Le Léonard de Paul Valéry

La fin du XIXe siècle correspond à un regain d’intérêt pour l’œuvre multiforme de Léonard de Vinci. À côté des historiens de l’art, des philosophes et des savants qui se sont passionnés, voire déchirés pour le génie italien, Paul Valéry occupe une place à part. Très tôt, il s’est plongé dans les publications des manuscrits de Léonard. Il devait en tirer une œuvre de jeunesse, Introduction à la méthode de Léonard de Vinci. Ce texte saisissant, évolutif, a accompagné Paul Valéry tout au long de son parcours d’écrivain, tout en rencontrant un accueil particulier et même en exerçant une véritable fascination chez certains ingénieurs du XXe siècle. C’est la première version de La Méthode, celle parue en 1895, que cet article propose de présenter.The end of the 19th century saw a renewed interest in the multifaceted work of Leonardo da Vinci. Alongside intellectuals who were passionate about the Italian genius, Paul Valéry occupies a special place. Very early on, he dived into the Leonardo's manuscripts, from which he wrote his first book, Introduction à la méthode de Léonard de Vinci. Paul Valéry worked on this text throughout his entire life. The Introduction fascinated the engineers who often drew inspiration from it in their design works. It is the first version of the book, published in 1895, which is presented here

An experimental study of the effect of the manipulation of the anxiety level through the use of sodium amytal on the learning of emotionally charged material

Thesis (Ed.D.)--Boston Universit

INTRUSION OF RECENT AIR IN POLAR STRATOSPHERE DURING SUMMER 2009 REVEALED BY BALLOON-BORNE IN SITU CO MEASUREMENTS

International audienceThe SPIRALE (Spectroscopie Infa-Rouge par Absorption de Lasers Embarqués) balloon-borne instrument has been launched twice within 17 days in the polar region (Kiruna, Sweden, 67.9°N-21.1°E) during summer, at the beginning and at the end of August 2009. In situ measurements of several trace gases have been performed including CO and O 3 between 10 and 34 km height, with very high vertical resolution (~5 m). The both flight results are compared and the CO stratospheric profile of the first flight presents specific structures associated with mid-latitude intrusion in the lowest stratospheric levels. Their interpretation is made with the help of results from several modeling tools (MIMOSA and FLEXTRA) and available satellite data (IASI). We also used the O 3 profile correlated with CO to calculate the proportion of recent air in the polar stratosphere. The results indicate the impact of East Asia urban pollution on the chemistry of polar stratosphere in summer

Idiosyncratic features in tRNAs participating in bacterial cell wall synthesis

The FemXWv aminoacyl transferase of Weissella viridescens initiates the synthesis of the side chain of peptidoglycan precursors by transferring l-Ala from Ala-tRNAAla to UDP-MurNAc-pentadepsipeptide. FemXWv is an attractive target for the development of novel antibiotics, since the side chain is essential for the last cross-linking step of peptidoglycan synthesis. Here, we show that FemXWv is highly specific for incorporation of l-Ala in vivo based on extensive analysis of the structure of peptidoglycan. Comparison of various natural and in vitro-transcribed tRNAs indicated that the specificity of FemXWv depends mainly upon the sequence of the tRNA although additional specificity determinants may include post-transcriptional modifications and recognition of the esterified amino acid. Site-directed mutagenesis identified cytosines in the G1–C72 and G2–C71 base pairs of the acceptor stem as critical for FemXWv activity in agreement with modeling of tRNAAla in the catalytic cavity of the enzyme. In contrast, semi-synthesis of Ala-tRNAAla harboring nucleotide substitutions in the G3–U70 wobble base pair showed that this main identity determinant of alanyl-tRNA synthetase is non-essential for FemXWv. The different modes of recognition of the acceptor stem indicate that specific inhibition of FemXWv could be achieved by targeting the distal portion of tRNAAla for the design of substrate analogues

ZOOTAXA

www.mapress.com/zootaxa

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

Antoine Valéry

Valéry Antoine. Antoine Valéry. In: Diplômées, n°198, 2001. Séminaire AFFDU - Currier (29-30 mars 2001) : Former à l'éthique : un défi pour l'enseignement supérieur en France, en Europe, aux Etats-Unis. pp. 146-147

Une traduction médiévale du dixième livre à Al-Mansor de Rhazès (un manuscrit conservé à la Bibliothèque Nationale de France)

LILLE2-BU Santé-Recherche (593502101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Prise en charge des syndromes démentiels et couverture des besoins des personnes âgées de 75 ans et plus dans le bassin de vie de deux Centres Mémoire de Proximité yvelinois

Intégrer les sujets âgés déments dans une filière de soins adaptée est un enjeu majeur de santé publique. Objectifs : Sur le bassin de vie référent d un Centre Mémoire de Proximité (CMP), analyse du profil, de la prise en charge et du ciblage des sujets déments parmi les consultants >= 75 ans du CMP, puis de la part des besoins couverts par le CMP pour les personnes >= 75 ans. Méthode : Description des caractéristiques médico-socio-démographiques des consultants sur 6 mois et comparaison à l estimation des besoins locaux (extrapolation de l étude PAQUID). Résultats : 179 patients >= 75 ans issus du territoire cible (48 % de l activité du CMP), d âge moyen 81 ans, 73 % de femmes, 66 % vivant à domicile, MMSE moyen 17 dont 33% >= 24 ; bilan diagnostic conforme aux recommandations, intervention thérapeutique fréquente, faible prise en charge psycho-sociologique ; ciblage élevé des syndromes démentiels (75 %), couverture des besoins estimés sur 6 mois (4 %) insuffisante particulièrement pour les personnes de plus de 85 ans, vivant en institution et à un stade avancé de démence. Conclusion : Cette évaluation permet de définir des axes de réflexion sur l optimisation des missions des CMP.ST QUENTIN EN YVELINES-BU (782972101) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF