Effects of Naltrexone on Pain Sensitivity and Mood in Fibromyalgia: No Evidence for Endogenous Opioid Pathophysiology

The pathophysiological mechanisms underlying fibromyalgia are still unknown, although some evidence points to endogenous opioid dysfunction. We examined how endogenous opioid antagonism affects pain and mood for women with and without fibromyalgia. Ten women with fibromyalgia and ten age- and gender-matched, healthy controls each attended two laboratory sessions. Each participant received naltrexone (50mg) at one session, and placebo at the other session, in a randomized and double-blind fashion. Participants were tested for changes in sensitivity to heat, cold, and mechanical pain. Additionally, we collected measures of mood and opioid withdrawal symptoms during the laboratory sessions and at home the night following each session. At baseline, the fibromyalgia group exhibited more somatic complaints, greater sensory sensitivity, more opioid withdrawal somatic symptoms, and lower mechanical and cold pain-tolerance than did the healthy control group. Neither group experienced changes in pain sensitivity due to naltrexone administration. Naltrexone did not differentially affect self-reported withdrawal symptoms, or mood, in the fibromyalgia and control groups. Consistent with prior research, there was no evidence found for abnormal endogenous opioid activity in women with fibromyalgia

Towards a science and practice of resilience in the face of pain

The primary objective of this paper is to discuss how a resilience approach to (chronic) pain may advance our current understanding of (mal)adaptation to pain. Different resilience perspectives are described, and future challenges for research, prevention and treatment of (chronic) pain are discussed. Literature searches were performed in Web of Science and PubMed to identify relevant literature on risk and resilience in the context of pain. Resilience can be best defined as the ability to restore and sustain living a fulfilling life in the presence of pain. The Psychological Flexibility Model, the Broaden-and-Build Theory, and Self-Determination Theory are described as theories that may provide insight into resilience within the context of (chronic) pain. We describe how a resilience paradigm shifts the outcomes to pursue in pain research and intervention and argue the need for including positive outcomes in addition to negative outcomes. Psychological flexibility, positive affect and basic psychological needs satisfaction are described as potentially important resilience mechanisms with the potential to target both sustainability and recovery from pain. A resilience approach to chronic pain may have important implications for the prevention and treatment of chronic pain problems, as it may give specific indications on how to empower patients to continue living a fulfilling life (in the presence of pain)

Measuring Daily Events and Experiences: Decisions for the Researcher

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98999/1/j.1467-6494.1991.tb00260.x.pd

Neighbourhood Social Resilience (NSR): Definition, Conceptualisation, and Measurement Scale Development

The literature on social resilience lacks a precise definition of this concept and a clear guideline on how to measure it. Particularly, social resilience at the neighbourhood scale has received remarkably little scholarly attention. This study contributes toward filling these gaps in the literature by developing and empirically testing the neighbourhood social resilience (NSR) model as a robust and reliable measurement instrument that integrates various aspects of this complex concept into one coherent and fine-grained psychometric model. The reliability and validity of the NSR model are empirically tested using questionnaire data collected from 234 respondents in five neighbourhoods of Dunedin city, New Zealand. Furthermore, a more nuanced definition for neighbourhood social resilience is provided. Results indicate that social resilience is a second-order and multidimensional concept incorporating eight dimensions. Each of these dimensions captures a distinct piece in the jigsaw of social resilience; therefore, failure to incorporate all dimensions may provide an incomplete picture of this complex phenomenon. Our research bridges the gap between top-down approach of stakeholders and policymakers and bottom-up perceptions and expectations of residents about social resilience of their urban neighbourhood

A model for quality of life measures in patients with dementia: Lawron's next step

The introduction of drugs that are claimed to improve cognitive function and activities of daily living in patients with Alzheimer's disease raises the question of whether these drugs also influence dementia patients' quality of life (QOL). We describe a hierarchic model of QOL of dementia patients, which can guide the development of measurement instruments. After initially discussing broadly QOL research, we focus on two highly important characteristics of the concept, its broadness and subjectivity, against the background of the relevant literature on QOL in dementia. Dementia-specific dimensions and domains are presented. We identify psychological well-being as the core dimension for QOL of patients with dementia. Copyright © 2004 S. Karger AG, Basel

Moving forward during major goal blockage: situational goal adjustment in women facing infertility

Individuals confronting chronic medical conditions often face profound challenges to cherished life goals. The primary aim of this study was to examine the associations of goal adjustment with psychological adjustment in the context of infertility. At study entry (T1; n = 97) and 6 months later (T2; n = 47), women in fertility treatment completed measures of goal blockage, goal adjustment ability, and psychological adjustment. At T1, greater perceived and actual goal blockage were related to negative psychological adjustment. Ability to disengage from the goal of biological parenthood was associated with less infertility-specific thought intrusion, whereas engagement with other goals was related to fewer depressive symptoms and greater positive states of mind. Greater general goal engagement was protective against the negative relationships between low goal disengagement and the dependent variables. Promoting letting go of the unattainable and investing in the possible may be a useful intervention to foster well-being among individuals experiencing profound goal blockage

Recent developments in team resilience research in elite sport

In this paper we review recent developments in team resilience research in elite sport. Although resilience has become a popular and well-researched topic from an individual (psychological) perspective, less attention has been paid to whether this construct is conceptually and operationally robust at a group level. In this review, we provide an overview of definitional aspects of team resilience followed by an outline of research in the general psychology literature, and a discussion of the findings of the first two studies of team resilience in elite sport. Recent developments in this area of sport psychology research suggest that an understanding of how teams mobilize their collective psychosocial resources to withstand stressors is essential for optimal performance