A modified approach to controller partitioning

The idea of computing a decentralized control law for the integrated flight/propulsion control of an aircraft by partitioning a given centralized controller is investigated. An existing controller partitioning methodology is described, and a modified approach is proposed with the objective of simplifying the associated controller approximation problem. Under the existing approach, the decentralized control structure is a variable in the partitioning process; by contrast, the modified approach assumes that the structure is fixed a priori. Hence, the centralized controller design may take the decentralized control structure into account. Specifically, the centralized controller may be designed to include all the same inputs and outputs as the decentralized controller; then, the two controllers may be compared directly, simplifying the partitioning process considerably. Following the modified approach, a centralized controller is designed for an example aircraft mode. The design includes all the inputs and outputs to be used in a specified decentralized control structure. However, it is shown that the resulting centralized controller is not well suited for approximation by a decentralized controller of the given structure. The results indicate that it is not practical in general to cast the controller partitioning problem as a direct controller approximation problem

Analysis of Sensor Coil Implemented in Maxwell-Wien Bridge Circuit for Detecting Ferrous and Non-Ferrous Particles

This paper presents an analysis of a wear debris sensor coil implemented in a Maxwell-Wien Bridge circuit used in detecting ferrous and non-ferrous particles. The sensor coil is designed to have a diameter approximately 15 times larger than the largest particle being detected. To detect particles up to 2 mm in diameter, a coil 30 mm in diameter was constructed. Simulations of the experiment indicate that the available particles should be detectable by the sensor coil. However, experimental results indicate that the Maxwell-Wien Bridge does not detect the available particles. Further simulations are presented accounting for parasitic capacitance of the sensor coil. The results from these simulations show that large parasitic capacitance affects the behavior of the bridge. The available particles were etched into smaller particles more typical of wear debris. It is expected that for a smaller coil, the effects of parasitic capacitance will be reduced

To Err is Normable: The Computation of Frequency-Domain Error Bounds from Time-Domain Data

This paper exploits the relationships among the time-domain and frequency-domain system norms to derive information useful for modeling and control design, given only the system step response data. A discussion of system and signal norms is included. The proposed procedures involve only simple numerical operations, such as the discrete approximation of derivatives and integrals, and the calculation of matrix singular values. The resulting frequency-domain and Hankel-operator norm approximations may be used to evaluate the accuracy of a given model, and to determine model corrections to decrease the modeling errors

Follicular helper T cells are required for systemic autoimmunity

Production of high-affinity pathogenic autoantibodies appears to be central to the pathogenesis of lupus. Because normal high-affinity antibodies arise from germinal centers (GCs), aberrant selection of GC B cells, caused by either failure of negative selection or enhanced positive selection by follicular helper T (TFH) cells, is a plausible explanation for these autoantibodies. Mice homozygous for the san allele of Roquin, which encodes a RING-type ubiquitin ligase, develop GCs in the absence of foreign antigen, excessive TFH cell numbers, and features of lupus. We postulated a positive selection defect in GCs to account for autoantibodies. We first demonstrate that autoimmunity in Roquinsan/san (sanroque) mice is GC dependent: deletion of one allele of Bcl6 specifically reduces the number of GC cells, ameliorating pathology. We show that Roquinsan acts autonomously to cause accumulation of TFH cells. Introduction of a null allele of the signaling lymphocyte activation molecule family adaptor Sap into the sanroque background resulted in a substantial and selective reduction in sanroque TFH cells, and abrogated formation of GCs, autoantibody formation, and renal pathology. In contrast, adoptive transfer of sanroque TFH cells led to spontaneous GC formation. These findings identify TFH dysfunction within GCs and aberrant positive selection as a pathway to systemic autoimmunity

Geometric and algebraic classification of quadratic differential systems with invariant hyperbolas

Let QSH be the whole class of non-degenerate planar quadratic differential systems possessing at least one invariant hyperbola. We classify this family of systems, modulo the action of the group of real affine transformations and time rescaling, according to their geometric properties encoded in the configurations of invariant hyperbolas and invariant straight lines which these systems possess. The classification is given both in terms of algebraic geometric invariants and also in terms of affine invariant polynomials and it yields a total of 205 distinct such configurations. We have 162 configurations for the subclass QSH(η>0) of systems which possess three distinct real singularities at infinity, and 43 configurations for the subclass QSH(η=0) of systems which possess either exactly two distinct real singularities at infinity or the line at infinity filled up with singularities. The algebraic classification, based on the invariant polynomials, is also an algorithm which makes it possible to verify for any given real quadratic differential system if it has invariant hyperbolas or not and to specify its configuration of invariant hyperbolas and straight lines

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques

HIV-1 mucosal transmission begins with virus or virus-infected cells moving through mucus across mucosal epithelium to infect CD4+ T cells. Although broadly neutralizing antibodies (bnAbs) are the type of HIV-1 antibodies that are most likely protective, they are not induced with current vaccine candidates. In contrast, antibodies that do not neutralize primary HIV-1 strains in the TZM-bl infection assay are readily induced by current vaccine candidates and have also been implicated as secondary correlates of decreased HIV-1 risk in the RV144 vaccine efficacy trial. Here, we have studied the capacity of anti-Env monoclonal antibodies (mAbs) against either the immunodominant region of gp41 (7B2 IgG1), the first constant region of gp120 (A32 IgG1), or the third variable loop (V3) of gp120 (CH22 IgG1) to modulate in vivo rectal mucosal transmission of a high-dose simian-human immunodeficiency virus (SHIV-BaL) in rhesus macaques. 7B2 IgG1 or A32 IgG1, each containing mutations to enhance Fc function, was administered passively to rhesus macaques but afforded no protection against productive clinical infection while the positive control antibody CH22 IgG1 prevented infection in 4 of 6 animals. Enumeration of transmitted/founder (T/F) viruses revealed that passive infusion of each of the three antibodies significantly reduced the number of T/F genomes. Thus, some antibodies that bind HIV-1 Env but fail to neutralize virus in traditional neutralization assays may limit the number of T/F viruses involved in transmission without leading to enhancement of viral infection. For one of these mAbs, gp41 mAb 7B2, we provide the first co-crystal structure in complex with a common cyclical loop motif demonstrated to be critical for infection by other retroviruses

Synthesis of Recursive Linear-Phase Filters for Fixed-Point Hardware Platforms

This study presents a methodology for recursive implementation of linear-phase finite impulse response (FIR) filters in fixed-point hardware platforms. The work uses a modified version of the switching and reset method to efficiently implement recursive linear-phase exponential filters. An error analysis is presented that defines the upper error bounds resulting from the switching and reset implementation of the exponential filters in fixed-point hardware. The exponential filters are then used as basis functions to synthesise other filters of interest. Gaussian filters are used as an example. The suggested recursive implementation delivers an accurate approximation of the Gaussian function. Unlike traditional techniques for implementing FIR filters, the hardware size of this recursive technique is O(1). In other words, increasing the order of a filter does not proportionally increase its hardware size. The results show that when implementing Gaussian filters on FPGAs, doubling the size of the filter, only increased the hardware size by an average of 6.12%

Inductive Coulter Counting: Detection and Differentiation of Metal Wear Particles in Lubricant

A device based on an inductive Coulter counting principle for detecting metal particles in lubrication oil is presented. The device detects the passage of ferrous and nonferrous particles by monitoring the inductance change in a coil. First, the sensing principle is demonstrated at the mesoscale using a solenoid. Next, a small planar coil suitable for use in a microscale device is tested. Static tests are conducted on the planar coil using iron and aluminum particles ranging from 80 to 500 µm. The testing results show that the coil can be used to detect and distinguish ferrous and nonferrous metal particles in lubrication oil; such particles can be indicative of potential machine faults in rotating and reciprocating machinery. The design concept demonstrated here can be extended to a microfluidic device for real-time monitoring of ferrous and nonferrous wear debris particles

Synthesis of Recursive Linear-Phase Filters for Fixed-Point Hardware Platforms

This study presents a methodology for recursive implementation of linear-phase finite impulse response (FIR) filters in fixed-point hardware platforms. The work uses a modified version of the switching and reset method to efficiently implement recursive linear-phase exponential filters. An error analysis is presented that defines the upper error bounds resulting from the switching and reset implementation of the exponential filters in fixed-point hardware. The exponential filters are then used as basis functions to synthesise other filters of interest. Gaussian filters are used as an example. The suggested recursive implementation delivers an accurate approximation of the Gaussian function. Unlike traditional techniques for implementing FIR filters, the hardware size of this recursive technique is O(1). In other words, increasing the order of a filter does not proportionally increase its hardware size. The results show that when implementing Gaussian filters on FPGAs, doubling the size of the filter, only increased the hardware size by an average of 6.12%