30 research outputs found
Bostonia
- Author
- Publication venue
- Boston University
- Publication date
- 01/01/2005
- Field of study
Founded in 1900, Bostonia magazine is Boston University's main alumni publication, which covers alumni and student life, as well as university activities, events, and programs
Effects of rare-earth co-doping on the local structure of rare-earth phosphate glasses using high and low energy X-ray diffraction
- Author
- Alisha J. Cramer
- Anderson
- Anderson
- Bingham
- Bingham
- Bowron
- Bowron
- Broer
- Brow
- Carini
- Cole
- Cole
- Cole
- Cole
- Cole
- Crawford
- Cromer
- Cromer
- Cromer
- Dupree
- Durville
- Fong
- George A. Saunders
- Harmann
- Harrison
- Hatch
- He
- Hoppe
- Hoppe
- Hoppe
- Hoppe
- Jacqueline M. Cole
- Laporta
- Liang
- Mark A. Roberts
- Martin
- Martin
- Martin
- Martin
- Martin
- Mierzejewski
- Mountjoy
- Mountjoy
- Qiu
- Richard A. Martin
- Robert J. Newport
- Saunders
- Schofield
- Tessa Brennan
- van Eck
- Veijo Honkimaki
- Vicky FitzGerald
- Zhang
- Publication venue
- 'Royal Society of Chemistry (RSC)'
- Publication date
- 01/01/2013
- Field of study
Rare-earth co-doping in inorganic materials has a long-held tradition of facilitating highly desirable optoelectronic properties for their application to the laser industry. This study concentrates specifically on rare-earth phosphate glasses, (R2O3)x(R'2O3)y(P2O5)1-(x+y), where (R, R') denotes (Ce, Er) or (La, Nd) co-doping and the total rare-earth composition corresponds to a range between metaphosphate, RP3O9, and ultraphosphate, RP5O14. Thereupon, the effects of rare-earth co-doping on the local structure are assessed at the atomic level. Pair-distribution function analysis of high-energy X-ray diffraction data (Qmax = 28 Å-1) is employed to make this assessment. Results reveal a stark structural invariance to rare-earth co-doping which bears testament to the open-framework and rigid nature of these glasses. A range of desirable attributes of these glasses unfold from this finding; in particular, a structural simplicity that will enable facile molecular engineering of rare-earth phosphate glasses with 'dial-up' lasing properties. When considered together with other factors, this finding also demonstrates additional prospects for these co-doped rare-earth phosphate glasses in nuclear waste storage applications. This study also reveals, for the first time, the ability to distinguish between P-O and PO bonding in these rare-earth phosphate glasses from X-ray diffraction data in a fully quantitative manner. Complementary analysis of high-energy X-ray diffraction data on single rare-earth phosphate glasses of similar rare-earth composition to the co-doped materials is also presented in this context. In a technical sense, all high-energy X-ray diffraction data on these glasses are compared with analogous low-energy diffraction data; their salient differences reveal distinct advantages of high-energy X-ray diffraction data for the study of amorphous materials
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A.
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R.
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O.
- Ademuyiwa Adesoji O.
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O.
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
- Ahmed Lopna Ahmed Mohamed
- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
- Ajah Jonathan
- Ajai Olalekan
- Ajao Akinlabi
- Ajiboye Anthony
- Akoto Elliot
- Akpenyi Onyinye
- Al Amin Shadid
- Al Attar Samaa Mahmoud
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- Al Bastawis Fatema
- Al Meligy Amgad
- Al Rafati Ahmad Abdel Razaq
- Al Raouf Eman Abd
- Al Saied Ghiath
- Al Subaie Norah
- Al-Bahrani Ahmed
- Al-Buhaisi Alaa
- Al-Dakka Emad
- Al-faqawi Maha
- Al-farram Hadeel
- Al-khatib Ahmed
- Al-Marakby Dina
- Al-saqqa Sara
- Al-Saqqa Sara W.
- Al-Slaibi Ibrahim
- Al-taher Taher
- AlaaelDein Shahinaz
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- Alamin Shadid
- Alamoudi Mohammed
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- Alcca Ticona Willy
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- Alexander Philip
- Alexander Philip
- Alexandre Challine
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- Alghamdi Mohammed Saleh A.
- Alhady Khaled
- Alhammali Tariq
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- Drake Thomas M.
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- Wilson Michael
- Wilson Michael
- Wimalge P. M. S. N.
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- Elsevier
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Immigration, Acculturation and Chronic Back and Neck Problems Among Latino-Americans
- Author
- A Anandacoomarasamy
- A Gollenberg
- A Thelin
- A Tsang
- AF Abraido-Lanza
- AF Abraido-Lanza
- AG Mainous III
- AG Mainous III
- AJ Romero
- B Palmer
- BE Pennell
- BI Martin
- BT Baune
- C Aceves-Gonzalez
- C Negy
- CH Barcenas
- DA Fishbain
- David Takeuchi
- DE Cortes
- DI Rubin
- DK Messias
- DP Guh
- E Volinn
- EA Viruell-Fuentes
- GK Singh
- H Antecol
- H Landrine
- H Raspe
- HR Schiphorst Preuper
- I Corral
- J McBeth
- J Zhang
- JH Lassetter
- JJ Soares
- K Demyttenaere
- KF Rust
- KM Scott
- L Franzini
- LH McCarthy
- M Alegria
- M Knight
- M Korff Von
- M Lofvander
- M Lofvander
- Mark Doescher
- MB Lofvander
- MC Yeh
- MM Baker
- N Fitzgerald
- NK Tang
- P Keeley
- PP Eamranond
- PP Eamranond
- PR Steffen
- Quynh Bui
- R Perez-Escamilla
- R Shiri
- R Webb
- RA Deyo
- RA Deyo
- RC Kessler
- SB Patten
- SG Heeringa
- SG Heeringa
- T Pincus
- TH Sach
- TW Strine
- Vicky Taylor
- WS Edwards
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
Higher acculturation is associated with increased obesity and depression among Latino-Americans, but not much is known about how acculturation is related to their prevalence of back and neck problems. This study examines whether acculturation is associated with the 12-month prevalence of self-reported chronic back or neck problems among US-born and immigrant Latinos. We performed multivariable logistic regression analysis of data from 2,553 noninstitutionalized Latino adults from the 2002–2003 National Latino and Asian American Survey (NLAAS). After adjusting for demographic, physical and mental health indicators, English proficiency, nativity and higher generational status were all significantly positively associated with the report of chronic back or neck problems. Among immigrants, the proportion of lifetime in the US was not significantly associated. Our findings suggest that the report of chronic back or neck problems is higher among more acculturated Latino-Americans independent of health status, obesity, and the presence of depression
A decade of the Oesophageal Cancer Clinical and Molecular Stratification Consortium
- Author
- Abbas Sujath
- Ang Y.
- Bagwan Izhar
- Bartlett Freddie
- Beggs Andrew
- Berrisford Richard
- Carroll Nick
- Chan David
- Chang Fuju
- Cheah Calvin
- Cheong Ed
- Ciccarelli F. d.
- Coleman H. g.
- Coles H.
- Contino G.
- Crichton Charles
- Crosby T.
- Davies Andrew r.
- Davies Jim
- Devonshire G.
- Edwards Paul a. w.
- Eldridge M.
- Fitzgerald R. c.
- Freeman A.
- Goh Vicky
- Gossage James a.
- Grabowska Anna
- Grace Ben l.
- Grehan N.
- Haidry Rehan
- Hanna George b.
- Hardwick Richard h.
- Hayes Stephen
- Hindmarsh Andrew
- Hupp Ted r.
- Jammula Sriganesh
- Kaye Philip
- Kumar Bhaskar
- Lagergren Jesper
- Lishman Suzy
- Loreno Christine
- Lovat Laurence
- Mahadeva Ula
- Malhotra Shalini
- Mccord M.
- Mcmanus Damian
- Millington Curtis
- Miremadi Ahmad
- Moorthy Krishna
- Nutzinger B.
- O’donovan Maria
- O’neill J. robert
- Parsons S. l.
- Peters C. j.
- Petty R.
- Preston Shaun r.
- Puig Sonia
- Redmond Aisling m.
- Safranek Peter
- Sanders Grant
- Saunders John h.
- Save Vicki
- Scott Michael
- Secrier Maria
- Sharrocks Andrew
- Skipworth R. j. e.
- Smyth E. c.
- Soomro I.
- Sothi Sharmila
- Sreedharan L.
- Sujendran Vijayendran
- Taniere Philippe
- Tripathi Monika
- Tucker Olga
- Turkington Richard c.
- Underwood T. j.
- Walker Robert c.
- Zamani S.
- Publication venue
- Publication date
- 19/12/2023
- Field of study
Recommended from our members
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
- Author
- Abbas Sujath
- Ang Yeng
- Bagwan Izhar
- Barr Hugh
- Beggs Andrew
- Benedetti Lorena
- Berrisford Richard
- Bornschein Jan
- Bower Lawrence
- Carroll Nick
- Cereda Matteo
- Chang Fuju
- Cheong Ed
- Ciccarelli Francesca D.
- Contino Gianmarco
- Crawte Jason
- Crichton Charles
- Davies Andrew
- Davies Jim
- de la Rue Rachel
- Devonshire Ginny
- Edwards Paul A. W.
- Eldridge Matthew
- Elliott Rachael Fels
- Fickling Will
- Fidziukiewicz Elwira
- Fitzgerald Rebecca C.
- Foxall Elizabeth
- Goh Vicky
- Gossage James
- Grabowska Anna
- Grace Ben L.
- Grehan Nicola
- Haidry Rehan
- Hanna George B.
- Harden Catherine
- Hayes Stephen J.
- Hindmarsh Andrew
- Howell Michael
- Hughes Caitriona
- Hupp Ted R.
- Igali Laszlo
- Jammula Sriganesh
- Katz-Summercorn Annalise
- Kaye Philip
- Khoo David
- Kumar Bhaskar
- Lagergren Jesper
- Lewis Mike
- Li Xiaodun
- Lishman Suzy
- Loureda Daniel
- Lovat Laurence
- Lynch Andy G.
- MacRae Shona
- Mahadeva Ula
- Malhotra Shalini
- McManus Damian
- Miremadi Ahmad
- Moorthy Krishna
- Mourikis Thanos P.
- Noorani Ayesha
- Northrop Alex
- Nulsen Joel
- Nutzinger Barbara
- Oakes Sarah
- Old Oliver
- O’Donovan Maria
- Parsons Simon L.
- Perner Juliane
- Peters Christopher J.
- Preston Shaun R.
- Puig Sonia
- Robert O’Neill J.
- Safranek Peter
- Sanders Grant
- Saunders John
- Save Vicki
- Scaffidi Paola
- Scott Michael
- Secrier Maria
- Sharrocks Andrew
- Shepherd Neil
- Skipworth Richard J. E.
- Soomro Irshad
- Sothi Sharmila
- Sujendran Vijayendran
- Suortamo Sari
- Taniere Philippe
- Tavaré Simon
- Temelkovski Damjan
- Tripathi Monika
- Tucker Olga
- Turkington Richard
- Underwood Timothy J.
- Walker Robert C.
- Yau Christopher
- Zylstra Janine
- Publication venue
- Nature Communications
- Publication date
- 14/07/2020
- Field of study
Abstract: The identification of cancer-promoting genetic alterations is challenging particularly in highly unstable and heterogeneous cancers, such as esophageal adenocarcinoma (EAC). Here we describe a machine learning algorithm to identify cancer genes in individual patients considering all types of damaging alterations simultaneously. Analysing 261 EACs from the OCCAMS Consortium, we discover helper genes that, alongside well-known drivers, promote cancer. We confirm the robustness of our approach in 107 additional EACs. Unlike recurrent alterations of known drivers, these cancer helper genes are rare or patient-specific. However, they converge towards perturbations of well-known cancer processes. Recurrence of the same process perturbations, rather than individual genes, divides EACs into six clusters differing in their molecular and clinical features. Experimentally mimicking the alterations of predicted helper genes in cancer and pre-cancer cells validates their contribution to disease progression, while reverting their alterations reveals EAC acquired dependencies that can be exploited in therapy
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.
- Author
- A Sarah Walker
- Abid Hussain
- Abiola Alli
- Abraham Gihawi
- Achyut Guleri
- Achyut Guleri
- Adam Jeans
- Adam Lewszuk
- Adam Mohamoodally
- Adam Wolstencroft
- Adele Marshall
- Adetunji Adedayo
- Adrian Lyons
- Agnieszka Skotnicka
- Ahalya Malachira
- Aiden Plant
- Alaric Colville
- Alex Chrdle
- Alex Peel
- Alex Szubert
- Alexander Szubert
- Ali Vaughn
- Alisha Beddoe
- Alison Eyre
- Alison Fair
- Alison Porges
- Alison Potter
- Alison Stolton
- Amanda Fife
- Amanda Moran
- Amandip Sahota
- Amita Patel
- Amy Driffill
- Amy Janvier
- Amy Murray
- Ana de Veciana
- Andrea Boyce
- Andree Evans
- Andrew Conbeer
- Andrew Flatt
- Andrew Potter
- Andrew Rosser
- Angela Cape
- Angela Dunne
- Angela Houston
- Angela King
- Angela McCadden
- Angela Parkin
- Ann Sarah Walker
- Anna L Goodman
- Anna McSkeane
- Anna Reyes
- Anna Sweeney
- Anne Anderson
- Anne Clarke
- Anthony Donnelly
- Antonia Scobie
- Antonio Querol-Rubiera
- Aodhan Breathnach
- Asha Mathews
- Atul Kotecha
- Avril Masdin
- Ayodele Ajayi
- Bala Subramanian
- Belinda Romans
- Ben Marks
- Benjamin Jeffs
- Bernadette Cook
- Bernadette Young
- Bernadette Young
- Bev Warner
- Bijal Patel
- Boingotlo Masake
- Brooke Jackson
- Cariad Evan
- Carlene Rowson
- Carlos Díaz-Montaña
- Carmen Cantell
- Carol Brooks
- Carole McPherson
- Caroline Andrews
- Caroline Bedford
- Caroline Renton
- Carolyn Hemsley
- Carrie Ridley
- Catherine Aldridge
- Charley Higham
- Charlote Armer
- Charlotte Eglinton
- Charlotte Gibbs
- Charlotte Russell
- Cherrelle de Souza
- Cheryl Bailey
- Chi Kai Tam
- Chi Kai Tam
- Chiara Borg
- Chris Brewer
- Chris Smalley
- Christop Lohan
- Christopher Sim
- Claire Keatley
- Claire Williams
- Clare Hamson
- Clare Hutchison
- Clare James
- Clare Tarbotton
- Clive Graham
- Clive Graham
- Colin Brown
- Colin Walker
- Cordelia Watson
- Cressida Auckland
- Cressida Auckland
- Cristina Suarez
- Dai Griffiths
- Dakshika Jeyaratnam
- Dakshika Jeyaratnam
- Damien Mack
- Damilola Otiko
- Daniel Greaves
- Daniela Shackcloth
- Dave Osborne
- David A Price
- David Ashley Price
- David Chadwick
- David Harvey
- David Harvey
- Debbie Johnson
- Deborah Gilliam
- Deepa Nayar
- Denise Ward
- Denise Ward
- Diane Swift
- Dominika Wlazly
- Donna Palmer
- Duncan Wyncoll
- Ed Moran
- Edmund Ong
- Efisia Sais
- Elaine Strachan
- Elen Witness
- Elian Liu
- Elizabeth Foote
- Elizabeth Woodford
- Ella Foncel
- Ellen Adams
- Emily Hetherington
- Emma Folland
- Emma Foreman
- Emma Lawrence
- Emma Moore
- Emmanuel Nsutebu
- Emmanuel Nsutebu
- Faith Okhuoya
- Fiona Walters
- Fleur Hudson
- Fleur Hudson
- Fozia Ahmad
- Gagan Kaler
- Gavin Barlow
- Gavin Barlow
- Gaynor Notcheva
- Gayti Islam
- Gemma Pill
- Geoffrey Howell
- Georgina Shaw
- Giordana Sorrentino
- Gonzalez-Ruiz Armando
- Graham FitzGerald
- Gus Cardoso
- Guy E Thwaites
- Guy Thwaites
- Hannah Allsop
- Hannah Crowther
- Hannah Gott
- Helen Chesterfield
- Helen Fairlamb
- Helen Preedy
- Helen Reynolds
- Helen Vassallo
- Helen Webb
- Helen Wilson
- Helen Winslow
- Helen Wooldridge
- Helena Bond
- Helena White
- Hesther Wilson
- Hezron Greaves
- Hilary Pateman
- Holly Burton
- Ilias Mariolis
- Ines De Abreu
- Ingrid Emmerson
- Isobel Ramsay
- Jack Briggs
- Jackie Westcott
- James Calderwood
- James Fellows
- James Meiring
- James Millard
- James Price
- Jane Cunningham
- Jane Minton
- Jane Minton
- Jane Thompson
- Janet Andrews
- Janet Cairns
- Janet Cairns
- Janet Middle
- Janine Gradwell
- Jason Biswas
- Jason Howard
- Jason Wong
- Jennifer Fitzpatrick
- Jennifer Fitzpatrick
- Jennifer Harrison
- Jess Mandiza
- Jill Deane
- Jill Lyons
- Jim Anson
- Jo Studham
- Joanna Allen
- Joanna Flanagan
- Joanne Gordon
- Joanne Malkin
- Joanne Thorpe
- Joanne Williams
- Joby Cole
- John Humphries
- John Paul
- John Sloss
- John Widdrington
- John Williams
- John Williams
- Jonathan D Edgeworth
- Jonathan D Edgeworth
- Jonathan Folb
- Jonathan Wilson
- Jordan Ewing
- Joseph Lewis
- Josephine Marange
- Judith Chapman
- Judith Platt
- Judy Sercombe
- Julia Greig
- Julia Greig
- Julia Halpin
- Julian Sutton
- Julian Sutton
- Julie Frudd
- Julie Mitchell
- Julie Sorrell
- Karen Bisnauthsing
- Karen Brookes
- Karen Martin
- Kate Ellis
- Kate Maitland
- Kate Maloney
- Kate Ripalda
- Katherine Cullen
- Katherine Curley
- Katherine Pagett
- Kathryn Birchall
- Kathryn Louise Taylor
- Kathryn Potts
- Katie Wilkins
- Katy Marden
- Katy Moore
- Keith Yip
- Kelly Attack
- Kevin Cole
- Kim Cox
- Kim Ryalls
- Kirandip Mandar
- Kirsty Baillie
- Kirsty Gladas
- Kristian Warnes
- Kristine Criste
- Laura Behar
- Laura Butland
- Laura Latter
- Laura Makey
- Laura O'Neil
- Laura Ortiz-Ruiz de Gordoa
- Laura Shewan
- Laura Watson
- Leanne Carwithen
- Leanne Galloway-Browne
- Leila Bahadur
- Lemonia Ftika
- Lenka Strakova
- Leon Peto
- Leona Trainor
- Leona Yabsley
- Lesley Rigden
- Leslie Masters
- Lewis Jones
- Li-An Brown
- Lillian Tsang
- Linda March
- Lindsey Masters
- Lisa Burgess
- Lisa Hurley
- Lizzie Roberts
- Lois Mlemba
- Louise Barrett
- Louise Robinson
- Louise Wright
- Luis Cotter
- Luke Anson
- Luke Bedford
- Lydia Rylance-Knight
- Lynne Smart
- Lynne Whitehead
- Lynsey Goodwin
- Lynsey Stephenson
- M Estee Török
- M Estée Török
- Maggie Cole
- Maggie Kalita
- Manish Pareek
- Manju Joy
- Manuel Fenech
- Maria Edwards
- Maria Hayes
- Maria Nadolski
- Marie-Claire Hoyle
- Marie-Claire West
- Marina Morgan
- Mark Bolton
- Mark Wallis
- Martin J Llewelyn
- Martin Llewelyn
- Martin Wiselka
- Martin Wiselka
- Martyn Cain
- Mary Wands
- Matthew Scarborough
- Matthew Scarborough
- Maxine Hough
- Mazhar Alam
- Mel Baxter
- Melanie Ekani
- Melanie Harrison
- Melanie Hutchings
- Melinda Munang
- Melody Smith
- Michael Ankcorn
- Michelle A Graver
- Michelle Wood
- Mike Marner
- Miranda Kean
- Mirriam Sangombe
- Muge Cevik
- Musa Kamfose
- N Claire Gordon
- Nadine Abberley
- Natalia Waddington
- Naval Vyse
- Neil Jenkins
- Neil Jenkins
- Neil Stone
- Nicholas Beeching
- Nicola Claire Gordon
- Nicola Ridley
- Nicola Smith
- Nicolas Cortes
- Nisa Khan
- Noah Yogo
- Orla Brady
- Pankaj Lal
- Pankaj Lal
- Paul Chadwick
- Paul Jones
- Paul McWhinney
- Paul McWhinney
- Paul R Chadwick
- Paul Roberts
- Paula Harlow
- Paula Sharratt
- Pauline Lambert
- Pavithra Natarajan
- Peter Flegg
- Peter Moss
- Peter Wilson
- Peter Wilson
- Polly Tarrant
- Rachel Abrahams
- Rachel Austin-Hutchison
- Rachel Bousfield
- Rachel Vincent
- Rahul Kurup
- Rajesh Jarghese
- Rakhee Chahuan
- Rasha Said
- Rashmi Sharma
- Rebecca B Saunderson
- Rebecca Palmer
- Rebecca Tagney
- Rebecca Warren
- Reni Jacob
- Richard Bellamy
- Richard Cunningham
- Richard Nendick
- Rob Porter
- Rob Wosley
- Robert Porter
- Robert Reed
- Robert Tilley
- Robert Tilley
- Roderick Balancio-Tolentino
- Rosie Fok
- Rosie Fok
- Ruth Millett
- Ruth Moroney
- Saadia Rahman
- Saba Qaiser
- Sally Batham
- Samantha Crossman
- Sani Aliyu
- Sanuki Perera
- Sara Taiyari
- Sarah A Wyllie
- Sarah Birchall
- Sarah Dyas
- Sarah Glover
- Sarah Meisner
- Sarah Meisner
- Sarah Moll
- Sarah Rippon
- Sarah Stevenson
- Sarah Thornthwaite
- Sarah Wyllie
- Scott Prentice
- Sebastien Martin
- Senait Haile
- Sephora Shaw
- Sergio Muñoz-Villaverde
- Sharon Sheehan
- Shirley Cooper
- Shirley Todd
- Shona Hughes
- Simon Matthews
- Simon Warren
- Sophie Collier
- Sophie Whiteley
- Stacey Donaldson
- Stacey Valentine
- Stephen Booth
- Stephen Coleman
- Stephen K Glass
- Stephen Mepham
- Stephen Morris-Jones
- Sue Kimachia
- Sue Williams
- Suryabrata Banerjee
- Susan Hopkins
- Susan Hopkins
- Susan Lord
- Suzanne Price
- Tamara Mitchell
- Tamika Chapter
- Tat Yam
- Tenessa Sargent
- Teresa Pettifer
- Theodore Gouliouris
- Tim Kemp
- Tim Planche
- Tim Planche
- Tina Burdett
- Tiphanie Clarke
- Tracey Dobson
- Tracey Mynes
- Tracey Platt
- Tracy Matheson-Smith
- Tristan Clark
- Una Poultney
- Veena Raviprakash
- Veenu Kollipara
- Vicki Lowthorpe
- Vicky Chu
- Victoria Dean
- Vusumuzi Shabangu
- Weronika Szypura
- Yvonne Jackson
- Zaheer Islam
- Zoe Martin
- Zoe Prime
- Zoe Swann
- Publication venue
- Lancet
- Publication date
- 14/12/2017
- Field of study
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment
Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
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- Upadhyaya Vijaid
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- Wijayarathna LS
- Williams Omolara
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- Wilson Michael
- Wilson Michael
- Wimalge PMSN
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- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world.
Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231.
Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001).
Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
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- Hall Alistair S
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- Krishnamurthy Vinodh
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- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
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- McPherson Duncan
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- Meead Adullah
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- Mengesha Mengistu G.
- Menna Maria Paola
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- Nabil Fatma
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- Nacion Aeris Jane D.
- Nadi Khaldoun
- Naegele Felix
- Naga Hani
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- Nanjiani Deedar
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- Nassar Mahmoud A.
- Nasser Sara
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- Natale Joseph
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- Newman Samuel
- Ngaserin Sabrina
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- Niewiera Marc
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- Nikolouzakis Taxiarchis
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- Ntalouka Maria P.
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- Olson Kristofor A.
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- Panahi Pedram
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- Piozzi Guglielmo Niccolò
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- Punjabi Prakash P
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- Purich Kieran
- Pérez Beatriz Gómez
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- Qader Kawthar
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- Querney Jill
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- Rauf Umme Habiba Abdul
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- Rezende Ricardo Fernandes
- Rhomberg Thomas
- Ribeiro João
- Riccetti Camilla
- Richard H.
- Rickard Jennifer
- Rincón Natalia Andrea Rivera
- Ripollés-Melchor Javier
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- Rodríguez Lorena Varela
- Rokohl Alexander Christopher
- Roland Christina L
- Rolinger Jens
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- Sabbagh Abdulrahman J.
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- Santoshi John Ashutosh
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- Saracoglu Ayten
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- Sayyed Raza
- Scabini Stefano
- Scacchi Andrea
- Scafa Anthony Kevin
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- Scaravilli Luca
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- Sodhai Vivek
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- Soljic Martina
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- Stoleriu Mircea Gabriel
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- Su Yu-Xiong
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- Subramani Yamini
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- Sue-Chue-Lam Colin
- Suer Muhammed Salih
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- Sultania Mahesh
- Sundarraju Shalini
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- Wafi Omar
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- Watcyn-Jones Tom
- Waterson Ben
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- Watson Matthew
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- Wheldon Luke
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- Williams Shekinah
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- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
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- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries