19 research outputs found
Depletion-mode Quantum Dots in Intrinsic Silicon
- Author
- Publication venue
- 'AIP Publishing'
- Publication date
- 08/01/2018
- Field of study
We report the fabrication and electrical characterization of depletion-mode
quantum dots in a two-dimensional hole gas (2DHG) in intrinsic silicon. We use
fixed charge in a SiO2â/Al2âO3â dielectric stack to induce a 2DHG at the
Si/SiO2â interface. Fabrication of the gate structures is accomplished with a
single layer metallization process. Transport spectroscopy reveals regular
Coulomb oscillations with charging energies of 10-15 meV and 3-5 meV for the
few- and many-hole regimes, respectively. This depletion-mode design avoids
complex multilayer architectures requiring precision alignment, and allows to
adopt directly best practices already developed for depletion dots in other
material systems. We also demonstrate a method to deactivate fixed charge in
the SiO2â/Al2âO3â dielectric stack using deep ultraviolet light, which
may become an important procedure to avoid unwanted 2DHG build-up in Si MOS
quantum bits.Comment: Accepted to Applied Physics Letters. 5 pages, 3 figure
Mutation Detection in Patients with Retinal Dystrophies Using Targeted Next Generation Sequencing
- Author
- A Beryozkin
- A Estrada-Cuzcano
- A Rivera
- AI den Hollander
- AJ Lotery
- AK Mayer
- AM Payne
- Andreas R. Janecke
- Anja K. Mayer
- Antje Bernd
- B Almoguera
- BalĂĄzs VarsĂĄnyi
- Bernd Wissinger
- C Vaché
- Charlotte M. Reiff
- Christian P. Hamel
- Christina Kamme
- CL Freund
- David G. Birch
- E Boulanger-Scemama
- E Shevach
- EM Sankila
- Erdmute Kunstmann
- F Coppieters
- F Wang
- GĂŒnther Rudolph
- H Li
- H Li
- HB Steele-Stallard
- I Perrault
- I Perrault
- J Neidhardt
- J Song
- JD Churchill
- JD Marshall
- JM Rozet
- John R. Heckenlively
- K White
- K Ye
- Klaus Rohrschneider
- KM Bujakowska
- L Zhao
- LS Sullivan
- M Akahori
- M Bauwens
- M Corton
- M Hebrard
- M Schmidts
- M Shan
- M Xu
- Max Schubach
- N Glöckle
- Nicola Glöckle
- Nicole Weisschuh
- P Le Quesne Stabej
- Pietro Maffei
- R Allikmets
- R Tan
- R Vervoort
- RA Lewis
- Richard G. Weleber
- Rita VĂĄmos
- RK OzgĂŒl
- RK OzgĂŒl
- S Gu
- S Hipp
- S Kohl
- S Roosing
- Samuel G. Jacobson
- SH Almal
- SH Lelieveld
- Sten Andreasson
- Susanne Kohl
- T Eisenberger
- T Naruto
- T Rio Frio
- TA Braun
- Thomas Rosenberg
- Tim M. Strom
- TP Dryja
- TY Lai
- Ulrich Kellner
- V Plagnol
- W Jaeger
- XF Huang
- Z Yang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2016
- Field of study
Retinal dystrophies (RD) constitute a group of blinding diseases that are characterized by clinical variability and pronounced genetic heterogeneity. The different nonsyndromic and syndromic forms of RD can be attributed to mutations in more than 200 genes. Consequently, next generation sequencing (NGS) technologies are among the most promising approaches to identify mutations in RD. We screened a large cohort of patients comprising 89 independent cases and families with various subforms of RD applying different NGS platforms. While mutation screening in 50 cases was performed using a RD gene capture panel, 47 cases were analyzed using whole exome sequencing. One family was analyzed using whole genome sequencing. A detection rate of 61% was achieved including mutations in 34 known and two novel RD genes. A total of 69 distinct mutations were identified, including 39 novel mutations. Notably, genetic findings in several families were not consistent with the initial clinical diagnosis. Clinical reassessment resulted in refinement of the clinical diagnosis in some of these families and confirmed the broad clinical spectrum associated with mutations in RD genes
Burden of disease scenarios for 204 countries and territories, 2022â2050: a forecasting analysis for the Global Burden of Disease Study 2021
- Author
- Ababneh Hazim S
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbasgholizadeh Rouzbeh
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd Al Magied Abdallah H A
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelkader Atef
- Abdelmasseh Michael
- Abdi Parsa
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abebe Mesfin
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Aboye Girma Beressa
- Abreu Lucas GuimaraÌes
- Absalan Abdorrahim
- Abualruz Hasan
- Abubakar Bilyaminu
- Abukhadijah Hana Jihad Jihad
- Addolorato Giovanni
- Adekanmbi Victor
- Adetunji Charles Oluwaseun
- Adetunji Juliana Bunmi
- Adeyeoluwa Temitayo Esther
- Adha Rishan
- Adhikary Ripon Kumar
- Adnani Qorinah Estiningtyas Sakilah
- Adzigbli Leticia Akua
- Afrashteh Fatemeh
- Afzal Muhammad Sohail
- Afzal Saira
- Agbozo Faith
- Agodi Antonella
- Agrawal Anurag
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahlstrom Austin J
- Ahmad Aqeel
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Sajjad
- Ahmad Shahzaib
- Ahmed Anisuddin
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Safoora
- Ahmed Syed Anees
- Akinosoglou Karolina
- Akkaif Mohammed Ahmed
- Akrami Ashley E
- Akter Ema
- Al Awaidy Salah
- Al Hasan Syed Mahfuz
- Al Mosa Amjad S
- Al Ta'ani Omar
- Al Zaabi Omar Ali Mohammed
- Al-Ajlouni Yazan
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Ibraheem Akram
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
- Al-Tammemi Ala'a B.
- Al-Tawfiq Jaffar A
- Al-Wardat Mohammad Sami
- Al-Worafi Yaser Mohammed
- Al-Zyoud Walid
- Alahdab Fares
- Alajlani Muaaz M
- Alalalmeh Samer O
- Alam Khurshid
- Alam Noore
- Alam Tahiya
- Alam Zufishan
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albakri Almaza
- Aldhaleei Wafa A
- Aldridge Robert W
- Alemohammad Seyedeh Yasaman
- Alemu Yihun Mulugeta
- Ali Abid
- Ali Amjad
- Ali Iman
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Victor Ekoche
- Ali Waad
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aljunid Syed Mohamed
- Alla François
- Almazan Joseph Uy
- Alqutaibi Ahmed Yaseen
- Alrawashdeh Ahmad
- Alrousan Sahel Majed
- Alsabri Mohammed A
- Altaany Zaid
- Altirkawi Khalid A
- Aluh Deborah Oyine
- Alvis-Guzman Nelson
- Aly Hany
- Alyahya Mohammad Sharif
- Alzoubi Karem H
- Amani Reza
- Ameyaw Edward Kwabena
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amugsi Dickson A
- Ancuceanu Robert
- Anderlini Deanna
- Anderson David B
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Andrews Erick Adrian
- Anil Abhishek
- Anil Sneha
- Anoushiravani Amir
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Boluwatife Stephen
- Anvari Saeid
- Anyasodor Anayochukwu Edward
- Appiah Francis
- Aquilano Michele
- Arab Juan Pablo
- Arabloo Jalal
- Arafa Elshaimaa A
- Arafat Mosab
- Aravkin Aleksandr Y
- Ardekani Ali
- Areda Demelash
- Aregawi Brhane Berhe
- Aremu Abdulfatai
- Ariffin Hany
- Arkew Mesay
- Armani Keivan
- Artamonov Anton A
- Arumugam Ashokan
- Asghari-Jafarabadi Mohammad
- Ashbaugh Charlie
- Astell-Burt Thomas
- Athari Seyyed Shamsadin
- Atorkey Prince
- Atout Maha Moh'd Wahbi
- Aujayeb Avinash
- Ausloos Marcel
- Awad Hamzeh
- Awotidebe Adedapo Wasiu
- Ayatollahi Haleh
- Ayuso-Mateos Jose L
- Azadnajafabad Sina
- Azeez Fahad Khan
- Azevedo Rui M S
- Badar Muhammad
- Baghdadi Soroush
- Bagheri Mahboube
- Bagheri Nasser
- Bai Ruhai
- Baker Jennifer L
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Balcha Wondu Feyisa
- Baltatu Ovidiu Constantin
- Barchitta Martina
- Bardideh Erfan
- Barker-Collo Suzanne Lyn
- Barqawi Hiba Jawdat
- Barteit Sandra
- Basiru Afisu
- Basso JoaÌo Diogo
- Bastan Mohammad-Mahdi
- Basu Sanjay
- Bauckneht Matteo
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- BaÌrnighausen Till Winfried
- Behnoush Amir Hossein
- Behzadi Payam
- Beiranvand Maryam
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bemanalizadeh Maryam
- Bensenor Isabela M
- Benzian Habib
- Beran Azizullah
- Berezvai Zombor
- Bernstein Robert S
- Bettencourt Paulo J G
- Beyene Kebede A
- Beyene Melak Gedamu
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhandari Dinesh
- Bharadwaj Ravi
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhattacharjee Natalia V
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhuiyan Mohiuddin Ahmed
- Bisignano Catherine
- Biswas Bijit
- BjĂžrge Tone
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bonakdar Hashemi Milad
- Bora Basara Berrak
- Borhany Hamed
- Bosoka Samuel Adolf
- Botero Carvajal Alejandro
- Bouaoud Souad
- Boufous Soufiane
- Boxe Christopher
- Boyko Edward J
- Brady Oliver J
- Braithwaite Dejana
- Brauer Michael
- Brazo-Sayavera Javier
- Brenner Hermann
- Brown Colin Stewart
- Browne Annie J
- Brugha Traolach
- Bryazka Dana
- Bulamu Norma B
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Busse Reinhard
- Bustanji Yasser
- Butt Zahid A
- Caetano dos Santos Florentino Luciano
- Calina Daniela
- Campos Luciana Aparecida
- Cao Shujin
- Capodici Angelo
- Carreras Giulia
- Carugno Andrea
- Carvalho MaÌrcia
- Castaldelli-Maia Joao Mauricio
- Castelpietra Giulio
- Cattaruzza Maria Sofia
- Caye Arthur
- CaÌrdenas Rosario
- Cegolon Luca
- Cembranel Francieli
- Cenko Edina
- Cerin Ester
- Chadban Steven J
- Chadwick Joshua
- Chakraborty Chiranjib
- Chakraborty Sandip
- Chalek Julian
- Chan Jeffrey Shi Kai
- Chandika Rama Mohan
- Chandy Sara
- Charan Jaykaran
- Chaudhary Anis Ahmad
- Chaurasia Akhilanand
- Chen An-Tian
- Chen Haowei
- Chen Meng Xuan
- Chen Simiao
- Cherbuin Nicolas
- Chi Gerald
- Chichagi Fatemeh
- Chimed-Ochir Odgerel
- Chimoriya Ritesh
- Ching Patrick R
- Chirinos-Caceres Jesus Lorenzo
- Chitheer Abdulaal
- Cho Daniel Youngwhan
- Cho William C S
- Choi Dong-Woo
- Chong Bryan
- Chong Chean Lin
- Chopra Hitesh
- Chu Dinh-Toi
- Chung Eric
- Chutiyami Muhammad
- Clayton Justin T
- Cogen Rebecca M
- Cohen Aaron J
- Columbus Alyssa
- Comfort Haley
- Conde Joao
- Connolly Jon T
- Cooper Ezra E K
- Cortese Samuele
- Cruz-Martins NataÌlia
- Çakmak Barsbay Mehtap
- D'Oria Mario
- da Silva Alanna Gomes
- Dadras Omid
- Dai Xiaochen
- Dai Zhaoli
- Dalton Bronte E
- Damiani Giovanni
- Dandona Lalit
- Dandona Rakhi
- Das Jai K
- Das Saswati
- Das Subasish
- Dash Nihar Ranjan
- Davletov Kairat
- De la Hoz Fernando Pio
- De Leo Diego
- Debopadhaya Shayom
- Delgado-Enciso Ivan
- Denova-GutieÌrrez Edgar
- Dervenis Nikolaos
- Desai Hardik Dineshbhai
- Devanbu Vinoth Gnana Chellaiyan
- Dewan Syed Masudur Rahman
- Dhama Kuldeep
- Dhane Amol S
- Dhingra Sameer
- Dias da Silva Diana
- Diaz Daniel
- Diaz Luis Antonio
- Diaz Michael J
- Dima Adriana
- Ding Delaney D
- do Prado Camila Bruneli
- Do Thao Huynh Phuong
- Dodangeh Masoud
- Dodangeh Milad
- Doegah Phidelia Theresa
- Dohare Sushil
- Dong Wanyue
- Doshi Rajkumar
- Dowou Robert Kokou
- Dsouza Haneil Larson
- Dsouza Viola
- Dube John
- Dumith Samuel C
- Duncan Bruce B
- Duraes Andre Rodrigues
- Duraisamy Senbagam
- Durojaiye Oyewole Christopher
- Dushpanova Anar
- Dutta Sulagna
- Dzianach Paulina Agnieszka
- Dziedzic Arkadiusz Marian
- Eboreime Ejemai
- Ebrahimi Kalan Mohammad
- Ebrahimi Alireza
- Edinur Hisham Atan
- Efendi Ferry
- Eikemo Terje Andreas
- Eini Ebrahim
- Ekundayo Temitope Cyrus
- El Arab Rabie Adel
- El Sayed Iman
- Elamin Osman
- Elemam Noha Mousaad
- ElGohary Ghada Metwally Tawfik
- Elhadi Muhammed
- Elmeligy Omar Abdelsadek Abdou
- Elmoselhi Adel B
- Elshaer Mohammed
- Elsohaby Ibrahim
- Eltahir Mohd. Elmagzoub
- Emeto Theophilus I
- Eshrati Babak
- Eslami Majid
- Esmaeili Zahra
- Fabin Natalia
- Fagbamigbe Adeniyi Francis
- Fagbule Omotayo Francis
- Falzone Luca
- Fareed Mohammad
- Farinha Carla Sofia e SaÌ
- Faris MoezAlIslam Ezzat Mahmoud
- Faro Andre
- Fasihi Kiana
- Fatehizadeh Ali
- Fauk Nelsensius Klau
- Fazylov Timur
- Feigin Valery L
- Fekadu Ginenus
- Feng Xiaoqi
- Fereshtehnejad Seyed-Mohammad
- Ferrara Pietro
- Ferreira Nuno
- Firew Belete Sewasew
- Fischer Florian
- Fitriana Ida
- Flavel Joanne
- Flor Luisa S
- Folayan Morenike Oluwatoyin
- Foley Kristen Marie
- Fonzo Marco
- Force Lisa M
- Foschi Matteo
- Freitas Alberto
- Fridayani Ni Kadek Yuni
- Fukutaki Kai Glenn
- Furtado JoaÌo M
- Fux Blima
- Gaal Peter Andras
- Gadanya Muktar A
- Gallus Silvano
- Ganesan Balasankar
- Ganiyani Mohammad Arfat
- Gautam Rupesh K
- Gebi Tilaye Gebru
- Gebregergis Miglas W
- Gebrehiwot Mesfin
- Getacher Lemma
- Getahun Genanew K A
- Gething Peter W
- Ghadimi Delaram J
- Ghadirian Fataneh
- Ghafarian Sadegh
- Ghailan Khalid Yaser
- Ghasemi MohammadReza
- Ghasempour Dabaghi Ghazal
- Ghazy Ramy Mohamed
- Ghoba Sama
- Gholami Ehsan
- Gholamrezanezhad Ali
- Gholizadeh Nasim
- Ghorbani Vajargah Pooyan
- Ghorbani Mahsa
- Ghotbi Elena
- Gil Artyom Urievich
- Gill Tiffany K
- Girmay Alem
- Glasbey James C
- Glushkova Ekaterina Vladimirovna
- Gnedovskaya Elena V
- Goldust Mohamad
- Goleij Pouya
- Golinelli Davide
- Gopalani Sameer Vali
- Goulart Alessandra C
- Gouravani Mahdi
- Goyal Anmol
- GoÌboÌloÌs Laszlo
- Grivna Michal
- Grosso Giuseppe
- Guarducci Giovanni
- Gubari Mohammed Ibrahim Mohialdeen
- Guicciardi Stefano
- GuimaraÌes Rafael Alves
- Gulati Snigdha
- Gulisashvili David
- Gunawardane Damitha Asanga
- Guo Cui
- Gupta Anish Kumar
- Gupta Rahul
- Gupta Rajeev
- Gupta Renu
- Gupta Sapna
- Gupta Vijai Kumar
- Haakenstad Annie
- Hadi Najah R
- Haep Nils
- Hafiz Abdul
- Haghmorad Dariush
- Haile Demewoz
- Haj-Mirzaian Arvin
- Hajj Ali Adel
- Hajj Ali Ali
- Halboub Esam S
- Haller Sebastian
- Halwani Rabih
- Hamagharib Abdullah Kanaan
- Hamdy Nadia M
- Hamoudi Rifat
- Hanifi Nasrin
- Hankey Graeme J
- Haq Zaim Anan
- Haque Md Rabiul
- Harapan Harapan
- Hargono Arief
- Haro Josep Maria
- Hasaballah Ahmed I
- Hasan S. M. Mahmudul
- Hasanian Mohammad
- Hasnain Md Saquib
- Hassan Amr
- Haubold Johannes
- Hay Simon I
- Hebert Jeffrey J
- Hegazi Omar E
- Heidari Mohammad
- Hemmati Mehdi
- Henson Claire A
- Herrera-Serna Brenda Yuliana
- Herteliu Claudiu
- Heydari Majid
- Hezam Kamal
- Hidayana Irma
- Hiraike Yuta
- Hoan Nguyen Quoc
- Holla Ramesh
- Hoogar Praveen
- Horita Nobuyuki
- Hossain Md Mahbub
- Hosseinzadeh Hassan
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Hu Chengxi
- Huang Junjie
- HultstroÌm Michael
- Hundie Tsegaye Gebreyes
- Hunt Aliza J
- Hushmandi Kiavash
- Hussain Javid
- Hussain M. Azhar
- Hussein Nawfal R
- Huynh Hong-Han
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Iftikhar Pulwasha Maria
- Ikiroma Adalia I
- Ikwegbue Paul Chukwudi
- Ilic Irena M
- Ilic Milena D
- Immurana Mustapha
- Isa Mustafa Alhaji
- Islam Md. Rabiul
- Islam Sheikh Mohammed Shariful
- Ismail Faisal
- Ismail Nahlah Elkudssiah
- Isola Gaetano
- Iwagami Masao
- Iyamu Ihoghosa Osamuyi
- Jacob Louis
- Jacobsen Kathryn H
- Jafarinia Morteza
- Jahankhani Kasra
- Jahanmehr Nader
- Jain Nityanand
- Jairoun Ammar Abdulrahman
- Jakhmola Mani Dr Ruchi
- Jamil Safayet
- Jamora Roland Dominic G
- Jatau Abubakar Ibrahim
- Javadov Sabzali
- Javaheri Tahereh
- Jayaram Shubha
- Jee Sun Ha
- Jeganathan Jayakumar
- Jiang Heng
- Jokar Mohammad
- Jonas Jost B
- Joseph Nitin
- Joshua Charity Ehimwenma
- JuÌrisson Mikk
- K Vaishali
- Kabir Ali
- Kabir Zubair
- Kadashetti Vidya
- Kalankesh Laleh R
- Kalra Sanjay
- Kamath Ashwin
- Kamath Rajesh
- Kamireddy Arun
- Kanaan Mona
- Kanchan Tanuj
- Kanmiki Edmund Wedam
- Kanmodi Kehinde Kazeem
- Kansal Sushil Kumar
- Karim Asima
- Karkhah Samad
- Kashoo Faizan Zaffar
- Kasraei Hengameh
- Kassel Molly B
- Katikireddi Srinivasa Vittal
- Kauppila Joonas H
- Kaur Harkiran
- Kayode Gbenga A
- Kazemi Foad
- Kazemian Sina
- Kebede Fassikaw
- Kendal Evie Shoshannah
- Kesse-Guyot Emmanuelle
- Khademvatan Shahram
- Khajuria Himanshu
- Khalaji Amirmohammad
- Khalid Asaad
- Khalid Nauman
- Khalilian Alireza
- Khamesipour Faham
- Khan Fayaz
- Khan Mohammad Jobair
- Khan Moien AB
- Khanmohammadi Shaghayegh
- Khatab Khaled
- Khatatbeh Haitham
- Khatatbeh Moawiah Mohammad
- Khatib Mahalaqua Nazli
- Khayat Kashani Hamid Reza
- Kheirallah Khalid A
- Khokhar Manoj
- Khormali Moein
- Khorrami Zahra
- Khosla Atulya Aman
- Khosravi Majid
- Khosrowjerdi Mahmood
- Khubchandani Jagdish
- Kifle Zemene Demelash
- Kim Grace
- Kim Julie Sojin
- Kim Min Seo
- Kim Yun Jin
- Kimokoti Ruth W
- Kisa Adnan
- Kisa Sezer
- Knibbs Luke D
- Knudsen Ann Kristin Skrindo
- Kochhar Sonali
- Kolahi Ali-Asghar
- Kompani Farzad
- Koren Gerbrand
- Korzh Oleksii
- Krishan Kewal
- Krishna Varun
- Krishnamoorthy Vijay
- Kucuk Bicer Burcu
- Kuddus Md Abdul
- Kuddus Mohammed
- Kuitunen Ilari
- Kujan Omar
- Kulimbet Mukhtar
- Kulkarni Vishnutheertha
- Kumar G Anil
- Kumar Harish
- Kumar Nithin
- Kumar Rakesh
- Kumar Vijay
- Kundu Amartya
- Kusuma Dian
- Kyei-Arthur Frank
- KytoÌ Ville
- Kyu Hmwe Hmwe
- La Vecchia Carlo
- Lacey Ben
- Ladan Muhammad Awwal
- Laflamme Lucie
- Lahariya Chandrakant
- Lai Daphne Teck Ching
- Lalloo Ratilal
- Lallukka Tea
- Lan Qing
- Lan Tuo
- Landires IvaÌn
- Lanfranchi Francesco
- Langguth Berthold
- Lansingh Van Charles
- Laplante-LeÌvesque Ariane
- Larijani Bagher
- Larsson Anders O
- Lasrado Savita
- Lauriola Paolo
- Lawlor Hilary R
- LaÌm Judit
- Le Huu-Hoai
- Le Long Khanh Dao
- Le Nhi Huu Hanh
- Le Thao Thi Thu
- Le Trang Diep Thanh
- Leasher Janet L
- Lee Doo Woong
- Lee Munjae
- Lee Paul H
- Lee Sang-woong
- Lee Seung Won
- Lee Shaun Wen Huey
- Lee Yo Han
- Leigh James
- Leong Elvynna
- Li Ming-Chieh
- Libra Massimo
- Ligade Virendra S
- Lim Lee-Ling
- Lim Stephen S
- Limenh Liknaw Workie
- Lindholm Daniel
- Lindstedt Paulina A
- Listl Stefan
- Liu Gang
- Liu Shiwei
- Liu Shuke
- Liu Xiaofeng
- Liu Xuefeng
- Llanaj Erand
- Loreche Arianna Maever
- Lotufo Paulo A
- Lozano Rafael
- LoÌpez-Bueno RubeÌn
- LoÌpez-Gil JoseÌ Francisco
- Lubinda Jailos
- Lucchetti Giancarlo
- Luo Lisha
- Lusk Jay B
- Lv Lei
- M Amin Hawraz Ibrahim
- Ma Zheng Feei
- Maass Kelsey Lynn
- Machairas Nikolaos
- Machoy Monika
- Madureira-Carvalho AÌurea M
- Magdy Abd El Razek Hassan
- Maghazachi Azzam A
- Mahadeshwara Prasad D. R.
- Mahalleh Mehrdad
- Mahasha Phetole Walter
- Mahmoud Mansour Adam
- Mahmoudi Elham
- Mahmoudvand Golnaz
- Makama Maureen
- Malakan Rad Elaheh
- Malhotra Kashish
- Malik Ahmad Azam
- Malta Deborah Carvalho
- Manla Yosef
- Mansour Ali
- Mansouri Mohammad Hadi
- Mansouri Pejman
- Mansouri Vahid
- Mansourian Marjan
- Mansournia Mohammad Ali
- Marasini Bishnu P
- Marateb Hamid Reza
- Maravilla Joemer C
- Mardi Parham
- Marjani Abdoljalal
- Markazi Moghadam Hamed
- Marrugo Arnedo Carlos Alberto
- Martinez Gabriel
- Martinez-Piedra Ramon
- Martins-Melo Francisco RogerlaÌndio
- Martorell Miquel
- Marx Wolfgang
- Marzo Roy Rillera
- Masoudi Sahar
- Mathangasinghe Yasith
- Mathioudakis Alexander G
- Mathur Medha
- Mathur Navgeet
- Mathur Neeta
- Matozinhos Fernanda Penido
- Mattumpuram Jishanth
- Maude Richard James
- Maugeri Andrea
- Mayeli Mahsa
- Mazidi Mohsen
- Mazzotti Antonio
- McGrath John J
- McKee Martin
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- Wojewodzic Marcin W
- Woldeyes Dawit Habte
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- Wolfe Charles D A
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- Wu Zenghong
- Wulf Hanson Sarah
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- Yigzaw Zeamanuel Anteneh
- YigÌit Arzu
- YigÌit Vahit
- Yin Dehui
- Yip Paul
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Yu Elaine A
- Yu Yong
- Yuan Chun-Wei
- Yusuf Hadiza
- Zafar Uzma
- Zafari Nima
- Zahid Mondal Hasan
- Zakham Fathiah
- Zaki Nazar
- Zerfu Taddese Alemu
- Zhang Haijun
- Zhang Jingya
- Zhang Liqun
- Zhang Yunquan
- Zhang Zhiqiang
- Zhao Xiu-Ju George
- Zhao Yang
- Zhao Zhongyi
- Zhong Chenwen
- Zhou Bolun
- Zhou Juexiao
- Zhou Shangcheng
- Zhu Bin
- Zhumagaliuly Abzal
- ZielinÌska Magdalena
- Zoghi Ghazal
- Zumla Alimuddin
- Zyoud Sa'ed H
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Future trends in disease burden and drivers of health are of great interest to policy makers and the public at large. This information can be used for policy and long-term health investment, planning, and prioritisation. We have expanded and improved upon previous forecasts produced as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) and provide a reference forecast (the most likely future), and alternative scenarios assessing disease burden trajectories if selected sets of risk factors were eliminated from current levels by 2050. Methods: Using forecasts of major drivers of health such as the Socio-demographic Index (SDI; a composite measure of lag-distributed income per capita, mean years of education, and total fertility under 25 years of age) and the full set of risk factor exposures captured by GBD, we provide cause-specific forecasts of mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) by age and sex from 2022 to 2050 for 204 countries and territories, 21 GBD regions, seven super-regions, and the world. All analyses were done at the cause-specific level so that only risk factors deemed causal by the GBD comparative risk assessment influenced future trajectories of mortality for each disease. Cause-specific mortality was modelled using mixed-effects models with SDI and time as the main covariates, and the combined impact of causal risk factors as an offset in the model. At the all-cause mortality level, we captured unexplained variation by modelling residuals with an autoregressive integrated moving average model with drift attenuation. These all-cause forecasts constrained the cause-specific forecasts at successively deeper levels of the GBD cause hierarchy using cascading mortality models, thus ensuring a robust estimate of cause-specific mortality. For non-fatal measures (eg, low back pain), incidence and prevalence were forecasted from mixed-effects models with SDI as the main covariate, and YLDs were computed from the resulting prevalence forecasts and average disability weights from GBD. Alternative future scenarios were constructed by replacing appropriate reference trajectories for risk factors with hypothetical trajectories of gradual elimination of risk factor exposure from current levels to 2050. The scenarios were constructed from various sets of risk factors: environmental risks (Safer Environment scenario), risks associated with communicable, maternal, neonatal, and nutritional diseases (CMNNs; Improved Childhood Nutrition and Vaccination scenario), risks associated with major non-communicable diseases (NCDs; Improved Behavioural and Metabolic Risks scenario), and the combined effects of these three scenarios. Using the Shared Socioeconomic Pathways climate scenarios SSP2-4.5 as reference and SSP1-1.9 as an optimistic alternative in the Safer Environment scenario, we accounted for climate change impact on health by using the most recent Intergovernmental Panel on Climate Change temperature forecasts and published trajectories of ambient air pollution for the same two scenarios. Life expectancy and healthy life expectancy were computed using standard methods. The forecasting framework includes computing the age-sex-specific future population for each location and separately for each scenario. 95% uncertainty intervals (UIs) for each individual future estimate were derived from the 2·5th and 97·5th percentiles of distributions generated from propagating 500 draws through the multistage computational pipeline. Findings: In the reference scenario forecast, global and super-regional life expectancy increased from 2022 to 2050, but improvement was at a slower pace than in the three decades preceding the COVID-19 pandemic (beginning in 2020). Gains in future life expectancy were forecasted to be greatest in super-regions with comparatively low life expectancies (such as sub-Saharan Africa) compared with super-regions with higher life expectancies (such as the high-income super-region), leading to a trend towards convergence in life expectancy across locations between now and 2050. At the super-region level, forecasted healthy life expectancy patterns were similar to those of life expectancies. Forecasts for the reference scenario found that health will improve in the coming decades, with all-cause age-standardised DALY rates decreasing in every GBD super-region. The total DALY burden measured in counts, however, will increase in every super-region, largely a function of population ageing and growth. We also forecasted that both DALY counts and age-standardised DALY rates will continue to shift from CMNNs to NCDs, with the most pronounced shifts occurring in sub-Saharan Africa (60·1% [95% UI 56·8â63·1] of DALYs were from CMNNs in 2022 compared with 35·8% [31·0â45·0] in 2050) and south Asia (31·7% [29·2â34·1] to 15·5% [13·7â17·5]). This shift is reflected in the leading global causes of DALYs, with the top four causes in 2050 being ischaemic heart disease, stroke, diabetes, and chronic obstructive pulmonary disease, compared with 2022, with ischaemic heart disease, neonatal disorders, stroke, and lower respiratory infections at the top. The global proportion of DALYs due to YLDs likewise increased from 33·8% (27·4â40·3) to 41·1% (33·9â48·1) from 2022 to 2050, demonstrating an important shift in overall disease burden towards morbidity and away from premature death. The largest shift of this kind was forecasted for sub-Saharan Africa, from 20·1% (15·6â25·3) of DALYs due to YLDs in 2022 to 35·6% (26·5â43·0) in 2050. In the assessment of alternative future scenarios, the combined effects of the scenarios (Safer Environment, Improved Childhood Nutrition and Vaccination, and Improved Behavioural and Metabolic Risks scenarios) demonstrated an important decrease in the global burden of DALYs in 2050 of 15·4% (13·5â17·5) compared with the reference scenario, with decreases across super-regions ranging from 10·4% (9·7â11·3) in the high-income super-region to 23·9% (20·7â27·3) in north Africa and the Middle East. The Safer Environment scenario had its largest decrease in sub-Saharan Africa (5·2% [3·5â6·8]), the Improved Behavioural and Metabolic Risks scenario in north Africa and the Middle East (23·2% [20·2â26·5]), and the Improved Nutrition and Vaccination scenario in sub-Saharan Africa (2·0% [â0·6 to 3·6]). Interpretation: Globally, life expectancy and age-standardised disease burden were forecasted to improve between 2022 and 2050, with the majority of the burden continuing to shift from CMNNs to NCDs. That said, continued progress on reducing the CMNN disease burden will be dependent on maintaining investment in and policy emphasis on CMNN disease prevention and treatment. Mostly due to growth and ageing of populations, the number of deaths and DALYs due to all causes combined will generally increase. By constructing alternative future scenarios wherein certain risk exposures are eliminated by 2050, we have shown that opportunities exist to substantially improve health outcomes in the future through concerted efforts to prevent exposure to well established risk factors and to expand access to key health interventions
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950â2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abdurehman Ame Mehadi
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- AbeldanÌo ZunÌiga Roberto Ariel
- Abhilash E S
- Abiodun Olugbenga Olusola
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Abreu Lucas GuimaraÌes
- Abrha Woldu Aberhe
- Abrigo Michael R M
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Aburuz Salahdein
- Acuna Juan Manuel
- Adair Tim
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adegboye Oyelola A
- Adekanmbi Victor
- Aden Bashir
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adeyeoluwa Temitayo Esther
- Adeyomoye Olorunsola Israel
- Adha Rishan
- Adibi Amin
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Abel
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afyouni Shadi
- Afzal Saira
- Agasthi Pradyumna
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmadzade Mohadese
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akinosoglou Karolina
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- Huang Junjie
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- Touvier Mathilde
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- Unim Brigid
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Urso Daniele
- Vacante Marco
- Vahdani Amir Mohammad
- Vaithinathan Asokan Govindaraj
- Valadan Tahbaz Sahel
- Valizadeh Rohollah
- Van den Eynde Jef
- Varavikova Elena
- Varga Orsolya
- Varma Siddhartha Alluri
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- Venketasubramanian Narayanaswamy
- Venugopal Deneshkumar
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- Verma Madhur
- Verma Pratibha
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- Vervoort Dominique
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- Watson Stefanie
- Weaver Marcia R
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- Weiss Daniel J
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- Wells Katherine M
- Wen Yi Feng
- Werdecker Andrea
- Westerman Ronny
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- Woolf Anthony D
- Wu Dongze
- Wulandari Ratna Dwi
- Xiao Hong
- Xu Bin
- Xu Xiaoyue
- Yadav Lalit
- Yaghoubi Sajad
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Ye Pengpeng
- Yesera Gesila Endashaw
- Yesodharan Renjulal
- Yesuf Subah Abderehim
- YigÌit Arzu
- YigÌit Vahit
- Yip Paul
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zahedi Mohammad
- Zahid Muhammad Nauman
- Zahir Mazyar
- Zakham Fathiah
- Zaki Nazar
- Zakzuk Josefina
- Zamagni Giulia
- Zaman Burhan Abdullah
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
- Zandi Milad
- Zandieh Ghazal G Z
- ZanghiÌ Aurora
- Zare Iman
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zeng Youjie
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Hongwei
- Zhang Yunquan
- Zhang Zhaofeng
- Zhang Zhenyu
- Zhao Hanqing
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Zhaohua
- Ziaeefar Pardis
- ZielinÌska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020â21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5â65·1] decline), and increased during the COVID-19 pandemic period (2020â21; 5·1% [0·9â9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98â5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50â6·01) in 2019. An estimated 131 million (126â137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7â17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8â24·8), from 49·0 years (46·7â51·3) to 71·7 years (70·9â72·5). Global life expectancy at birth declined by 1·6 years (1·0â2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67â8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4â52·7]) and south Asia (26·3% [9·0â44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
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Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990â2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Ababneh Hazim S
- Abate Yohannes Habtegiorgis
- Abbafati Cristiana
- Abbasgholizadeh Rouzbeh
- Abbasi-Kangevari Mohsen
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdollahifar Mohammad-Amin
- Abdoun Meriem
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abebe Mesfin
- Abebe Samrawit Shawel
- Abedi Aidin
- Abegaz Kedir Hussein
- Abhilash E S
- Abidi Hassan
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abolmaali Meysam
- Abouzid Mohamed
- Aboye Girma Beressa
- Abreu Lucas GuimarĂŁes
- Abrha Woldu Aberhe
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Gharbieh Eman
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Abualruz Hasan
- Abubakar Bilyaminu
- Aburuz Salahdein
- Accrombessi Manfred Mario Kokou
- Adal Tadele Girum
- Adamu Abdu A
- Addo Isaac Yeboah
- Addolorato Giovanni
- Adebiyi Akindele Olupelumi
- Adekanmbi Victor
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adetunji Juliana Bunmi
- Adeyeoluwa Temitayo Esther
- Adeyinka Daniel Adedayo
- Adeyomoye Olorunsola Israel
- Admass Biruk Adie Adie
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afolabi Aanuoluwapo Adeyimika
- Afzal Muhammad Sohail
- Afzal Saira
- Agampodi Suneth Buddhika
- Agasthi Pradyumna
- Aggarwal Manik
- Aghamiri Shahin
- Agide Feleke Doyore
- Agodi Antonella
- Agrawal Anurag
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Sajjad
- Ahmad Shahzaib
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmed Ali
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Mehrunnisha Sharif
- Ahmed Meqdad Saleh
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Akara Essona Matatom
- Akbarialiabad Hossein
- Akinosoglou Karolina
- Akinyemiju Tomi
- Akkaif Mohammed Ahmed
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Azzam Sayer
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Omari Basem
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Alahdab Fares
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- Alalwan Tariq A
- Alam Khurshid
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- Alcalde-Rabanal Jacqueline Elizabeth
- Aldawsari Khalifah A
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- Alema Haileselasie Berhane
- Alemayohu Mulubirhan Assefa
- Alemi Sharifullah
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- Ali Abid
- Ali Amjad
- Ali Liaqat
- Ali Mohammed Usman
- Ali Rafat
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- Ali Syed Shujait Shujait
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Alikhani Reyhaneh
- Alimohamadi Yousef
- Aliyi Ahmednur Adem
- Aljasir Mohammad A M
- Aljunid Syed Mohamed
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- Ghashghaee Ahmad
- Ghassemi Fariba
- Ghazy Ramy Mohamed
- Ghimire Ajnish
- Ghoba Sama
- Gholamalizadeh Maryam
- Gholamian Asadollah
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- Sunkersing David
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- TADAKAMADLA JYOTHI
- Tadakamadla Santosh Kumar
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- Taiba Jabeen
- Takahashi Ken
- Talaat Iman M
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- Tan Ker-Kan
- Tandukar Sarmila
- Tang Haosu
- Tang Hong K
- Tarigan Ingan Ukur
- Tariku Mengistie Kassahun
- Tariqujjaman Md
- Tarkang Elvis Enowbeyang
- Tavakoli Oliaee Razieh
- Tavangar Seyed Mohammad
- Taveira Nuno
- Tefera Yibekal Manaye
- Temsah Mohamad-Hani
- Temsah Reem Mohamad Hani
- Teramoto Masayuki
- Tesler Riki
- Teye-Kwadjo Enoch
- Thakur Rishu
- Thangaraju Pugazhenthan
- Thankappan Kavumpurathu Raman
- Tharwat Samar
- Thayakaran Rasiah
- Thomas Nihal
- Thomas Nikhil Kenny
- Thomson Azalea M
- Thrift Amanda G
- Thum Chern Choong Chern
- Thygesen Lau Caspar
- Tian Jing
- Tichopad Ales
- Ticoalu Jansje Henny Vera
- Tillawi Tala
- Tiruye Tenaw Yimer
- Titova Mariya Vladimirovna
- Tonelli Marcello
- Topor-Madry Roman
- Toriola Adetunji T
- Torre Anna E
- Touvier Mathilde
- Tovani-Palone Marcos Roberto
- Tran Jasmine T
- Tran Nghia Minh
- Trico Domenico
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- Villanueva Gabriela Ines
- Vinayak Manish
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- Whisnant Joanna L
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- Wilandika Angga
- Wilkerson Caroline
- Willeit Peter
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- Wojewodzic Marcin W
- Woldegebreal Demewoz H
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- Wolfe Charles D A
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- Wong Yen Jun
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- Xiao Hong
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- Xu Wang-Dong
- Xu Xiaoyue
- Xu Yvonne Yiru
- Yadollahpour Ali
- Yamagishi Kazumasa
- Yang Danting
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Yaribeygi Habib
- Ye Pengpeng
- Yehualashet Sisay Shewasinad
- Yesiltepe Metin
- Yesuf Subah Abderehim
- Yezli Saber
- Yi Siyan
- Yigezu Amanuel
- Yip Paul
- Yismaw Malede Berihun
- Yismaw Yazachew
- YiÄit Arzu
- YiÄit Vahit
- Yon Dong Keon
- Yonemoto Naohiro
- Yoon Seok-Jun
- You Yuyi
- Younis Mustafa Z
- Yousefi Zabihollah
- Yu Chuanhua
- Yu Yong
- Yuh Faith H
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zakham Fathiah
- Zaki Nazar
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
- Zangiabadian Moein
- Zar Heather J
- Zare Iman
- Zarrintan Armin
- Zeariya Mohammed G M
- Zeinali Zahra
- Zhang Haijun
- Zhang Jianrong
- Zhang Jingya
- Zhang Liqun
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Hanqing
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Lei
- Ziafati Makan
- ZieliĆska Magdalena
- Zitoun Osama A
- Zoladl Mohammad
- Zou Zhiyong
- Zuhlke Liesl J
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Ărnlöv Johan
- Ć ekerija Mario
- Publication venue
- Elsevier
- Publication date
- 01/01/2024
- Field of study
BACKGROUND Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COVID-19 pandemic. When systematically analysed, mortality rates and life expectancy allow comparisons of the consequences of causes of death globally and over time, providing a nuanced understanding of the effect of these causes on global populations. METHODS The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 cause-of-death analysis estimated mortality and years of life lost (YLLs) from 288 causes of death by age-sex-location-year in 204 countries and territories and 811 subnational locations for each year from 1990 until 2021. The analysis used 56â604 data sources, including data from vital registration and verbal autopsy as well as surveys, censuses, surveillance systems, and cancer registries, among others. As with previous GBD rounds, cause-specific death rates for most causes were estimated using the Cause of Death Ensemble model-a modelling tool developed for GBD to assess the out-of-sample predictive validity of different statistical models and covariate permutations and combine those results to produce cause-specific mortality estimates-with alternative strategies adapted to model causes with insufficient data, substantial changes in reporting over the study period, or unusual epidemiology. YLLs were computed as the product of the number of deaths for each cause-age-sex-location-year and the standard life expectancy at each age. As part of the modelling process, uncertainty intervals (UIs) were generated using the 2·5th and 97·5th percentiles from a 1000-draw distribution for each metric. We decomposed life expectancy by cause of death, location, and year to show cause-specific effects on life expectancy from 1990 to 2021. We also used the coefficient of variation and the fraction of population affected by 90% of deaths to highlight concentrations of mortality. Findings are reported in counts and age-standardised rates. Methodological improvements for cause-of-death estimates in GBD 2021 include the expansion of under-5-years age group to include four new age groups, enhanced methods to account for stochastic variation of sparse data, and the inclusion of COVID-19 and other pandemic-related mortality-which includes excess mortality associated with the pandemic, excluding COVID-19, lower respiratory infections, measles, malaria, and pertussis. For this analysis, 199 new country-years of vital registration cause-of-death data, 5 country-years of surveillance data, 21 country-years of verbal autopsy data, and 94 country-years of other data types were added to those used in previous GBD rounds. FINDINGS The leading causes of age-standardised deaths globally were the same in 2019 as they were in 1990; in descending order, these were, ischaemic heart disease, stroke, chronic obstructive pulmonary disease, and lower respiratory infections. In 2021, however, COVID-19 replaced stroke as the second-leading age-standardised cause of death, with 94·0 deaths (95% UI 89·2-100·0) per 100â000 population. The COVID-19 pandemic shifted the rankings of the leading five causes, lowering stroke to the third-leading and chronic obstructive pulmonary disease to the fourth-leading position. In 2021, the highest age-standardised death rates from COVID-19 occurred in sub-Saharan Africa (271·0 deaths [250·1-290·7] per 100â000 population) and Latin America and the Caribbean (195·4 deaths [182·1-211·4] per 100â000 population). The lowest age-standardised death rates from COVID-19 were in the high-income super-region (48·1 deaths [47·4-48·8] per 100â000 population) and southeast Asia, east Asia, and Oceania (23·2 deaths [16·3-37·2] per 100â000 population). Globally, life expectancy steadily improved between 1990 and 2019 for 18 of the 22 investigated causes. Decomposition of global and regional life expectancy showed the positive effect that reductions in deaths from enteric infections, lower respiratory infections, stroke, and neonatal deaths, among others have contributed to improved survival over the study period. However, a net reduction of 1·6 years occurred in global life expectancy between 2019 and 2021, primarily due to increased death rates from COVID-19 and other pandemic-related mortality. Life expectancy was highly variable between super-regions over the study period, with southeast Asia, east Asia, and Oceania gaining 8·3 years (6·7-9·9) overall, while having the smallest reduction in life expectancy due to COVID-19 (0·4 years). The largest reduction in life expectancy due to COVID-19 occurred in Latin America and the Caribbean (3·6 years). Additionally, 53 of the 288 causes of death were highly concentrated in locations with less than 50% of the global population as of 2021, and these causes of death became progressively more concentrated since 1990, when only 44 causes showed this pattern. The concentration phenomenon is discussed heuristically with respect to enteric and lower respiratory infections, malaria, HIV/AIDS, neonatal disorders, tuberculosis, and measles. INTERPRETATION Long-standing gains in life expectancy and reductions in many of the leading causes of death have been disrupted by the COVID-19 pandemic, the adverse effects of which were spread unevenly among populations. Despite the pandemic, there has been continued progress in combatting several notable causes of death, leading to improved global life expectancy over the study period. Each of the seven GBD super-regions showed an overall improvement from 1990 and 2021, obscuring the negative effect in the years of the pandemic. Additionally, our findings regarding regional variation in causes of death driving increases in life expectancy hold clear policy utility. Analyses of shifting mortality trends reveal that several causes, once widespread globally, are now increasingly concentrated geographically. These changes in mortality concentration, alongside further investigation of changing risks, interventions, and relevant policy, present an important opportunity to deepen our understanding of mortality-reduction strategies. Examining patterns in mortality concentration might reveal areas where successful public health interventions have been implemented. Translating these successes to locations where certain causes of death remain entrenched can inform policies that work to improve life expectancy for people everywhere. FUNDING Bill & Melinda Gates Foundation
Global, regional, and national burden of disorders affecting the nervous system, 1990â2021: a systematic analysis for the Global Burden of Disease Study 2021
- Author
- Abate Yohannes Habtegiorgis
- Abbas Jaffar
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abbastabar Hedayat
- Abd-Rabu Rami
- Abdelmasseh Michael
- Abdollahi Mohammad
- Abdollahi Mozhan
- Abdollahifar Mohammad-Amin
- Abdulah Deldar Morad
- Abdullahi Auwal
- Abedi Aidin
- Abedi Vida
- Abeldaño Zuñiga Roberto Ariel
- Abidi Hassan
- Abiodun Olumide
- Aboagye Richard Gyan
- Abolhassani Hassan
- Aboyans Victor
- Abrha Woldu Aberhe
- Abu-Gharbieh Eman
- Abualhasan Ahmed
- Aburuz Salahdein
- Adamu Lawan Hassan
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adekanmbi Victor
- Adekiya Tayo Alex
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Tsion
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afzal Saira
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Sajjad
- Ahmadzade Amir Mahmoud
- Ahmed Ali
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Jivan Qasim
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akade Seyed Esma'il
- Akbari Morteza
- Akbarialiabad Hossein
- Akhlaghi Shiva
- Akinosoglou Karolina
- Akinyemi Rufus Olusola
- Akonde Maxwell
- Al Hasan Syed Mahfuz
- AL-Ahdal Tareq Mohammed Ali
- Al-amer Rasmieh Mustafa
- Al-Gheethi Adel Ali Saeed
- Al-Omari Basem
- Al-Shahi Salman Rustam
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Alahdab Fares
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldawsari Khalifah A
- Alemi Hediyeh
- Alemi Sharifullah
- Algammal Abdelazeem M
- Alhalaiqa Fadwa Alhalaiqa Naji
- Alhassan Robert Kaba
- Ali Abid
- Ali Endale Alemayehu
- Ali Liaqat
- Ali Mohammed Usman
- Ali Musa Mohammed
- Ali Rafat
- Ali Shahid
- Ali Syed Shujait Shujait
- Ali Zahid
- Alif Sheikh Mohammad
- Alimohamadi Yousef
- Aliyi Ahmednur Adem
- Aljofan Mohamad
- Aljunid Syed Mohamed
- Alladi Suvarna
- Almazan Joseph Uy
- Almustanyir Sami
- Alqahtani Jaber S
- Alqasmi Ibrahim
- Alqutaibi Ahmed Yaseen
- Altaany Zaid
- Altirkawi Khalid A
- Alvis-Guzman Nelson
- Aly Hany
- Aly Safwat
- Alzoubi Karem H
- Amani Reza
- Amindarolzarbi Alireza
- Amiri Sohrab
- Amirzade-Iranaq Mohammad Hosein
- Amu Hubert
- Amugsi Dickson A
- Amusa Ganiyu Adeniyi
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Anderson David B
- Andrei Catalina Liliana
- Androudi Sofia
- Angappan Dhanalakshmi
- Angesom Teklit W
- Anil Abhishek
- Ansari-Moghaddam Alireza
- Anwer Razique
- Arafat Mosab
- Aravkin Aleksandr Y
- Areda Demelash
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- Arifin Hidayat
- Arkew Mesay
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Aruleba Raphael Taiwo
- Asadi-Pooya Ali A
- Asena Tilahun Ferede
- Asghari-Jafarabadi Mohammad
- Ashraf Muhammad
- Ashraf Tahira
- Atalell Kendalem Asmare
- Athari Seyyed Shamsadin
- Atinafu Bantalem Tilaye Tilaye
- Atorkey Prince
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Aujayeb Avinash
- Avan Abolfazl
- Ayala Quintanilla Beatriz Paulina
- Ayatollahi Haleh
- Ayinde Olatunde O
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azizi Zahra
- Azizian Khalil
- Azzam Ahmed Y
- Babaei Mahsa
- Badar Muhammad
- Badiye Ashish D
- Baghdadi Soroush
- Bagherieh Sara
- Bai Ruhai
- Baig Atif Amin
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- Banach Maciej
- Bandyopadhyay Soham
- Banerjee Indrajit
- Baran Mehmet Firat
- Barboza Miguel A
- Barchitta Martina
- Bardhan Mainak
- Barker-Collo Suzanne Lyn
- Barrow Amadou
- Bashash Davood
- Bashiri Hamideh
- Bashiru Hameed Akande
- Basiru Afisu
- Basso JoĂŁo Diogo
- Basu Sanjay
- Batiha Abdul-Monim Mohammad
- Batra Kavita
- Baune Bernhard T
- Bedi Neeraj
- Begde Ahmet
- Begum Tahmina
- Behnam Babak
- Behnoush Amir Hossein
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- Belgaumi Uzma Iqbal
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- Benfor Bright
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- Bensenor Isabela M
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- Beyene Kebede A
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- Bhagat Devidas S
- Bhangdia Kayleigh
- Bhardwaj Nikha
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- Bhargava Ashish
- Bhaskar Sonu
- Bhat Ajay Nagesh
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Rajbir
- Bijani Ali
- Bikbov Boris
- Bilalaga Mariah Malak
- Biswas Atanu
- Bitaraf Saeid
- Bitra Veera R
- BjĂžrge Tone
- Bodolica Virginia
- Bodunrin Aadam Olalekan
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- Brown Julie
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- Cao Bochen
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- Cerin Ester
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- Chan Jeffrey Shi Kai
- Chanie Gashaw Sisay
- Charan Jaykaran
- Chattu Vijay Kumar
- Chekol Abebe Endeshaw
- Chen Hui
- Chen Jianqi
- Chi Gerald
- Chichagi Fatemeh
- Chidambaram Saravana Babu
- Chimoriya Ritesh
- Ching Patrick R
- Chitheer Abdulaal
- Chong Yuen Yu
- Chopra Hitesh
- Choudhari Sonali Gajanan
- Chowdhury Enayet Karim
- Chowdhury Rajiv
- Christensen Hanne
- Chu Dinh-Toi
- Chukwu Isaac Sunday
- Chung Eric
- Coberly Kaleb
- Columbus Alyssa
- Comachio Josielli
- Conde Joao
- Cortesi Paolo Angelo
- Costa Vera Marisa
- Cousin Ewerton
- Couto Rosa A S
- Criqui Michael H
- Cruz-Martins NatĂĄlia
- CĂĄrdenas Rosario
- D'Amico Emanuele
- Dabbagh Ohadi Mohammad Amin
- Dadana Sriharsha
- Dadras Omid
- Dai Xiaochen
- Dai Zhaoli
- Danawi Hadi A
- Dandona Lalit
- Dandona Rakhi
- Darwish Amira Hamed
- Das Saswati
- Das Subasish
- Dascalu Ana Maria
- Dash Nihar Ranjan
- Dashti Mohsen
- De la Hoz Fernando Pio
- de la Torre-Luque Alejandro
- De Leo Diego
- Dean Frances E
- Dehghan Amin
- Dehghan Azizallah
- Dejene Hiwot
- Demant Daniel
- Demetriades Andreas K
- Demissie Solomon
- Deng Xinlei
- Desai Hardik Dineshbhai
- Devanbu Vinoth Gnana Chellaiyan
- Dhama Kuldeep
- Dharmaratne Samath Dhamminda
- Dhimal Meghnath
- Dias da Silva Diana
- Diaz Daniel
- Dibas Mahmoud
- Ding Delaney D
- Dinu Monica
- Dirac M Ashworth
- Diress Mengistie
- Do Thanh Chi
- Do Thao Huynh Phuong
- Doan Khanh Duy Khanh
- Dodangeh Milad
- Doheim Mohamed Fahmy
- Dokova Klara Georgieva
- Dongarwar Deepa
- Dsouza Haneil Larson
- Dua Tarun
- Dube John
- Duraisamy Senbagam
- Durojaiye Oyewole Christopher
- Dutta Sulagna
- Dziedzic Arkadiusz Marian
- Edinur Hisham Atan
- Eissazade Negin
- Ekholuenetale Michael
- Ekundayo Temitope Cyrus
- El Nahas Nevine
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- Elahi Najafi Mohammad Amin
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- Elhabashy Hala Rashad
- Elhadi Muhammed
- Elilo Legesse Tesfaye
- Ellenbogen Richard G
- Elmeligy Omar Abdelsadek Abdou
- Elmonem Mohamed A
- Elshaer Mohammed
- Elsohaby Ibrahim
- Emamverdi Mehdi
- Emeto Theophilus I
- Endres Matthias
- Esezobor Christopher Imokhuede
- Eskandarieh Sharareh
- Fadaei Abdolmajid
- Fagbamigbe Adeniyi Francis
- Fahim Ayesha
- Faramarzi Ali
- Fares Jawad
- Farjoud Kouhanjani Mohsen
- Faro Andre
- Farzadfar Farshad
- Fatehizadeh Ali
- Fathi Mobina
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- Fatima Syeda Anum Fatima
- Feigin Valery L
- Feizkhah Alireza
- Fereshtehnejad Seyed-Mohammad
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- Ferreira Nuno
- Fetensa Getahun
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- Fischer Florian
- Fonseca Ana Catarina
- Force Lisa M
- Fornari Arianna
- Foroutan Behzad
- Fukumoto Takeshi
- Gadanya Muktar A
- Gaidhane Abhay Motiramji
- Galali Yaseen
- Galehdar Nasrin
- Gan Quan
- Gandhi Aravind P
- Ganesan Balasankar
- Gardner William M
- Garg Naval
- Gau Shuo-Yan
- Gautam Rupesh K
- Gebre Teshome
- Gebrehiwot Mesfin
- Gebremeskel Gebreamlak Gebremedhn
- Gebreslassie Haftay Gebremedhin
- Getacher Lemma
- Ghaderi Yazdi Bardiya
- Ghadirian Fataneh
- Ghaffarpasand Fariborz
- Ghanbari Reza
- Ghasemi MohammadReza
- Ghazy Ramy Mohamed
- Ghimire Sailaja
- Gholami Ali
- Gholamrezanezhad Ali
- Ghotbi Elena
- Ghozy Sherief
- Gialluisi Alessandro
- Gill Paramjit Singh
- Glasstetter Logan M
- Gnedovskaya Elena V
- Golchin Ali
- Golechha Mahaveer
- Goleij Pouya
- Golinelli Davide
- Gomes-Neto Mansueto
- Goulart Alessandra C
- Goyal Anmol
- Gray Richard J
- Grivna Michal
- Guadie Habtamu Alganeh
- Guan Bin
- Guarducci Giovanni
- Guicciardi Stefano
- Gunawardane Damitha Asanga
- Guo Hanbing
- Gupta Bhawna
- Gupta Rajeev
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vivek Kumar
- Gutiérrez Reyna Alma
- Habibzadeh Farrokh
- Hachinski Vladimir
- Haddadi Rasool
- Hadei Mostafa
- Hadi Najah R
- Haep Nils
- Hagins Hailey
- Haile Teklehaimanot Gereziher
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- Hammoud Ahmad
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- Hao Junwei
- Harapan Harapan
- Hareru Habtamu Endashaw
- Hargono Arief
- Harlianto Netanja I.
- Haro Josep Maria
- Hartman Nicholas Nathaniel
- Hasaballah Ahmed I.
- Hasan Faizul
- Hasani Hamidreza
- Hasanian Mohammad
- Hassan Amr
- Hassan Shoaib
- Hassanipour Soheil
- Hassankhani Hadi
- Hassen Mohammed Bheser
- Haubold Johannes
- Hay Simon I
- Hayat Khezar
- Hegazy Mohamed I
- Heidari Golnaz
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- Heidari-Soureshjani Reza
- Hesami Hamed
- Hezam Kamal
- Hiraike Yuta
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- Holla Ramesh
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- Horita Nobuyuki
- Hossain Md Mahbub
- Hossain Md. Belal
- Hossain Sahadat
- Hosseinzadeh Hassan
- Hosseinzadeh Mehdi
- Hostiuc Sorin
- Hu Chengxi
- Huang Junjie
- Huda Md. Nazmul
- Hussain Javid
- Hussein Nawfal R
- Huynh Hong-Han
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Ilaghi Mehran
- Ilesanmi Olayinka Stephen
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- Immurana Mustapha
- Iravanpour Farideh
- Islam Sheikh Mohammed Shariful
- Ismail Faisal
- Iso Hiroyasu
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- Iwagami Masao
- Iwu Chidozie C D
- Iyer Mahalaxmi
- Jaan Ali
- Jacob Louis
- Jadidi-Niaragh Farhad
- Jafari Mahboobeh
- Jafarinia Morteza
- Jafarzadeh Abdollah
- Jahankhani Kasra
- Jahanmehr Nader
- Jahrami Haitham
- Jaiswal Abhishek
- Jakovljevic Mihajlo
- Jamora Roland Dominic G
- Jana Somnath
- Javadi Nilofer
- Javed Saad
- Javeed Saad
- Jayapal Sathish Kumar
- Jayaram Shubha
- Jiang Heng
- Johnson Catherine Owens
- Johnson Walter D
- Jokar Mohammad
- Jonas Jost B
- Joseph Abel
- Joseph Nitin
- Joshua Charity Ehimwenma
- JĂŒrisson Mikk
- Kabir Ali
- Kabir Zubair
- Kabito Gebisa Guyasa
- Kadashetti Vidya
- Kafi Fatemeh
- Kalani Rizwan
- Kalantar Farnaz
- Kaliyadan Feroze
- Kamath Ashwin
- Kamath Sagarika
- Kanchan Tanuj
- Kandel Amit
- Kandel Himal
- Kanmodi Kehinde Kazeem
- Karajizadeh Mehrdad
- Karami Jafar
- Karanth Shama D
- Karaye Ibraheem M
- Karch André
- Karimi Behnagh Arman
- Karimi Aliasghar
- Karimi Hanie
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- Kaur Harkiran
- Kaur Navjot
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- Kazemi Foad
- Keikavoosi-Arani Leila
- Keller Cathleen
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- Khadembashiri Mohammad Amin
- Khader Yousef Saleh
- Khafaie Morteza Abdullatif
- Khajuria Himanshu
- Khalaji Amirmohammad
- Khamesipour Faham
- Khammarnia Mohammad
- Khan Suheb Mahammed Ziauddin
- Khan Maseer
- Khan Moien AB
- Khan Yusra H
- Khanmohammadi Shaghayegh
- Khanna Tripti
- Khatab Khaled
- Khatatbeh Haitham
- Khatatbeh Moawiah Mohammad
- Khateri Sorour
- Khatib Mahalaqua Nazli
- Khayat Kashani Hamid Reza
- Khonji Mohammad Saeid
- khorashadizadeh Fatemeh
- Khormali Moein
- Khubchandani Jagdish
- Kian Saeid
- Kim Grace
- Kim Jihee
- Kim Min Seo
- Kim Yun Jin
- Kimokoti Ruth W
- Kisa Adnan
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- Kosen Soewarta
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- Kuate Defo Barthelemy
- Kuddus Md Abdul
- Kumar Ashish
- Kumar G Anil
- Kumar Manasi
- Kumar Nithin
- Kumsa Netsanet Bogale
- Kundu Satyajit
- Kurniasari Maria Dyah
- Kusuma Dian
- Kuttikkattu Ambily
- Kyu Hmwe Hmwe
- La Vecchia Carlo
- Ladan Muhammad Awwal
- Lahariya Chandrakant
- Laksono Tri
- Lal Dharmesh Kumar
- Lallukka Tea
- Lami Faris Hasan
- Landires IvĂĄn
- Langguth Berthold
- Lasrado Savita
- Latief Kamaluddin
- Latifinaibin Kaveh
- Lau Kathryn Mei-Ming
- Laurens Matthew B
- Lawal Basira Kankia
- Le Long Khanh Dao
- Le Thao Thi Thu
- Ledda Caterina
- Lee Munjae
- Lee Sang-woong
- Lee Seung Won
- Lee Wei-Chen
- Lee Yo Han
- Leonardi Matilde
- Lerango Temesgen L
- Li Ming-Chieh
- Li Wei
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- Lim Stephen S
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- Liu Chaojie
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- Liu Wei
- Lo Chun-Han
- Lo Warren David
- Lobo Stany W
- Logroscino Giancarlo
- Lopes Graciliana
- Lopukhov Platon D
- Lorenzovici LĂĄszlĂł
- Lorkowski Stefan
- Loureiro Joana A
- Lubinda Jailos
- Lucchetti Giancarlo
- Lutzky Saute Ricardo
- LĂĄm Judit
- Ma Zheng Feei
- Mabrok Mahmoud
- Machoy Monika
- Madadizadeh Farzan
- Magdy Abd El Razek Mohammed
- Maghazachi Azzam A
- Maghbouli Nastaran
- Mahjoub Soleiman
- Mahmoudi Morteza
- Majeed Azeem
- MalagĂłn-Rojas Jeadran N.
- Malakan Rad Elaheh
- Malhotra Kashish
- Malik Ahmad Azam
- Malik Iram
- Mallhi Tauqeer Hussain
- Malta Deborah Carvalho
- Manilal Aseer
- Mansouri Vahid
- Mansournia Mohammad Ali
- Marasini Bishnu P
- Marateb Hamid Reza
- Maroufi Seyed Farzad
- Martinez-Raga Jose
- Martini Santi
- Martins-Melo Francisco RogerlĂąndio
- Martorell Miquel
- Marzo Roy Rillera
- Massano JoĂŁo
- Mathangasinghe Yasith
- Mathews Elezebeth
- Maude Richard James
- Maugeri Andrea
- Maulik Pallab K
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- Mazaheri Maryam
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- Mendez-Lopez Max Alberto Mendez
- Mendoza Walter
- Mendoza-Cano Oliver
- Menezes Ritesh G
- Merati Mohsen
- Meretoja Atte
- Merkin Alexander
- Mersha Abera M
- Mestrovic Tomislav
- Mi Tianyue
- Miazgowski Tomasz
- Michalek Irmina Maria
- Mihretie Ephrem Tesfaye
- Minh Le Huu Nhat
- Mirfakhraie Reza
- Mirica Andreea
- Mirrakhimov Erkin M
- Mirzaei Mehdi
- Misganaw Awoke
- Misra Sanjeev
- Mithra Prasanna
- Mizana Biru Abdissa
- Moberg Madeline E
- Mohamadkhani Ashraf
- Mohamed Nouh Saad
- Mohammadi Esmaeil
- Mohammadi Hiwa
- Mohammadi Shadieh
- Mohammadi Soheil
- Mohammadshahi Marita
- Mohammed Mustapha
- Mohammed Salahuddin
- Mohammed Shafiu
- Mohan Syam
- Mojiri-forushani Hoda
- Moka Nagabhishek
- Mokdad Ali H
- Molinaro Sabrina
- Monasta Lorenzo
- Moniruzzaman Md
- Montazeri Fateme
- Moradi Maryam
- Moradi Yousef
- Moradi-Lakeh Maziar
- Moraga Paula
- Morovatdar Negar
- Morrison Shane Douglas
- Mosapour Abbas
- Mosser Jonathan F
- Mossialos Elias
- Motaghinejad Majid
- Mousavi Parsa
- Mousavi Seyed Ehsan
- Mubarik Sumaira
- Muccioli Lorenzo
- Mughal Faraz
- Mukoro George Duke
- Mulita Admir
- Mulita Francesk
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- Musaigwa Fungai
- Mustafa Ahmad
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- Muthu Sathish
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- Nagarajan Ahamarshan Jayaraman
- Naghavi Pirouz
- Naik Ganesh R
- Nainu Firzan
- Nair Tapas Sadasivan
- Najmuldeen Hastyar Hama Rashid
- Nakhostin Ansari Noureddin
- Nambi Gopal
- Namdar Areshtanab Hossein
- Nargus Shumaila
- Nascimento Bruno Ramos
- Naser Abdallah Y
- Nashwan Abdulqadir J J
- Nasoori Hadis
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- Natto Zuhair S
- Nauman Javaid
- Nayak Biswa Prakash
- Nazri-Panjaki Athare
- Negaresh Mohammad
- Negash Hadush
- Negoi Ionut
- Negoi Ruxandra Irina
- Negru Serban Mircea
- Nejadghaderi Seyed Aria
- Nematollahi Mohammad Hadi
- Nesbit Olivia D
- Newton Charles Richard James
- Nguyen Dang H
- Nguyen Hau Thi Hien
- Nguyen Hien Quang
- Nguyen Ngoc-Trinh Thi
- Nguyen Phat Tuan
- Nguyen Van Thanh
- Niazi Robina Khan
- Nichols Emma
- Nikolouzakis Taxiarchis Konstantinos
- Niranjan Vikram
- Nnyanzi Lawrence Achilles
- Noman Efaq Ali
- Noroozi Nafise
- Norrving Bo
- Noubiap Jean Jacques
- Nri-Ezedi Chisom Adaobi
- Ntaios George
- Nurrika Dieta
- Nuñez-Samudio Virginia
- O'Donnell Martin James
- Oancea Bogdan
- Odetokun Ismail A
- Ogunsakin Ropo Ebenezer
- Oguta James Odhiambo
- Oh In-Hwan
- Okati-Aliabad Hassan
- Okeke Sylvester Reuben
- Okekunle Akinkunmi Paul
- Okonji Osaretin Christabel
- Okwute Patrick Godwin
- Olagunju Andrew T
- Olaiya Muideen Tunbosun
- Olana Matifan Dereje
- Olatubi Matthew Idowu
- Oliveira GlĂĄucia Maria Moraes
- Olufadewa Isaac Iyinoluwa
- Olusanya Bolajoko Olubukunola
- Omar Bali Ahmed
- Ong Kanyin Liane
- Ong Sokking
- Onwujekwe Obinna E
- Ordak Michal
- Orji Aislyn U
- Ortega-Altamirano Doris V
- Osuagwu Uchechukwu Levi
- Otstavnov Nikita
- Otstavnov Stanislav S
- Ouyahia Amel
- Owolabi Mayowa O
- P A Mahesh Padukudru
- Pacheco-Barrios Kevin
- Padubidri Jagadish Rao
- Pal Pramod Kumar
- Palange Padmavali Nanaji
- Palladino Claudia
- Palladino Raffaele
- Palma-Alvarez Raul Felipe
- Pan Feng
- Panagiotakos Demosthenes
- Panda-Jonas Songhomitra
- Pandey Anamika
- Pandey Ashok
- Pandian Jeyaraj Durai
- Pangaribuan Helena Ullyartha
- Pantazopoulos Ioannis
- Pardhan Shahina
- Parija Pragyan Paramita
- Parikh Romil R
- Park Seoyeon
- Parthasarathi Ashwaghosha
- Pashaei Ava
- Patel Jay
- Patil Shankargouda
- Patoulias Dimitrios
- Pawar Shrikant
- Pedersini Paolo
- Pensato Umberto
- Pereira David M
- Pereira Jeevan
- Pereira Maria Odete
- Peres Mario F P
- Perico Norberto
- Perna Simone
- Petcu Ionela-Roxana
- Petermann-Rocha Fanny Emily
- Pham Hoang Tran
- Phillips Michael R
- Pinilla-Monsalve Gabriel D
- Piradov Michael A
- Plotnikov Evgenii
- Poddighe Dimitri
- Polat Burcu
- Poluru Ramesh
- Pond Constance Dimity
- Poudel Govinda Raj
- Pouramini Alireza
- Pourbagher-Shahri Ali Mohammad
- Pourfridoni Mohammad
- Pourtaheri Naeimeh
- Prakash Peralam Yegneswaran
- Prakash Sanjay
- Prakash V
- Prates Elton Junio Sady
- Pritchett Natalie
- Purnobasuki Hery
- Qasim Nameer Hashim
- Qattea Ibrahim
- Qian Gangzhen
- Radhakrishnan Venkatraman
- Raee Pourya
- Raeisi Shahraki Hadi
- Rafique Ibrar
- Raggi Alberto
- Raghav Pankaja Raghav
- Rahati Meghdad M
- Rahim Fakher
- Rahimi Zahra
- Rahimifard Mahban
- Rahman Md Obaidur
- Rahman Mohammad Hifz Ur
- Rahman Mosiur
- Rahman Muhammad Aziz
- Rahmani Youshanlouei Hamed
- Rahmani Amir Masoud
- Rahmani Shayan
- Rahmati Masoud
- Raj Moolambally Sheetal
- Rajabpour-Sanati Ali
- Ramadan Hazem
- Ramasamy Shakthi Kumaran
- Ramasubramani Premkumar
- Ramazanu Sheena
- Rancic Nemanja
- Rao Indu Ramachandra
- Rao Sowmya J
- Rapaka Deepthi
- Rashedi Vahid
- Rashid Ahmed Mustafa
- Rashidi Alavijeh Mehran
- Rashidi Mohammad-Mahdi
- Rasouli-Saravani Ashkan
- Rawaf Salman
- Razo Christian
- Redwan Elrashdy Moustafa Mohamed
- Rekabi Bana Atefe
- Remuzzi Giuseppe
- Rezaei Nazila
- Rezaei Negar
- Rezaei Nima
- Rezaeian Mohsen
- Rhee Taeho Gregory
- Riad Abanoub
- Robinson Stephen R
- Rodrigues MĂłnica
- Rodriguez Jefferson Antonio Buendia
- Roever Leonardo
- Rogowski Emma L B
- Romoli Michele
- Ronfani Luca
- Roy Pramanik Koushik
- Roy Priyanka
- Rubagotti Enrico
- Ruiz Milagros A
- Russ Tom C
- S Sunnerhagen Katharina
- Saad Aly M A
- Saadatian Zahra
- Saber Korosh
- SaberiKamarposhti Morteza
- Sacco Simona
- Saddik Basema
- Sadeghi Erfan
- Sadeghian Saeid
- Saeed Umar
- Saeed Usman
- Safdarian Mahdi
- Safi Sher Zaman
- Sagar Rajesh
- Sagoe Dominic
- Saheb Sharif-Askari Fatemeh
- Saheb Sharif-Askari Narjes
- Sahebkar Amirhossein
- Sahoo Soumya Swaroop
- Sahraian Mohammad Ali
- Sajedi Seyed Aidin
- Sakshaug Joseph W
- Saleh Mohamed A
- Salehi Omran Hossein
- Salem Marwa Rashad
- Salimi Sohrab
- Samadi Kafil Hossein
- Samadzadeh Sara
- Samargandy Saad
- Samodra Yoseph Leonardo
- Samuel Vijaya Paul
- Samy Abdallah M
- Sanadgol Nima
- Sanjeev Rama Krishna
- Sanmarchi Francesco
- Santomauro Damian Francesco
- Santri Ichtiarini Nurullita
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- Saravanan Aswini
- Sarveazad Arash
- Satpathy Maheswar
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- Sayyah Mehdi
- Scarmeas Nikolaos
- Schiess Nicoline
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- Schuermans Art
- Schwarzinger Michaël
- Schwebel David C
- Seeher Katrin Maria
- Selvaraj Siddharthan
- Sendekie Ashenafi Kibret
- Sengupta Pallav
- Senthilkumaran Subramanian
- Serban Dragos
- Sergindo Mihretu Tagesse
- Servili Chiara
- Sethi Yashendra
- SeyedAlinaghi SeyedAhmad
- Seylani Allen
- Shabani Mohammad
- Shabany Maryam
- Shafie Mahan
- Shahabi Saeed
- Shahbandi Ataollah
- Shahid Samiah
- Shahraki-Sanavi Fariba
- Shahsavari Hamid R
- Shahwan Moyad Jamal
- Shaikh Masood Ali
- Shaji KS
- Sham Sunder
- Shama Adisu Tafari T
- Shamim Muhammad Aaqib
- Shams-Beyranvand Mehran
- Shamsi Mohammad Anas
- Shanawaz Mohd
- Sharath Medha
- Sharfaei Sadaf
- Sharifan Amin
- Sharma Manoj
- Sharma Rajesh
- Shashamo Bereket Beyene
- Shayan Maryam
- Sheikhi Rahim Ali
- Shekhar Shashank
- Shen Jiabin
- Shenoy Suchitra M
- Shetty Pavanchand H
- Shiferaw Desalegn Shiferaw
- Shigematsu Mika
- Shiri Rahman
- Shittu Aminu
- Shivakumar K M
- Shokri Fereshteh
- Shool Sina
- Shorofi Seyed Afshin
- Shrestha Sunil
- Siankam Tankwanchi Akhenaten Benjamin
- Siddig Emmanuel Edwar
- Sigfusdottir Inga Dora
- Silva JoĂŁo Pedro
- Silva LuĂs Manuel Lopes Rodrigues
- Sinaei Ehsan
- Singh Balbir Bagicha
- Singh Garima
- Singh Paramdeep
- Singh Surjit
- Sirota Sarah Brooke
- Sivakumar Shravan
- Sohag Abdullah Al Mamun
- Solanki Ranjan
- Soleimani Hamidreza
- Solikhah Solikhah
- Solomon Yerukneh
- Solomon Yonatan
- Song Suhang
- Song Yimeng
- Sotoudeh Houman
- Spartalis Michael
- Stark Benjamin A
- Starnes Joseph R
- Starodubova Antonina V
- Stein Dan J
- Steiner Timothy J
- Steinmetz Jaimie D
- Stovner Lars Jacob
- Suleman Muhammad
- Suliankatchi Abdulkader Rizwan
- Sultana Abida
- Sun Jing
- Sunkersing David
- Sunny Angel
- Susianti Hani
- Swain Chandan Kumar
- Szeto Mindy D
- Tabarés-Seisdedos Rafael
- Tabatabaei Seyyed Mohammad
- Tabatabai Shima
- Tabish Mohammad
- Taheri Majid
- Tahvildari Azin
- Tajbakhsh Ardeshir
- Tampa Mircea
- Tamuzi Jacques JL Lukenze
- Tan Ker-Kan
- Tang Haosu
- Tareke Minale
- Tarigan Ingan Ukur
- Tat Nathan Y
- Tat Vivian Y
- Tavakoli Oliaee Razieh
- Tavangar Seyed Mohammad
- Tavasol Arian
- Tefera Yibekal Manaye
- Tehrani-Banihashemi Arash
- Temesgen Worku Animaw
- Temsah Mohamad-Hani
- Teramoto Masayuki
- Tesfaye Amensisa Hailu
- Tesfaye Edosa Geta
- Tesler Riki
- Thakali Ocean
- Thangaraju Pugazhenthan
- Thapa Rajshree
- Thapar Rekha
- Thomas Nikhil Kenny
- Thrift Amanda G
- Ticoalu Jansje Henny Vera
- Tillawi Tala
- Toghroli Razie
- Tonelli Marcello
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Nghia Minh
- Tran Ngoc-Ha
- Tran Phu Van
- Tromans Samuel Joseph
- Truelsen Thomas Clement
- Truyen Thien Tan Tri Tai
- Tsatsakis Aristidis
- Tsegay Guesh Mebrahtom
- Tsermpini Evangelia Eirini
- Tualeka Abdul Rohim
- Tufa Derara Girma
- Ubah Chukwudi S
- Udoakang Aniefiok John
- Ulhaq Inam
- Umair Muhammad
- Umakanthan Srikanth
- Umapathi Krishna Kishore
- Unim Brigid
- Unnikrishnan Bhaskaran
- Vaithinathan Asokan Govindaraj
- Vakilian Alireza
- Valadan Tahbaz Sahel
- Valizadeh Rohollah
- Van den Eynde Jef
- Vart Priya
- Varthya Shoban Babu
- Vasankari Tommi Juhani
- Vaziri Siavash
- Vellingiri Balachandar
- Venketasubramanian Narayanaswamy
- Verras Georgios-Ioannis
- Vervoort Dominique
- Villafañe Jorge Hugo
- Villani Leonardo
- Vinueza Veloz Andres Fernando
- Viskadourou Maria
- Vladimirov Sergey Konstantinovitch
- Vlassov Vasily
- Volovat Simona Ruxandra
- Vos Theo
- Vu Loc Tri
- Vujcic Isidora S
- Wagaye Birhanu
- Waheed Yasir
- Wahood Waseem
- Walde Mandaras Tariku
- Wang Fang
- Wang Shu
- Wang Yanzhong
- Wang Yuan-Pang
- Waqas Muhammad
- Waris Abdul
- Weerakoon Kosala Gayan
- Weintraub Robert G
- Weldemariam Abrha Hailay
- Westerman Ronny
- Whisnant Joanna L
- Wickramasinghe Dakshitha Praneeth
- Wickramasinghe Nuwan Darshana
- Willekens Barbara
- Wilner Lauren B
- Winkler Andrea Sylvia
- Wolfe Charles D A
- Wu Ai-Min
- Wulf Hanson Sarah
- Xu Suowen
- Xu Xiaoyue
- Yadollahpour Ali
- Yaghoubi Sajad
- Yahya Galal
- Yamagishi Kazumasa
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Yehualashet Sisay Shewasinad
- Yeshaneh Alex
- Yesiltepe Metin
- Yi Siyan
- YiÄit Arzu
- YiÄit Vahit
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Yusuf Hadiza
- Zadey Siddhesh
- Zahedi Mohammad
- Zakham Fathiah
- Zaki Nazar
- Zali Alireza
- Zamagni Giulia
- Zand Ramin
- Zandieh Ghazal G Z
- Zangiabadian Moein
- Zarghami Amin
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zegeye Zelalem Banjaw
- Zeukeng Francis
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Hanqing
- Zhao Yang
- Zheng Peng
- Zhou Hengxing
- Zhu Bin
- Zhumagaliuly Abzal
- ZieliĆska Magdalena
- Zikarg Yossef Teshome
- Zoladl Mohammad
- Ărnlöv Johan
- Publication venue
- Elsevier
- Publication date
- 01/04/2024
- Field of study
BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378â521), affecting 3·40 billion (3·20â3·62) individuals (43·1%, 40·5â45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7â26·7) between 1990 and 2021. Age-standardised rates of deaths per 100â000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6â38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5â32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7â2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed
Depletion-mode quantum dots in intrinsic silicon
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Delaying surgery for patients with a previous SARS-CoV-2 infection
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- Sohei Satoi
- Sohini Chakrabortee
- Ssa Qadri
- Stephen J Price
- Stephen Tabiri
- Steve Bromage
- Stuart C Winter
- Sudha Sundar
- Sudha Sundar
- Susan Moug
- Susan Moug
- Syed Was
- Symeon Metallidis
- T A Lawal
- T Abbott
- T Aiken
- T Alnumani
- T Arif
- T Armao
- T Avlund
- T Bin Traiki
- T Boyle
- T Bozanovic
- T Bright
- T BĂ€chler
- T Campagnaro
- T Casiraghi
- T Chase
- T Colloc
- T Combellack
- T Connelly
- T Correia de SĂĄ
- T Cuming
- T Curl-Roper
- T Derksen
- T Drake
- T E Topczewski
- T Elmoslemany
- T Erol
- T Fahmawee
- T Fontana
- T Frisoni
- T Fullmer
- T Gala
- T Gallagher
- T Garmanova
- T Golda
- T Gould
- T Grassi
- T Grivas
- T Grove
- T GĂłmez Sanz
- T Hilton
- T Hossain
- T Hovhannisyan
- T Janjic
- T Jones
- T K Madhuri
- T KarahasanoÄlu
- T Kato
- T Kaya
- T Khan
- T Klatte
- T Liakakos
- T M Sorour
- T Maccabe
- T Marina Martin
- T Martin
- T Miguel
- T Nambirajan
- T Nelli
- T Newman
- T NicolĂĄs-LĂłpez
- T Nouh
- T Nugent
- T O Klatte
- T Perra
- T Pina-Vaz
- T Pissanou
- T Poli
- T Raymond
- T Reinhard
- T Revez
- T Richards
- T Routledge
- T Royle
- T Saafan
- T Sammour
- T Santarius
- T Schiergens
- T Sehgal
- T Shortland
- T Sian
- T Sidiropoulos
- T T Sholadoye
- T Tammaro
- T Theodosopoulos
- T Tsirlis
- T Uson-Bouthelier
- T Van Wyngaard
- T Vanounou
- T Vieira Caroço
- T Violante
- T Vollkommer
- T Walton
- T Wasim
- T Welsch
- T Williams
- Tabassum Khan
- Tatiana Garmanova
- Thomas D Pinkney
- Thomas Konney
- Thomas M Drake
- Tobias Klatte
- Tom Ef Abbott
- U Akgor
- U Andaleeb
- U Bork
- U Bumbasirevic
- U Butt
- U De Andres Olabarria
- U Fernandes
- U Fumagalli Romario
- U G Vo
- U Grossi
- U Jayarajah
- U M Jariod Ferrer
- U Ribeiro Junior
- U Ronellenfitsch
- U Selbong
- U Speth
- V Alexoudi
- V Annessi
- V Bascarevic
- V Capizzi
- V Chiarella
- V Cozza
- V D Mandato
- V De Simone
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- V Fernandes
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- V Gata
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- Veeru Kasivisvanathan
- W Butt
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- W Garrett
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- W J Wong
- W Knight
- W Lee
- W Marx
- W McCormick
- W McGahan
- W Mugla
- W Oosterlinck
- W Raby-Smith
- W Smolka
- W Van Houdt
- W Yang
- Willemijn van der Plas
- Wong Mpk
- X De Sousa
- X Morales
- X S Tan
- Y Aawsaj
- Y Al-Tamimi
- Y Arkha
- Y Ayasra
- Y Bashir
- Y El Bouazizi
- Y Fayed
- Y H Lam
- Y Kanemitsu
- Y Kara
- Y Kirmizi
- Y Levy-Zauberman
- Y Litvina
- Y Perez
- Y T Liew
- Y Tanase
- Y Viswanath
- Y Ying
- Z Al-Ishaq
- Z Aldayri
- Z Aliyeva
- Z Bayhan
- Z Chia
- Z Dzamic
- Z H Belkhadir
- Z Inic
- Z Jawad
- Z Jezdic
- Z Katusic
- Z Krivokapic
- Z Lakkis
- Z Li
- Z M Barrett-Brown
- Z Mahasin
- Z Seymour
- Z Vilendecic
- Z Zakaria
- Ă De la Hoz RodrĂguez
- à Fernåndez Camuñas
- Ă Ryan
- Ćœ GrubaÄ
- Đ ĐĐ°ĐŒĐ°Đ»ĐŸĐČ
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Not availabl
Elective Cancer Surgery in COVID-19âFree Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
- Author
- Aawsaj Y
- Abad Gurumeta A
- Abad-Motos A
- Abate E
- Abatini C
- Abbadessa F
- Abbas AM
- Abbassi-Ghadi N
- Abbott D
- Abbott T
- Abbott Tom EF
- Abd Elazeem HAS
- Abdalla M
- Abdallah M
- Abdel Al S
- Abdel Jalil R
- Abdeldayem H
- Abdelkader Salama I
- Abdelkarem MM
- Abdelkarim M
- Abdelmajeed A
- Abdelrahman A
- Abdelrahman S
- Abdelsamed A
- Abdou M
- Abdulkareem A
- Abdulwahed E
- Abdur-Rahman L
- Abel MK
- AbellĂĄn M
- Aboelkassem Ibrahim A
- Abosamak NE
- Abou Chaar MK
- Abou Chaar Mohammad K.
- Abou-Khalil J
- Abouassi A
- Aboulkassem H
- Abreu da Silva A
- Abu Zaânouneh FJ
- Abu J
- Abu-Nayla I
- Abubakar A
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acrich E
- Adamina M
- Adamina Michel
- Adamoli L
- Addae-Boateng E
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adiamah A
- Adishesh M
- Agapov M
- Agarwal Arnav
- Aggarwal A
- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agoston P
- Agrawal A
- Agresta F
- Aguado H
- Aguilar Gonzalez M
- Aguzzoli L
- Ahad S
- Ahmadi N
- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
- Ajlan A
- Akalin M
- Akaydin E
- Akeel N
- Akgor U
- Akhtar MA
- Akhter Rahman MM
- Akilli H
- Akin E
- Akkour K
- Akkulak Murat
- Akmenkalne L
- Al Abdallah M
- Al Awwad S
- Al Habes H
- Al Maadany FS
- Al Raddadi R
- AL Sayed M
- Al-Habib A
- Al-Habsi R
- Al-Ishaq Z
- Al-Khayal K
- Al-Masri M
- Al-Mohammad A
- Al-mukhtar A
- Al-Najjar H
- Al-omishy H
- Al-Sarireh B
- Al-Tamimi Y
- Alaa S
- AlAamer O
- Aladeojebi A
- Alakaloko Felix
- Alam F
- Alam N
- Alam R
- Alameer Ehab
- Alamri A
- Alamri Alex
- Alanbuki A
- Alatar A
- Alawneh F
- Alazawi D
- Albertsmeier M
- Albertsmeiers Markus
- Albi Martin B
- Alburakan A
- Alcaide Matas F
- Alconchel F
- Aldayri Z
- Aldecoa Ansorregui I
- Alderson Derek
- Aldokali N
- AleksiÄ L
- Alemanno G
- Alexoudi V
- Alfaro-Goldaracena A
- Alfieri S
- Alghamdi M
- Alhalal H
- Alhamed A
- Alharthi M
- Alharthi R
- Alhassan B
- Alhassan N
- Alhefdhi A
- Ali karar AA
- Ali AK
- Ali M
- Ali S
- Aliyeva Z
- Aljanadi F
- Aljiffry M
- Alkadeeki GZ
- Alkarak S
- Allemand C
- Allison J
- Almalik O
- Almasri M
- Almeciga A
- Almeida A
- Almeida AC
- Almeida JI
- Almgla N
- Almond M
- Almond Max
- Alnumani T
- Alobeed O
- Alomair A
- Alonso de la Fuente N
- Alonso Poza A
- Alonso-Lamberti L
- Alotaibi N
- Alqannas M
- Alresaini F
- Alriyees L
- Alsaif A
- Alsaif F
- Alsalamah R
- Alsaraireh O
- Alselaim N
- Alser Osaid
- Alshaar Muhammad
- Alshahrani M
- Alshammari S
- Alshareea E
- Alsharif F
- Alshaygy I
- Alshryda Sattar
- Alsobhi S
- Althobaiti W
- Altintoprak F
- Alurralde C
- Alvarez E
- Alvarez MR
- Alyami M
- Alzamanan M
- Amaral MJ
- Ameerally P
- Amin Sahid N
- Amira G
- Amonkar S
- Amorim E
- Ampollini L
- Amrani L
- Anania G
- Anastasi A
- Anchuelo Latorre J
- Andaleeb U
- Andaya V
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- Andrijasevic S
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- Angelou D
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- Annamalai S
- Annessi V
- Ansarin M
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- Antoniades K
- Antonopoulou MI
- Anula R
- Anwar S
- Anzak A
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- Aprile A
- Aquila F
- Aragon Achig EJ
- Aremu I
- Aremu M
- Aresu G
- Aribi N
- Aribi S
- Arican C
- Arif T
- Arigoni M
- Arikan AE
- Arkadopoulos N
- Arkha Y
- Armao T
- Armatura G
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- AscensĂŁo J
- Ashcroft J
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- Assalaarachchi H
- Asti E
- Astreidis I
- AtaĂde Gomes Gustavo Mendonça
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- Athanasiou A
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- Atherton R
- Athwal R
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- Attia D
- Augestad Knut Magne
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- Ayasra F
- Ayasra Faris
- Ayasra Y
- Aydin C
- Ayhan A
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- Ayubi A
- Azam M
- Azamat Ä°F
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- Azizeldine MG
- Azizi A
- Azzam AY
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- Baietti AM
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- BailĂłn M
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- Balasubramanian I
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- Banky B
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- Barlow Emma
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- Batstone M
- Batstone Martin
- Battista MJ
- Bauer M
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- Baxevanidou K
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- Blazquez Martin A
- Boal M
- BobiĆski M
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- Bocchialini G
- Bocciolone L
- Boddaert G
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- Bonci E
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- Branquinho A
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- Breda D
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- Bretherton Chris
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- Bristow Rob
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- Bromage Steve
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- Byrne M
- Bywater Edward
- BĂ mbina F
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- Böttcher A
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- Cadwell-Sneath S
- Cagigal Ortega EP
- Cagigas Fernandez C
- Cahill J
- Caiado A
- Caimari B
- Caird S
- Cairncross L
- Caiña Ruiz R
- Caja Vivancos P
- Cakmak G
- CalabrĂČ M
- Callanan D
- Calvo Espino P
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- Campagnaro T
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- on behalf of the COVIDSurg Collaborative
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- ĂlgĂ„ A
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- Ăolak E
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- ĂÄĂŒcĂŒ H
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- Äoza I
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- Ć ÄepanoviÄ V
- ĆœateckĂœ J
- ĐĐ°ĐŒĐ°Đ»ĐŸĐČ Đ
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 01/01/2021
- Field of study
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Aawsaj Y
- Abadia M
- AbadâGurumeta A
- AbadâMotos A
- Abassy J
- Abate E
- Abbasov A
- Abbott D
- Abbott Tom EF
- Abdalla M
- Abdeldayem H
- Abdelkabir M
- Abdelkader Salama I
- Abdelkarim M
- Abdelsamed A
- Abdulfattah F
- Abdulwahed E
- AbdurâRahman LO
- Abel MK
- Abelevich A
- Abiyere H
- Aboelkassem Ibrahim A
- Aboharp Hasan Z
- Abou Chaar MK
- Abreu da Silva A
- Abubakar A
- Abukhalaf SA
- Abukhalaf Sadi
- Acebes GarcĂa F
- Achalandabaso Boira M
- Acher A
- Acosta MĂ©rida MA
- Acrich E
- Adam Essa Adam ME
- Adamina M
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Aderombi A
- Adeyeye A
- Adeyeye A
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- Adiamah A
- Adisa Adewale
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- Agapov M
- Agarwal Arnav
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- Aghayeva A
- Agilinko J
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguado LĂłpez H
- Aguiar JĂșnior S
- Aguilar Gonzalez M
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- Ahmed ME
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- Ahmeidat A
- Ahn JH
- Aiken T
- Aimé A
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- Akaydin E
- Akbas A
- Akhtar MA
- Akhtar N
- Akhter Rahman MM
- Akin E
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al ahmad F
- Al Asadi T
- Al Awwad S
- Al Ayed A
- Al Habes H
- Al Riyami S
- AL Sayed M
- Alaa S
- AlAamer O
- Aladeojebi A
- Alagoa Joao A
- Alakaloko Felix
- Alam F
- Alameer Ehab
- Alamri Alex
- Alanazi F
- Alawneh F
- Albaqami F
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- Albertsmeier Markus
- Alcaide Matas F
- Alconchel F
- AlcĂĄzar JA
- Alderson Derek
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- Alkadiki Ghadah Z
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- Alser Osaid
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- Augestad Knut Magne
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- Bretherton Chris
- Brewer H
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- Brocklehurst M
- Bromage Steve
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- Bywater Edward
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- CapitanâMorales L
- Capkinoglu E
- Capolupo GT
- Capunge I
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- Caram EL
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- Cato LD
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- Charre L
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- Chatzikomnitsa P
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- Chevallay M
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- Cohen Paul
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- Colquhoun Alexandra
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- CrausâMiguel A
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- Yousof EA
- Youssef M
- Yurttas C
- YĂĄnez C
- YĂŒksel E
- Zafar SN
- Zakaria AD
- Zakaria Z
- Zakharenko A
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- Zanus G
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- ZeliÄ M
- Zengin AK
- Zerbib P
- Zervas K
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- Zhang H
- Zizzo M
- Zmora O
- Zografos C
- Zonta S
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- Zourntou S
- Zubaidi A
- Ăngelo M
- ĂlgĂ„ A
- Ăelebi F
- Ăolak E
- Ăfner D
- Ăhlberger L
- Ăzant A
- Ăzçay N
- ĂÄĂŒcĂŒ H
- ĂberrĂŒck L
- Äoza I
- Ćawnicka A
- ĆœateckĂœ J
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2022
- Field of study
AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4âweeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4âweeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, PÂ =Â 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, PâConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease