13 research outputs found
Promising self-emulsifying drug delivery system loaded with lycopene from red guava (Psidium guajava L.): in vivo toxicity, biodistribution and cytotoxicity on DU-145 prostate cancer cells
- Author
- Albuquerque Lucas F. F.
- Arcanjo Daniel D. R.
- Barros Ana Luisa A. N.
- BĂĄo SĂŽnia N.
- C. Martins Maria do Carmo
- Cabral Wanessa F.
- da Silva Ingrid Gracielle M.
- de Almeida Miguel P.
- dos S. Borges Tatiana K.
- dos Santos Raimunda C.
- Eaton Peter
- Kuckelhaus Selma A. S.
- Leite José Roberto S. A.
- Moreira Daniel C.
- PlĂĄcido Alexandra
- S. Brito Ana Karolinne
- Saldanha-AraĂșjo Felipe
- Silva-Carvalho Amandda Ă.
- Vasconcelos Andreanne G.
- Publication venue
- SpringerOpen
- Publication date
- 01/11/2021
- Field of study
Background
Self-emulsifying drug delivery systems (SEDDSs) have attracted attention because of their effects on solubility and bioavailability of lipophilic compounds. Herein, a SEDDS loaded with lycopene purified from red guava (nanoLPG) was produced. The nanoemulsion was characterized using dynamic light scattering (DLS), zeta potential measurement, nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), lycopene content quantification, radical scavenging activity and colloidal stability in cell culture medium. Then, in vivo toxicity and tissue distribution in orally treated mice and cytotoxicity on human prostate carcinoma cells (DU-145) and human peripheral blood mononuclear cells (PBMC) were evaluated.
Results
NanoLPG exhibited physicochemical properties with a size around 200 nm, negative zeta-potential, and spherical morphology. The size, polydispersity index, and zeta potential parameters suffered insignificant alterations during the 12 month storage at 5 °C, which were associated with lycopene stability at 5 °C for 10 months. The nanoemulsion showed partial aggregation in cell culture medium at 37 °C after 24 h. NanoLPG at 0.10 mg/mL exhibited radical scavenging activity equivalent to 0.043â±â0.002 mg Trolox/mL. The in vivo studies did not reveal any significant changes in clinical, behavioral, hematological, biochemical, and histopathological parameters in mice orally treated with nanoLPG at 10 mg/kg for 28 days. In addition, nanoLPG successfully delivered lycopene to the liver, kidney and prostate in mice, improved its cytotoxicity against DU-145 prostate cancer cellsâprobably by pathway independent on classical necrosis and apoptosisâand did not affect PBMC viability.
Conclusions
Thus, nanoLPG stands as a promising and biosafe lycopene delivery system for further development of nanotechnology-based health products
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
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- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
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- Alser Osaid
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- Raggio E
- Rai L
- Rajan S
- Rakvin I
- Ramasamy S
- Ramesh P
- Ramirez Jimenez LJ
- Ramos-De La Medina Antonio
- Rao S
- Rashid A
- Rasoaherinomenjanahary F
- Rattizzato S
- Ratto C
- Raval M
- Razafindrahita JB
- Razali Md
- Real Corte J
- Recordare A
- Reddy P
- Refky B
- Rega D
- Reim D
- Reinhard T
- Revez T
- Reynolds IS
- Ribeiro A
- Ribeiro CG
- Ribeiro R
- Ribolla M
- Rice D
- Richards T
- Richards Toby
- Riddell A
- Ridgway PF
- Righini E
- Rimonda R
- Ringressi MN
- Risaliti M
- Riva C
- Rivas R
- Rivera Carlos Jose Perez
- Rizzi A
- Rk Sriram
- Roberts Keith
- Robertson Faith
- Rodrigues Pereira A
- Romano M
- Ronellenfitsch U
- Rosa F
- Roslani AC
- Roslani April C
- Rosseau Gail
- Rossi S
- Roszkowski R
- Rottoli M
- Roux A
- Ruivo A
- Ruiz Castro C
- Russo IS
- Rutegard Martin
- Ruzzenente A
- Ryan EJ
- Ryan M
- Saad MM
- Sabry A
- Sagnotta A
- Sahid Nik Amin
- Saklani A
- Sakr A
- Saksena AR
- Salama Abdelkader
- Saleem A
- Salem H
- Salem M
- Salgado-Nesme N
- Salindera S
- Sallam I
- Samadov E
- Samih A
- Samison LH
- Sammarco G
- Sammour T
- Sampietro GM
- Sani Ali S
- Santos Costa D
- Santos Irene
- Santos PMDD
- Santos R
- Santos-Sousa H
- Sapienza P
- Saraiva P
- Sarjanoja E
- Sarre C
- Sartarelli L
- Sasia D
- Satoi Sohei
- Sayyed R
- Sayyed Raza
- Scabini S
- Scalabre A
- Scanu AM
- Schache Andrew
- Schache Andrew G
- Schaller Karl
- Schiavo M
- Schiergens T
- Schineis C
- Schizas D
- Schlesinger N
- Schnitzbauer Andreas A
- Scotton G
- Scrima O
- Seeliger B
- Seenivasagam Kottayasamy R
- Seenivasagam Rajkumar Kottayasamy
- Seguin-givelet A
- Segura-Sampedro Juan Jose
- Sehouli Jalid
- Seleim A
- Selmani J
- Sena G
- Senossi O
- Servadei Franco
- Seshadri Ayloor R
- Seyi-Olajide Justina O
- Sganga G
- Shah ZA
- Sharabiany S
- Sharma Neil
- Shaw Catherine A
- Shaw Richard
- Shehata S
- Shenit K
- Sherief M
- Sherif A
- Sherif Ahmed Elshawadfy
- Sherif G
- Shokuhi P
- Sholadoye TT
- Shu Sebastian
- Shylasree TS
- Siaw-Acheampong Kwabena
- Sibilla MG
- Siddiqui MT
- Sidek Mohamed AS
- Sidiropoulos T
- Silva A
- Silva M
- Silva N
- Silva R
- Silvestre D
- Simoes JFF
- Simoes Joana FF
- Singh Jagdeep K
- Singh MP
- Singh R
- Singh S
- Skrovina M
- Smart Neil
- Smart Neil J
- Smith H
- Smith J
- Soares Sampaio A
- Soh JY
- Sokolov M
- Soliman H
- Soltan H
- Soreide Kjetil
- Soriero D
- Sorrentino L
- Souadka A
- Sousa R
- Sousa S
- Spagni G
- Spampinato MG
- Spartalis E
- Spiezio G
- Spinelli A
- Spinelli Antonino
- Spolini A
- St John S
- Stavrinidou O
- Steidle C
- Stevenson J
- Stewart Grant D
- Strate T
- Stylianidis G
- Subhi MT
- Subocius A
- Subramaniam S
- Sund Malin
- Sundar Sudha
- Susztak N
- Sutherland A
- Swinson B
- Syed WAS
- Syllaios A
- Szubota I
- Tabiri Stephen
- Tactuk N
- Taddei A
- Taibi A
- Talaat M
- Tamini N
- Tammaro P
- Tan JA
- Tanzanu M
- Tartaglia D
- Tasis N
- Tavares F
- Tawheed A
- Teh C
- Teixeira J
- Teixeira M
- Testa V
- Thanapal MR
- Thekinkattil Dinesh
- Theodosopoulos T
- Thian A
- Tirloni L
- Tirotta Fabio
- Tojal A
- Tolani MA
- Tom K
- Tonini V
- Tooulias A
- Townen Philip
- Townend D
- Townend Philip
- Travaglio E
- Tribillon E
- Tropeano FP
- Tsiaoussis I
- Tsoulfas G
- Tsoulfas Georgios
- Tucci R
- Tufo A
- Turk K
- Turri G
- Tzedakis S
- Tzovaras G
- Ugolini G
- Umair M
- Umar A
- Urbani A
- Usai A
- Uzunoglu FG
- Vaccarella G
- Vale R
- Valenzuela J
- Vallance Abigail
- Van de Putte D
- Van den Eynde J
- Van den Eynde R
- van der Plas Willemijn
- Van Heinsbergen M
- Van Nieuwenhove Y
- Van Ramshorst G
- van Ramshorst Gabrielle H
- Varghese Chris
- Vasey C
- Vassiliu P
- Vaz S
- Vaz-Pereira R
- Veetil Kannummal S
- Vendrame C
- Venskutonis D
- Vergari R
- Vernon L
- Vescio G
- Vezakis A
- Vidya Raghavan
- Vieira A
- Vieira B
- Vignali A
- Vignotto C
- Vilar-Compte D
- Vimalachandran Dale
- Vimalchandra Dale
- Violante T
- Vishnoi JR
- Vitali A
- Vo UG
- Volpin E
- Von Papen M
- Vovola F
- Waldron A
- Walker P
- Walkes K
- Wani R
- Waqar SH
- Warren Oliver J
- Watson E
- Wedderburn Duane
- Weitz J
- Welsch T
- Werner J
- Whelan M
- Wilkins Alex
- Willaert W
- Wimmer A
- Winter D
- Winter Stuart C
- Wong MP
- Wood M
- Wrigh Naomi
- Wullschleger M
- Xavier R
- Xenaki S
- Xynos E
- Yadev I
- Yang W
- Ye G
- Yezzaji H
- Yiallourou A
- Yousof EA
- Yunus Mohd MF
- Yurttas C
- Zakaria AD
- Zakaria Z
- Zambon M
- Zanus G
- Zatecky J
- Zelic M
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zizzo M
- Zmora O
- Zografos C
- Zonta S
- Zourntou S
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, Pâ<â0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, PÂ =Â 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, PÂ =Â 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Testing a global standard for quantifying species recovery and assessing conservation impact.
- Author
- Acebes Pablo
- Akçakaya H Resit
- Alfaro-Shigueto Joanna
- Alvarez-Clare Silvia
- Andriantsimanarilafy Raphali Rodlis
- Arbetman Marina
- Azat Claudio
- Bacchetta Gianluigi
- Badola Ruchi
- Barcelos LuĂs MD
- Barreiros Joao Pedro
- Basak Sayanti
- Bennett Elizabeth L
- Berger Danielle J
- Bhattacharyya Sabuj
- Bino Gilad
- Borges Paulo AV
- Boughton Raoul K
- Brockmann H Jane
- Brooks Thomas M
- Buckley Hannah L
- Burfield Ian J
- Burton James
- Camacho-Badani Teresa
- Cano-Alonso Luis Santiago
- Carmichael Ruth H
- Carrero Christina
- Carroll John P
- Catsadorakis Giorgos
- Chapple David G
- Chapron Guillaume
- Chowdhury Gawsia Wahidunnessa
- Claassens Louw
- Cogoni Donatella
- Constantine Rochelle
- Craig Christie Anne
- Cunningham Andrew A
- da Rosa PatrĂcia
- Dahal Nishma
- Daltry Jennifer C
- Das Goura Chandra
- Dasgupta Niladri
- Davey Alexandra
- Davies Katharine
- de Lima Thales Moreira
- de Mitcheson Yvonne J Sadovy
- Develey Pedro
- Elangovan Vanitha
- Fairclough David
- Febbraro Mirko Di
- Fenu Giuseppe
- Fernandes Fernando Moreira
- Fernandez Eduardo Pinheiro
- Finucci Brittany
- Foley Catherine M
- Ford Matthew
- Forstner Michael RJ
- Földesi Rita
- Garcia-Sandoval Ricardo
- GarcĂa NĂ©stor
- Gardner Penny C
- Garibay-Orijel Roberto
- Gatan-Balbas Marites
- Gauto Irene
- Ghazi Mirza Ghazanfar Ullah
- Godfrey Stephanie S
- Gollock Matthew
- GonzĂĄlez Benito A
- Grace Molly K
- Grant Tandora D
- Gray Thomas
- Gregory Andrew J
- Gryzenhout Marieka
- Guernsey Noelle C
- Gupta Garima
- Hagen Christian A
- Hagen Christina
- Hall Madison B
- Hallerman Eric
- Hare Kelly
- Hart Tom
- Hartdegen Ruston
- Harvey-Brown Yvette
- Hatfield Richard
- Hawke Tahneal
- Heath Anna
- Hedges Simon
- Hermes Claudia
- Hilton-Taylor Craig
- Hitchmough Rod
- Hochkirch Axel
- Hoffmann Michael
- Hoffmann Pablo Melo
- Howarth Charlie
- Hudson Michael A
- Hussain Syed Ainul
- Huveneers Charlie
- Jacques HĂ©lĂšne
- Jenkins Richard
- Jorgensen Dennis
- Katdare Suyash
- Katsis Lydia KD
- Kaul Rahul
- Kaunda-Arara Boaz
- Keith David A
- Keith-Diagne Lucy
- Kraus Daniel T
- Lindeman Ken
- Linsky Jean
- Long Barney
- Louis Edward
- Loy Anna
- Lughadha Eimear Nic
- Mallon David P
- Mangel Jeffrey C
- Marinari Paul E
- Martin Gabriel M
- Martinelli Gustavo
- McGowan Philip JK
- McInnes Alistair
- Meijaard Erik
- Millard Michael J
- Milner-Gulland EJ
- Mirande Claire
- Money Daniel
- Monks Joanne M
- Morales Carolina Laura
- Mumu Nazia Naoreen
- Negrao Raquel
- Nguyen Anh Ha
- Niloy Md Nazmul Hasan
- Norbury Grant Leslie
- Nordmeyer Cale
- Norris Darren
- O'Brien Mark
- Oda Gabriela Akemi
- Orsenigo Simone
- Outerbridge Mark Evan
- Pasachnik Stesha
- Pike Charlotte
- Pilkington Fred
- Plumb Glenn
- Portela Rita de Cassia Quitete
- Prohaska Ana
- Pérez-Jiménez Juan Carlos
- Quintana Manuel G
- Rakotondrasoa Eddie Fanantenana
- Ranglack Dustin H
- Rankou Hassan
- Rawat Ajay Prakash
- Reardon James Thomas
- Rheingantz Marcelo Lopes
- Richter Stephen C
- Rivers Malin C
- Rodriguez Jon Paul
- Rogers Luke Rollie
- Rose Paul
- Royer Emily
- Ryan Catherine
- Salmon Lily
- Salvador Carlos Henrique
- Samways Michael J
- Sanjuan Tatiana
- Sasaki Hiroshi
- Schutz Emmanuel
- Scott Heather Ann
- Scott Robert Michael
- Serena Fabrizio
- Sharma Surya P
- Shuey John A
- Silva Carlos Julio Polo
- Simaika John P
- Smith David R
- Souza Dos Santos Amanda
- Spaet Julia LY
- Stephenson PJ
- Stuart Simon N
- Sultana Shanjida
- Talukdar Bibhab Kumar
- Tatayah Vikash
- Teles Barbosa Mendes Eduardo
- Thomas Philip
- Tringali Angela
- Trinh-Dinh Hoang
- Tuboi Chongpi
- Usmani Aftab Alam
- van Grunsven Roy HA
- van Weerd Merlijn
- Vasco-Palacios AĂda M
- Virens Jo
- Vié Jean-Christophe
- Walker Alan
- Wallace Bryan
- Waller Lauren J
- Wang Hongfeng
- Wearn Oliver R
- Weigmann Simon
- Willcox Daniel
- Woinarski John
- Yong Jean WH
- Young Richard P
- Young Stuart
- Publication venue
- Conserv Biol
- Publication date
- 01/01/2021
- Field of study
Recognizing the imperative to evaluate species recovery and conservation impact, in 2012 the International Union for Conservation of Nature (IUCN) called for development of a "Green List of Species" (now the IUCN Green Status of Species). A draft Green Status framework for assessing species' progress toward recovery, published in 2018, proposed 2 separate but interlinked components: a standardized method (i.e., measurement against benchmarks of species' viability, functionality, and preimpact distribution) to determine current species recovery status (herein species recovery score) and application of that method to estimate past and potential future impacts of conservation based on 4 metrics (conservation legacy, conservation dependence, conservation gain, and recovery potential). We tested the framework with 181 species representing diverse taxa, life histories, biomes, and IUCN Red List categories (extinction risk). Based on the observed distribution of species' recovery scores, we propose the following species recovery categories: fully recovered, slightly depleted, moderately depleted, largely depleted, critically depleted, extinct in the wild, and indeterminate. Fifty-nine percent of tested species were considered largely or critically depleted. Although there was a negative relationship between extinction risk and species recovery score, variation was considerable. Some species in lower risk categories were assessed as farther from recovery than those at higher risk. This emphasizes that species recovery is conceptually different from extinction risk and reinforces the utility of the IUCN Green Status of Species to more fully understand species conservation status. Although extinction risk did not predict conservation legacy, conservation dependence, or conservation gain, it was positively correlated with recovery potential. Only 1.7% of tested species were categorized as zero across all 4 of these conservation impact metrics, indicating that conservation has, or will, play a role in improving or maintaining species status for the vast majority of these species. Based on our results, we devised an updated assessment framework that introduces the option of using a dynamic baseline to assess future impacts of conservation over the short term to avoid misleading results which were generated in a small number of cases, and redefines short term as 10 years to better align with conservation planning. These changes are reflected in the IUCN Green Status of Species Standard
ABC-SPH risk score for in-hospital mortality in COVID-19 patients : development, external validation and comparison with other available scores
- Author
- Almeida Rafaela S.C.
- Anschau Fernando
- Aranha Fernando G.
- AraĂșjo ThaĂza SimĂŽnia M.A.
- Assaf Pedro L.
- Bartolazzi Frederico
- Bastos Gisele A.N.
- Bicalho Maria Aparecida Camargos
- Boersma Eric
- Borges do Nascimento Israel J.
- Botoni Fernando A.
- Cabral MĂĄderson A.S.
- Campos Roberta X.
- Cardoso Marilia M.A.
- Cardoso Ricardo B.
- Carneiro Marcelo
- Carvalho Rafael L.R.
- Castro LuĂs C.
- Cezar Edilson
- Chatkin José Miguel
- Cimini Christiane C.R.
- Costa André S.M.
- Couto Luciana S.F.
- Crespo NatĂĄlia T.
- Crestani Gabriela P.
- da Silva Carla Thais C.A.
- de Abreu Roger M.
- de Alvarenga Joice C.
- de Carvalho CĂntia A.
- de Castro Bruno Mateus
- de Morais JĂșlia D.P.
- de Moura Luis Cesar S.
- de Oliveira Leonardo S.
- de Oliveira Neimy R.
- de Oliveira Thainara C.
- Diniz Thulio Henrique O.
- do Vale Vitor Augusto L.
- dos Santos Kauane Aline M.
- dos Santos Veridiana B.
- Duani Helena
- Etges Ana Paula B.S.
- Farace BĂĄrbara L.
- Fereguetti Tatiani O.
- Ferrara Daniel T.M.O.
- Ferreira Maria Angélica P.
- Figueiredo Meire P.
- Finger Renan G.
- Floriani Maiara A.
- Francisco Saionara C.
- Glaeser Andressa B.
- Godoy Mariana F.
- Gomes Caroline D.
- Gomes Isabela M.
- Gomes Virginia Mara R.
- GuimarĂŁes Henrique C.
- GuimarĂŁes JĂșlia D.S.S.
- GuimarĂŁes Silvana M.M.
- GuimarĂŁes-JĂșnior Milton H.
- Kopittke Luciane
- Kroger Emanuele Marianne S.
- Kurtz Tatiana
- Lima Maria Clara P.B.
- Lucas Fernanda B.
- Lutkmeier Raquel
- Madeira GlĂcia Cristina de C.
- Madureira Angélica Aparecida C.
- Marcolino Milena S.
- Martelli PetrÎnio José de L.
- Martins Karina Paula M.P.
- Martins Raphael C.
- MaurĂlio Amanda O.
- Menezes Rochele M.
- Molina Romero Israel
- Monteiro Luanna S.
- Mourato Rodolfo Lucas S.
- Nascimento Guilherme F.
- Noal Helena Carolina
- Nogueira Matheus C.A.
- Oliveira Luana M.
- Oliveira Talita F.
- Pacheco Liliane S.
- Pereira Elayne C.
- Pereira Susany AnastĂĄcia
- Pinheiro LĂlian S.
- Pires Magda C.
- Polanczyk Carisi A.
- Ponce Daniela
- Pontes Karen Cristina J.R.
- Pozza Roberta
- Ramires Yuri C.
- Ramos Carolina M.
- Ramos Lucas Emanuel F.
- Rangel NatĂĄlia L.
- RaventĂłs Berta
- Rugolo Juliana M.
- Ruschel Karen B.
- Sales Thais L.S.
- Sampaio NatĂĄlia C.S.
- Santos Luisa Elem A.
- Schwarzbold Alexandre V.
- Scotton Ana Luiza B.A.
- Silva Rafael T.
- Silva Rufino de F.
- Silveira Daniel V.
- Sousa Lucas de D.
- Souza MaĂra D.
- Souza-Silva Maira V.R.
- SĂĄnchez-MontalvĂĄ AdriĂĄn
- Tofani Marcela G.T.
- Universitat AutĂČnoma de Barcelona
- Valacio Reginaldo Aparecido
- Vallt Felipe B.
- Vianna Heloisa R.
- Vietta Giovanna G.
- Weber André P.
- Ziegelmann Patricia K.
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones. Consecutive patients (â„ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between March-July, 2020. The model was validated in the 1054 patients admitted during August-September, as well as in an external cohort of 474 Spanish patients. Median (25-75th percentile) age of the model-derivation cohort was 60 (48-72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO/FiO ratio, platelet count, and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829-0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833-0.885]) and Spanish (0.894 [95% CI 0.870-0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/). An easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation was designed and validated for early stratification of in-hospital mortality risk of patients with COVID-19
ABC<sub>2</sub>-SPH risk score for in-hospital mortality in COVID-19 patients
- Author
- AdriĂĄn SĂĄnchez-MontalvĂĄ
- Alexandre V. Schwarzbold
- Amanda O. MaurĂlio
- Ana Luiza B.A. Scotton
- Ana Paula B.S. Etges
- Andressa B. Glaeser
- André P. Weber
- André S.M. Costa
- Angelinda R. Bhering
- Angélica Aparecida C. Madureira
- Berta RaventĂłs
- Bruno Mateus de Castro
- BĂĄrbara L. Farace
- Carisi A. Polanczyk
- Carla Thais C.A. da Silva
- Carolina M. Ramos
- Caroline D. Gomes
- Christiane C.R. Cimini
- CĂntia A. de Carvalho
- Daniel T.M.O. Ferrara
- Daniel V. Silveira
- Daniela Ponce
- Edilson Cezar
- Elayne C. Pereira
- Emanuele Marianne S. Kroger
- Felipe B. Vallt
- Fernanda B. Lucas
- Fernando A. Botoni
- Fernando Anschau
- Fernando G. Aranha
- Frederico Bartolazzi
- Gabriela P. Crestani
- Giovanna G. Vietta
- Gisele A.N. Bastos
- GlĂcia Cristina de C. Madeira
- Guilherme F. Nascimento
- H. (Eric) Boersma
- Helena Carolina Noal
- Helena Duani
- Heloisa R. Vianna
- Henrique C. GuimarĂŁes
- Isabela M. Gomes
- Israel J. Borges do Nascimento
- Israel Molina
- Joanna d.Arc L. Batista
- Joice C. de Alvarenga
- José Miguel Chatkin
- Juliana M. Rugolo
- JĂșlia D.P. de Morais
- JĂșlia D.S.S. GuimarĂŁes
- Karen B. Ruschel
- Karen Cristina J.R. Pontes
- Karina Paula M.P. Martins
- Kauane Aline M. dos Santos
- Leonardo S. de Oliveira
- Liliane S. Pacheco
- Luana M. Oliveira
- Luanna S. Monteiro
- Lucas de D. Sousa
- Lucas Emanuel F. Ramos
- Luciana S.F. Couto
- Luciane Kopittke
- Luis Cesar S. de Moura
- Luisa Elem A. Santos
- LuĂs C. Castro
- LĂlian S. Pinheiro
- Magda C. Pires
- Maiara A. Floriani
- Maira V.R. Souza-Silva
- Marcela G.T. Tofani
- Marcelo Carneiro
- Maria Angélica P. Ferreira
- Maria Aparecida C. Bicalho
- Mariana F. Godoy
- Marilia M.A. Cardoso
- Matheus C.A. Nogueira
- MaĂra D. Souza
- MB (Maria) Lima
- Meire P. Figueiredo
- Milena S. Marcolino
- Milton H. GuimarĂŁes-JĂșnior
- MĂĄderson A.S. Cabral
- NatĂĄlia C.S. Sampaio
- NatĂĄlia L. Rangel
- NatĂĄlia T. Crespo
- Neimy R. de Oliveira
- Patricia K. Ziegelmann
- Pedro L. Assaf
- PetrÎnio José de L. Martelli
- Rafael L.R. Carvalho
- Rafael T. Silva
- Rafaela S.C. Almeida
- Raphael C. Martins
- Raquel Lutkmeier
- Reginaldo Aparecido Valacio
- Renan G. Finger
- Ricardo B. Cardoso
- Roberta Pozza
- Roberta X. Campos
- Rochele M. Menezes
- Rodolfo Lucas S. Mourato
- Roger M. de Abreu
- Rufino de F. Silva
- Saionara C. Francisco
- Silvana M.M. GuimarĂŁes
- Silvia F. AraĂșjo
- Susany AnastĂĄcia Pereira
- Talita F. Oliveira
- Tatiana Kurtz
- Tatiani O. Fereguetti
- Thainara C. de Oliveira
- Thais L.S. Sales
- ThaĂza SimĂŽnia M.A. AraĂșjo
- Thulio Henrique O. Diniz
- Veridiana B. dos Santos
- Virginia Mara R. Gomes
- Vitor Augusto L. do Vale
- Yuri C. Ramires
- Publication venue
- 'Elsevier BV'
- Publication date
- 24/07/2021
- Field of study
Objectives: The majority of available scores to assess mortality risk of coronavirus disease 2019 (COVID-19) patients in the emergency department have high risk of bias. Therefore, this cohort aimed to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients and to compare this score with other existing ones. Methods: Consecutive patients (â„ 18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Logistic regression analysis was performed to develop a prediction model for in-hospital mortality, based on the 3978 patients admitted between MarchâJuly, 2020. The model was validated in the 1054 patients admitted during AugustâSeptember, as well as in an external cohort of 474 Spanish patients. Results: Median (25â75th percentile) age of the model-derivation cohort was 60 (48â72) years, and in-hospital mortality was 20.3%. The validation cohorts had similar age distribution and in-hospital mortality. Seven significant variables were included in the risk score: age, blood urea nitrogen, number of comorbidities, C-reactive protein, SpO2/FiO2 ratio, platelet count, and heart rate. The model had high discriminatory value (AUROC 0.844, 95% CI 0.829â0.859), which was confirmed in the Brazilian (0.859 [95% CI 0.833â0.885]) and Spanish (0.894 [95% CI 0.870â0.919]) validation cohorts, and displayed better discrimination ability than other existing scores. It is implemented in a freely available online risk calculator (https://abc2sph.com/). Conclusions: An easy-to-use rapid scoring system based on characteristics of COVID-19 patients commonly available at hospital presentation was designed and validated for early stratification of in-hospital mortality risk of patients with COVID-19.</p
Implementation of a Brazilian Cardioprotective Nutritional (BALANCE) Program for improvement on quality of diet and secondary prevention of cardiovascular events: A randomized, multicenter trial
- Author
- Adorne Elaine F.
- Almeida Andreza S.
- Almeida Karine M.M.
- Alves Luciana V.S.
- AmbrĂłzio CĂntia Lima
- Amparo Fernanda Cassulo
- Andrade Ana C.L.
- Araujo Suzi H.A. de
- AraĂșjo Celme B.P. de
- AraĂșjo Edite M.V.M.C. de
- AraĂșjo Givaldo A.
- Asoo Marina T.
- AtaĂde Bruno R.B. de
- Bachettini Nathalia Perleberg
- Backes Luciano Marcelo
- Barbosa Elza C.B.
- Barbosa Janaina M.A.
- Barbosa Socorro N.A.A.
- Barreto Ana L.
- Barretta Claiza
- Beiersdorf JĂąniffer R.
- Berbigier Marina Carvalho
- Bersch-Ferreira Ăngela Cristine
- Bertacco Renata T.A.
- Bertoldi Eduardo Gehling
- Bertoni Vanessa Maria
- Berwanger OtĂĄvio
- Bittencourt CĂ©lia R.O.
- Bobadra Sara
- Boemo Jorge L.
- Boklis Mirena
- Borges LĂșcia Rota
- Bortonili Vera M.S.
- Bosquetti Rosa
- Bragança Guilherme Cassão Marques
- Bressan Josefina
- Bruscato Neide Maria
- Caiado Alessandra C.
- Caldas Ana Paula Silva
- Cantanhede RosĂąngela C.A.
- Cantarelli Maiara
- Cardoso Andrea F.R.
- Cardoso Isadora B.
- Cardoso Roberta G.M.
- Carli Waldemar de
- Carlos Daniele M.O.
- Carvalho Ana P.P.F.
- Carvalho Helen M.S.
- Cavalcanti Alexandre Biasi
- Chiesa Fernanda L.
- Closs Vera Elizabeth
- Cordeiro CĂntia G.N.C.
- Costa Francisco A.
- Costa Laura Maggi da
- Costa LaĂs B. da
- Costa Lilian P.S.
- Costa Rosana Perim
- Coura Amanda G.L.
- Cunha Natalia Morais
- Damiani MĂŽnica
- Dantas Clenise F.
- David Marta M.
- Deucher Keyla L.A.L.
- Dias Luciana Pereira P.
- Dobke Fernanda
- dos Santos Alexsandro Ferreira
- dos Santos Cristiano P.
- dos Santos Elisa Maia
- dos Santos Karina G.
- Dourado Camila
- Duarte Rita C.L.
- Dutra Eliane S.
- e Lima Susi B.
- El Kik Raquel Milani
- Fagundes Vanessa C.F.O.
- Farias Geysa Maria Nogueira
- FelĂcio Matheus B.
- Feres Naoel Hassan
- Ferreira Raphaela Costa
- Ferreira Rosielle Batista
- Fischer Simone Cristina Matheus
- Formentini Franciane Silvana
- Fracasso Bianca M.
- Frehner Caroline
- Freitas Thiago T. de
- Galante Andrea Polo
- Garlini LuĂza M.
- Gastaud Alexandre
- Gonçalves Luciana B.
- GratĂŁo LĂșcia Helena Almeida
- Guterres Aldair S.
- Hermsdorff H. H.
- Holzbach Luciana Carla
- HonĂłrio Camila R.
- Ito Marina K.
- Izar Maria Cristina de Oliveira
- Jesus Monique T. de
- Jesus Sende O. de
- JĂșnior AndrĂ© E.S.
- JĂșnior DĂ©lcio G.S.
- Kato Juliana T.
- Kesties Josiele
- Kovacs Cristiane
- Kumbier Magali C.C.
- Lara Enilda de Sousa
- Leda Neuma M.F.S.
- Lima Luana R.M. de
- Lima Mariana E.P.
- Longo Aline
- Lopes JĂșlia D.
- Los Santos MĂŽnica L.P. de
- Lucas Marilia C.S.
- Luna Adriana B.
- Machado Bruna G.
- Machado Malaine M.A.
- MacHado Valéria Arruda
- Magnoni Carlos Daniel
- Maquiné Rebecca O.
- Marcadenti Aline
- Marinho Helyde Albuquerque
- Marotto Deborah
- Martins Celma Muniz G.
- Martins PatrĂcia R.T.
- Matos Cristina Henschel de
- Medeiros Auriene L.
- Meneses Tatiana M.X. de
- Missias Karina C.S.
- Modanese Paulo V.G.
- Monteiro Aline S.
- Moraes Maria Antonieta Pereira de
- Morais Jadson M.
- Moreira Annie Seixas Bello
- Moreira Priscila
- Moriguchi Emilio Hideyuki
- Mota Luis G.S.
- Nagano Francisca E.Z.
- Napparo Alechandra S.
- Nascimento Viviane O.G.
- Navarro LaĂs N.P.
- Necchi Rodrigo
- Neto José Albuquerque de Figueiredo
- Nunes Cristine E.
- Oliveira Bianca A.S. de
- Oliveira Juliana Dantas de
- Onofrei Mihaela
- Pagano Raira
- Paiva Catharina C.J.
- Palmeira Moacyr M.
- Paula Lais S. de
- Pellegrini LĂvia A.
- Penafort Andreza M.
- Pereira Juliana L.
- Peçanha Daniela O.
- Pinheiro Josilene Maria Ferreira
- Pinho ClĂĄudia Porto Sabino
- Pinho Priscila M. de
- Pinto SĂŽnia Lopes
- Poloni Soraia
- Pretto Alessandra Doumid Borges
- QueirĂłs Ana Paula O. de
- Ramos Maria E.M.
- Ramos Salvador S.
- Rampazzo Daniela
- Rech Rafael Luiz
- Reis Luisa F.
- Ribas Bruna L.P.
- Ribeiro Carine S.A.
- Rocha Barbara R.S. da
- Rodrigues Isa GalvĂŁo
- Rodrigues Juliane Araujo
- Rodrigues Milena Pozzatto
- Rodrigues Priscila A.
- Ruschel Karen Brasil
- Russo Diana S.
- Sabino LetĂcia S.
- Sahade Viviane
- Salamoni Joyce
- Sangali Tamirys D.
- Sant'Anna Viviane A.R.
- Santos Maria A.
- Santos Michelle R.
- Santos Renato Hideo Nakagawa
- Sasso Sandramara
- Schiavini JĂ©ssica
- Shirmann Gabriela S.
- Shumacher Marina
- Silva Alessandra da
- Silva Glauber B. da
- Silva Jacqueline Tereza da
- Silva Kellen Cristine
- Silva Lannay F. da
- Silva Luisa P.
- Silva LĂvia M.A.J.
- Silva Maria B.G.
- Silva Neyla E.
- Silva Nilma F. da
- Silva Renata A. da
- Silva Suzana A. da
- Soares Rafael Marques
- Sousa AntĂŽnio Carlos Sobral
- Sousa RosĂąngela Maria Lopes de
- Souza Camila V.S. de
- Souza Gabriela CorrĂȘa
- Souza Paula
- Souza Simone R.
- Souza Tainah S.
- Specht Clarice M.
- Taboada Maria I.S.
- Teixeira Adriana Fonseca
- Teixeira Camile S.
- Teixeira Joise M.
- Telles Cristina T.
- Torreglosa Camila Ragne
- Torres Rosileide S.
- Trescastro Eduardo P.
- Uehara Rose M.
- Vasconcelos Sandra Mary Lima
- Vasconcelos Valdiana B.
- VerĂssimo Adriana O.L.
- Vian Izabele
- Vieira Jaqueline S.O.
- Vieira Sabrina A.
- Vivian Lilian
- Weber Bernardete
- Zampieri Fernando G.
- Zuchinali Priccila
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: Appropriate dietary recommendations represent a key part of secondary prevention in cardiovascular disease (CVD). We evaluated the effectiveness of the implementation of a nutritional program on quality of diet, cardiovascular events, and death in patients with established CVD. Methods: In this open-label, multicenter trial conducted in 35 sites in Brazil, we randomly assigned (1:1) patients aged 45 years or older to receive either the BALANCE Program (experimental group) or conventional nutrition advice (control group). The BALANCE Program included a unique nutritional education strategy to implement recommendations from guidelines, adapted to the use of affordable and regional foods. Adherence to diet was evaluated by the modified Alternative Healthy Eating Index. The primary end point was a composite of all-cause mortality, cardiovascular death, cardiac arrest, myocardial infarction, stroke, myocardial revascularization, amputation, or hospitalization for unstable angina. Secondary end points included biochemical and anthropometric data, and blood pressure levels. Results: From March 5, 2013, to Abril 7, 2015, a total of 2534 eligible patients were randomly assigned to either the BALANCE Program group (n = 1,266) or the control group (n = 1,268) and were followed up for a median of 3.5 years. In total, 235 (9.3%) participants had been lost to follow-up. After 3 years of follow-up, mean modified Alternative Healthy Eating Index (scale 0-70) was only slightly higher in the BALANCE group versus the control group (26.2 ± 8.4 vs 24.7 ± 8.6, P <.01), mainly due to a 0.5-serving/d greater intake of fruits and of vegetables in the BALANCE group. Primary end point events occurred in 236 participants (18.8%) in the BALANCE group and in 207 participants (16.4%) in the control group (hazard ratio, 1.15; 95% CI 0.95-1.38; P =.15). Secondary end points did not differ between groups after follow-up. Conclusions: The BALANCE Program only slightly improved adherence to a healthy diet in patients with established CVD and had no significant effect on the incidence of cardiovascular events or death. © 2019 The Author
Delaying surgery for patients with a previous SARS-CoV-2 infection
- Author
- A A Ali Karar
- A A Kerawala
- A A Marra
- A Abad Gurumeta
- A Abad-Motos
- A Abdelmajeed
- A Abdelrahman
- A Abdelsamed
- A Abdulkareem
- A Aboelkassem Ibrahim
- A Abouassi
- A Abreu da Silva
- A Abubakar
- A Acher
- A Aderombi
- A Adeyeye
- A Adiamah
- A Aggarwal
- A Aghayeva
- A Agnes
- A Agrawal
- A Ahmeidat
- A Aimé
- A Ajlan
- A Al-Habib
- A Al-Mohammad
- A Al-Mukhtar
- A Aladeojebi
- A Alamri
- A Alanbuki
- A Alatar
- A Alburakan
- A Alfaro-Goldaracena
- A Alhamed
- A Alhefdhi
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- A Almeida
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- A Alonso Poza
- A Alsaif
- A Anastasi
- A Antic
- A Anzak
- A Aprile
- A Arminio
- A Arulanantham
- A Askari
- A Asqalan
- A Athanasiou
- A Ayhan
- A Ayman
- A Ayubi
- A Azizi
- A B Martins
- A Bacon
- A Baker
- A Balakrishnan
- A Bandiera
- A Banerjee
- A Barrabe
- A Beamish
- A Bellacci
- A Belli
- A Belvedere
- A Benkabbou
- A Bhalla
- A Bhangu
- A BillĂš
- A Bin Nasser
- A Biondi
- A Blatt
- A Blazquez Martin
- A Boddy
- A Bokhari
- A Bondurri
- A Boulton
- A Boutall
- A Branquinho
- A Brunelli
- A Brunt
- A Bruscino
- A Budacan
- A Burahee
- A Böttcher
- A C Almeida
- A C Deus
- A C Roslani
- A C Soares
- A C Vieira Paiva Lopes
- A Caiado
- A Camillo
- A Canas-Martinez
- A Cano
- A Carabias
- A Chandock
- A Charalabopoulos
- A Che Jusoh
- A Chebaro
- A Chessa
- A Chiappini
- A Chitul
- A Choudhry
- A Chowdhury
- A Colquhoun
- A Conesa
- A Cordova
- A Costanzi
- A Cotoia
- A Cotter
- A Crichton
- A Cuadrado-GarcĂa
- A Currie
- A Cvetkovic
- A D Bueno Cañones
- A D Rajgor
- A D Zakaria
- A D'Amore
- A D'Urso
- A Daly
- A Davies
- A Day
- A De Gea Rico
- A De Manzoni Garberini
- A De Pablo GarcĂa-Cuenca
- A De Troia
- A De Virgilio
- A Dehal
- A Desai
- A Di Bartolomeo
- A Di Bella
- A Di Somma
- A Diamantis
- A Doyle
- A Durrani
- A E Arikan
- A E Sherif
- A Eastmond
- A El Ouahabi
- A Elawad
- A Eldaly
- A Elhamshary
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- A Ezanno
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- A Fazenda
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- A Ferrero
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- A Fiorini
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- A Fowler
- A Fox
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- A Freitas
- A Frena
- A Fuson
- A G Carta
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- A Gabre-Kidan
- A Gagliano
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- A Gatti
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- A Gaunt
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- A GegĂșndez SimĂłn
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- A Gklavas
- A Glencer
