairfax
- Brian R. Walker
- Caecilie Trier
- Carla M. T. Tiesler
- Carol A. Wang
- Carolina Medina-Gomez
- Catharina E. M. van Beijsterveldt
- Charlotta Pisinger
- Christian T. Have
- Christine Power
- Christopher J. Groves
- Cilius E. Fonvig
- CJ Hoggart
- CJ Willer
- Claudia H. T. Tam
- Claudia Langenberg
- Cornelia M. van Duijn
- Craig E. Pennell
- D Haig
- D Szklarczyk
- Dale R. Nyholt
- David M. Evans
- David M. Hougaard
- David P. Strachan
- David Torrents
- Debbie A. Lawlor
- Denise M. Scholtens
- Dennis O. Mook-Kanamori
- Diana L. Cousminer
- DJ Barker
- Dorret I. Boomsma
- E Grundberg
- E Huerta-Sánchez
- Eco J. C. N. de Geus
- EE Schadt
- Eileen Tai Hui Boh
- Eleanor Davies
- Eleftheria Zeggini
- Elina Hyppönen
- Elisabeth M. van Leeuwen
- Elisabeth Thiering
- Elisabeth Widén
- Emil V. R. Appel
- Eskil Kreiner
- F Zou
- Felix R. Day
- Fernando Rivadeneira
- Frank D. Mentch
- Frank Geller
- Frank J. A. van Rooij
- Friman Sánchez
- Frits R. Rosendaal
- G Zhang
- George Davey Smith
- George McMahon
- George V. Dedoussis
- Gibran Hemani
- Gonneke Willemsen
- H Aschard
- Haja N. Kadarmideen
- Hakon Hakonarson
- Hanieh Yaghootkar
- Hans Bisgaard
- Harri Niinikoski
- Harry Campbell
- HJ Westra
- HM Kang
- Hugoline G. de Haan
- IA Adzhubei
- Inga Prokopenko
- Ioanna Ntalla
- J Harrow
- J Marchini
- J Peters
- J Picado-Leonard
- J Tyrrell
- J Yang
- J Yang
- James F. Wilson
- Janine F. Felix
- JC Escobar
- Jens-Christian Holm
- Jessica Tyrrell
- Jian’an Luan
- Jing Hua Zhao
- JK Pickrell
- JN Painter
- Joachim Heinrich
- Johan G. Eriksson
- Johannes Waage
- John P. Newnham
- John R. B. Perry
- Jonathan P. Bradfield
- Jorma S. Viikari
- Josep M. Mercader
- Jouke-Jan Hottenga
- JP Ioannidis
- JR Gibbs
- JS Tyrrell
- Juan Fernandez-Tajes
- Judith B. Borja
- K Hao
- K Lage
- Kalliope Panoutsopoulou
- Karen L. Mohlke
- Katharina E. Schraut
- Katherine S. Ruth
- Katja Pahkala
- Ken K. Ong
- Klaus Bønnelykke
- Krina T. Zondervan
- Kyle J. Gaulton
- LA Diver
- Lavinia Paternoster
- Lawrence J. Beilin
- LD Ward
- Leo-Pekka Lyytikäinen
- Linda S. Adair
- Lisbeth Carstensen
- LJ Eaves
- Louise A. Diver
- M Horikoshi
- M Urbanek
- Mads Melbye
- Mads V. Hollegaard
- Marcus A. Tuke
- Marie Standl
- Mario Murcia
- Mariona Bustamante
- Marjo-Riitta Järvelin
- Marjolein N. Kooijman
- Mark I. McCarthy
- Martine Vrijheid
- MC Whitlock
- Michael Nodzenski
- Michael Stumvoll
- Mika Kähönen
- Momoko Horikoshi
- Mustafa Atalay
- Natalia Vilor-Tejedor
- Natalie R. van Zuydam
- NE Allen
- Neil R. Robertson
- Nicholas J. Timpson
- Nicholas J. Wareham
- Nicole M. Warrington
- Niels Grarup
- Niina Pitkänen
- Nilufer Rahmioglu
- Olli T. Raitakari
- Oluf Pedersen
- P Flicek
- P Kumar
- Pedro Marques-Vidal
- Peter K. Joshi
- Peter Kovacs
- Peter Vollenweider
- Po-Ru Loh
- PR Loh
- Q Li
- R Mägi
- Rachel M. Freathy
- Raimo Joro
- Rebecca M. Reynolds
- Rico Rueedi
- RM Reynolds
- Robert A. Scott
- Robin N. Beaumont
- Ronald C. W. Ma
- Ruifang Li-Gao
- S Purcell
- S Wang
- Samuel E. Jones
- Santhi K. Ganesh
- Sara M. Willems
- SB Montgomery
- Scott M. MacKenzie
- Seang-Mei Saw
- SK Ganesh
- Struan F. A. Grant
- Susan M. Ring
- Sylvain Sebert
- Sílvia Bonàs-Guarch
- T Johnson
- T Lappalainen
- Tarunveer S. Ahluwalia
- Terho Lehtimäki
- The UK10K Project Consortium
- Thorkild I. A. Sørensen
- Timo A. Lakka
- Timothy M. Frayling
- Torben Hansen
- TT Koopmann
- TW Winkler
- V Pezzi
- Vasiliki Lagou
- Vincent W. V. Jaddoe
- Virpi Lindi
- Wieland Kiess
- William L. Lowe
- Wing Hung Tam
- X Wang
- XH Xu
- Xu Wang
- Y Baran
- Yik-Ying Teo
- Ying Wu
- Zoltán Kutalik
- Publication venue
- Nature
- Publication date
- 01/01/2016
- Field of study
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10−8). Overall, approximately 15% of variance in BW was captured by assays of fetal genetic variation. Using genetic association alone, we found strong inverse genetic correlations between BW and systolic blood pressure (R g = -0.22, P = 5.5 × 10−13), T2D (R g = -0.27, P = 1.1 × 10−6) and coronary artery disease (R g = -0.30, P = 6.5 × 10−9). In addition, using large -cohort datasets, we demonstrated that genetic factors were the major contributor to the negative covariance between BW and future cardiometabolic risk. Pathway analyses indicated that the protein products of genes within BW-associated regions were enriched for diverse processes including insulin signalling, glucose homeostasis, glycogen biosynthesis and chromatin remodelling. There was also enrichment of associations with BW in known imprinted regions (P = 1.9 × 10−4). We demonstrate that life-course associations between early growth phenotypes and adult cardiometabolic disease are in part the result of shared genetic effects and identify some of the pathways through which these causal genetic effects are mediated.For a full list of the funders pelase visit the publisher's website and look at the supplemetary material provided. Some of the funders are: British Heart Foundation, Cancer Research UK, Medical Research Council, National Institutes of Health, Royal Society and Wellcome Trust
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Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial.
- Author
- Abbass Hakam
- Adhikari Neill
- Affleck Julia
- Agno Sathianathan Ronan
- Ahmad Norfaizan
- Ahmed Iram
- Ainscough Kate
- Al Qasim Eman
- Al Swaidan Lolowa
- Al-Bassam Wisam
- Al-Beidh Farah
- Al-Beidh Farah
- Albert Martin
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Allan Angela
- Allan Elizabeth
- Allen Louise
- Allibone Suzanne
- Amaro dos Santos Catorze Teodoro
- Anderson Tom
- Andric Zdravko
- Angus Derek
- Angus Derek C
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Annane Djillali
- Anstey Matthew
- Antcliffe David
- Aparicio Christelle
- Appelt Peter
- Arabi Yaseen
- Arabi Yaseen
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arishi Hatim
- Arnold Donald
- Asghar Adeeba
- Ashelford Angela
- Attwood Ben
- Austin Karen
- Aysel Florescu Simin
- Azaiz Amine
- Babel Jakša
- Babio-Galan Maite
- Badie Julio
- Bagshaw Sean
- Baillie Kenneth
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbazza Leanne
- Barber Russell
- Barge Deborah
- Barnes Nicky
- Baršić Bruno
- Bashyal Archana
- Basile Kim
- Bass Frances
- Bates Michelle
- Bauchmuller Kris
- Bean Sarah
- Beane Abigail
- Beane Abigail
- Beasley Richard
- Begin Phillipe
- Bellemare David
- Benettaib Fatna
- Benzekri Dalila
- Berdaguer Fernando Daniel
- Bergin Colin
- Berry Lindsay
- Berry Lindsay
- Berry Scott
- Berry Scott
- Bhimani Zahra
- Bhimani Zahra
- Bihari Shailesh
- Bihari Shilesh
- Binnie Alexandra
- Bion Julian
- Biradar Vishwanath
- Birch Janine
- Birch Jenny
- Birchall Katie
- Birkinshaw Isobel
- Black Ethel
- Bloos Frank
- Board Jasmin
- Bone Allsion
- Bonner Stephen
- Bonten Marc
- Bonten Marc
- Borgatta Barbara
- Borrill Zoe
- Bosch Ziekenhuis Jeroen
- Boschert Catherine
- Bossard Isabelle
- Boumahni Dounia
- Bourgoin Charlotte
- Bourne Michelle
- Bourne Richard
- Bouwman Wietske
- Bowler Helen
- Boyd Craig
- Bracke Stephanie
- Bradbury Charlotte
- Bradbury Charlotte
- Bradley-Potts Joanne
- Brailsford Jane
- Brain Matthew
- Brant Emily
- Breen Patrick
- Brett Stephen
- Brewer Chris
- Brickell Kathy
- Brightling Chris
- Brillinger Nicole
- Brimfield Lutece
- Brinkerhoff Gail
- Brochard Laurent
- Brohi Farooq
- Browne Troy
- Brunkhorst Frank
- Brunkhorst Frank
- Budd Joanna
- Buehner Ulrike
- Buhr Heidi
- Bullman Laetitia
- Burns Karen
- Burt Karen
- Buscher Hergen
- Butler Amelia
- Butler M
- Buxton Meredith
- Buxton Meredith
- Buzgau Adrian
- Byrne Deborah
- Byrne Kathleen
- Bélteczki János
- Cabreros Leilani
- Calfee Carolyn
- Callender Owen
- Campbell Andy
- Campbell Hilary
- Campbell Lewis
- Camsooksai Julie
- Caplin Cecile
- Carbonneau Elaine
- Carmona Flores Rosario
- Carr-Knott Lisa
- Carrier François Martin
- Carrier Marc
- Cartner Brittney
- Casey Ruth
- Casey Siobhan
- Castro Ferreira Ricardo Manuel
- Cate Heidi
- Cathcart Susanne
- Cavayas Alexandros
- Cawley Kathryn
- Cazzola Federica
- Centofanti John
- Chablani Manish
- Chamara Warnapura Loku
- Chan Carmen
- Chan Charles
- Chan Peter
- Charlewood Richard
- Charron Cyril
- Chartier Delphine
- Chasse Michael
- Chassé Michaël
- Chen Yan
- Cheng Allen
- Cheng Allen C
- Cherian Shiney
- Cheung Winston
- Chhablani Manish
- Chudeau Nicolas
- Cirstea Emanuel
- Clarey Emma
- Claridge Helen
- Clark Michele
- Clark Sarah
- Claxton Andrew
- Clermont Giles
- Cloutier Ève
- Coburn Susan
- Codreanu Daniel
- Coghlan Phoebe
- Cole Jade
- Coles Holly
- Coles Jennifer
- Colin Gwenhael
- Collier Dawn
- Collins Daniel
- Collins Emma
- Collins Joanne
- Connor Jason
- Cooke Jill
- Cooper Jamie
- Cooper Melanie
- Cornell Sarah
- Cort Jon
- Courtin Laura
- Cowdrey Keri-Anne
- Cowley Nicholas
- Cowton Amanda
- Coyne Mark
- Craner Michelle
- Craven Thomas
- Creagh-Brown Ben
- Crisp Nikki
- Croft Maria
- Cusack Rebecca
- Cutler Sean
- Cviljevic Sabina
- Cárcel Fernández Sheila
- Daly James
- Daly Zoe
- Daneman Nick
- Dark Paul
- Darreau Cédric
- Dasgin Joanne
- Davey Miriam
- Davidson Neil
- Davies Gwyneth
- Davies Louisa
- Davies Michelle
- Dawda Ashlish
- Day Christopher
- De Beaux Fiona
- De Bus Liesbet
- de Courcy-Golder Kim
- de Jager P
- de Jong Menno
- De Jong Menno
- de Jonge E
- de la Fuente Martos Carmen
- de Lima Pereira Tiago Nuno Alfaro
- de Man Angelique
- De Waele Jan
- Dearden Joy
- Dechert William
- Deelchand Vashish
- Dela Rosa Arnold
- Dell Amanda
- Demetriou Carrie
- Depante Maria Theresa
- Depuydt Pieter
- Dequin PierreFrançois
- Derde Lennie
- Derde Lennie
- Detry Michelle
- Detry Michelle
- Deye Nicolas
- Digby Stephen
- Distler Michael
- Doble Patricia
- Donnelly Adrian
- Donnison Phil
- Doran Peter
- Dragija Lidija
- Driscoll Alana
- Drummond Andrew
- Duan Erick
- Duffy Eamon
- Duke Graeme
- Duncan Tracey
- Duplaix Mathilde
- Dushianthan Ahilanandan
- Dyas Sarah
- D’Aragon Frédérick
- D’Souza Ramsy
- Effelaar Evelien
- Elhassan Munzir
- Elin Hall Rebecca
- Ellis Christine
- Elmahi Einas
- Elsefi Tarek
- English Shane
- Estcourt Lise
- Estcourt Lise
- Estensen Kristen
- Everitt Robert
- Evers Mirjam
- Farahi Neda
- Fartoukh Muriel
- Faulkner Beverley
- Faulkner Maria
- Fazekas Ágnes
- Felton Tim
- Ferguson Niall
- Ferguson Susan
- Fergusson Dean
- Fernández de Pinedo Artaraz Ziortza
- Ferrier Janet
- Fierens Jan
- Finn André
- Finn Stephanie
- Fischer Roy
- Fitzgerald Mark
- Fitzgerald Mark
- Fletcher Simon
- Flint Neil
- Forbes Andrew
- Forbes Loretta
- Forton Daniel
- Fortune Louise
- Fottrell-Gould Deirdre
- Fowler Rob
- Fowler Robert
- Fox Claire
- Francia Federica
- Francoeur Charles
- Frey Anna
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- Frohlich Stephen
- Fysh Ed
- Gallagher Linda Jude
- Ganguly Saibal
- Ganpat Radhika
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- Gordon Anthony
- Gordon Anthony C
- Gordon Elizabeth
- Gosbell Iain
- Gould Richard
- Grecu Irina
- Green Cameron
- Green Cameron
- Gregory Jane
- Gresha Rebecca
- Grimmer Lisa
- Grimwade Kate
- Guilder E
- Guitton Christophe
- Hacking Danielle
- Hadebe Bernard
- Hagel Stefan
- Haidar Ghady
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- Hall Kathryn
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- Hamilton-Davies Colin
- Hamlyn Vincent
- Hammond Naomi
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- Hawkins Nancy
- Hay Sophie Kennedy
- Hayes Kati
- Hayes Leanne
- Hays Carole
- Health Monash
- Heinonen Jonna
- Heming Nicholas
- Henderson Seton
- Henderson Steven
- Henning Jeremy
- Henry Joanne
- Heritier Stephane
- Hickey Naomi
- Higgins Alisa M
- Higgins Lisa
- Hill Helen
- Hills Thomas
- Hills Tom
- Hird Clare
- Hodgson Carol
- Hoff Uwe
- Hoiting Oscar
- Holland Nicky
- Hollos Laszlo
- Homes Jennifer
- Hope David
- Hopkins Phil
- Hormis Anil
- Horton Michelle
- Horton Sarah
- Horvat Christopher
- Horvat Christopher
- Howcroft Clare
- Howle Ryan
- Huang David
- Huckle Abby
- Hughes Emma
- Hugill Keith
- Hullegie Sebastiaan
- Hullegie Sebastiaan J
- Hulley Amanda
- Hulme Jonathan
- Hunt Beverley
- Hunter Stephanie
- Hutter Joanne
- Hutton Paula
- Innes Richard
- Ireland Jane
- Isgro Graziella
- Ivatt Helen
- Jackson Matthew
- Jackson Shane
- Jackson Susan
- Jacques Nicola
- Jacquier Sophie
- Jagannathan Vijay
- Janin Pierre
- Jarczak Dominik
- Jeblaoui Asma
- Jeffrey Helen
- Jenkins Sarah
- Jha Rajeev
- Jhanji Shaman
- Johns Maggie
- Johnson David
- Johnson Rebekah
- Johnston Paul
- Jones Andrea
- Jones Jo
- Joseph Sibet
- José Nuno
- Juhaz Vera
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- Lawler Patrick R
- Lawless Patrick
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- van Bentum Puijk Wilma
- van Bentum-Puijk Wilma
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van de Veerdonk Frank
- van de Veerdonk Frank
- Van Der Heyden Kym
- van der Poll Tom
- van’t Hoff Willian
- Vates Jennifer
- Vautier Sarah
- Vazquez-Grande Gloria
- Venkatesh Bala
- Venkatesh Balasubramanian
- Venz Ellen
- Verlander Mark
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- Victor Saji
- Vieillard-Baron Antoine
- Voicu Sebastian
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- Walker Rachel
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- Walsh Tim
- Walsham James
- Ward Kathryn
- Warnock Majella
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watters Malcolm
- Waugh Victoria
- Webb Steve
- Webb Steven A
- Wedd Steve
- Weismann Dirk
- Weissman Alexandra
- Wells Colin
- Welters Ingeborg
- Wetherill Bill
- Whelan Ruth
- Whileman Amanda
- Whitbread Jennifer
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Wibrow Bradley
- Wigbers J
- Wilby Elizabeth
- Wild Laura
- Wild Laura
- Wilding Laura
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Erin
- Williams Hannah
- Williams Karen
- Williams Patricia
- Williams Patricia
- Williams Penny
- Williams Tony
- Williams Virginie
- Williamson Dawn
- Williamson James
- Wilson Karen
- Wilson Maggie
- Wiseman Sophie
- Wong Helen
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Writing Committee for the REMAP-CAP Investigators
- Xavier Kugan
- Xia Le Tai Charlotte
- Yarad Elizabeth
- Yates David
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Yusuff Hakeem
- Zaharia Miahela Florentina
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zarychanski Ryan
- Zhao Xiao Bei
- Zinzoni Vanessa
- Zitter Letizia
- Đimoti Renata
- Publication venue
- JAMA: Journal of the American Medical Association
- Publication date
- 06/10/2020
- Field of study
Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, Setting, and Participants: An ongoing adaptive platform trial testing multiple interventions within multiple therapeutic domains, for example, antiviral agents, corticosteroids, or immunoglobulin. Between March 9 and June 17, 2020, 614 adult patients with suspected or confirmed COVID-19 were enrolled and randomized within at least 1 domain following admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at 121 sites in 8 countries. Of these, 403 were randomized to open-label interventions within the corticosteroid domain. The domain was halted after results from another trial were released. Follow-up ended August 12, 2020. Interventions: The corticosteroid domain randomized participants to a fixed 7-day course of intravenous hydrocortisone (50 mg or 100 mg every 6 hours) (n = 143), a shock-dependent course (50 mg every 6 hours when shock was clinically evident) (n = 152), or no hydrocortisone (n = 108). Main Outcomes and Measures: The primary end point was organ support-free days (days alive and free of ICU-based respiratory or cardiovascular support) within 21 days, where patients who died were assigned -1 day. The primary analysis was a bayesian cumulative logistic model that included all patients enrolled with severe COVID-19, adjusting for age, sex, site, region, time, assignment to interventions within other domains, and domain and intervention eligibility. Superiority was defined as the posterior probability of an odds ratio greater than 1 (threshold for trial conclusion of superiority >99%). Results: After excluding 19 participants who withdrew consent, there were 384 patients (mean age, 60 years; 29% female) randomized to the fixed-dose (n = 137), shock-dependent (n = 146), and no (n = 101) hydrocortisone groups; 379 (99%) completed the study and were included in the analysis. The mean age for the 3 groups ranged between 59.5 and 60.4 years; most patients were male (range, 70.6%-71.5%); mean body mass index ranged between 29.7 and 30.9; and patients receiving mechanical ventilation ranged between 50.0% and 63.5%. For the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively, the median organ support-free days were 0 (IQR, -1 to 15), 0 (IQR, -1 to 13), and 0 (-1 to 11) days (composed of 30%, 26%, and 33% mortality rates and 11.5, 9.5, and 6 median organ support-free days among survivors). The median adjusted odds ratio and bayesian probability of superiority were 1.43 (95% credible interval, 0.91-2.27) and 93% for fixed-dose hydrocortisone, respectively, and were 1.22 (95% credible interval, 0.76-1.94) and 80% for shock-dependent hydrocortisone compared with no hydrocortisone. Serious adverse events were reported in 4 (3%), 5 (3%), and 1 (1%) patients in the fixed-dose, shock-dependent, and no hydrocortisone groups, respectively. Conclusions and Relevance: Among patients with severe COVID-19, treatment with a 7-day fixed-dose course of hydrocortisone or shock-dependent dosing of hydrocortisone, compared with no hydrocortisone, resulted in 93% and 80% probabilities of superiority with regard to the odds of improvement in organ support-free days within 21 days. However, the trial was stopped early and no treatment strategy met prespecified criteria for statistical superiority, precluding definitive conclusions. Trial Registration: ClinicalTrials.gov Identifier: NCT02735707
Mitochondrial physiology
- Author
- Aasander Frostner Eleonor
- Abdel-Rahman Engy Ali
- Abdul Karim Norwahidah
- Abumrad Nada A
- Acuna-Castroviejo Dario
- Adiele Reginald C
- Ahn Bumsoo
- Alencar Mayke Bezerra
- Ali Sameh S
- Almeida Angeles
- Alton Lesley
- Alves Marco G
- Amati Francesca
- Amoedo Nivea Dias
- Amorim Ricardo
- Anderson Ethan J
- Andreadou Ioanna
- Antunes Diana
- Arago Marc
- Aral Cenk
- Arandarcikaite Odeta
- Arias-Reyes Christian
- Armand Anne-Sophie
- Arnould Thierry
- Avram Vlad F
- Axelrod Christopher L
- Bailey Damian M
- Bairam Aida
- Bajpeyi Sudip
- Bajzikova Martina
- Bakker Barbara M
- Banni Aml
- Bardal Tora
- Barlow J
- Bastos Sant'Anna Silva Ana Carolina
- Batterson Philip M
- Battino Maurizio
- Bazil Jason N
- Beard Daniel A
- Bednarczyk Piotr
- Beleza Jorge
- Bello Fiona
- Ben-Shachar Dorit
- Bento Guida Jose Freitas
- Bergdahl Andreas
- Berge Rolf K
- Bergmeister Lisa
- Bernardi Paolo
- Berridge Michael V
- Bettinazzi Stefano
- Bishop David J
- Blier Pierre U
- Blindheim Dan Filip
- Boardman Neoma T
- Boersheim Elisabet
- Boetker Hans Erik
- Borchard Sabine
- Boros Mihaly
- Borras Consuelo
- Borutaite Vilma
- Botella Javier
- Bouillaud Frederic
- Bouitbir Jamal
- Boushel Robert C
- Bovard Josh
- Bravo-Sagua Roberto
- Breton Sophie
- Brown David A
- Brown Guy C
- Brown Robert Andrew
- Brozinick Joseph T
- Buettner Garry R
- Burtscher Johannes
- Bustos Matilde
- Calabria Elisa
- Calbet Jose AL
- Calzia Enrico
- Cannon Daniel T
- Cano Sanchez Maria Consolacion
- Canto Alvarez Carles
- Cardinale Daniele A
- Cardoso Luiza HD
- Carvalho Eugenia
- Casado Pinna Marta
- Cassar Samantha
- Castelo Rueda Maria Paulina
- Castilho Roger F
- Cavalcanti-de-Albuquerque Joao Paulo
- Cecatto Cristiane
- Celen Murat C
- Cervinkova Zuzana
- Chabi Beatrice
- Chakrabarti Lisa
- Chakrabarti Sasanka
- Chaurasia Bhagirath
- Chen Quan
- Chicco Adam J
- Chinopoulos Christos
- Chowdhury Subir Kumar
- Cizmarova Beata
- Clementi Emilio
- Coen Paul M
- Cohen Bruce H
- Coker Robert H
- Collin-Chenot Anne
- Coughlan Melinda T
- Coxito Pedro
- Crisostomo Luis
- Crispim Marcell
- Crossland Hannah
- Dahdah Norma Ramon
- Dalgaard Louise T
- Dambrova Maija
- Danhelovska Tereza
- Darveau Charles-A
- Darwin Paula M
- Das Anibh Martin
- Dash Ranjan K
- Davidova Eliska
- Davis Michael S
- Dayanidhi Sudarshan
- De Bem Andreza Fabro
- De Goede Paul
- De Palma Clara
- De Pinto Vito
- Dela Flemming
- Dembinska-Kiec Aldona
- Detraux Damian
- Devaux Yvan
- Di Marcello Marco
- Di Paola Floriana Jessica
- Dias Candida
- Dias Tania R
- Diederich Marc
- Distefano Giovanna
- Djafarzadeh Siamak
- Doermann Niklas
- Doerrier Carolina
- Dong Lan-Feng
- Donnelly Chris
- Drahota Zdenek
- Duarte Filipe Valente
- Dubouchaud Herve
- Duchen Michael R
- Dumas Jean-Francois
- Durham William J
- Dymkowska Dorota
- Dyrstad Sissel E
- Dyson Alex
- Dzialowski Edward M
- Eaton Simon
- Ehinger Johannes K
- Elmer Eskil
- Endlicher Rene
- Engin Ayse Basak
- Escames Germaine
- Evinova Andrea
- Ezrova Zuzana
- Falk Marni J
- Fell David A
- Ferdinandy Peter
- Ferko Miroslav
- Fernandez-Ortiz Marisol
- Fernandez-Vizarra Erika
- Ferreira Julio Cesar B
- Ferreira Rita Maria P
- Ferri Alessandra
- Fessel Joshua Patrick
- Festuccia William T
- Filipovska Aleksandra
- Fisar Zdenek
- Fischer Christine
- Fischer Michael J
- Fisher Gordon
- Fisher Joshua J
- Fontanesi Flavia
- Forbes-Hernandez Tamara Y
- Ford Ellen
- Fornaro Mara
- Fuertes Agudo Marina
- Fulton Montana
- Galina Antonio
- Galkin Alexander
- Gallee Leon
- Galli Gina L J
- Gama Perez Pau
- Gan Zhenji
- Ganetzky Rebecca
- Gao Yun
- Garcia Geovana S
- Garcia-Rivas Gerardo
- Garcia-Roves Pablo Miguel
- Garcia-Souza Luiz F
- Garlid Keith D
- Garrabou Gloria
- Garten Antje
- Gastaldelli Amalia
- Gayen Jiaur
- Genders Amanda J
- Genova Maria Luisa
- Giampieri Francesca
- Giovarelli Matteo
- Glatz Jan FC
- Gnaiger Erich
- Goikoetxea Usandizaga Naroa
- Goncalo Teixeira da Silva Rui
- Goncalves Debora Farina
- Gonzalez- Armenta Jenny L
- Gonzalez-Franquesa Alba
- Gonzalez-Freire Marta
- Gonzalo Hugo
- Goodpaster Bret H
- Gorr Thomas A
- Gourlay Campbell W
- Grams Bente
- Granata Cesare
- Grefte Sander
- Grilo Luis
- Guarch Meritxell Espino
- Gueguen Naig
- Gumeni Sentiljana
- Haas Clarissa
- Haavik Jan
- Hachmo Yafit
- Haendeler Judith
- Haider Markus
- Hajrulahovic Anesa
- Hamann Andrea
- Han Jin
- Han Woo Hyun
- Hancock Chad R
- Hand Steven C
- Handl Jiri
- Hansikova Hana
- Hardee Justin P
- Hargreaves Iain P
- Harper Mary- Ellen
- Harrison David K
- Hassan Hazirah
- Hatokova Zuzana
- Hausenloy Derek J
- Heales Simon JR
- Hecker Matthias
- Heiestad Christina
- Hellgren Kim T
- Henrique Alexandrino
- Hepple Russell T
- Hernansanz- Agustin Pablo
- Hewakapuge Sudinna
- Hickey Anthony J
- Ho Dieu Hien
- Hoehn Kyle L
- Hoel Fredrik
- Holland Olivia J
- Holloway Graham P
- Holzner Lorenz
- Hoppel Charles L
- Hoppel Florian
- Hoppeler Hans
- Houstek Josef
- Huete-Ortega Maria
- Hyrossova Petra
- Iglesias-Gonzalez Javier
- Indiveri Cesare
- Irving Brian A
- Isola Raffaella
- Iyer Shilpa
- Jackson Christopher Benjamin
- Jadiya Pooja
- Jana Prado Fabian
- Jandeleit-Dahm Karin
- Jang David H
- Jang Young Charles
- Janowska Joanna
- Jansen Kirsten M
- Jansen-Duerr Pidder
- Jansone Baiba
- Jarmuszkiewicz Wieslawa
- Jaskiewicz Anna
- Jaspers Richard T
- Jedlicka Jan
- Jerome Estaquier
- Jespersen Nichlas Riise
- Jha Rajan Kumar
- Jones John G
- Joseph Vincent
- Juhasz Laszlo
- Jurczak Michael J
- Jurk Diana
- Jusic Amela
- Kaambre Tuuli
- Kaczor Jan Jacek
- Kainulainen Heikki
- Kampa Rafal Pawel
- Kandel Sunil Mani
- Kane Daniel A
- Kapferer Werner
- Kapnick Senta
- Kappler Lisa
- Karabatsiakis Alexander
- Karavaeva Iuliia
- Karkucinska-Wieckowska Agnieszka
- Kaur Sarbjot
- Keijer Jaap
- Keller Markus A
- Keppner Gloria
- Khamoui Andy V
- Kidere Dita
- Kilbaugh Todd
- Kim Hyoung Kyu
- Kim Julian KS
- Kimoloi Sammy
- Klepinin Aleksandr
- Klepinina Lyudmila
- Klingenspor Martin
- Klocker Helmut
- Kolassa Iris
- Komlodi Timea
- Koopman Werner JH
- Kopitar-Jerala Natasa
- Kowaltowski Alicia J
- Kozlov Andrey V
- Krajcova Adela
- Krako Jakovljevic Nina
- Kristal Bruce S
- Krycer James R
- Kuang Jujiao
- Kucera Otto
- Kuka Janis
- Kwak Hyo Bum
- Kwast Kurt E
- Kwon Oh Sung
- Laasmaa Martin
- Labieniec-Watala Magdalena
- Lagarrigue Sylviane
- Lai Nicola
- Lalic Nebojsa M
- Land John M
- Lane Nick
- Laner Verena
- Lanza Ian R
- Laouafa Sofien
- Laranjinha Joao
- Larsen Steen
- Larsen Terje S
- Lavery Gareth G
- Lazou Antigone
- Ledo Ana Margarida
- Lee Hong Kyu
- Leeuwenburgh Christiaan
- Lehti Maarit
- Lemieux Helene
- Lenaz Giorgio
- Lerfall Joergen
- Li Pingan Andy
- Li Puma Lance
- Liang Liping
- Liepins Edgars
- Lin Chien-Te
- Liu Jiankang
- Lopez Garcia Luis Carlos
- Lucchinetti Eliana
- Ma Tao
- Macedo Maria Paula
- Machado Ivo F
- Maciej Sarah
- MacMillan-Crow Lee Ann
- Magalhaes Jose
- Magri Andrea
- Majtnerova Pavlina
- Makarova Elina
- Makrecka-Kuka Marina
- Malik Afshan N
- Marcouiller Francois
- Marechal Amandine
- Markova Michaela
- Markovic Ivanka
- Martin Daniel S
- Martins Ana Dias
- Martins Joao D
- Maseko Tumisang Edward
- Maull Felicia
- Mazat Jean-Pierre
- McKenna Helen T
- McKenzie Matthew
- McMillan Duncan GG
- McStay Gavin P
- Mendham Amy
- Menze Michael A
- Mercer John R
- Merz Tamara
- Messina Angela
- Meszaros Andras
- Methner Axel
- Michalak Slawomir
- Mila Guasch Maria
- Minuzzi Luciele M
- Misirkic Marjanovic Maja
- Moellering Douglas R
- Moisoi Nicoleta
- Molina Anthony JA
- Montaigne David
- Moore Anthony L
- Moore Christy
- Moreau Kerrie
- Moreira Bruno P
- Moreno-Sanchez Rafael
- Mracek Tomas
- Muccini Anna Maria
- Munro Daniel
- Muntane Jordi
- Muntean Danina M
- Murray Andrew James
- Musiol Eva
- Nabben Miranda
- Nair K Sreekumaran
- Nehlin Jan O
- Nemec Michal
- Nesci Salvatore
- Neufer P Darrell
- Neuzil Jiri
- Neviere Remi
- Newsom Sean A
- Norman Jennifer
- Nozickova Katerina
- Nunes Sara
- Nuoffer Jean-Marc
- O'Brien Katie A
- O'Brien Kristin
- O'Gorman Donal
- Olgar Yusuf
- Oliveira Ben
- Oliveira Jorge
- Oliveira Marcos Tulio
- Oliveira Marcus F
- Oliveira Paulo J
- Oliveira Pedro Fontes
- Olsen Rolf Erik
- Orynbayeva Zulfiya
- Osiewacz Heinz D
- Paez Hector
- Pak Youngmi Kim
- Pallotta Maria Luigia
- Palmeira Carlos
- Parajuli Nirmala
- Passos Joao F
- Passrugger Manuela
- Patel Hemal H
- Pavlova Nadia
- Pavlovic Kasja
- Pecina Petr
- Pedersen Tina M
- Perales Jose Carles
- Pereira da Silva Grilo da Silva Filomena
- Pereira Rita
- Pereira Susana P
- Perez Valencia Juan Alberto
- Perks Kara L
- Pesta Dominik
- Petit Patrice X
- Pettersen Nitschke Ina Katrine
- Pichaud Nicolas
- Pichler Irene
- Piel Sarah
- Pietka Terri A
- Pinho Sonia A
- Pino Maria F
- Pirkmajer Sergej
- Place Nicolas
- Plangger Mario
- Porter Craig
- Porter Richard K
- Preguica Ines
- Prigione Alessandro
- Procaccio Vincent
- Prochownik Edward V
- Prola Alexandre
- Pulinilkunnil Thomas
- Puskarich Michael A
- Puurand Marju
- Radenkovic Filip
- Ramzan Rabia
- Rattan Suresh IS
- Reano Simone
- Reboredo-Rodriguez Patricia
- Rees Bernard B
- Renner-Sattler Kathrin
- Rial Eduardo
- Robinson Matthew M
- Roden Michael
- Rodrigues Ana Sofia
- Rodriguez Enrique
- Rodriguez-Enriquez Sara
- Roesland Gro Vatne
- Rohlena Jakub
- Rolo Anabela Pinto
- Ropelle Eduardo R
- Roshanravan Baback
- Rossignol Rodrigue
- Rossiter Harry B
- Rousar Tomas
- Rubelj Ivica
- Rybacka-Mossakowska Joanna
- Saada Reisch Ann
- Safaei Zahra
- Salin Karine
- Salvadego Desy
- Sandi Carmen
- Saner Nicholas
- Santos Diana
- Sanz Alberto
- Sardao Vilma
- Sarlak Saharnaz
- Sazanov Leonid A
- Scaife Paula
- Scatena Roberto
- Schartner Melanie
- Scheibye-Knudsen Morten
- Schilling Jan M
- Schlattner Uwe
- Schmitt Sabine
- Schneider Gasser Edith Mariane
- Schoenfeld Peter
- Schots Pauke C
- Schulz Rainer
- Schwarzer Christoph
- Scott Graham R
- Selman Colin
- Sendon Pamella Marie
- Shabalina Irina G
- Sharma Pushpa
- Sharma Vipin
- Shevchuk Igor
- Shirazi Reza
- Shiroma Jonathan G
- Siewiera Karolina
- Silber Ariel M
- Silva Ana Maria
- Sims Carrie A
- Singer Dominique
- Singh Brijesh Kumar
- Skolik Robert A
- Smenes Benedikte Therese
- Smith James
- Soares Felix Alexandre Antunes
- Sobotka Ondrej
- Sokolova Inna
- Solesio Maria E
- Soliz Jorge
- Sommer Natascha
- Sonkar Vijay K
- Sova Marina
- Sowton Alice P
- Sparagna Genevieve C
- Sparks Lauren M
- Spinazzi Marco
- Stankova Pavla
- Starr Jonathan
- Stary Creed
- Stefan Eduard
- Stelfa Gundega
- Stepto Nigel K
- Stevanovic Jelena
- Stiban Johnny
- Stier Antoine
- Stocker Roland
- Storder Julie
- Sumbalova Zuzana
- Suomalainen Anu
- Suravajhala Prashanth
- Svalbe Baiba
- Swerdlow Russell H
- Swiniuch Daria
- Szabo Ildiko
- Szewczyk Adam
- Szibor Marten
- Tanaka Masashi
- Tandler Bernard
- Tarnopolsky Mark A
- Tausan Daniel
- Tavernarakis Nektarios
- Teodoro Joao Soeiro
- Tepp Kersti
- Thakkar Himani
- Thapa Maheshwor
- Thyfault John P
- Tomar Dhanendra
- Ton Riccardo
- Torp May-Kristin
- Torres-Quesada Omar
- Towheed Atif
- Treberg Jason R
- Tretter Laszlo
- Trewin Adam J
- Trifunovic Aleksandra
- Trivigno Catherine
- Tronstad Karl Johan
- Trougakos Ioannis P
- Truu Laura
- Tuncay Erkan
- Turan Belma
- Tyrrell Daniel J
- Urban Tomas
- Urner Sofia
- Valentine Joseph Marco
- Van Bergen Nicole J
- Van der Ende Miranda
- Varricchio Frederick
- Vaupel Peter
- Vella Joanna
- Vendelin Marko
- Vercesi Anibal E
- Verdaguer Ignasi Bofill
- Vernerova Andrea
- Victor Victor Manuel
- Vidimce Josif
- Vieira Ligo Teixeira Camila
- Viel Christian
- Vieyra Adalberto
- Vilks Karlis
- Villena Josep A
- Vincent Vinnyfred
- Vinogradov Andrey D
- Viscomi Carlo
- Vitorino Rui Miguel Pinheiro
- Vlachaki Walker Julia
- Vogt Sebastian
- Volani Chiara
- Volska Kristine
- Votion Dominique-Marie
- Vujacic-Mirski Ksenija
- Wagner Brett A
- Ward Marie Louise
- Warnsmann Verena
- Wasserman David H
- Watala Cezary
- Wei Yau-Huei
- Weinberger Klaus M
- Weissig Volkmar
- White Sarah Haverty
- Whitfield Jamie
- Wickert Anika
- Wieckowski Mariusz R
- Wiesner Rudolf J
- Williams Caroline M
- Winwood-Smith Hugh
- Wohlgemuth Stephanie E
- Wohlwend Martin
- Wolff Jonci Nikolai
- Wrutniak-Cabello Chantal
- Wuest Rob CI
- Yokota Takashi
- Zablocki Krzysztof
- Zanon Alessandra
- Zanou Nadege
- Zaugg Kathrin
- Zaugg Michael
- Zdrazilova Lucie
- Zhang Yizhu
- Zhang Yong
- Zikova Alena
- Zischka Hans
- Zorzano Antonio
- Zujovic Tijana
- Zurmanova Jitka
- Zvejniece Liga
- Publication venue
- Publication date
- 01/01/2020
- Field of study
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
Mitochondrial physiology
- Author
- >Gonzalez-Francesqua A
- Aasander Frostner Eleonor
- Abdel-Rahman Engy Ali
- Abdul Karim Norwahidah
- Abumrad Nada A
- Acuna-Castroviejo Dario
- Adiele Reginald C
- Ahn Bumsoo
- Alencar MB
- Ali Sameh S
- Almeida Angeles
- Alton Lesley
- Alves Marco G
- Amati Francesca
- Amoedo Nivea Dias
- Amorim Ricardo
- Anderson Ethan J
- Andreadou Ioanna
- Antunes Diana
- Arago Marc
- Aral Cenk
- Arandarcikaite Odeta
- Arias-Reyes Christian
- Armand Anne-Sophie
- Arnould Thierry
- Avram Vlad Florian
- Axelrod Christopher L
- Bailey Damian M
- Bairam Aida
- Bajpeyi Sudip
- Bajzikova Martina
- Bakker Barbara M
- Banni A
- Bardal Tora
- Barlow Jonathan
- Bastos Sant'Anna Silva Ana Carolina
- Batterson Philip
- Battino Maurizio
- Bazil Jason
- Beard Daniel A
- Bednarczyk Piotr
- Beleza Jorge
- Bello Fiona
- Ben-Shachar Dorit
- Bergdahl Andreas
- Berge Rolf K
- Bergmeister Lisa
- Bernardi Paolo
- Berridge Michael V
- Bettinazzi Stefano
- Bishop David
- Blier Pierre U
- Blindheim Dan Filip
- Boardman Neoma T
- Boetker Hans Erik
- Borchard Sabine
- Boros Mihaly
- Borras Consuelo
- Borsheim Elisabet
- Borutaite Vilma
- Botella Javier
- Bouillaud Frederic
- Bouitbir Jamal
- Boushel Robert C
- Bovard Josh
- Bravo-Sagua Roberto
- Breton Sophie
- Brown David A
- Brown Guy C
- Brown Robert A
- Brozinick Joseph T
- Buettner Garry R
- Burtscher Johannes
- Bustos Matilde
- Calabria Elisa
- Calbet Jose A
- Calzia Enrico
- Cannon Daniel T
- Cano Sanchez Maria
- Canto Alvarez Carlos
- Cardinale D
- Cardoso Luiza Helena Daltro
- Carvalho Eugenia
- Casado Pinna Marta
- Cassar Samantha
- Castelo Maria P
- Castilho Roger F
- Cavalcanti-de-Albuquerque Joao Paulo
- Cecatto Cristiane
- Celen Murat C
- Cervinkova Zuzana
- Chabi Beatrice
- Chakrabarti Lisa
- Chakrabarti Sasanka
- Chaurasia Bhagirath
- Chen Qi
- Chicco Adam J
- Chinopoulos Christos
- Chowdhury Subir K
- Cizmarova Beata
- Clementi Emilio
- Coen Paul M
- Cohen Bruce H
- Coker Robert H
- Collin-Chenot Anne
- Coughlan MT
- Coxito Pedro
- Crisostomo Luis
- Crispim Marcell
- Crossland Hannah
- Dahdah Norma
- Dalgaard Louise T
- Dambrova Maija
- Danhelovska Tereza
- Darveau Charles A
- Darwin Paula M
- Das Anibh M
- Dash Ranjan K
- Davidova Eliska
- Davis Michael S
- Dayanidhi Sudarshan
- De Bem Andreza Fabro
- De Goede Paul
- De Palma Clara
- De Pinto Vito
- Dela Flemming
- Dembinska-Kiec Aldona
- Detraux Damien
- Devaux Yvan
- Di Marcello Marco
- Di Paola Floriana Jessica
- Dias Candida
- Dias Tania R
- Diederich Marc
- Distefano Giovanna
- Djafarzadeh Siamak
- Doermann Niklas
- Doerrier Carolina
- Dong Lan-Feng
- Donnelly Chris
- Drahota Zdenek
- Duarte Filipe Valente
- Dubouchaud Herve
- Duchen Michael R
- Dumas Jean-Francois
- Durham William J
- Dymkowska Dorota
- Dyrstad Sissel E
- Dyson Alex
- Dzialowski Edward M
- Eaton Simon
- Ehinger Johannes
- Elmer Eskil
- Endlicher Rene
- Engin Ayse B
- Escames Germaine
- Evinova Andrea
- Ezrova Zuzana
- Falk Marni Joy
- Fell David A
- Ferdinandy Peter
- Ferko Miroslav
- Fernandez-Ortiz Marisol
- Fernandez-Vizarra Erika
- Ferreira Julio Cesar Batista
- Ferreira Rita
- Ferri Alessandra
- Fessel Joshua P
- Festuccia WT
- Filipovska Aleksandra
- Fisar Zdenek
- Fischer Christine
- Fischer Michael
- Fisher Gordon
- Fisher Joshua J
- Fontanesi Flavia
- Forbes-Hernandez Tamara Y
- Ford Ellen
- Fornaro Mara
- Fuertes Agudo Marina
- Fulton Montana
- Galina Antonio
- Galkin Alexander
- Gallee Leon
- Galli Gina L
- Gama Perez Pau
- Gan Zhenji
- Ganetzky Rebecca
- Gao Yun
- Garcia Geovana S
- Garcia-Rivas Gerardo
- Garcia-Roves Pablo Miguel
- Garcia-Souza Luiz Felipe
- Garlid Keith D
- Garrabou Gloria
- Garten Antje
- Gastaldelli Amalia
- Gayen Jiaur
- Genders Amanda J
- Genova Maria Luisa
- Giampieri Francesca
- Giovarelli Matteo
- Glatz Jan FC
- Gnaiger Erich
- Goikoetxea Usandizaga Naroa
- Goncalo Teixeira da Silva Rui
- Goncalves Debora Farina
- Gonzalez-Armenta Jenny L
- Gonzalez-Freire Marta
- Gonzalo Hugo
- Goodpaster Bret H
- Gorr Thomas A
- Gourlay Campbell W
- Grams Bente
- Granata Cesare
- Grefte Sander
- Grilo Luis
- Guarch Meritxell Espino
- Gueguen Naig
- Guida G
- Gumeni Sentiljana
- Haas Clarissa B
- Haavik Jan
- Hachmo Yafit
- Haendeler Judith
- Haider Markus
- Hajrulahovic Anesa
- Hamann Andrea
- Han Jin
- Han Woo Hyun
- Hancock Chad R
- Hand Steven C
- Handl Jiri
- Hansikova Hana
- Hardee Justin P
- Hargreaves Ian P
- Harper Mary Ellen
- Harrison David K
- Hassan Hazirah
- Hatokova Zuzana
- Hausenloy Derek J
- Heales Simon JR
- Hecker Matthias
- Heiestad Christina
- Hellgren Kim T
- Henrique Alexandrino
- Hepple Russell T
- Hernansanz-Agustin Pablo
- Hewakapuge Sudinna
- Hickey Anthony J
- Ho Dieu Hien
- Hoehn Kyle L
- Hoel Frederik
- Holland Olivia J
- Holloway Graham P
- Holzner Lorenz
- Hoppel Charles L
- Hoppel Florian
- Hoppeler H
- Houstek Josef
- Huete-Ortega Maria
- Hyrossova Petra
- Iglesias-Gonzalez Javier
- Indiveri Cesare
- Irving Brian A
- Isola Raffaella
- Iyer Shilpa
- Jackson Christophe B
- Jadiya Pooja
- Jana Prado Fabian
- Jandeleit-Dahm K
- Jang David H
- Jang Young C
- Janowska Joanna
- Jansen Kirsten
- Jansen-Duerr Pidder
- Jansone Baiba
- Jarmuszkiewicz Wieslawa
- Jaskiewicz Anna
- Jaspers Richard T
- Jedlicka Jan
- Jerome Estaquier
- Jespersen Nichlas R
- Jha Rajan K
- John G JG
- Joseph Vincent
- Juhasz Laszlo
- Jurczak Michael J
- Jurk Diana
- Jusic Amela
- Kaambre Tuuli
- Kaczor Jan J
- Kainulainen Heikki
- Kampa Rafal Pawel
- Kandel Sunil M
- Kane Daniel A
- Kapferer Werner
- Kapnick Senta
- Kappler Lisa
- Karabatsiakis Alexander
- Karavaeva Iuliia
- Karkucinska-Wieckowska Agnieszka
- Kaur Sarbjot
- Keijer Jaap
- Keller Markus A
- Keppner Gloria
- Khamoui Andy V
- Kidere Dita
- Kilbaugh Todd
- Kim Hyoung Kyu
- Kim Julian KS
- Kimoloi Sammy
- Klepinin Aleksandr
- Klepinina Lyudmila
- Klingenspor Martin
- Klocker Helmut
- Kolasa Iris
- Komlódi Timea
- Koopman Werner JH
- Kopitar-Jerala Natasa
- Kowaltowski Alicia J
- Kozlov Andrey V
- Krajcova Adela
- Krako Jakovljevic Nina
- Kristal Bruce S
- Krycer Jamer R
- Kuang Jujiao
- Kucera Otto
- Kuka Janis
- Kwak Hyo Bum
- Kwast Kurt
- Kwon Oh Sung
- Laasmaa Martin
- Labieniec-Watala Magdalena
- Lagarrigue Sylviane
- Lai Nicola
- Lalic Nebojsa M
- Land John M
- Lane Nick
- Laner Verena
- Lanza Ian R
- Laouafa Sofien
- Laranjinha Joäo
- Larsen Steen
- Larsen Terje S
- Lavery Gareth G
- Lazou Antigone
- Ledo Ana Margarida
- Lee Hong Kyu
- Leeuwenburgh Christiaan
- Lehti Maarit
- Lemieux Helene
- Lenaz Giorgio
- Lerfall Jorgen
- Li Puma Lance
- Li Pingan A
- Liang Liping
- Liepins Edgars
- Lin Chien-Te
- Liu Jiankang
- Lopez Luis C
- Lucchinetti Eliana
- Ma Tao
- Macedo Maria P
- Machado Ivo F
- Maciej Sarah
- MacMillan-Crow Lee Ann
- Magalhaes Jose
- Magri Andrea
- Majtnerova Pavlina
- Makarova Elina
- Makrecka-Kuka Marina
- Malik Afshan N
- Marcouiller Francois
- Marechal Amandine
- Markova Michaela
- Markovic Ivanka
- Martin Daniel S
- Martins Ana Dias
- Martins Joao D
- Maseko Tumisang Edward
- Maull Felicia
- Mazat Jean Pierre
- McKenna Helen T
- McKenzie Matthew
- McMillan Duncan GG
- McStay Gavin P
- Menndham A
- Menze Michael A
- Mercer John R.
- Merz Tamara
- Messina Angela
- Meszaros Andras T
- Methner Axel
- Michalak Slawomir
- Mila Guasch Maria
- Minuzzi Luciele M
- Misirkic Marjanovic Maja
- Moellering Douglas R
- Moisoi Nicoleta
- Molina Anthony JA
- Montaigne David
- Moore Anthony L
- Moore Christy
- Moreau Kerrie
- Moreira Bruno P
- Moreno-Sanchez Rafael
- Mracek Tomas
- Muccini Anna Maria
- Munro Daniel
- Muntane Jordi
- Muntean Danina M
- Murray Andrew J
- Musiol Eva
- Nabben Miranda
- Nair K Sreekumaran
- Nehlin Jan O
- Nemec Michal
- Nesci Salvatore
- Neufer P Darrell
- Neuzil Jiri
- Neviere Remi
- Newsom Sean A.
- Norman Jennifer
- Nozickova Katerina
- Nunes Sara
- Nuoffer Jean-Marc
- O'Brien Katie A
- O'Brien Kristin
- O'Gorman Donal
- Olgar Yusuf
- Oliveira Ben
- Oliveira Jorge
- Oliveira Marcos Tulio
- Oliveira Marcus F
- Oliveira Paulo J
- Oliveira Pedro F
- Olsen Rolf Erik
- Orynbayeva Zulfiya
- Osiewacz Heinz D
- Paez Hector
- Pak Youngmi K
- Pallotta Maria L
- Palmeira Carlos M
- Parajuli Nirmala
- Passos Joao F
- Passrugger Manuela
- Patel Hemal H
- Pavlova Nadia
- Pavlovic Kasja
- Pecina Petr
- Pedersen Tina M
- Perales Jose Carles
- Pereira da Silva Grilo da Silva Filomena
- Pereira Rita
- Pereira Susana
- Perez Valencia Juan A
- Perks Kara L
- Pesta Dominik
- Petit Patrice X
- Pettersen Ina Katrine Nitschke
- Pichaud Nicolas
- Pichler Irene
- Piel Sarah
- Pietka Terri A
- Pinho Sonia A
- Pino Maria F
- Pirkmajer Sergej
- Place Nicolas
- Plangger Mario
- Porter Craig
- Porter Richard K
- Preguica Ines
- Prigione Alessandro
- Procaccio Vincent
- Prochownik Edward V
- Prola Alexandre
- Pulinilkunnil Thomas
- Puskarich Michael A
- Puurand Marju
- Radenkovic Filip
- Ramzan Rabia
- Rattan Suresh IS
- Reano Simone
- Reboredo-Rodriguez Patricia
- Rees Bernard B
- Renner-Sattler Kathrin
- Rial Eduardo
- Robinson Matthew M
- Roden Michael
- Rodrigues Ana Sofia
- Rodriguez Enrique
- Rodriguez-Enriquez Sara
- Roesland Gro Vatne
- Rohlena Jakub
- Rolo Anabela Pinto
- Ropelle Eduardo R
- Roshanravan Baback
- Rossignol Rodrigue
- Rossiter Harry B
- Rousar Tomas
- Rubelj Ivica
- Rybacka-Mossakowska Joanna
- Saada Ann
- Safaei Zahra
- Saharnaz Sarlak
- Salin Karine
- Salvadego Desy
- Sandi Carmen
- Saner Nicholas
- Sanz Alberto
- Sazanov Leonid A
- Scatena Roberto
- Schartner Melanie
- Scheibye-Knudsen Morten
- Schilling Jan M
- Schlattner Uwe
- Schoenfeld Peter
- Schots Pauke C
- Schulz Rainer
- Schwarzer Christoph
- Scott Graham R
- Selman Colin
- Shabalina Irina G
- Sharma Pushpa
- Sharma Vipin
- Shevchuk Igor
- Shirazi Reza
- Shiroma Jonathan G
- Siewiera Karolina
- Silber Ariel M
- Silva Ana Maria
- Sims Carrie A
- Singer Dominique
- Singh Brijesh Kumar
- Skolik Robert A
- Smenes Benedikte Therese
- Smith James
- Soares Félix Alexandre Antunes
- Sobotka Ondrej
- Sokolova Inna
- Solesio Maria E
- Sommer Natascha
- Sonkar Vijay K
- Sowton Alice P
- Sparagna Genevieve C
- Sparks Lauren M
- Spinazzi Marco
- Stankova Pavla
- Starr Jonathan
- Stary Creed
- Stelfa Gundega
- Stepto Nigel K
- Stiban Johnny
- Stier Antoine
- Stocker Roland
- Storder Julie
- Sumbalova Zuzana
- Suomalainen Wartiovaara Anu
- Suravajhala Prashanth
- Svalbe Baiba
- Swerdlow Russel H
- Swiniuch Daria
- Szabo Ildiko
- Szewczyk Adam
- Szibor Marten
- Tanaka Masashi
- Tandler Bernard
- Tarnopolsky Mark A
- Tausan Daniel
- Tavernarakis Nektarios
- Teodoro J
- Tepp Kersti
- Thakkar Himani
- Thapa Maheshwo
- Thyfault John P
- Tomar Dhanendra
- Ton Riccardo
- Torp May-Kristin
- Towheed Atif
- Tretter Laszlo
- Trewin Adam J
- Trifunovic Aleksandra
- Trivigno Catherine
- Tronstad Karl Johan
- Trougakos Ioannis P
- Truu Laura
- Tuncay Erkan
- Turan Belma
- Tyrrell Daniel J
- Urban Tomas
- Urner Sofia
- Valentine Joseph Marco
- Van Bergen Nicole J
- Varricchio Frederick
- Vella Joanna
- Vendelin Marko
- Vercesi Anibal E
- Verdaguer Ignasi Bofill
- Vernerova Andrea
- Victor Victor Manuel
- Vidimce Josif
- Vieira Ligo Teixeira Camila
- Viel Christian
- Vieyra Adalberto
- Vilks Karlis
- Villena Joseph A
- Vincent Vinnyfred
- Vinogradov Andrey D
- Viscomi Carlo
- Vitorino Rui Miguel Pinheiro
- Vogt Sebastian
- Volani Chiara
- Volska Kristine
- Votion Dominique-Marie
- Vujacic-Mirski Ksenija
- Wagner Brett A
- Ward Marie Louise
- Warnsmann Verena
- Wasserman David H
- Watala Cezary
- Wei Yau-Huei
- Weissig Volkmar
- Whitfield Jamie
- Wickert Anika
- Wieckowski Mariusz R
- Wiesner Rudolf J
- Williams Caroline M
- Winwood-Smith Hugh
- Wohlgemuth Stephanie E
- Wohlwend Martin
- Wolff Jonci Nikolai
- Wrutniak-Cabello Chantal
- Wuest Rob C I
- Yokota Takashi
- Zablocki Krzysztof
- Zanon Alessandra
- Zanou Nadege
- Zaugg Kathrin
- Zaugg Michael
- Zdrazilova Lucie
- Zhang Yi Zhu
- Zhang Yong
- Zikova Alena
- Zischka Hans
- Zorzano Antonio
- Zvejniece Liga
- Publication venue
- Oroboros Ecosystem
- Publication date
- 20/05/2020
- Field of study
As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
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- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
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- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
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- Curran Adam
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- Daum Christopher
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- Evans Gareth
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- Fujiyama Asao
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- Georgescu Anca
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- Hamilton Matt
- Hamlett John
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- Israni Sanjay
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- Jacintho Mark
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- Jacob Leni Susan
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- Jaklevic Joseph
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- Jareborg Niclas
- Jarek Michael
- Jassal Bijay
- Jeffery Grant
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- Jewett Phillip E.
- Jia Jia
- Jia Jia
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- Jiang Lu
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- Jones Myrna D.
- Jones Steven
- Jong Pieter De
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- Keenan Stephen
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- Kershaw Joanna
- Kettleborough Ross
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- Kojima Kazuyasu
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- Kong Yi
- Korf Ian
- Kosiura Anna
- Kou Zhaohui
- Kovar Christie L.
- Krawczyk Marie-Claude
- Kremitzki Colin
- Kremmidiotis Gabriel
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- Kruchowski Scott S.
- Kube Michael
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- Lander Eric S.
- Landers Tom
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- Lucier Raymond L.
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- Madabhushi Ramki
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- Nash William
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- Perez Lesette M.
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- Sutherland Robert D.
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- Tong Jingli
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- Ukegbu Ogechi Nkemdirim
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- Un Chun
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- Upson Darren
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- Wagner-McPherson Caryn
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- Walker Davian L.
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- Wall Melanie
- Wall Randy E.
- Wallace John
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- Zhang Xiuqing
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- Zhang Yilin
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- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Differential cross section measurements for the production of a W boson in association with jets in proton–proton collisions at √s = 7 TeV
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Aleksandrov Aleksandar
- Alexander James
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anderson Jacob
- Andrea Jeremy
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Argiro Stefano
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Aubin Alexandre
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M
- Babb John
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
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- Banerjee Sudeshna
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- Wagner-Kuhr Jeannine
- Walker Matthew
- Wallny Rainer
- Walsh Roberval
- Waltenberger Wolfgang
- Wang Dayong
- Wang Fuqiang
- Wang Jian
- Wang Quan
- Wang Xianyou
- Wang Zheng
- Wardle Nicholas
- Wayand Stefan
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Weiler Thomas
- Weinberg Marc
- Welke Charles
- Wendland Lauri
- Weng Yao
- Werner Jeremy Scott
- West Christopher
- Wetzel James
- Whitbeck Andrew
- Whitmore Juliana
- Wickramage Nadeesha
- Wilbur Scott
- Wilken Rachel
- Wilkinson Richard
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- Wimpenny Stephen
- Winer Brian L
- Winn Dave
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- Wood Jeffrey Scott
- Wood John
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- Worm Steven
- Wright Douglas
- Wulsin Howard Wells
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xie Si
- Xie Wei
- Xu Lingshan
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yücel Mete
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zito Giuseppe
- Zou Wei
- Zsigmond Anna Julia
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (pT) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (HT), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb[superscript −1]. The measured cross sections are compared to predictions from Monte Carlo generators, MadGraph + pythia and sherpa, and to next-to-leading-order calculations from BlackHat + sherpa. The differential cross sections are found to be in agreement with the predictions, apart from the pT distributions of the leading jets at high pT values, the distributions of the HT at high-HT and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values.United States. Dept. of EnergyNational Science Foundation (U.S.)Alfred P. Sloan Foundatio
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- Author
- Aase Handberg
- Abhijna R Ballal
- Abhimanyu Thakur
- Abuelreich Sarah
- Achille Anselmo
- Adam L Maddox
- Adityas Purnianto
- Adrian E Morelli
- Adrian L Harris
- Adriana F Paes Leme
- Adriana T Larregina
- Afrodité Németh
- Afsareen Bano
- Agnieszka Razim
- Agustin Enciso-Martinez
- Ahmed Ge Ibrahim
- Ahmed Somaida
- Aija Linē
- Ainhoa Alberro
- Ajay P Singh
- Akbar L Marzan
- Akhil Srivastava
- Akira Yokoi
- Al Charest
- Alain R Brisson
- Alan J Zimmerman
- Albano Cáceres-Verschae
- Aled Clayton
- Aleksandra Inic-Kanada
- Aleksei Tikhonov
- Alena Ivanova
- Alessandra Ciullo
- Alessandro Gori
- Alessio Noghero
- Alex J Rai
- Alexander Otahal
- Alexander R Ivanov
- Alexis G Murillo Carrasco
- Alice Gualerzi
- Alicia Galinsoga
- Alicia Llorente
- Aliosha I Figueroa-Valdés
- Alireza Fazeli
- Alissa M Weaver
- Alok Raghav
- Alvaro Compañ-Bertomeu
- Amanda Khoo
- Amanda Salviano-Silva
- Amandine Bonifay
- Amankeldi A Salybekov
- Amélie Nadeau
- Amin Zakeri
- Amirmohammad Nasiri Kenari
- Amit K Srivastava
- Amy A Baxter
- Amy C Kauffman
- Amy H Buck
- An Hendrix
- Ana C Torrecilhas
- Ana I Salazar-Puerta
- Ana O'Loghlen
- Anabela Cordeiro-da-Silva
- Anaïs Bécot
- Anders T Boysen
- Andras G Miklosi
- Andras Saftics
- András I Försönits
- Andre J van Wijnen
- Andrea Galisova
- Andrea Ridolfi
- Andrea Zendrini
- Andreas Möller
- Andreia M Silva
- Andreina Schoeberlein
- Andreu Matamoros-Angles
- Andrew Devitt
- Andrew F Hill
- Andrew Lai
- Andrew Rowland
- André Cronemberger-Andrade
- André Görgens
- Andries Zijlstra
- Angela M Zivkovic
- Angelica Ortiz
- Angelo Musicò
- Ann M Wehman
- Anna Antoniou
- Anna C Berardi
- Anna Cifuentes-Rius
- Anna D Krasnodembskaya
- Anna Koncz
- Anna M Schmid
- Anna Romolo
- Annaïg J Rozo
- Annalisa Radeghieri
- Annie Frelet-Barrand
- Annika Pfeiffer
- Anthony W Ferrante Jr
- Antje M Zickler
- Antoine Karoichan
- Antonella Bongiovanni
- Antonia Hufnagel
- Antonia Reale
- Antonio da Silva Novaes
- Antonio Marcilla
- Apolonija Bedina-Zavec
- Apurba Dev
- Asa M Wheelock
- Ashish Kumar
- Ashley E Russell
- Ashok K Shetty
- Asima Bhattacharyya
- Attila Oláh
- Augusto Zani
- Aurelia Rughetti
- Aurelio Lorico
- Aurélie Ledreux
- Avital A Rodal
- Ayesha Saleem
- Ákos M Lőrincz
- Áurea M Gabriel
- Bagabas Reem
- Baharak Hosseinkhani
- Bahnisikha Barman
- Bairen Pang
- Bas Wm van Balkom
- Batuhan T Bozkurt
- Beate Vestad
- Benedetta Bussolati
- Benjamin Jurek
- Benjamin Mary
- Bergese Paolo
- Berglind E Benediktsdóttir
- Bernadett R Bodnár
- Bernd Giebel
- Bert Dhondt
- Berta Puig
- Beth Coyle
- Beth Holder
- Bianca C Pachane
- Biao Lu
- Bingdong Sui
- Birke J Benedikter
- Blenkiron Cherie
- Bo Li
- Bojana Milutinovic
- Bong Hwan Sung
- Bonita H Powell
- Brachyahu M Kestecher
- Bradley Whitehead
- Brian Dobosh
- Bridges Esther M.
- Brucale Marco
- Bruce A Stanton
- Burger Dylan
- Bussolati Benedetta
- Buzas Edit I.
- Byeong Hyeon Choi
- Cai Houjian
- Camille Ettelaie
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- Carla Mazzeo
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- Carmen Jerónimo
- Carney Randy P.
- Carolina Balbi
- Carolina Soekmadji
- Caroline Gilbert
- Caroline J Reddel
- Catherine A Sánchez
- Catherine Martel
- Cecilia Bucci
- Cecilia Lässer
- Celine Elie-Caille
- Cécile E Malnou
- Changhai Tian
- Changjin Lee
- Chantal M Boulanger
- Charisse N Winston
- Charles J Blijdorp
- Charles P Lai
- Charlotte Lawson
- Chaya Brodie
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- Chungmin Han
- Claudia M Radu
- Cláudio Pinheiro
- Clémence Belleannée
- Clotilde Billottet
- Clotilde Théry
- Cocucci Emanuele
- Colin L Hisey
- Cora L Alvarez
- Coralie L Guerin
- Crescitelli Rossella
- Crislyn D'Souza-Schorey
- Cristina Fornaguera
- Cristina Pr Xavier
- Cristóbal Cerda-Troncoso
- D Craig Hooper
- D Michiel Pegtel
- Daan Paget
- Dakota Gustafson
- Dalila Iannotta
- Daniel Bachurski
- Daniel H Kim
- Daniel J MacPhee
- Daniel S Lark
- Daniel W Hagey
- Daniela Boselli
- Daniela Freitas
- Daniela L Papademetrio
- Daniele D'Arrigo
- Daniele Noël
- Danielle J Beetler
- Danilo Mladenović
- David A Armstrong
- David A Routenberg
- David C Lyden
- David D Roberts
- David J Lundy
- David Juncker
- David Laurin
- David Otaegui
- David P Al-Adra
- David R Brigstock
- David Rf Carter
- David Rufino-Ramos
- David W Greening
- Davide Zocco
- Deanna F Shea
- Deborah Ci Goberdhan
- Delaram Khamari
- Denis Corbeil
- Dennis K Jeppesen
- Di Vizio Dolores
- Diego Kyburz
- Dilara C Ozkocak
- Dimitri Aubert
- Dina Ak Ahmed
- Dinesh Upadhya
- Dionysios C Watson
- Dirk P Dittmer
- Dirk Strunk
- Dmitry Ter-Ovanesyan
- Dolores Di Vizio
- Dominic Guanzon
- Donald G Phinney
- Dong Jun Park
- Dong-Gyu Jo
- Dong-Sup Lee
- Dongin Kim
- Dorian Forte
- Dorival M Rodrigues-Junior
- Doste R Mamand
- Driedonks Tom A. P.
- Dylan Burger
- Edina Gyukity-Sebestyén
- Edison Salas-Huenuleo
- Edit I Buzas
- Eduardo Marbán
- Eduardo Martínez-Martínez
- Eduardo Reategui
- Edveena Hanser
- Edwin van der Pol
- Efrat Levy
- Eisuke Dohi
- Elena Aikawa
- Elena Izquierdo
- Elena Khomyakova
- Elena S Martens-Uzunova
- Elena Vacchi
- Elham Hosseini-Beheshti
- Elias Sulaiman
- Elisa Lázaro-Ibáñez
- Elisa Tonoli
- Elise Madec
- Elizabeth R Dellar
- Elke Pogge von Strandmann
- Ellis K Fok
- Elżbieta Karnas
- Emanuele Cocucci
- Emilia Scharrig
- Emilio Di Ianni
- Emma Kc Symonds
- Enis Kostallari
- Eqbal Mohamadi
- Erdbrügger Uta
- Erez Eitan
- Eric Boilard
- Erica Bazzan
- Ernesto Gargiulo
- Esmahan Durmaz
- Estefanía Lozano-Andrés
- Esther M Bridges
- Esther Nm Nolte-'t Hoen
- Eszter Á Tóth
- Etienne Doré
- Etienne Moussay
- Eva Rohde
- Eva-Maria Krämer-Albers
- Evan A Gizzie
- Ewa K Zuba-Surma
- Ewa Ł Stępień
- Émilie Velot
- Fabian Braun
- Fabiana Geraci
- Fabienne Archer
- Fabrice Lucien
- Faezeh Shekari
- Faisal J Alibhai
- Falcon‐Perez Juan M.
- Farah Fatima
- Farrukh Aqil
- Fatah Kashanchi
- Fatemeh Momen-Heravi
- Fausto Almeida
- Federica Collino
- Federico Cocozza
- Federico Colombo
- Ferdinando Pucci
- Fernanda Jadue
- Fernando Souza-Fonseca-Guimaraes
- Flora Guerra
- Florian Puhm
- Fons Aj van de Loo
- Francesc E Borràs
- Francesca Perut
- Francesco Valle
- Francois Mullier
- Frank Rm Stassen
- Franz L Ricklefs
- Fred H Hochberg
- Frederic St-Denis-Bissonnette
- Frederik J Verweij
- Fu Qing‐Ling
- Fumihiko Urabe
- Gabrielis Kundrotas
- Gabriella Dobra
- Gabriella Pocsfalvi
- Gagan Deep
- Ganesh V Shelke
- Ganesha Poojary
- Ganna Stepanova
- Geneviève Bart
- Georges E Grau
- Georgia K Atkin-Smith
- Georgios Giamas
- Géraldine C Genard
- Ghasem Hosseini Salekdeh
- Gi-Hoon Nam
- Giorgia Melli
- Giovanni Camussi
- Giuseppina Poppa
- Gloria Alvarez-Llamas
- Goberdhan Deborah C. I.
- Gorjana Rackov
- Graca Raposo
- Gregory E Rice
- Gregory Lavieu
- Guanshu Liu
- Guido Jenster
- Guillaume van Niel
- Guoku Hu
- Guoping Li
- Hadi Valadi
- Hafiza Padinharayil
- Hakho Lee
- Han Sang Kim
- Hang Yin
- Hannah K Jackson
- Hanser Edveena
- Hao Chen
- Hao Zhang
- Hargita Hegyesi
- Harmeet Malhi
- Harris Adrian L.
- Harry Holthofer
- Harry Vm Spiers
- Haseeb Zubair
- Haughey Norman J.
- Heather H Pua
- Hendrix An
- Henrique Girão
- Heon-Jin Lee
- Hernando A Del Portillo
- Hernán González-King Garibotti
- Héctor Peinado
- Hidetoshi Tahara
- Hilal A Rather
- Hill Andrew F.
- Hiroaki Komuro
- Honami Naora
- Hongkuan Fan
- Houjian Cai
- Huaqi Su
- Hugo R Caires
- Hyo Jung An
- Hyungsoon Im
- Igea D'Agnano
- Igor V Kurochkin
- Ilaria Giusti
- Ilaria Prada
- Iliya Lefterov
- Imola Cs Szigyártó
- In-San Kim
- Indira Prasadam
- Inge Nelissen
- Ioannis Azoidis
- Irene Bertolini
- Irina Nazarenko
- Irma Schabussova
- Isabel Barranco
- Ivan J Vechetti
- Ivan Kh Poon
- Ivanov Alexander R.
- Ivica Marić
- J Brian Byrd
- Jacky G Goetz
- Jacob A Cleary
- Jamal Ghanam
- Jameel M Inal
- James G Patton
- Jan Lötvall
- Jan Van Deun
- Jana Zarubova
- Jane Howard
- Janine Stam
- Janis A Müller
- Janne Leivo
- Janos Zempleni
- Janusz Rak
- Jascinta P Santavanond
- Jason P Webber
- Javier Ramirez-Ricardo
- Javier Sotillo
- Jean-Marie Bach
- Jeff Bouffard
- Jeff Wm Bulte
- Jeffrey L Franklin
- Jeffrey S Schorey
- Jen Alexander-Brett
- Jenifer Pendiuk Goncalves
- Jennifer C Jones
- Jens C Luoto
- Jens Gruber
- Jerome Paggetti
- Jessica Gobbo
- Jessica Schiavi-Tritz
- Jessie Santoro
- Jiao Jiao Li
- Jing Jin
- Jiri Hrdy
- Jisook Moon
- Joanne Lannigan
- Joao N Ferreira
- Joaquin Seras-Franzoso
- Joel Ej Beaumont
- Johan Skog
- Johann M Gudbergsson
- Johanna Mm Puutio
- Johannes Oesterreicher
- John J Bissler
- John J Miklavcic
- John J Tomes
- John P Nolan
- Johnathon D Anderson
- Jonathan Degosserie
- Jonathan Leor
- Joost Pg Sluijter
- Jordi Roca
- Joseph Whitley
- Joshua A Welsh
- Joshua D Spitzberg
- Jovanovic‐Talisman Tijana
- Joy Wolfram
- Juan M Falcon-Perez
- Juan P Tosar
- Juhee Park
- Julia C Gross
- Julia Kuligowski
- Julia V Burnier
- Julian Swatler
- Julie A Saugstad
- Julie Constanzo
- Julien Saint-Pol
- Juntaro Matsuzaki
- Justus C Ndukaife
- Júlia Costa
- Kaiping Burrows
- Kaloyan Takov
- Kanchana K Ayyar
- Karen Forbes
- Karin Ekström
- Karolina Soroczyńska
- Kasper M Rouschop
- Kasra Khalaj
- Katelyn A Bruno
- Katherine E White
- Kathleen M Lennon
- Kathrin Gärtner
- Kathryn L Howe
- Katrin S Reiners
- Kazunari Akiyoshi
- Kelly Coutant
- Kelly Cs Roballo
- Kendall R Van Keuren-Jensen
- Kenneth W Witwer
- Kenny Man
- Kentaro Jingushi
- Kerstin Menck
- Kevin Leandro
- Khairul I Ansari
- Kieran Brennan
- Kimberley L Alexander
- Kirsi Rilla
- Kirsty M Danielson
- Kiyotaka Shiba
- Koen Breyne
- Koji Ueda
- Konxhe Kulaj
- Krishna P Maremanda
- Krishnan Anand
- Kristyna Turkova
- Krisztina Buzas
- Krisztina Németh
- Krisztina Pálóczi
- Krisztina V Vukman
- Kruh‐Garcia Nicole A.
- Ku'ulei‐Lyn Faustino Vroniqa
- Kyburz Diego
- Kyle I Mentkowski
- Kyle P Bramich
- Kyungmoo Yea
- Laura Bongiovanni
- Laura Grech
- Laura J Vella
- Laura Yedigaryan
- Lauren A Newman
- Lausonia Ramaswamy
- Lawrence W Chamley
- Lässer Cecilia
- Leandra K Figueroa-Hall
- Lei Zheng
- Lenassi Metka
- Lennon Kathleen M.
- Leon G Coleman Jr
- Leonardo Nimrichter
- Leonid Margolis
- Leonidas A Phylactou
- Leonora Balaj
- Lesley Cheng
- Liang Dong
- Liang Wu
- Lien Lippens
- Lifang Yang
- Lila Drittanti
- Liliia Paniushkina
- Lim Sai Kiang
- Ling-Qing Yuan
- Linglei Jiang
- Lissette Retana Moreira
- Loes Teeuwen
- Loïc Steiner
- Lorena Martin-Jaular
- Lorena Urbanelli
- Lorraine O'Driscoll
- Lothar C Dieterich
- Louise C Laurent
- Lötvall Jan
- Luca Musante
- Lucas Walther
- Lucia Paolini
- Lucia R Languino
- Lucienne Tritten
- Lucio Barile
- Ludovic Vinay
- Ludwig Ermann Lundberg
- Luis A Ortiz
- Luis Arteaga-Blanco
- Luis Mariñas-Pardo
- Luis Pereira de Almeida
- Luisa Weiss
- Luke C McIlvenna
- Luke van der Koog
- Lynn Pulliam
- M Helena Vasconcelos
- M Madhy Garcia Garcia
- M. AlbaneseMembro del Collaboration Group
- Maarten P Bebelman
- Maddox Adam L.
- Magdalena E Wysmołek
- Magdalena J Lorenowicz
- Mahlegha Ghavami
- Mahoney Mỹ G.
- Maiken Mellergaard
- Maimonah E Al-Masawa
- Maja Kosanović
- Makon-Sébastien Njock
- Malene Møller Jørgensen
- Malgorzata Czystowska-Kuzmicz
- Mangesh D Hade
- Manuel Gomez-Florit
- Manuel Varas-Godoy
- Manuela Basso
- Marc-André Langlois
- Marca Hm Wauben
- Marcel I Ramirez
- Marcela A Cucher
- Marcelo A Mori
- Marcin Jurga
- Marcio L Rodrigues
- Marco Brucale
- Marco Falasca
- Margaret M Mc Gee
- Margarida Viola
- Maria D Mayan
- Maria Eldh
- Maria Elena Cicardi
- Maria Harmati
- Maria I Guillén
- Maria Kaparakis-Liaskos
- Maria Noé Garcia
- Mariama Mbengue
- Marianne S Joerger-Messerli
- Marieke T Roefs
- Marija Holcar
- Marije E Kuipers
- Marina Cretich
- Mario Gimona
- Mariola J Ferraro
- Marit Inngjerdingen
- María Fernández-Rhodes
- María José Alcaraz
- María Yáñez-Mó
- Mark C Allenby
- Mark D Hulett
- Mark J McCann
- Mark J McVey
- Mark L Weiss
- Mark Samuels
- Mark Santos
- Marni D Boppart
- Marta Garcia-Contreras
- Marta Monguió-Tortajada
- Martens‐Uzunova Elena S.
- Martijn Jc van Herwijnen
- Martin E van Royen
- Martin Olivier
- Martin Wolf
- Martina Gabrielli
- Marvin Droste
- Mary Bebawy
- Maryam Azlan
- Marzena Kurzawa-Akanbi
- Masaharu Somiya
- Masahiko Kuroda
- Masahiro Morimoto
- Masako Harada
- Masamitsu Kanada
- Masood Kamali-Moghaddam
- Massimo Bottini
- Massimo Dominici
- Mateja E Kreft
- Mathilde Bergamelli
- Mathilde Mosser
- Matias Ostrowski
- Mats Van Delen
- Mattia I Morandi
- Maurizio Muraca
- Mauro Manno
- Max Piffoux
- Mátyás Bukva
- Md Matiur Rahman
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- Meadhbh Á Brennan
- Meena Kumari
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- Michael W Graner
- Michael W Pfaffl
- Michele Zanoni
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- Migara K Jayasinghe
- Migmar Tsamchoe
- Miguel Flores-Bellver
- Mikael Klingeborn
- Mikhail Skliar
- Miriam Romano
- Miroslava Katsur
- Miroslaw T Kornek
- Mizenko Rachel R.
- Modeline N Longjohn
- Mohammad Rahbari
- Mohanty Sujata
- Mona Batish
- Monika Baj-Krzyworzeka
- Monika Pietrowska
- Möller Andreas
- Muhammad Nawaz
- Muller Fabbri
- Muthuvel Jayachandran
- Myltykbay S Rysmakhanov
- Mỹ G Mahoney
- Nadezhda Nikiforova
- Nadim Tawil
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- Natalia J Krawczynska
- Natalie R Bauer
- Natasa Zarovni
- Natasha S Barteneva
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- Nicole Meisner-Kober
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- Nieuwland Rienk
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- Nihar Godbole
- Nilufar Ali
- Norman J Haughey
- O'Driscoll Lorraine
- Ochiya Takahiro
- Oksana Kehoe
- Ole Østergaard
- Oleg S Tutanov
- Olesia Gololobova
- Olga Shatnyeva
- Olivier Blanc-Brude
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- Oskar Staufer
- Oumaima Stambouli
- Owen G Davies
- Pamali Fonseka
- Paola A Martinez-Murillo
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- Paola de Candia
- Paolo Bergese
- Paolo Neviani
- Paolo V Fioretti
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- Pascal Colosetti
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- Pilar Martin-Duque
- Pingping Han
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- Qi Hui Poh
- Qiang Chen
- Qin Zhang
- Qing-Ling Fu
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- Quan Lu
- Quentin Lemaire
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- Shikha Rani
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- Sneha Raju
- Soazig Le Lay
- Sofija Glamočlija
- Solange Landreville
- Somchai Chutipongtanate
- Sonal Sukreet
- Soo Kim
- Sophie Cavallero
- Sophie Rome
- Soren Jacobsen
- Ssang-Goo Cho
- Stanley M Lemon
- Stanley S Stylli
- Stefan Schneider
- Stefania Raimondo
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- Stephanie F Rutter
- Stephanie Jung
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- Subhadip Ghatak
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- Suresh Mathivanan
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- Susanne Krasemann
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- Tom G Keulers
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- Tong Wang
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- Tosar Juan P.
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- Tsuneya Ikezu
- Ursula S Sandau
- Useckaite Zivile
- Uta Erdbrügger
- Valentina R Minciacchi
- Valentina Zappulli
- Valeria Barreca
- Valle Francesco
- van der Pol Edwin
- van Herwijnen Martijn J. C.
- Varga Zoltan
- Vasiliki Mahairaki
- Vasiliy S Chernyshev
- Vatsal Deliwala
- Veer Bala Gupta
- Vendula Pospichalova
- Vengala Rao Yenuganti
- Venkatesh Kumar Chetty
- Vera A Tang
- Vera Mugoni
- Vera Tscherrig
- Verity J Ford
- Verline Justilien
- Veronica Huber
- Veronika Kralj-Iglic
- Veronika Stoka
- Victor Bodart-Santos
- Vijaya Sunkara
- Vikramsingh Gujar
- Viktoria Szeifert
- Viktoria Weber
- Vincent Hyenne
- Vincent Yeung
- Vincenza Dolo
- Violaine Moreau
- Vito G D'Agostino
- Vivek Kumar Gupta
- Vladimir Bokun
- Vroniqa Ku'ulei-Lyn Faustino
- Vytautas Žėkas
- Wai-Leng Lee
- Wanessa F Altei
- Wauben Marca H. M.
- Wehman Ann M.
- Wei Duan
- Wei Guo
- Wei Seong Toh
- Welsh Joshua A.
- Wen-Wei Chang
- Wilfrid Boireau
- Wilfried W Bazié
- Willem Stoorvogel
- Williams Sarah
- Witwer Kenneth W.
- Wolfgang Holnthoner
- Wyatt N Vreeland
- Xabier Osteikoetxea
- Xandra O Breakefield
- Xavier Loyer
- Xiaomei Yan
- Xiaoqin Wang
- Xinhua Lei
- Xinlei Li
- Xiuming Liang
- Yagmur Yildizhan
- Yang You
- Yasuo Inoshima
- Yi Wen
- Yinghong Zhou
- Yingtang Gao
- Yiyao Huang
- Yoel Sadovsky
- Yohan Kim
- Yong Song Gho
- Yongkang Yang
- Yonis Bare
- Yoon-Kyoung Cho
- Yoshinobu Takakura
- Young-Gyun Park
- Yu Fujita
- Yu Xiao
- Yuki Yamamoto
- Yumi Kumagai
- Yunjie Wu
- Yunxi Chen
- Yusuke Yamamoto
- Yusuke Yoshioka
- Yvan Courageux
- Yvonne Couch
- Zach Troyer
- Zendrini Andrea
- Zheng Lei
- Zheng Zhao
- Zijlstra Andries
- Zimmerman Alan J.
- Zivile Useckaite
- Zoltan Varga
- Zoltán Varga
- Zoltán Wiener
- Zucai Suo
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its 'Minimal Information for Studies of Extracellular Vesicles', which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly
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