1,347 research outputs found

    The ligand binding mechanism of the MloK1 ion channel

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    Integration ethologischer und funktioneller Merkmale in Zuchtprogramme für die Sau von morgen

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    Das Projekt „FreeSow“ hatte zum Ziel, Sauen hinsichtlich ihrer Eignung für freiere Abferkelsysteme und alternative Haltungsverfahren zu charakterisieren und diese Eigenschaften in die zukünftige Zuchtplanung zu integrieren, um einen wichtigen Beitrag zur nachhaltigen Tierzucht zu leisten. Da Systeme ohne Fixierung besondere Herausforderungen mit sich bringen, wird von einer in ihnen gehaltenen Sau erwartet, dass sie sowohl eine gute Mütterlichkeit gegenüber ihren Ferkeln aufweist als auch mögliche Interaktionen mit dem Menschen toleriert. Daher wurden im Projekt verschiedene Verhaltenstests zur Beschreibung des Verhaltens der Sauen entwickelt und angewandt. Für die praktische Datenerfassung über zwei Jahre standen der Basiszuchtbetrieb Garlitz (BHZP) mit 80 Bewegungsbuchten für detaillierte Untersuchungen und die ökologische Sauenhaltung des LBZ-Echem (LWK) für die Validierung unter ökologischen Bedingungen zur Verfügung. Umfangreiche Datenerhebungen und -analysen zur Tiergesundheit und zum Wohlbefindens bildeten einen weiteren Schwerpunkt. Alle im Rahmen des Projektes entwickelten Verhaltenstests zur Toleranz gegenüber menschlichen Interaktionen erwiesen sich als geeignet, um das Verhalten der Sauen in praxi zu charakterisieren. Die geschätzten Heritabilitäten für die Merkmale, die sich mittels Test ergaben und Verhalten der Sauen gegenüber Menschen charakterisierten, lagen im Bereich von h² = 0,131 bis h² = 1.87. Diese Erblichkeitsgrade lassen eine erfolgreiche züchterische Bearbeitung zu. Zudem fanden sich bei Genom-weiten Assoziationsstudien erste Hinweise auf vielversprechende SNPs. Für die Nutzung in einem Sauenplaner wurden neue Merkmale des Tierverhaltens entwickelt und integriert, so dass eine einfache Dokumentationsmöglichkeit für den Sauenhalter geschaffen worden ist. Bereits während der Projektlaufzeit wurde die Selektion gegen unerwünschte Verhaltensweisen von Sauen in Abferkelsystemen mit größerer Bewegungsmöglichkeit umgesetzt

    Biomarkers as Proxies to Analyse Land-Use History in Northern Jordan

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    In the semi-arid 'Decapolis region' in northern Jordan, due severe land degradation in the past, 'barren' and 'impoverished' landscapes can be found today. It is widely believed that land degradation in these regions was caused by ancient land use, e.g. overgrazing due to ‘Arab mismanagement'. However, the connection of degradation with land use is far from certain. The 'Decapolis region' is located in an approximately 100 km wide transition zone from Mediterranean to steppe and desert climate. Therefore, the landscape in this region is highly sensitive to climate variations. A major sedimentation phase in the late 6th century AD appears to represent a significant climate change towards more aridity, and might be connected with a cluster of heavy rainfall events in northern Jordan. In fact, more recent studies have found that periods of predominantly pastoral land use in northern Jordan were connected with natural reforestation. Since a dating of sedimentation alone does not deliver clues about the precise reason of deposition, a multidisciplinary team is analyzing the land-use history in the ‘Decapolis’ region. This presentation focusses on ongoing biomarker analyses. Samples were selected considering geoarchaeological data, including phosphorus concentrations, archaeological data, including distribution of potsherds and other fragments on ancient fields and data of further disciplines. Vegetation changes are investigated by analyses of n-alkanes and terpenoids. Manuring with faeces is analysed by specific steroids that are indicative for faeces deposition. Preliminary results showed a high input of omnivorous (pigs, humans) faeces in some areas. Manuring with faeces of herbivores seemed to be less important

    Entangled Stories: The Red Jews in Premodern Yiddish and German Apocalyptic Lore

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    “Far, far away from our areas, somewhere beyond the Mountains of Darkness, on the other side of the Sambatyon River…there lives a nation known as the Red Jews.” The Red Jews are best known from classic Yiddish writing, most notably from Mendele's Kitser masoes Binyomin hashlishi (The Brief Travels of Benjamin the Third). This novel, first published in 1878, represents the initial appearance of the Red Jews in modern Yiddish literature. This comical travelogue describes the adventures of Benjamin, who sets off in search of the legendary Red Jews. But who are these Red Jews or, in Yiddish, di royte yidelekh? The term denotes the Ten Lost Tribes of Israel, the ten tribes that in biblical times had composed the Northern Kingdom of Israel until they were exiled by the Assyrians in the eighth century BCE. Over time, the myth of their return emerged, and they were said to live in an uncharted location beyond the mysterious Sambatyon River, where they would remain until the Messiah's arrival at the end of time, when they would rejoin the rest of the Jewish people. This article is part of a broader study of the Red Jews in Jewish popular culture from the Middle Ages through modernity. It is partially based on a chapter from my book, Umstrittene Erlöser: Politik, Ideologie und jüdisch-christlicher Messianismus in Deutschland, 1500–1600 (Göttingen: Vandenhoeck & Ruprecht, 2011). Several postdoctoral fellowships have generously supported my research on the Red Jews: a Dr. Meyer-Struckmann-Fellowship of the German Academic Foundation, a Harry Starr Fellowship in Judaica/Alan M. Stroock Fellowship for Advanced Research in Judaica at Harvard University, a research fellowship from the Heinrich Hertz-Foundation, and a YIVO Dina Abramowicz Emerging Scholar Fellowship. I thank the organizers of and participants in the colloquia and conferences where I have presented this material in various forms as well as the editors and anonymous reviewers of AJS Review for their valuable comments and suggestions. I am especially grateful to Jeremy Dauber and Elisheva Carlebach of the Institute for Israel and Jewish Studies at Columbia University, where I was a Visiting Scholar in the fall of 2009, for their generous encouragement to write this article. Sue Oren considerably improved my English. The style employed for Romanization of Yiddish follows YIVO's transliteration standards. Unless otherwise noted, translations from the Yiddish, Hebrew, German, and Latin are my own. Quotations from the Bible follow the JPS translation, and those from the Babylonian Talmud are according to the Hebrew-English edition of the Soncino Talmud by Isidore Epstein

    Reconceptualising adaptation to climate change as part of pathways of change and response

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    The need to adapt to climate change is now widely recognised as evidence of its impacts on social and natural systems grows and greenhouse gas emissions continue unabated. Yet efforts to adapt to climate change, as reported in the literature over the last decade and in selected case studies, have not led to substantial rates of implementation of adaptation actions despite substantial investments in adaptation science. Moreover, implemented actions have been mostly incremental and focused on proximate causes; there are far fewer reports of more systemic or transformative actions. We found that the nature and effectiveness of responses was strongly influenced by framing. Recent decision-oriented approaches that aim to overcome this situation are framed within a "pathways" metaphor to emphasise the need for robust decision making within adaptive processes in the face of uncertainty and inter-temporal complexity. However, to date, such "adaptation pathways" approaches have mostly focused on contexts with clearly identified decision-makers and unambiguous goals; as a result, they generally assume prevailing governance regimes are conducive for adaptation and hence constrain responses to proximate causes of vulnerability. In this paper, we explore a broader conceptualisation of "adaptation pathways" that draws on 'pathways thinking' in the sustainable development domain to consider the implications of path dependency, interactions between adaptation plans, vested interests and global change, and situations where values, interests, or institutions constrain societal responses to change. This re-conceptualisation of adaptation pathways aims to inform decision makers about integrating incremental actions on proximate causes with the transformative aspects of societal change. Case studies illustrate what this might entail. The paper ends with a call for further exploration of theory, methods and procedures to operationalise this broader conceptualisation of adaptation

    The circadian clock rephases during lateral root organ initiation in Arabidopsis thaliana

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    The endogenous circadian clock enables organisms to adapt their growth and development to environmental changes. Here we describe how the circadian clock is employed to coordinate responses to the key signal auxin during lateral root (LR) emergence. In the model plant, Arabidopsis thaliana, LRs originate from a group of stem cells deep within the root, necessitating that new organs emerge through overlying root tissues. We report that the circadian clock is rephased during LR development. Metabolite and transcript profiling revealed that the circadian clock controls the levels of auxin and auxin-related genes including the auxin response repressor IAA14 and auxin oxidase AtDAO2. Plants lacking or overexpressing core clock components exhibit LR emergence defects. We conclude that the circadian clock acts to gate auxin signalling during LR development to facilitate organ emergence
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