470 research outputs found
Joint Planck and WMAP CMB Map Reconstruction
We present a novel estimate of the cosmological microwave background (CMB)
map by combining the two latest full-sky microwave surveys: WMAP nine-year and
Planck PR1. The joint processing benefits from a recently introduced component
separation method coined "local-generalized morphological component analysis''
(LGMCA) based on the sparse distribution of the foregrounds in the wavelet
domain. The proposed estimation procedure takes advantage of the IRIS 100
micron as an extra observation on the galactic center for enhanced dust
removal. We show that this new CMB map presents several interesting aspects: i)
it is a full sky map without using any inpainting or interpolating method, ii)
foreground contamination is very low, iii) the Galactic center is very clean,
with especially low dust contamination as measured by the cross-correlation
between the estimated CMB map and the IRIS 100 micron map, and iv) it is free
of thermal SZ contamination.Comment: Astronomy and Astrophysics, accepte
Planck CMB Anomalies: Astrophysical and Cosmological Secondary Effects and the Curse of Masking
Large-scale anomalies have been reported in CMB data with both WMAP and
Planck data. These could be due to foreground residuals and or systematic
effects, though their confirmation with Planck data suggests they are not due
to a problem in the WMAP or Planck pipelines. If these anomalies are in fact
primordial, then understanding their origin is fundamental to either validate
the standard model of cosmology or to explore new physics. We investigate three
other possible issues: 1) the trade-off between minimising systematics due to
foreground contamination (with a conservative mask) and minimising systematics
due to masking, 2) astrophysical secondary effects (the kinetic Doppler
quadrupole and kinetic Sunyaev-Zel'dovich effect), and 3) secondary
cosmological signals (the integrated Sachs-Wolfe effect). We address the
masking issue by considering new procedures that use both WMAP and Planck to
produce higher quality full-sky maps using the sparsity methodology (LGMCA
maps). We show the impact of masking is dominant over that of residual
foregrounds, and the LGMCA full-sky maps can be used without further processing
to study anomalies. We consider four official Planck PR1 and two LGMCA CMB
maps. Analysis of the observed CMB maps shows that only the low quadrupole and
quadrupole-octopole alignment seem significant, but that the planar octopole,
Axis of Evil, mirror parity and cold spot are not significant in nearly all
maps considered. After subtraction of astrophysical and cosmological secondary
effects, only the low quadrupole may still be considered anomalous, meaning the
significance of only one anomaly is affected by secondary effect subtraction
out of six anomalies considered. In the spirit of reproducible research all
reconstructed maps and codes will be made available for download here
http://www.cosmostat.org/anomaliesCMB.html.Comment: Summary of results given in Table 2. Accepted for publication in
JCAP, 4th August 201
PRISM: Recovery of the primordial spectrum from Planck data
The primordial power spectrum describes the initial perturbations that seeded
the large-scale structure we observe today. It provides an indirect probe of
inflation or other structure-formation mechanisms. In this letter, we recover
the primordial power spectrum from the Planck PR1 dataset, using our recently
published algorithm PRISM. PRISM is a sparsity-based inversion method, that
aims at recovering features in the primordial power spectrum from the empirical
power spectrum of the cosmic microwave background (CMB). This ill-posed inverse
problem is regularised using a sparsity prior on features in the primordial
power spectrum in a wavelet dictionary. Although this non-parametric method
does not assume a strong prior on the shape of the primordial power spectrum,
it is able to recover both its general shape and localised features. As a
results, this approach presents a reliable way of detecting deviations from the
currently favoured scale-invariant spectrum. We applied PRISM to 100 simulated
Planck data to investigate its performance on Planck-like data. We also tested
the algorithm's ability to recover a small localised feature at
Mpc, which caused a large dip at in the angular power
spectrum. We then applied PRISM to the Planck PR1 power spectrum to recover the
primordial power spectrum. We find no significant departures from the fiducial
Planck PR1 near scale-invariant primordial power spectrum with
and .Comment: 4 pages, 2 figures, Accepted in A&A; Updated to match the final
accepted versio
WMAP 9-year CMB estimation using sparsity
Recovering the Cosmic Microwave Background (CMB) from WMAP data requires
galactic foreground emissions to be accurately separated out. Most component
separation techniques rely on second order statistics such as Internal Linear
Combination (ILC) techniques. In this paper, we present a new WMAP 9-year CMB
map, with 15 arcmin resolution, which is reconstructed using a recently
introduced sparse component separation technique, coined Local Generalized
Morphological Component Analysis (LGMCA). LGMCA emphasizes on the sparsity of
the components to be retrieved in the wavelet domain. We show that although
derived from a radically different separation criterion ({i.e. sparsity), the
LGMCA-WMAP 9 map and its power spectrum are fully consistent with their more
recent estimates from WMAP 9.Comment: Submitted to A&A (revised
Mechanistic Issues of the Interaction of the Hairpin-Forming Domain of tBid with Mitochondrial Cardiolipin
BACKGROUND: The pro-apoptotic effector Bid induces mitochondrial apoptosis in synergy with Bax and Bak. In response to death receptors activation, Bid is cleaved by caspase-8 into its active form, tBid (truncated Bid), which then translocates to the mitochondria to trigger cytochrome c release and subsequent apoptosis. Accumulating evidence now indicate that the binding of tBid initiates an ordered sequences of events that prime mitochondria from the action of Bax and Bak: (1) tBid interacts with mitochondria via a specific binding to cardiolipin (CL) and immediately disturbs mitochondrial structure and function idependently of its BH3 domain; (2) Then, tBid activates through its BH3 domain Bax and/or Bak and induces their subsequent oligomerization in mitochondrial membranes. To date, the underlying mechanism responsible for targeting tBid to mitochondria and disrupting mitochondrial bioenergetics has yet be elucidated. PRINCIPAL FINDINGS: The present study investigates the mechanism by which tBid interacts with mitochondria issued from mouse hepatocytes and perturbs mitochondrial function. We show here that the helix alphaH6 is responsible for targeting tBid to mitochondrial CL and disrupting mitochondrial bioenergetics. In particular, alphaH6 interacts with mitochondria through electrostatic interactions involving the lysines 157 and 158 and induces an inhibition of state-3 respiration and an uncoupling of state-4 respiration. These changes may represent a key event that primes mitochondria for the action of Bax and Bak. In addition, we also demonstrate that tBid required its helix alphaH6 to efficiently induce cytochrome c release and apoptosis. CONCLUSIONS: Our findings provide new insights into the mechanism of action of tBid, and particularly emphasize the importance of the interaction of the helix alphaH6 with CL for both mitochondrial targeting and pro-apoptotic activity of tBid. These support the notion that tBid acts as a bifunctional molecule: first, it binds to mitochondrial CL via its helix alphaH6 and destabilizes mitochondrial structure and function, and then it promotes through its BH3 domain the activation and oligomerization of Bax and/or Bak, leading to cytochrome c release and execution of apoptosis. Our findings also imply an active role of the membrane in modulating the interactions between Bcl-2 proteins that has so far been underestimated
Discovery and Description of Ebola Zaire Virus in 1976 and Relevance to the West African Epidemic During 2013-2016.
BACKGROUND: In 1976, the first cases of Ebola virus disease in northern Democratic Republic of the Congo (then referred to as Zaire) were reported. This article addresses who was responsible for recognizing the disease; recovering, identifying, and naming the virus; and describing the epidemic. Key scientific approaches used in 1976 and their relevance to the 3-country (Guinea, Sierra Leone, and Liberia) West African epidemic during 2013-2016 are presented. METHODS: Field and laboratory investigations started soon after notification, in mid-September 1976, and included virus cell culture, electron microscopy (EM), immunofluorescence antibody (IFA) testing of sera, case tracing, containment, and epidemiological surveys. In 2013-2016, medical care and public health work were delayed for months until the Ebola virus disease epidemic was officially declared an emergency by World Health Organization, but research in pathogenesis, clinical presentation, including sequelae, treatment, and prevention, has increased more recently. RESULTS: Filoviruses were cultured and observed by EM in Antwerp, Belgium (Institute of Tropical Medicine); Porton Down, United Kingdom (Microbiological Research Establishment); and Atlanta, Georgia (Centers for Disease Control and Prevention). In Atlanta, serological testing identified a new virus. The 1976 outbreak (280 deaths among 318 cases) stopped in 2 years. Transmission indices (R0) are higher in all 3 countries than in 1976. CONCLUSIONS: An international commission working harmoniously in laboratories and with local communities was essential for rapid success in 1976. Control and understanding of the recent West African outbreak were delayed because of late recognition and because authorities were overwhelmed by many patients and poor community involvement. Despite obstacles, research was a priority in 1976 and recently
GREAT3 results I: systematic errors in shear estimation and the impact of real galaxy morphology
We present first results from the third GRavitational lEnsing Accuracy
Testing (GREAT3) challenge, the third in a sequence of challenges for testing
methods of inferring weak gravitational lensing shear distortions from
simulated galaxy images. GREAT3 was divided into experiments to test three
specific questions, and included simulated space- and ground-based data with
constant or cosmologically-varying shear fields. The simplest (control)
experiment included parametric galaxies with a realistic distribution of
signal-to-noise, size, and ellipticity, and a complex point spread function
(PSF). The other experiments tested the additional impact of realistic galaxy
morphology, multiple exposure imaging, and the uncertainty about a
spatially-varying PSF; the last two questions will be explored in Paper II. The
24 participating teams competed to estimate lensing shears to within systematic
error tolerances for upcoming Stage-IV dark energy surveys, making 1525
submissions overall. GREAT3 saw considerable variety and innovation in the
types of methods applied. Several teams now meet or exceed the targets in many
of the tests conducted (to within the statistical errors). We conclude that the
presence of realistic galaxy morphology in simulations changes shear
calibration biases by per cent for a wide range of methods. Other
effects such as truncation biases due to finite galaxy postage stamps, and the
impact of galaxy type as measured by the S\'{e}rsic index, are quantified for
the first time. Our results generalize previous studies regarding sensitivities
to galaxy size and signal-to-noise, and to PSF properties such as seeing and
defocus. Almost all methods' results support the simple model in which additive
shear biases depend linearly on PSF ellipticity.Comment: 32 pages + 15 pages of technical appendices; 28 figures; submitted to
MNRAS; latest version has minor updates in presentation of 4 figures, no
changes in content or conclusion
Clinical Manifestations and Case Management of Ebola Haemorrhagic Fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical manifestations and case management for 26 hospitalised laboratory-confirmed EHF patients. Clinical findings are congruous with previously reported EHF infections. The most frequently experienced symptoms were non-bloody diarrhoea (81%), severe headache (81%), and asthenia (77%). Seven patients reported or were observed with haemorrhagic symptoms, six of whom died. Ebola care remains difficult due to the resource-poor setting of outbreaks and the infection-control procedures required. However, quality data collection is essential to evaluate case definitions and therapeutic interventions, and needs improvement in future epidemics. Organizations usually involved in EHF case management have a particular responsibility in this respect
Planck 2013 results. XXII. Constraints on inflation
We analyse the implications of the Planck data for cosmic inflation. The Planck nominal mission temperature anisotropy measurements, combined with the WMAP large-angle polarization, constrain the scalar spectral index to be ns = 0:9603 _ 0:0073, ruling out exact scale invariance at over 5_: Planck establishes an upper bound on the tensor-to-scalar ratio of r < 0:11 (95% CL). The Planck data thus shrink the space of allowed standard inflationary models, preferring potentials with V00 < 0. Exponential potential models, the simplest hybrid inflationary models, and monomial potential models of degree n _ 2 do not provide a good fit to the data. Planck does not find statistically significant running of the scalar spectral index, obtaining dns=dln k = 0:0134 _ 0:0090. We verify these conclusions through a numerical analysis, which makes no slowroll approximation, and carry out a Bayesian parameter estimation and model-selection analysis for a number of inflationary models including monomial, natural, and hilltop potentials. For each model, we present the Planck constraints on the parameters of the potential and explore several possibilities for the post-inflationary entropy generation epoch, thus obtaining nontrivial data-driven constraints. We also present a direct reconstruction of the observable range of the inflaton potential. Unless a quartic term is allowed in the potential, we find results consistent with second-order slow-roll predictions. We also investigate whether the primordial power spectrum contains any features. We find that models with a parameterized oscillatory feature improve the fit by __2 e_ _ 10; however, Bayesian evidence does not prefer these models. We constrain several single-field inflation models with generalized Lagrangians by combining power spectrum data with Planck bounds on fNL. Planck constrains with unprecedented accuracy the amplitude and possible correlation (with the adiabatic mode) of non-decaying isocurvature fluctuations. The fractional primordial contributions of cold dark matter (CDM) isocurvature modes of the types expected in the curvaton and axion scenarios have upper bounds of 0.25% and 3.9% (95% CL), respectively. In models with arbitrarily correlated CDM or neutrino isocurvature modes, an anticorrelated isocurvature component can improve the _2 e_ by approximately 4 as a result of slightly lowering the theoretical prediction for the ` <_ 40 multipoles relative to the higher multipoles. Nonetheless, the data are consistent with adiabatic initial conditions
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