- A Gomes da Costa
- A Gori
- A Goyal
- A Gronchi
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- A Guglielmi
- A GuimarĂŁes
- A Gupta
- A Gutierrez Calvo
- A Gvaramadze
- A GĂłmez-Pedraza
- A H Hussain
- A H Khan
- A Habeeb
- A Hainsworth
- A Hamad
- A Hannah
- A Hanson
- A Harky
- A Hasenburg
- A Hawkins
- A Haynes
- A Haynes
- A Henry
- A Herman
- A HernĂĄndez Gutierrez
- A Heuer
- A Hmedat
- A Hogan
- A Hunt
- A I Gutiérrez Fernåndez
- A I Kilani
- A I Soriano
- A I Tercero-Uribe
- A Ibrahim
- A Ionescu
- A Jah
- A Jain
- A Jamal
- A Jibril
- A Jiménez
- A Joshi
- A Jotic
- A K Ali
- A K Andrade
- A K Lala
- A K Scafa
- A K Zengin
- A Kahn
- A Kamocka
- A Kanatas
- A Kappenberger
- A Karamarkovic
- A Karim
- A Kattakayam
- A Kaufmann
- A Kawai
- A Kent
- A Khajuria
- A Khan
- A Khoja
- A Kirk
- A Kisiel
- A Kler
- A KocataĆ
- A Koh
- A Kolias
- A KollĂ r
- A Kolusarı
- A Kourdouli
- A Kouyoumdjian
- A Kredan
- A Kumar
- A Königsrainer
- A L De Oliveira LĂłpez
- A L EbbehĂžj
- A L Picardo
- A Laforest
- A Lagares
- A Laios
- A Laird
- A Landaluce-Olavarria
- A Lanzon
- A Larentzakis
- A Lauretta
- A Lim
- A Loayza
- A Loehrer
- A Lopez Abad
- A Louvrier
- A Lovece
- A Lowery
- A Lyons
- A LĂĄzaro
- A LĂłpez Campillo
- A M Abbas
- A M Baietti
- A M Castaño-Leon
- A M Correia
- A M Lacy
- A M Majbar
- A M Minaya Bravo
- A M Ntziovara
- A M Pathanki
- A M Perrone
- A M Scanu
- A Macchi
- A Madhavan
- A Madkhali
- A Maffioli
- A Maffuz-Aziz
- A Maghrabi
- A Maiga
- A Majkowska
- A Mansuri
- A Mantevas
- A Marano
- A Marchbank
- A Marco Garrido
- A Margalit
- A Martin-Ucar
- A Martinez German
- A Marçal
- A Mashat
- A Maw
- A McCanny
- A Mccarthy
- A McLennan
- A McMillan
- A Melo
- A Menon
- A Merchan
- A Merdrignac
- A MiljkoviÄ
- A Millan
- A Mingoli
- A Minicozzi
- A Mirabella
- A Modabber
- A Mohammad
- A Moro
- A Morris
- A Morsi
- A Morton
- A Mosca
- A Moumen
- A Muratore
- A Mustafa
- A N Sanli
- A Nabil
- A Nakas
- A Nawawi
- A Nobre Pinto
- A Nogués
- A Oar
- A Oliveira
- A Osorio
- A Otero
- A Ovaitt
- A P Ferreira Pinto
- A P Pezzuto
- A Parello
- A Parente
- A Parseliunas
- A Patel
- A Patel
- A Paunovic
- A Pearce
- A Pereira
- A Pereira-Neves
- A Peryt
- A Petrillo
- A Piras
- A Pisani Ceretti
- A Pisanu
- A Polydorou
- A Popoola
- A Porcu
- A Provozina
- A Pucar
- A PĂ©rez NĂșñez
- A Qasem
- A Quennell
- A Qureshi
- A Ramachandran
- A Ramos Bonilla
- A Ramwell
- A Ribeiro
- A Rizzi
- A Robinson
- A Robson
- A Rodolakis
- A Rodrigues
- A Rodriguez Fraga
- A Rogers
- A Rogers
- A Romero de Diego
- A Rowcroft
- A Ruivo
- A Ruiz Escobar
- A Ruzzenente
- A S Bodla
- A S Coonar
- A S Crugnale
- A S Memon
- A S Mohamed Sidek
- A S Yahaya
- A Sabry
- A Sachdeva
- A Sagnotta
- A Said Bayazeed
- A Salamah
- A Salazar
- A Saleem
- A Samih
- A Samir Abdelaal
- A Samkari
- A Samy
- A Santoro
- A Sanz Larrainzar
- A Saratziotis
- A Sarin
- A Sayasneh
- A Scalabre
- A Schache
- A Seguin-Givelet
- A Seleim
- A SgrĂČ
- A Shabana
- A Sharkey
- A Sharma
- A Sheel
- A Shenfine
- A Sherif
- A Shuwayyah
- A Singh
- A Soares
- A Solth
- A Souadka
- A Spinelli
- A Ssentongo
- A Stanimirovic
- A Stavroglou
- A Stefanovic
- A Stepanyan
- A Subocius
- A Sultana
- A Sutherland
- A Syllaios
- A SĂĄnchez-Pernaute
- A Taddei
- A Taibi
- A Tailor
- A Tang
- A Tedde
- A Thomas
- A Thompson
- A Tojal
- A Tooulias
- A Torne
- A Torres
- A Townson
- A Trivic
- A Tufo
- A Turnbull
- A Urbani
- A Urbieta
- A Usai
- A Valente da Costa
- A Vallance
- A Valle Rubio
- A Varazzani
- A Vazquez Fernandez
- A Vezakis
- A Vieira
- A Vignali
- A Vitali
- A Wali
- A Wilkins
- A Wimmer
- A Woodham
- A Y Azzam
- A Yiallourou
- A Yıldırım
- A Yildiz
- A Youssef
- A Zubaidi
- A Zullo
- A ĂlgĂ„
- Abd Elazeem Has
- Abhinav Tiwari
- Abigail Vallance
- Adesoji Ademuyiwa
- Adesoji O Ademuyiwa
- Adrian Marchbank
- Ahmad Qureshi
- Akshay Patel
- Alan McNeill
- Alessandro Brunelli
- Alessandro Gronchi
- Alex Alamri
- Alex Wilkins
- Alexandra Colquhoun
- Alexis P Arnaud
- Aman S Coonar
- Amanpreet Brar
- Ana Minaya-Bravo
- Ana Minaya-Bravo
- Ana Minaya-Bravo
- Ana Minaya-Bravo
- Anant Desai
- Anant Desai
- Andreas A Schnitzbauer
- Andreas K Demetriades
- Andrew G Schache
- Andrew Knight
- Andrew Loehrer
- Andrew Schache
- Andrey Litvin
- Aneel A Bhangu
- Aneel A Bhangu
- Aneel Bhangu
- Angelos Kolias
- Angelos Kolias
- Anna Fagotti
- Antonino Spinelli
- Antonio Ramos-De la Medina
- April C Roslani
- Arda Isik
- Arnav Agarwal
- B A Fahey
- B Al-Sarireh
- B Albi Martin
- B Alhassan
- B Ayub
- B B Ozmen
- B Baca
- B Bakmaz
- B Banky
- B Barmayehvar
- B Barrat
- B Bartalucci
- B Bozkırlı
- B Brown
- B Caimari
- B Challacombe
- B Chumbinho
- B Cimenoglu
- B Cirillo
- B Citgez
- B Collard
- B Costeira
- B Cros
- B Davidson
- B De Andrés Asenjo
- B De Simone
- B Devauchelle
- B Dias
- B Diéguez
- B DĂaz-Feijoo
- B El Ahmadi
- B Gil Ibañez
- B Giray
- B Gricks
- B Griffiths
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- B Mantoglu
- B Martin-Perez
- B McAree
- B Narice
- B Nunez-Garcia
- B PatrĂcio
- B Pramodana
- B PĂ©rez-Saborido
- B Rai
- B S Kamera
- B S Ong
- B Seeliger
- B Sheu
- B Soyak
- B Steel
- B Swinson
- B Tadic
- B Thakur
- B Ugarte-Sierra
- B Vieira
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- C A Espinosa
- C A Guariglia
- C Abatini
- C Agostini
- C Allemand
- C Alurralde
- C Anthoulakis
- C Arican
- C Ashmore
- C Aydin
- C Azevedo
- C B Kulle
- C Baker
- C Baldi
- C Barry
- C Barry
- C Bassi
- C BaĂa
- C Belluco
- C Bergamini
- C BescĂłs
- C Beyrne
- C Bezede
- C Bisset
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- C Bong
- C Boyle
- C Burgess
- C Busch
- C C Foo
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- C Chan
- C Chan
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- C Christou
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- C Dawson
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- C Di Martino
- C Donohue
- C Eiriz Fernandez
- C Evans
- C Evans
- C Eveno
- C F Feo
- C Ferreira
- C Ferron
- C Fitzgerald
- C Fleming
- C Fotopoulou
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- C Freyschlag
- C G Gil
- C G Mitrofan
- C Gambacciani
- C Gan
- C Gaskill
- C Gemmell
- C Gill
- C Giménez Francés
- C Gracia-Roche
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- C Grundy
- C Guerci
- C Halloran
- C Hammer
- C Hardie
- C Heaton
- C Heron
- C Hidalgo Salinas
- C Hill
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- Thomas Konney
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- U Akgor
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- W Yang
- Willemijn van der Plas
- Wong Mpk
- X De Sousa
- X Morales
- X S Tan
- Y Aawsaj
- Y Al-Tamimi
- Y Arkha
- Y Ayasra
- Y Bashir
- Y El Bouazizi
- Y Fayed
- Y H Lam
- Y Kanemitsu
- Y Kara
- Y Kirmizi
- Y Levy-Zauberman
- Y Litvina
- Y Perez
- Y T Liew
- Y Tanase
- Y Viswanath
- Y Ying
- Z Al-Ishaq
- Z Aldayri
- Z Aliyeva
- Z Bayhan
- Z Chia
- Z Dzamic
- Z H Belkhadir
- Z Inic
- Z Jawad
- Z Jezdic
- Z Katusic
- Z Krivokapic
- Z Lakkis
- Z Li
- Z M Barrett-Brown
- Z Mahasin
- Z Seymour
- Z Vilendecic
- Z Zakaria
- Ă De la Hoz RodrĂguez
- à Fernåndez Camuñas
- Ă Ryan
- Ćœ GrubaÄ
- Đ ĐĐ°ĐŒĐ°Đ»ĐŸĐČ
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Not availabl
Elective Cancer Surgery in COVID-19âFree Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
- Abbas AM
- Abbassi-Ghadi N
- Abbott D
- Abbott T
- Abbott Tom EF
- Abd Elazeem HAS
- Abdalla M
- Abdallah M
- Abdel Al S
- Abdel Jalil R
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarem MM
- Abdelkarim M
- Abdelmajeed A
- Abdelrahman A
- Abdelrahman S
- Abdelsamed A
- Abdou M
- Abdulkareem A
- Abdulwahed E
- Abdur-Rahman L
- Abel MK
- AbellĂĄn M
- Aboelkassem Ibrahim A
- Abosamak NE
- Abou Chaar MK
- Abou Chaar Mohammad K.
- Abou-Khalil J
- Abouassi A
- Aboulkassem H
- Abreu da Silva A
- Abu Zaânouneh FJ
- Abu J
- Abu-Nayla I
- Abubakar A
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Adamoli L
- Addae-Boateng E
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Adishesh M
- Agapov M
- Agarwal Arnav
- Aggarwal A
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agoston P
- Agrawal A
- Agresta F
- Aguado H
- Aguilar Gonzalez M
- Aguzzoli L
- Ahad S
- Ahmadi N
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Ajlan A
- Akalin M
- Akaydin E
- Akeel N
- Akgor U
- Akhtar MA
- Akhter Rahman MM
- Akilli H
- Akin E
- Akkour K
- Akkulak Murat
- Akmenkalne L
- Al Abdallah M
- Al Awwad S
- Al Habes H
- Al Maadany FS
- Al Raddadi R
- AL Sayed M
- Al-Habib A
- Al-Habsi R
- Al-Ishaq Z
- Al-Khayal K
- Al-Masri M
- Al-Mohammad A
- Al-mukhtar A
- Al-Najjar H
- Al-omishy H
- Al-Sarireh B
- Al-Tamimi Y
- Alaa S
- AlAamer O
- Aladeojebi A
- Alakaloko Felix
- Alam F
- Alam N
- Alam R
- Alameer Ehab
- Alamri A
- Alamri Alex
- Alanbuki A
- Alatar A
- Alawneh F
- Alazawi D
- Albertsmeier M
- Albertsmeiers Markus
- Albi Martin B
- Alburakan A
- Alcaide Matas F
- Alconchel F
- Aldayri Z
- Aldecoa Ansorregui I
- Alderson Derek
- Aldokali N
- AleksiÄ L
- Alemanno G
- Alexoudi V
- Alfaro-Goldaracena A
- Alfieri S
- Alghamdi M
- Alhalal H
- Alhamed A
- Alharthi M
- Alharthi R
- Alhassan B
- Alhassan N
- Alhefdhi A
- Ali karar AA
- Ali AK
- Ali M
- Ali S
- Aliyeva Z
- Aljanadi F
- Aljiffry M
- Alkadeeki GZ
- Alkarak S
- Allemand C
- Allison J
- Almalik O
- Almasri M
- Almeciga A
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- Almond Max
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- Alonso Poza A
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- Alsaif A
- Alsaif F
- Alsalamah R
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- Alser Osaid
- Alshaar Muhammad
- Alshahrani M
- Alshammari S
- Alshareea E
- Alsharif F
- Alshaygy I
- Alshryda Sattar
- Alsobhi S
- Althobaiti W
- Altintoprak F
- Alurralde C
- Alvarez E
- Alvarez MR
- Alyami M
- Alzamanan M
- Amaral MJ
- Ameerally P
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- Amira G
- Amonkar S
- Amorim E
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- Anania G
- Anastasi A
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- Andaleeb U
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- Angelou D
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- Annessi V
- Ansarin M
- Anthoulakis C
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- Antonopoulou MI
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- Aremu I
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- Arigoni M
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- Armatura G
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- Assalaarachchi H
- Asti E
- Astreidis I
- AtaĂde Gomes Gustavo Mendonça
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- Atherton R
- Athwal R
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- Attia D
- Augestad Knut Magne
- Avci EK
- Avlund T
- Awad S
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Aydin C
- Ayhan A
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- Azevedo José
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- Batstone Martin
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- Kalkat M
- Kamal M
- Kamal N
- Kamarajah Sivesh K
- KamburoÄlu MB
- Kamera BS
- Kamocka A
- Kamoka E
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- Kanemitsu Y
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- Kantola V
- Kapoor S
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- Karamarkovic A
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- Kobayashi E
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- Kredan A
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- Ledesma FS
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- on behalf of the COVIDSurg Collaborative
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- Zouzoulas D
- Zubaidi A
- Zullo A
- Ăngelo M
- ĂlgĂ„ A
- ĂapoÄlu R
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
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- Ć ÄepanoviÄ V
- ĆœateckĂœ J
- ĐĐ°ĐŒĐ°Đ»ĐŸĐČ Đ
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acosta MĂ©rida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
- Adi H
- Adiamah A
- Adisa Adewale
- Afzal MF
- Agapov M
- Agarwal Arnav
- Aggarwal M
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguado LĂłpez H
- Aguiar JĂșnior S
- Aguilar Gonzalez M
- Ahmed A
- Ahmed A
- Ahmed K
- Ahmed ME
- Ahmed Z
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Akalin M
- Akaydin E
- Akbas A
- Akhtar MA
- Akhtar N
- Akhter Rahman MM
- Akin E
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al ahmad F
- Al Asadi T
- Al Awwad S
- Al Ayed A
- Al Habes H
- Al Riyami S
- AL Sayed M
- Alaa S
- AlAamer O
- Aladeojebi A
- Alagoa Joao A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alamri Alex
- Alanazi F
- Alawneh F
- Albaqami F
- Albertsmeier M
- Albertsmeier Markus
- Alcaide Matas F
- Alconchel F
- AlcĂĄzar JA
- Alderson Derek
- Aldokali N
- AleksiÄ L
- Alemanno G
- Alfaifi J
- Alfieri S
- Alfonso Garcia M
- Algallai M
- Alghamdi M
- Alghuliga A
- Alhamed A
- Alharthi M
- Alhassan N
- Ali karar AA
- Ali Sani S
- Ali AA
- Ali M
- Ali S
- Alishi Y
- Aliyeva Z
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- Alkadiki Ghadah Z
- Alkhateb S
- Allue M
- Almaadany Faraj S
- Almassaudi A
- Almeida AC
- Almeida JI
- AlmeidaâReis R
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- Almond Max
- Alnumani T
- Alobaysi S
- Alobeed O
- Alonso de la Fuente N
- Alonso Poza A
- AlonsoâLamberti L
- Alqahtani D
- Alqannas M
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- Alsayadi R
- Alselaim N
- Alser Osaid
- Alshaar Muhammad
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- Alsharif F
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- Altomare DF
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- Alzaede S
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- Amaral MJ
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- Amorim E
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- Anania G
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- Angelou D
- Angenete E
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- Annamalai S
- Annessi V
- Annicchiarico A
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- Antonopoulou MI
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- Arulanantham A
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- Ashcroft J
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- Ashoush F
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- Athanasiou A
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- Attia D
- Augestad Knut Magne
- Avci EK
- Avellana R
- Aversano A
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- Ayasra F
- Ayasra Faris
- Ayasra Y
- Aydin C
- Ayloor Seshadri R
- Ayorinde J
- Aytac E
- Ayub B
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- Azevedo C
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- Badahdah F
- Badra R
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- Bagraith K
- Baguley M
- Baig M
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- BaiĂŁo JM
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- Baker O
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- Bakmaz B
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- Balasubramaniam D
- Balconi A
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- Banky B
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- Barisic G
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- Barlow C
- Barlow Emma
- Barod Ravi
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- Batstone Martin
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- Bellolio F
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- Bhasin S
- Bhat GA
- Bhat MA
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- Bianchini M
- Bianco F
- Bianco F
- Biel Juan Rey
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- Marialva J
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- MarieâMacron L
- Marinello P
- Marino Cosentino L
- Marino M
- Marino MV
- Markaryan D
- Markovic I
- Markovic V
- Marques R
- Marques T
- Marqueta De Salas M
- Marra AA
- Marra E
- Marreiro A
- Marson Ella J
- Marte G
- Martel A
- Martin E
- Martin E
- Martin Janet
- Martin ST
- Martinek L
- Martinez German A
- Martins dos Santos G
- Martins JordĂŁo D
- Martins A
- Martins D
- Martins R
- MartinâPerez B
- MartinâPerez E
- MartĂn Anoro LF
- MartĂn L
- MartĂnez Chicote C
- MartĂnezâHurtado E
- MartĂnezâPinedo C
- MartĂnezâPĂ©rez P
- MartĂnâArĂ©valo J
- Marx W
- Marzi F
- Marçal A
- MarĂn H
- Masciandaro A
- Mashat A
- Mashbari Hassan N
- Massey LH
- Massie E
- Massobrio A
- Mastoridis S
- Math S
- Mathew S
- MatiÄ S
- Matos Costa P
- Matute M
- Maté Mate P
- MatĂasâGarcĂa B
- Maw A
- Mazingi Dennis
- Mazzotta E
- Mazzotti F
- McAleer J
- McAree B
- McCanny A
- Mccluney S
- Mccormick P
- McDermott FD
- McElhinney K
- McEwen R
- McGivern K
- McGrath John S
- McIlmunn C
- McIntosh S
- McIntyre J
- McKay Siobhan
- Mckay Siobhan C
- McKevitt K
- McLean Kenneth A
- McNaught C
- McNeill Alan
- McNicol F
- MdRazali. I null
- Mehigan BJ
- Mehraj A
- Meimaâvan Praag EM
- Mekhael M
- MelchorâRuan J
- Melenhorst J
- Melhem S
- Memon AS
- Memos N
- Mendes F
- Mendes JR
- MendozaâMoreno F
- Meneghini S
- Mercado MĂ
- Merdrignac A
- Merh R
- Meriç S
- Messner F
- Metallidis Symeon
- Metwalli M
- Metzger J
- Michalopoulos N
- Michalski C
- Michel M
- Micic D
- Migliore M
- Mignot G
- Miguel T
- Mihanovic J
- Mihmanli M
- Miladinov M
- MilanoviÄ M
- Milic LJ
- Mills Emily C
- Mills SJ
- Milne K
- Minaya Bravo AM
- MinayaâBravo Ana
- MinayaâBravo Ana
- MinayaâBravo Ana
- Mingoli A
- Minicozzi A
- Minto G
- Mir I
- Mirabella A
- Miranda P
- Mirica RM
- Mirnezami R
- Mishra N
- Mishra S
- Mishra T
- Misra S
- Mitchell D
- Mitchell S
- Mithany R
- Mitra JK
- Mitrofan C
- Mittal R
- Mittal Rohin
- Miu V
- Mochet S
- Modolo Maria Marta
- Modolo Maria Marta
- Moftah M
- Moggia E
- Mohamed Sidek AS
- Mohammad Z
- Mohammed MM
- MohammedJibreel M
- Mohan H
- Mohan Helen M
- Mohan Helen M
- Mohd Azman ZA
- Mohd Yunus MF
- Mohsine R
- Mongelli F
- Montauban P
- Montelatici M
- Monteleone M
- Montella MT
- Montori G
- Montuori M
- Moore Rachel
- Moorthy M
- Morais H
- Moras L
- MoraâGuzmĂĄn I
- Morelli L
- Moretto G
- Morgan R
- Moritani K
- MoroâValdezate D
- Morris A
- Morsi A
- Mosley F
- Moss J
- Moszkowicz David
- Moug S
- Moug Susan
- Moug Susan
- Moura F
- Mourad M
- Mshelbwala P
- Msherghi A
- Mudawi I
- Muduly D
- Muguerza JM
- Muiesan P
- Mukherjee S
- Muller B
- Mulligan CS
- Mungo S
- Muratore A
- Murawa D
- Murgese A
- Murphy C
- Musetti S
- Mustafa A
- Mutter D
- Muzamil J
- Muñoz Camarena JM
- MuñozâAtienza V
- MuñozâBellvis L
- Naar L
- Nacif L
- Nafees Ahmed R
- Nageh MA
- Nahm C
- Najarian M
- Nally D
- Namazov Ä°
- Nankivell Paul
- Narahari Krishna
- Nassa H
- Nassif M
- Natale J
- Naumann D
- Navaratne L
- Nazir S
- Neary P
- Neary PM
- Neely D
- Negoi I
- Negoi Ionut
- Negoita VM
- Nel D
- Nelli T
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Neri J
- Nespoli LC
- Nessim C
- Neville Iuri
- Newman S
- Newman T
- Newton C
- Newton K
- Ng HJ
- Ng Joe
- Ng S
- Ng V
- Ng V
- Ngo CW
- NgâKamstra Joshua S
- NicolĂĄsâLĂłpez T
- Nikaj H
- Nikolaou S
- Nikolic S
- Niquen Milagros
- Nisar P
- Nitschke C
- Nogueira O
- Nogueiro J
- Nogués A
- Noiret B
- Nolan GJ
- Norcini C
- Nordberg M
- Notte F
- Nouh T
- Novello S
- Novikova A
- Nowak K
- Ntirenganya Faustin
- Nugent E
- Nunes Coelho M
- Nunes R
- NunezâGarcia B
- NunooâMensah JW
- Nuñez Del Barrio H
- Nwabuoku SE
- NĂșñez J
- Obeidat K
- Ocaña J
- OchagavĂa S
- Oguttu B
- Okafor B
- Okunlola A
- Olaogun J
- Olasehinde O
- Oldfield F
- Oliva Mompean F
- Oliveira A
- Olivier J
- Olivieri M
- Olivos Maricarmen
- Olori S
- Olson KA
- Olute A
- Omar W
- Omeroglu S
- Ong SL
- Onos L
- Oosterlinck W
- Oosterling S
- Opocher E
- Ortega VĂĄzquez I
- Ortiz de SolĂłrzano Aurusa FJ
- Ortiz LĂłpez D
- Osagie O
- Oseira A
- Osman N
- Osorio Ramos A
- Otero A
- Otoniel LR
- Oussama Kacimi
- Outani Oumaima
- Ovejero Merino E
- Owen H
- Owens P
- Oyende O
- Ozben V
- Ozcelık MF
- Ozgediz D
- Ozmen BB
- OâBrien H
- OâBrien S
- OâDonnell S
- OâMalley S
- OâRiordan J
- OâShea M
- P Delrio
- Pacheco SĂĄnchez D
- PadillaâValverde D
- Padmore G
- Pagano G
- Pajan H
- Palagi S
- Palma P
- Palmeri M
- Panahi P
- Pandey D
- Paniagua GarcĂa Señorans M
- Papaconstantinou I
- Papadopoulos V
- Papagni V
- Papatheodorou P
- Paquette N
- Parasyris S
- Pareek P
- Pareja Rene
- Parello A
- Parente A
- Parini S
- Parise P
- Park J
- Parkin E
- Parkins K
- Parlanti D
- Parmar C
- Parra Baños PA
- Parray FQ
- Parreira R
- ParreñoâSacdalan Marie Dione
- ParreñoâSacdalan Marie Dione
- Parseliunas A
- Parwaiz I
- Pasini F
- Paspaliari D
- Pata Francesco
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Patel K
- Patel M
- Patel P
- Patil S
- Patrone R
- PatrĂcio B
- Pattyn P
- Pattyn P
- Pavlov M
- Pedrazzani C
- Pedro J
- Pedro V
- Peirce C
- Pejnovic L
- Pejovic I
- Pellegrino L
- Pellino G
- Pellino Gianluca
- Peluso C
- Penumadu P
- Pera R
- Peralta Ferreira M
- Pereca J
- Pereira Rodrigues A
- Pereira A
- Pereira C
- Pereira I
- Pereira R
- Perez Gonzalez M
- Perez D
- Pergolini I
- Perivoliotis K
- Peros G
- Perotto LO
- Perra T
- Perrone G
- Persad A
- Persiani R
- Pertile D
- Peteja M
- Petrillo A
- Peyroteo M
- Pezzuto AP
- Peña Ros E
- Peña Soria MJ
- Pham H
- Phan D
- Phang PT
- Phillips E
- Picardo AL
- Picciariello A
- Picciochi Maria
- Pickett L
- PicĂłn RodrĂguez R
- Pieniowski E
- Piessen G
- Pina S
- Pinilla Morales RE
- Pinkney Thomas D
- Pinotti E
- Pinto J
- Pipara A
- Piper Rory J
- Pipitone Federico NS
- Pirozzolo G
- Pirzada A
- Pisani Ceretti A
- Pisanu A
- Pius Ogolekwu I
- PlaâMarti V
- Pockney P
- Pockney Peter
- Pockney Peter
- Pockney Peter
- Podda M
- Poeze M
- Poggioli G
- Police A
- Polydorou A
- PolâFachin L
- Ponchietti L
- Popoola AA
- Porcu A
- Portinari M
- PosadasâTrujillo OE
- PosmaâBouman L
- Potter R
- Pourcher G
- Powell S
- Pozotou I
- Praetorius C
- Pramesh CS
- Prando D
- Presl J
- Price C
- Price Stephen J
- Prieto Calvo M
- Prieto Nieto MI
- Pronk AJM
- Prosperi P
- Provozina A
- Pruvot FR
- Pujari R
- Pujol Cano N
- PĂ©rez SĂĄnchez MA
- PĂ©rezâSaborido B
- Qadan M
- Qasem A
- Qatora MS
- Quante M
- Quintana Martinic M
- QuirogaâValcĂĄrcel A
- Qureshi Ahmad
- Qureshi AU
- RabyâSmith W
- Radenkovic Dejan
- Raggio E
- Rai L
- Rajan S
- Rajaretnam N
- Rakvin I
- Ramachandran A
- Ramalho de Almeida F
- Ramamoorthy R
- Ramasamy S
- Ramcharan S
- Ramesh P
- Ramirez Faraco M
- Ramirez Romero P
- Ramos Bonilla A
- Ramos D
- RamosâDe la Medina Antonio
- RamosâMartĂn P
- Ramwell A
- Rao S
- Rapaport S
- Rashid A
- Rashid MM
- Rasoaherinomenjanahary F
- Rattizzato S
- Ratto C
- Raval M
- Ravindrakumar S
- Ravindran S
- Rayamajhi S
- Raymond T
- Razafindrahita JB
- Recordare A
- Reddy P
- Redfern J
- Refky B
- Rega D
- Rega D
- Regina de Sampaio L
- Reilly J
- Reim D
- Reinhard T
- Revez T
- Rey Ferro M
- Rey Valcarcel C
- Reynolds IS
- Ribeiro A
- Ribeiro CG
- Ribeiro R
- Ribolla M
- Rice D
- Richards S
- Richards T
- Richards Toby
- Riddell A
- Ridgway PF
- Righini E
- Riley C
- Rimonda R
- Ringressi MN
- RipollĂ©sâMelchor J
- Riquoir Altamirano C
- Risaliti M
- Riva C
- Rivas R
- Rivera Carlos Jose Perez
- RiveraâAlonso D
- Rizk M
- Rizzi A
- Roberts Keith
- Roberts Keith
- Robertson Faith
- Robinson A
- Roca Calvo MJ
- Rodrigo VSD
- Rodrigues K
- Rodriguez Artigas JM
- Rodriguez JL
- RodrĂguez GĂłmez L
- Rodwell H
- Rogers LJ
- Rogers M
- Rojo LĂłpez JA
- RoldĂłn Golet M
- Romano M
- Romero Bañuelos E
- Romero de Diego A
- Ronellenfitsch U
- Rooney SM
- Rosa F
- Rose J
- Roslani AC
- Roslani April C
- Rosseau Gail
- Rossi S
- Roszkowski R
- Rottoli M
- Roux A
- Roxo V
- Roy Mahapatra S
- Royle T
- RubioâPerez I
- Ruivo A
- Ruiz Esquide M
- Ruiz Manzanera JJ
- Ruiz Soriano M
- RuizâEscobar A
- RuizâMarĂn M
- Russ J
- Russo IS
- RutegÄrd M
- RutegÄrd Martin
- RutegÄrd Martin
- Rutherford D
- Ruzgar NM
- Ruzzenente A
- Ryan M
- Ryan ĂJ
- Ryska O
- RĂo Lafuente FD
- S RRR
- Saad MM
- Saafan T
- Saavedra J
- Sabry A
- Saeed S
- Saez Carlin P
- Sagar J
- Sagnotta A
- Sahid Nik Amin
- Sahin I
- Sahnan K
- Saklani A
- Sakr A
- Saksena AR
- Salazar A
- Saleem A
- Saleem A
- Saleh M
- Salem H
- Salem H
- Salem M
- Salerno G
- Sales Mallafré R
- SalgadoâNesme N
- Salim A
- SalimoÄlu S
- Salindera S
- Sallam I
- Samadov E
- Samih A
- Samir Abdelaal A
- Samison LH
- Samkari A
- Sammarco G
- Sammour T
- Sampaio da NĂłvoa Gomes Miguel II
- Sampaio Soares A
- Sampietro GM
- San Miguel C
- Sanchez Cabezudo Noguera F
- Sanchez Gonzalez J
- Sanchez Jimenez R
- SanchezâCasado AB
- SanchezâPelaez D
- Sanchon L
- SanchoâMuriel J
- Sanli AN
- Santanach C
- Santarrufina Martinez S
- SanteroâRamirez MS
- Santos Bezerra T
- Santos IrĂšne
- Santos PMDD
- Santos R
- SantosâSousa H
- Sanz Larrainzar A
- Sanz Ortega G
- SanzâLĂłpez R
- Sapienza P
- Sapre D
- Saraiva P
- Sarantitis I
- Sarigul M
- Sarin A
- Sarjanoja E
- Sarma DR
- Sarpel U
- Sarre C
- Sartarelli L
- Sarveswaran J
- Sasapu K
- Sasia D
- Satoi Sohei
- Satoi Sohei
- SaudĂ S
- Sauvain M
- Sauvat F
- Saverio Salomone Di
- Saverio Salomone Di
- SavkoviÄ N
- Sayyed R
- Sayyed Raza
- Scabini S
- Scalabre A
- Scanu AM
- Schache Andrew
- Schache Andrew G
- Schaller Karl
- Scheiwiller A
- Schiavo M
- Schiergens T
- Schineis C
- Schizas D
- Schlesinger N
- Schnitzbauer Andreas A
- Schwartz PB
- Scott L
- Scotton G
- Scrima O
- Sebai A
- Seebah K
- Seeliger B
- Seenivasagam Rajkumar Kottayasamy
- Seguinâgivelet A
- SeguraâSampedro JJ
- SeguraâSampedro Juan JosĂ©
- Sehgal T
- Sehouli Jalid
- Seleim A
- Selmani J
- Semina E
- Sena G
- Senossi O
- Serevina OL
- Serralta de Colsa D
- Serrano GonzĂĄlez J
- SerranoâNavidad M
- Sert Ä°
- Servadei Franco
- SeyiâOlajide Justina O.
- Seymour Z
- Sganga G
- SgrĂČ A
- Shah J
- Shah S
- Shah ZA
- Shaikh I
- Shaikh S
- Shakoor Z
- Shanthakunalan K
- Sharabiany S
- Sharma Neil
- Sharma P
- Shaw Catherine A
- Shaw Richard
- Shaw Richard
- Sheel A
- Shehata S
- Shenit K
- Sheridan K
- Sherief M
- Sherif A
- Sherif Ahmed Elshawadfy
- Sherif G
- Shokuhi P
- Sholadoye TT
- Shortland T
- Shream S
- Shrestha A
- Shu Sebastian
- Shylasree TS
- Sian T
- SiawâAcheampong Kwabena
- Sibilla MG
- Siddiqui MT
- Sidiropoulos T
- Silva A
- Silva M
- Silva N
- Silva R
- Silveira Nunes I
- Silvestre D
- SimÔes JFF
- Singh AA
- Singh Jagdeep K
- Singh MP
- Singh R
- Singh S
- Singh S
- Sion M
- Skrovina M
- Smart Neil
- Smart Neil J
- Smith C
- Smith H
- Smith J
- Smith L
- Soh JY
- Sohrabi C
- Sokolov M
- Solari F
- Soldevila Verdeguer C
- Soliman H
- Soltan H
- Soreide Kjetil
- Soriano AI
- Soriero D
- Sorrentino L
- Sorribas Grifell M
- Sosa Duran EE
- SosaâRodrĂguez MV
- Soto Montesinos C
- Souadka A
- SoulĂ© MartĂnez CE
- Sousa Fernandes M
- Sousa R
- Sousa S
- Spagni G
- Spampinato MG
- Spanu A
- Spartalis E
- Spencer N
- Spiezio G
- Spinelli A
- Spinelli Antonino
- Spolini A
- Sreedharan L
- Srikumar B
- Sriram RK
- Srishankar S
- SroczyĆski P
- St John S
- Stafford J
- Stavrinidou O
- Stebbing J
- Steele C
- Steidle C
- Steinke J
- Stevens K
- Stevenson J
- Stevic D
- Stewart Grant D
- Stewart Grant D
- Stewart KE
- Stockdale T
- Stoica B
- Strate T
- Stylianides N
- Stylianidis G
- Subhi MT
- Subocius A
- Subramaniam S
- Sud A
- Sund Malin
- Sundar Sudha
- Sundar Sudha
- Sundaram Venkatesan G
- Sundhu M
- SusztĂĄk N
- Sutherland A
- Swinson B
- Syed WAS
- Syllaios A
- Szatmary P
- Szubota I
- SĂĄnchez del Pueblo C
- SĂĄnchez Fuentes N
- SĂĄnchez Tocino JM
- SĂĄnchezâGarcĂa S
- SĂĄnchezâGuillĂ©n L
- Tabiri Stephen
- Tactuk N
- Taddei A
- Tadic B
- Taibi A
- Talaat M
- Talal ElâAbur I
- Talukder S
- Talwar R
- Tamini N
- Tammaro P
- Tan JA
- Tan KHM
- Tan XS
- Tanal M
- Tang AM
- Tanzanu M
- Tartaglia D
- Tasis N
- Tatar OC
- Tavares F
- Tawheed A
- Tayeh S
- Taylor Elliott H
- Tebala GD
- Teh C
- Teixeira J
- Teixeira M
- TejeroâPintor FJ
- Telma K
- Testa V
- Tewari N
- Tezas S
- Thaha MA
- Thalgaspitiya SPB
- Thanapal MR
- Thekinkattil Dinesh
- Theodosopoulos T
- Theophilidou E
- Thian A
- Thomas A
- Thompson D
- Thrumurthy S
- Thulasiraman SV
- Timbrell S
- Tirloni L
- Tirotta Fabio
- Titu S
- Tiwari Abhinav
- Tojal A
- Tokocin M
- Tolani MA
- Tom K
- Tonini V
- Tooulias A
- Torres Arcos C
- Torres A
- Townend D
- Townend Philip
- Townend Philip
- Townson A
- Trabulsi N
- Travaglio E
- Trebol J
- Tribillon E
- Troncoso Pereira P
- Tropeano FP
- Trout Isobel M
- Trujillo DĂaz J
- Tsai L
- Tsarkov P
- Tsiaoussis I
- Tsirlis T
- Tsoulfas G
- Tsoulfas Georgios
- Tsui G
- Tucci R
- Tufo A
- Tugmen C
- Tulina I
- Tuncer K
- Turina M
- Turk K
- Turnbull A
- TurradoâRodriguez V
- Turri G
- Tweedle E
- Tzedakis S
- Tzovaras G
- TĂ©bar Zamora A
- UgarteâSierra B
- Ugolini G
- Ullrich S
- UludaÄ SS
- Umair M
- Umar A
- Uras C
- Urbani A
- Urbieta A
- Usai A
- Uslu G
- Usta MA
- Utkan NZ
- Utrilla Fornals A
- Uy Magadia E
- Uyanik MS
- Uzunoglu FG
- Vaccarella G
- Valbuena Jabares V
- ValdesâHernandez J
- Vale R
- Valenzuela JI
- Valero Soriano M
- Vallance Abigail
- Valle Rubio A
- Valverde S
- Van de Putte D
- Van den Eynde J
- Van den Eynde R
- van der Plas Willemijn
- Van Heinsbergen M
- Van Nieuwenhove Y
- Van Ramshorst G
- van Ramshorst Gabrielle H
- Vanker R
- Varcada M
- Varghese Chris
- Varma MG
- Vartanoglu T
- Vasconcelos M
- Vasey C
- VasljeviÄ J
- Vassiliu P
- Vaz S
- VazâPereira R
- Velasquez Cuasquen BG
- Velchuru V
- Velickovic D
- Velidedeoglu M
- Vendrame C
- Venn M
- Venn Mary L
- Venskutonis D
- Vera Mansilla C
- Verberne C
- Vergari R
- Vernon L
- Vervoort D
- Vescio G
- Vezakis A
- Veziant J
- Videira JF
- Vidya Raghavan
- Vidya Raghavan
- Vieira Barros A
- Vieira Caroço T
- Vieira Paiva Lopes AC
- Vieira A
- Vieira B
- Vignali A
- Vignotto C
- Vigorita V
- Vijayan D
- VilarâCompte D
- Villalabeitia Ateca I
- Villalonga B
- Vimalachandran D
- Vimalachandran Dale
- Vimalchandran Dale
- Violante T
- Vishnoi JR
- Viswanath Y
- Vitali A
- Vitone L
- Vives RV
- Vo UG
- Volpin E
- Von Papen M
- Vovola F
- Vucic N
- VĂĄzquez FernĂĄndez A
- VÄcÄraÈ AB
- Wadham B
- Waldron A
- Walker P
- Walkes K
- WalÄdziak M
- Wani R
- Waqar SH
- Warren O
- Warren Oliver J
- Watson E
- Watson LJ
- Watson N
- Wedderburn Duane
- Weitz J
- Welsch T
- Werner J
- Westwood E
- Whelan M
- Whitmore H
- Wilkin RJW
- Wilkins A
- Wilkins Alex
- Willaert W
- Williams G
- Williams K
- Williams O
- Wilson M
- Wilson M
- Wimmer A
- Winter D
- Winter Stuart C
- Wong MP
- Wood M
- Woods R
- Worku D
- Wright Naomi
- Wullschleger M
- Xavier R
- Xenaki S
- Xynos E
- Y J
- Yadev I
- Yalkın Ă
- Yanar H
- Yang W
- Yanishev A
- Yassin N
- Ye G
- Yepes Cano AF
- Yesantharao P
- Yetkin G
- Yezzaji H
- YeĆilyurt D
- Yiallourou A
- Yigitbas H
- Yildirim A
- Yildiz A
- Yildiz A
- Young R
- Yousof EA
- Youssef M
- Yurttas C
- YĂĄnez C
- YĂŒksel E
- Zafar SN
- Zakaria AD
- Zakaria Z
- Zakharenko A
- Zambon M
- ZamfirâChiruâAnton M
- Zanus G
- Zegarac M
- ZeliÄ M
- Zengin AK
- Zerbib P
- Zervas K
- Zese M
- Zhang H
- Zizzo M
- Zmora O
- Zografos C
- Zonta S
- Zorrilla OrtĂșzar J
- Zourntou S
- Zubaidi A
- Ăngelo M
- ĂlgĂ„ A
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- Ăzant A
- Ăzçay N
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ćawnicka A
- ĆœateckĂœ J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Outcomes from elective colorectal cancer surgery during the SARSâCoVâ2 pandemic
- Author
- 6\u11f\ufcc\ufc H
- 6fner D
- 6hlberger L
- \u106oza I
- \uc2ngelo M
- \uc4lg\ue5 A
- \uc7elebi F
- \uc7olak E
- Aawsaj Y
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- Zubaidi AM
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Aim
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic.
Method
This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data.
Results
From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58â14.06), postoperative SARS-CoV-2 (16.90, 7.86â36.38), male sex (2.46, 1.01â5.93), age >70 years (2.87, 1.32â6.20) and advanced cancer stage (3.43, 1.16â10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%).
Conclusion
Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks