1,554 research outputs found
Studying Cat (Felis catus) Diabetes: Beware of the Acromegalic Imposter
Naturally occurring diabetes mellitus (DM) is common in domestic cats (Felis catus). It has been proposed as a model for human Type 2 DM given many shared features. Small case studies demonstrate feline DM also occurs as a result of insulin resistance due to a somatotrophinoma. The current study estimates the prevalence of hypersomatotropism or acromegaly in the largest cohort of diabetic cats to date, evaluates clinical presentation and ease of recognition. Diabetic cats were screened for hypersomatotropism using serum total insulin-like growth factor-1 (IGF-1; radioimmunoassay), followed by further evaluation of a subset of cases with suggestive IGF-1 (>1000 ng/ml) through pituitary imaging and/ or histopathology. Clinicians indicated pre-test suspicion for hypersomatotropism. In total 1221 diabetic cats were screened; 319 (26.1%) demonstrated a serum IGF-1>1000 ng/ml (95% confidence interval: 23.6-28.6%). Of these cats a subset of 63 (20%) underwent pituitary imaging and 56/63 (89%) had a pituitary tumour on computed tomography; an additional three on magnetic resonance imaging and one on necropsy. These data suggest a positive predictive value of serum IGF-1 for hypersomatotropism of 95% (95% confidence interval: 90-100%), thus suggesting the overall hypersomatotropism prevalence among UK diabetic cats to be 24.8% (95% confidence interval: 21.2-28.6%). Only 24% of clinicians indicated a strong pre-test suspicion; most hypersomatotropism cats did not display typical phenotypical acromegaly signs. The current data suggest hypersomatotropism screening should be considered when studying diabetic cats and opportunities exist for comparative acromegaly research, especially in light of the many detected communalities with the human disease
Volume 02
Introduction from Dean Dr. Charles Ross
Mike\u27s Nite: New Jazz for an Old Instrument by Joseph A. Mann
Investigation of the use of Cucumis Sativus for Remediation Of Chromium from Contaminated Environmental Matrices: An Interdisciplinary Instrumental Analysis Project by Kathryn J. Greenly, Scott E. Jenkins, and Andrew E. Puckette
Development of GC-MS and Chemometric Methods for the Analysis of Accelerants in Arson Cases by Scott Jenkins
Building and Measuring Scalable Computing Systems by Daniel M. Honey and Jeffery P. Ravenhorst
Nomini Hall: A Case Study in the Use of Archival Resources as Guides for Excavation at An Archaeological Site by Jamie Elizabeth Mesrobian
Two Stories: In Ohio and How to Stay Out of the Brazilian Army by Thomas Scott
Forgerson des Hommes/Stealing the Steel in Zola\u27s Men by Jay Crowell
Paul Gauguin\u27s Escape into Primitivism by Sarah Spangenberg
Lee Krasner, Abstract Expressionist by Amy S. Eason
Artist Book “Paris” by Kenny Wolfe
Artist Book “Sequence of Every Day” by Liz Hale
Artist Book “Apple Tree” by Rachel Bouchard
Artist Book “Not so Pretty in Pink” by Will Semonco
Artist Book “Look into the Moon” by Carley York
Artist Books “Extra” and “Green” by Ryan Higgenbothom
Artist Book “Re-growing Appalachia” by Adrienne Heinbaugh
Artist Books “Cheeziest”, “Uh-oh” and “The Girl with the Glasses” by Melissa Dorton
“Self-Reflection” by Madeline Hunter
Artist Book “The Princess and the Frog” by June Ashmore
“Hunter’s Niche” and “The Wild” by Clark Barkley
“To Thine Own Self be True” by Jay Haley
“Not Funny” Ten-Minute Play Festiva
Volume 03
Introduction from Dean Dr. Charles Ross
Little Shop of Horrors by Longwood Theater Department
Who Has the Hottest Hotsauce in Farmville: A Quantitative Comparison of Sauces from Local Restaurants by Cheryl Peck and Charles Hoever
Precipitation Effects on the Growth of White Oaks and Virginia Pines on the Mt. Vernon Plantation by Brittany Anderson
Design and Synthesis of Novel Ion Binding Molecules for Self-Assembly and Sensing Applications by J. Ervin Sheldon
A Statistical Analysis of Algorithms for Playing SameGame by Richard Hayden
Intersecting Cylinders at Arbitrary Angles by Yuri Calustro
Putting a Foot in the Revolving Door: Strategies for Reducing Teacher Attrition by Candice Fleming and Rebecca Franklin
The Effect of Presentation on Spanish Vocabulary Recall by Ashley Yocum
How Attractive Are You? Individuals Sensitivity to Number of Sexual Partners by Danielle M. Jagoda and Cristina M. Valdivieso
Culturally Relevant Practices for Teaching Code-Switching to African-American Students in Kindergarten Classrooms by Jameka Jones
Two Poems – “Dust” and “Check Out Girls” by Amy Ellis
Three Poems – “Rosewood Massacre, 1923”, “Jarring” and “Reverence” by Ashley Maser
Three Poems – “Dirty Thunderstorm”, “Summer Hide \u27N Seek Car Tag” and “Bliss” by Erikk Shupp
Analysis of the Wilton Diptych by Jamie Yurasits
“Nod”, “Corriline” “Flying” “Familiar” by Alexander Leonhart
Papermaking by Kenny Wolfe and Sally Meadows
“Plant” by J. Haley, Amy Jackson, and Morgan Howard
“Dare to Dart” by Amy Jackson, Adrienne Heinbaugh and Melissa Dorton
Untitled Photographs by Hopson
“Lockets” by Morgan Howard
Graphic Designs and Untitled Photographs by Ciarra Stalker
Selections from a Senior Recital by Joshua Davi
Compressed representation of a partially defined integer function over multiple arguments
In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one
Pushing the Boundaries of Amnesia and Myopia: A Critical Review of the Literature on Identity in Management and Organization Studies
The aim of this article is to review a selection of the literature on identity at work in Management and Organization Studies (MOS) in order to raise critical questions concerning what we see as the dangers of a certain amnesia and myopia. Insofar as some of the contemporary literature neglects to engage with the historical and multidisciplinary past and present, there is a tendency to leave common-sense understandings of identity unexamined, thereby reproducing everyday preoccupations with securing the self. By contrast with such rational individualism, we seek a more embodied understanding of identity, where it is a means of building our ethical engagements and capacities for community living. By failing to problematize identity, there is little recognition of how attempts to secure the self are invariably self-defeating if only because they are necessarily contingent on the other who is unpredictable and uncontrollable. The main contribution of the article is to show how this failure to interrogate identity is far from benign since it often results in reinforcing everyday preoccupations with the self that can turn into narcissism, and deflect and curtail alternative practices of embodied engagement. We trust that our deliberations will be helpful in advancing the ‘road less travelled’, where studies advance beyond taking identity for granted, and move instead towards more embodied understandings of ethical engagement
Recent advances in understanding the roles of whole genome duplications in evolution
Ancient whole-genome duplications (WGDs)—paleopolyploidy events—are key to solving Darwin’s ‘abominable mystery’ of how flowering plants evolved and radiated into a rich variety of species. The vertebrates also emerged from their invertebrate ancestors via two WGDs, and genomes of diverse gymnosperm trees, unicellular eukaryotes, invertebrates, fishes, amphibians and even a rodent carry evidence of lineage-specific WGDs. Modern polyploidy is common in eukaryotes, and it can be induced, enabling mechanisms and short-term cost-benefit assessments of polyploidy to be studied experimentally. However, the ancient WGDs can be reconstructed only by comparative genomics: these studies are difficult because the DNA duplicates have been through tens or hundreds of millions of years of gene losses, mutations, and chromosomal rearrangements that culminate in resolution of the polyploid genomes back into diploid ones (rediploidisation). Intriguing asymmetries in patterns of post-WGD gene loss and retention between duplicated sets of chromosomes have been discovered recently, and elaborations of signal transduction systems are lasting legacies from several WGDs. The data imply that simpler signalling pathways in the pre-WGD ancestors were converted via WGDs into multi-stranded parallelised networks. Genetic and biochemical studies in plants, yeasts and vertebrates suggest a paradigm in which different combinations of sister paralogues in the post-WGD regulatory networks are co-regulated under different conditions. In principle, such networks can respond to a wide array of environmental, sensory and hormonal stimuli and integrate them to generate phenotypic variety in cell types and behaviours. Patterns are also being discerned in how the post-WGD signalling networks are reconfigured in human cancers and neurological conditions. It is fascinating to unpick how ancient genomic events impact on complexity, variety and disease in modern life
PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts
The evolutionary significance of polyploidy
Polyploidy, or the duplication of entire genomes, has been observed in prokaryotic and eukaryotic organisms, and in somatic and germ cells. The consequences of polyploidization are complex and variable, and they differ greatly between systems (clonal or non-clonal) and species, but the process has often been considered to be an evolutionary 'dead end'. Here, we review the accumulating evidence that correlates polyploidization with environmental change or stress, and that has led to an increased recognition of its short-term adaptive potential. In addition, we discuss how, once polyploidy has been established, the unique retention profile of duplicated genes following whole-genome duplication might explain key longer-term evolutionary transitions and a general increase in biological complexity
The Science Performance of JWST as Characterized in Commissioning
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
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