Emissivity coatings for low-temperature space radiators Quarterly progress report, 1 Jan. - 31 Mar. 1966

Solar absorptance and emittance of candidate zinc oxides/silicone and zinc oxide/potassium silicate coatings measured at room temperature for application to space radiator

Homosexual Orientation in Males: Evolutionary and Ethological Aspects

Evolutionary theory proposes that adaptive traits are reproduced more successfully than maladaptive traits. Accordingly, natural selection should favour heterosexuality as it facilitates reproduction and the propagation of genes. However, the question becomes, what has maintained homosexuality in a small but consistent percentage of the human population? Research into the evolutionary and hormonal factors associated with a homosexual orientation have yielded provocative but inconsistent results. It also suggests that human sexual orientation, and in particular homosexual orientation, is too complex to be described by one simple model or a single research discipline. The current paper treads a new path and emphasises an integrative approach for the understanding of homosexuality. The authors examine the combined effects of evolutionary factors and neurohormonal processes on the development of a homosexual orientation. It is suggested that research into the topic could benefit from an examination of and change in some of the assumptions upon which much past research has been based

Human Pheromones: Integrating Neuroendocrinology and Ethology

The effect of sensory input on hormones is essential to any explanation of mammalian behavior, including aspects of physical attraction. The chemical signals we send have direct and developmental effects on hormone levels in other people. Since we don't know either if, or how, visual cues might have direct and developmental effects on hormone levels in other people, the biological basis for the development of visually perceived human physical attraction is currently somewhat questionable. In contrast, the biological basis for the development of physical attraction based on chemical signals is well detailed

Rurality as a Moderator of Perception of Need for Medical Care and Patient Satisfaction

Many individuals experience barriers to accessing medical care, especially in rural areas. Some barriers are attitudinal and represent perceptions of quality care. Patient satisfaction and perceived need for medical care are two such attitudinal barriers related to health care utilization, yet the relationship between these variables has not been explored. Using data from an online survey, the current study examined the association between these variables, and further, whether rurality status moderated this association. Results indicated a significant correlation between patient satisfaction and perception of need. Although the overall moderation model was significant, perception of need was not significantly associated with patient satisfaction, and rurality status did not significantly moderate the relationship. However, the covariates of sexual orientation and income did significantly predict patient satisfaction. This study highlights the complex associations of patient satisfaction, as well as the importance of social determinants of health in patients’ perceptions of quality of care

Patterns of General- and Eating Disorder-Related Psychopathology in Relation to Weight Change in Treatment-Seeking Children

Few studies have examined the compounded impact of general psychopathology and eating disorder (ED) psychopathology on weight change in youth with overweight/obesity (OW/OB). We characterized patterns of general psychopathology and ED psychopathology in children with OW/OB and examined the impact on weight change following family-based behavioral obesity treatment (FBT). Children (n=172) with OW/OB participated in 4 months of FBT. General psychopathology (i.e., anxiety, depression), ED psychopathology (i.e., shape concern, weight concern, loss of control (LOC) eating), and child percent overweight (%OW) were assessed at baseline. Latent profile analysis identified patterns of general and ED psychopathology at baseline. Multiple linear regression examined whether profiles were associated with %OW at 4 months adjusting for child sex, age, race, ethnicity, household socioeconomic status, and baseline %OW. Results indicated a three-profile structure: low psychopathology (LOW); high psychopathology without LOC (HIGH); and high psychopathology plus LOC (HIGH+LOC). There were no significant differences between LOW vs. HIGH (LSM = 0.45, SE = 1.60, p = .96, 95% CI = -3.13, 4.23), LOW vs. HIGH+LOC (LSM = -0.31, SE = 1.74, p = .98, 95% CI = -4.43, 3.82), or HIGH vs. HIGH+LOC (LSM = -0.76, SE = 1.46, p = .86, 95% CI: -4.21, 2.70) in degree of weight change following FBT. Regardless of profiles, children achieved clinically significant weight loss. Prospective data are needed to examine the durability of treatment effects among these youth with concurrent psychopathology

The Nicastrin ectodomain adopts a highly thermostable structure

Nicastrin is a type I transmembrane glycoprotein, which is part of the high molecular weight gamma-secretase complex. gamma-Secretase is one of the key players associated with the generation of Alzheimer's disease pathology, since it liberates the neurotoxic amyloid beta-peptide. Four proteins Nicastrin, anterior pharynx-defective-1 (Aph-1), presenilin enhancer-2 (Pen-2) and Presenilin are essential to form the active gamma-secretase complex. Recently it has been shown, that Nicastrin has a key function in stabilizing the mature gamma-secretase complex and may also be involved in substrate recognition. So far no structural data for the Nicastrin ectodomain or any other gamma-secretase component are available. We therefore used Circular Dichroism (CD) spectroscopy to demonstrate that Nicastrin, similar to its homologues, the Streptomyces griseus aminopeptidase (SGAP) and the transferrin receptor (TfR), adopts a thermostable secondary structure. Furthermore, the Nicastrin ectodomain has an exceptionally high propensity to refold after thermal denaturation. These findings provide evidence to further support the hypothesis that Nicastrin may share evolutionary conserved properties with the aminopeptidase and the transferrin receptor family

Emissivity coatings for low-temperature space radiators Quarterly progress report, 1 Jul. - 30 Sep. 1966

Low solar absorption emissivity coatings for low temperature spacecraft radiators - ultraviolet radiation test