Dynamics & Predictions in the Co-Event Interpretation

Sorkin has introduced a new, observer independent, interpretation of quantum mechanics that can give a successful realist account of the 'quantum microworld' as well as explaining how classicality emerges at the level of observable events for a range of systems including single time 'Copenhagen measurements'. This 'co-event interpretation' presents us with a new ontology, in which a single 'co-event' is real. A new ontology necessitates a review of the dynamical & predictive mechanism of a theory, and in this paper we begin the process by exploring means of expressing the dynamical and predictive content of histories theories in terms of co-events.Comment: 35 pages. Revised after refereein

Spacetime topology from the tomographic histories approach: Part II

As an inverse problem, we recover the topology of the effective spacetime that a system lies in, in an operational way. This means that from a series of experiments we get a set of points corresponding to events. This continues the previous work done by the authors. Here we use the existence of upper bound in the speed of transfer of matter and information to induce a partial order on the set of events. While the actual partial order is not known in our operational set up, the grouping of events to (unordered) subsets corresponding to possible histories, is given. From this we recover the partial order up to certain ambiguities that are then classified. Finally two different ways to recover the topology are sketched and their interpretation is discussed.Comment: 21 pages, slight change in title and certain minor corrections in this second version. To apear in IJT

Spacetime topology from the tomographic histories approach I: Non-relativistic Case

The tomographic histories approach is presented. As an inverse problem, we recover in an operational way the effective topology of the extended configuration space of a system. This means that from a series of experiments we get a set of points corresponding to events. The difference between effective and actual topology is drawn. We deduce the topology of the extended configuration space of a non-relativistic system, using certain concepts from the consistent histories approach to Quantum Mechanics, such as the notion of a record. A few remarks about the case of a relativistic system, preparing the ground for a forthcoming paper sequel to this, are made in the end.Comment: 19 pages, slight chang in title and corrected typos in second version. To appear to a special proceedings issue (Glafka 2004) of the International Journal of Theoretical Physic

Spacetime Coarse Grainings in the Decoherent Histories Approach to Quantum Theory

We investigate the possibility of assigning consistent probabilities to sets of histories characterized by whether they enter a particular subspace of the Hilbert space of a closed system during a given time interval. In particular we investigate the case that this subspace is a region of the configuration space. This corresponds to a particular class of coarse grainings of spacetime regions. We consider the arrival time problem and the problem of time in reparametrization invariant theories as for example in canonical quantum gravity. Decoherence conditions and probabilities for those application are derived. The resulting decoherence condition does not depend on the explicit form of the restricted propagator that was problematic for generalizations such as application in quantum cosmology. Closely related is the problem of tunnelling time as well as the quantum Zeno effect. Some interpretational comments conclude, and we discuss the applicability of this formalism to deal with the arrival time problem.Comment: 23 pages, Few changes and added references in v

Twistor form of massive 6D superparticle

The massive six-dimensional (6D) superparticle with manifest (n, 0) supersymmetry is shown to have a supertwistor formulation in which its “hidden” (0, n) supersymmetry is also manifest. The mass-shell constraint is replaced by Spin(5) spin-shell constraints which imply that the quantum superparticle has zero superspin; for n = 1 it propagates the 6D Proca supermultiplet.PKT acknowledges support from the UK Science and Technology Facilities Council (grant ST/L000385/1). AJR is supported by a grant from the London Mathematical Society.This is the final version of the article. It was first available from IOP Science via http://dx.doi.org/10.1088/1751-8113/49/2/02540

The Generalized Second Law implies a Quantum Singularity Theorem

The generalized second law can be used to prove a singularity theorem, by generalizing the notion of a trapped surface to quantum situations. Like Penrose's original singularity theorem, it implies that spacetime is null geodesically incomplete inside black holes, and to the past of spatially infinite Friedmann--Robertson--Walker cosmologies. If space is finite instead, the generalized second law requires that there only be a finite amount of entropy producing processes in the past, unless there is a reversal of the arrow of time. In asymptotically flat spacetime, the generalized second law also rules out traversable wormholes, negative masses, and other forms of faster-than-light travel between asymptotic regions, as well as closed timelike curves. Furthermore it is impossible to form baby universes which eventually become independent of the mother universe, or to restart inflation. Since the semiclassical approximation is used only in regions with low curvature, it is argued that the results may hold in full quantum gravity. An introductory section describes the second law and its time-reverse, in ordinary and generalized thermodynamics, using either the fine-grained or the coarse-grained entropy. (The fine-grained version is used in all results except those relating to the arrow of time.) A proof of the coarse-grained ordinary second law is given.Comment: 46 pages, 8 figures. v2: discussion of global hyperbolicity revised (4.1, 5.2), more comments on AdS. v3: major revisions including change of title. v4: similar to published version, but with corrections to plan of paper (1) and definition of global hyperbolicity (3.2). v5: fixed proof of Thm. 1, changed wording of Thm. 3 & proof of Thm. 4, revised Sec. 5.2, new footnote

Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer

Breast cancer metastasis remains a clinical challenge, even within a single patient across multiple sites of the disease. Genome-wide comparisons of both the DNA and gene expression of primary tumors and metastases in multiple patients could help elucidate the underlying mechanisms that cause breast cancer metastasis. To address this issue, we performed DNA exome and RNA sequencing of matched primary tumors and multiple metastases from 16 patients, totaling 83 distinct specimens. We identified tumor-specific drivers by integrating known protein-protein network information with RNA expression and somatic DNA alterations and found that genetic drivers were predominantly established in the primary tumor and maintained through metastatic spreading. In addition, our analyses revealed that most genetic drivers were DNA copy number changes, the TP53 mutation was a recurrent founding mutation regardless of subtype, and that multiclonal seeding of metastases was frequent and occurred in multiple subtypes. Genetic drivers unique to metastasis were identified as somatic mutations in the estrogen and androgen receptor genes. These results highlight the complexity of metastatic spreading, be it monoclonal or multiclonal, and suggest that most metastatic drivers are established in the primary tumor, despite the substantial heterogeneity seen in the metastases

Invariant class operators in the decoherent histories analysis of timeless quantum theories

The decoherent histories approach to quantum theory is applied to a class of reparametrization invariant models, which includes systems described by the Klein-Gordon equation, and by a minisuperspace Wheeler-DeWitt equation. A key step in this approach is the construction of class operators characterizing the questions of physical interest, such as the probability of the system entering a given region of configuration space without regard to time. In non-relativistic quantum mechanics these class operators are given by time-ordered products of projection operators. But in reparametrization invariant models, where there is no time, the construction of the class operators is more complicated, the main difficulty being to find operators which commute with the Hamiltonian constraint (and so respect the invariance of the theory). Here, inspired by classical considerations, we put forward a proposal for the construction of such class operators for a class of reparametrization-invariant systems. They consist of continuous infinite temporal products of Heisenberg picture projection operators. We investigate the consequences of this proposal in a number of simple models and also compare with the evolving constants method

2- and 3-substituted imidazo [1,2-a] pyrazines as inhibitors of bacterial type IV secretion

A novel series of 8-amino imidazo[1,2-a]pyrazine derivatives has been developed as inhibitors of the VirB11 ATPase HP0525, a key component of the bacterial type IV secretion system. A flexible synthetic route to both 2- and 3-aryl substituted regioisomers has been developed. The resulting series of imidazo[1,2-a]pyrazines has been used to probe the structure–activity relationships of these inhibitors, which show potential as antibacterial agents

Robustness and device independence of verifiable blind quantum computing

Recent advances in theoretical and experimental quantum computing bring us closer to scalable quantum computing devices. This makes the need for protocols that verify the correct functionality of quantum operations timely and has led to the field of quantum verification. In this paper we address key challenges to make quantum verification protocols applicable to experimental implementations. We prove the robustness of the single server verifiable universal blind quantum computing protocol of Fitzsimons and Kashefi (2012) in the most general scenario. This includes the case where the purification of the deviated input state is in the hands of an adversarial server. The proved robustness property allows the composition of this protocol with a device-independent state tomography protocol that we give, which is based on the rigidity of CHSH games as proposed by Reichardt, Unger and Vazirani (2013). The resulting composite protocol has lower round complexity for the verification of entangled quantum servers with a classical verifier and, as we show, can be made fault tolerant.Comment: Shortly before uploading the first version on the arxiv, the authors became aware of parallel and independent research by Hajdusek, Perez-Delgado and Fitzsimons, which also addresses device-independent verifiable blind quantum computing and appeared the same day on the arxi