Do North American Migratory Barren-Ground Caribou Subpopulations Cycle?

Unlike all other members of the deer family, subpopulations of barren-ground caribou (Rangifer tarandus groenlandicus) are typically sine-cyclic. We used Bayesian Information Criteria (BIC) to rank competing population dynamics models for 11 North American barren-ground caribou subpopulations. Nine of these subpopulations were best described as sine-cyclic with periods ranging from a minimum of 26 years (Bluenose-East and Porcupine) to a maximum of 55 years (Western Arctic); and amplitudes ranging from a minimum of 8 455 (Cape Bathurst) to a maximum of 327 432 (George River). Time series estimates of subpopulation abundance generated by the sine cycle models showed good correspondence to published subpopulation estimates of abundance for all nine sine-cyclic subpopulations (r = 0.978; p < 0.001). Lack of demographic closure (migration between subpopulations) was evident in both of the subpopulations that were not identified as sine-cyclic. Barren-ground caribou subpopulation amplitudes were mostly determined by subpopulation total range size and summer range productivity (R2 = 0.962; p < 0.001) and subpopulation periods were mostly determined by amplitude, total range productivity, and land surface temperature (R2 = 0.950; p < 0.001). Time series estimates of subpopulation abundance generated from the respective environmental regression models were highly correlated (r = 0.964; p < 0.001) to the published subpopulation estimates of abundance for the set of 9 sine-cyclic subpopulations. Extended (> 3 generations) subpopulation declines are a natural feature of cyclic barren-ground caribou subpopulations. Trends in species abundance based on pooled assemblages of asynchronous cyclic subpopulations should be interpreted with caution.Contrairement à tous les autres membres de la famille des cervidés, les sous-populations de caribous de la toundra (Rangifer tarandus groenlandicus) suivent généralement un cycle sinusoïdal. Nous avons employé des critères d’information bayésiens (BIC) pour classer des modèles de dynamique des populations concurrentiels pour 11 sous-populations nord-américaines de caribous de la toundra. Neuf de ces sous-populations correspondaient mieux à une description de cycle sinusoïdal avec des périodes allant d’un minimum de 26 ans (Bluenose-Est et Porcupine) à un maximum de 55 ans (Arctique de l’Ouest); et des amplitudes allant d’un minimum de 8 455 (cap Bathurst) à un maximum de 327 432 (rivière George). Les estimations des séries chronologiques de l’abondance des sous-populations obtenues à l’aide des modèles de cycles sinusoïdaux ont affiché une bonne correspondance par rapport aux estimations publiées de l’abondance des sous-populations pour l’ensemble des neuf sous-populations de cycle sinusoïdal (r = 0,978; p < 0,001). Le manque de fermeture démographique (migration entre les sous-populations) était évident dans les deux sous-populations qui n’étaient pas considérées comme suivant un cycle sinusoïdal. L’amplitude des sous-populations de caribous de la toundra était principalement déterminée par la taille de l’aire de répartition totale et la productivité de l’aire d’estivage (R2 = 0,962; p < 0,001), et les périodes de sous-populations étaient principalement déterminées par l’amplitude, la productivité de l’aire de répartition totale et la température en surface des terres (R2 = 0,950; p < 0,001). Les estimations des séries chronologiques de l’abondance des sous-populations produites au moyen des modèles respectifs de régression environnementale étaient fortement corrélées (r = 0,964; p < 0,001) aux estimations publiées de l’abondance des sous-populations pour l’ensemble des neuf sous-populations de cycle sinusoïdal. Les déclins prolongés (> 3 générations) de sous-populations sont une caractéristique naturelle des sous-populations cycliques de caribous de la toundra. Les tendances caractérisant l’abondance des espèces en fonction d’assemblages regroupés de sous-populations cycliques asynchrones devraient être interprétées avec prudence

Covariations of chromospheric and photometric variability of the young Sun analogue HD 30495: evidence for and interpretation of mid-term periodicities

This study reports the synchronization between the chromospheric and photometric variability at time-scale of about 1.6–1.8 yr as observed for the young, rapidly rotating solar analogue HD 30495. In addition, HD 30495 may be presenting evidence of surface differential rotation at time-scales of about 11 d and 21 d, as well as the sunspot-like decadal cycles at 11–12 yr or so. We apply a new gapped wavelet method of time–frequency analysis for studying the variability in a new composite of the chromospheric S-index (1967–2018) and the longest photometric Δ(b + y)/2 index (1993–2018). We discuss and interpret our results in relation to other observed mid-term periodicities roughly of the same time-scales that had been found recently from not only chromospheric and photospheric activity indices but also from coronal X-ray emissions as observed in a considerably large set of stellar samples including those young Sun analogues from the Kepler satellite project. Thus, there is an apparent universality of such mid-term activity modulation time-scales as this solar-stellar magnetic phenomenon is well observed directly for a host of solar activity related indices covering the photopsheric, chromospheric, coronal, and even the heliospheric (utilizing the measures of incoming galactic cosmic rays as a probe of activity variations) activity records. This is why we made a further attempt to interpret the results in search of a realistic generation mechanism as well as spatio-temporal persistency of the phenomenon under a wide scenario of dynamo simulations

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Impacts of the Tropical Pacific/Indian Oceans on the Seasonal Cycle of the West African Monsoon

The current consensus is that drought has developed in the Sahel during the second half of the twentieth century as a result of remote effects of oceanic anomalies amplified by local land–atmosphere interactions. This paper focuses on the impacts of oceanic anomalies upon West African climate and specifically aims to identify those from SST anomalies in the Pacific/Indian Oceans during spring and summer seasons, when they were significant. Idealized sensitivity experiments are performed with four atmospheric general circulation models (AGCMs). The prescribed SST patterns used in the AGCMs are based on the leading mode of covariability between SST anomalies over the Pacific/Indian Oceans and summer rainfall over West Africa. The results show that such oceanic anomalies in the Pacific/Indian Ocean lead to a northward shift of an anomalous dry belt from the Gulf of Guinea to the Sahel as the season advances. In the Sahel, the magnitude of rainfall anomalies is comparable to that obtained by other authors using SST anomalies confined to the proximity of the Atlantic Ocean. The mechanism connecting the Pacific/Indian SST anomalies with West African rainfall has a strong seasonal cycle. In spring (May and June), anomalous subsidence develops over both the Maritime Continent and the equatorial Atlantic in response to the enhanced equatorial heating. Precipitation increases over continental West Africa in association with stronger zonal convergence of moisture. In addition, precipitation decreases over the Gulf of Guinea. During the monsoon peak (July and August), the SST anomalies move westward over the equatorial Pacific and the two regions where subsidence occurred earlier in the seasons merge over West Africa. The monsoon weakens and rainfall decreases over the Sahel, especially in August.Peer reviewe

Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV