Evaluation of viticulture in Cappadocia in the scope of gastronomy tourism

Bu çalışmada, Türkiye’de bağcılık için önemli merkezlerden biri olan Kapadokya’da bağcılığın mevcut durumu ortaya konularak, üzümlerden elde edilen yöresel ürünlerin gastronomi turizmi kapsamında nasıl değerlendirilebileceği üzerinde durulmuştur. Araştırmanın alanı Kapadokya bölgesi olarak belirlenmiştir. Araştırmada nitel yaklaşım çerçevesinde veri toplama tekniği olarak doküman incelenmesi ile yarı yapılandırılmış görüşme gerçekleştirilmiş, veri analiz yöntemi olarak da içerik analizinden faydalanılmıştır. Görüşmeler bölgedeki 21 bağcılık ve turizm paydaşı ile gerçekleştirilmiştir. Araştırma sonucunda bu bölgede bağcılığın geliştirilmesi ve üzümden elde edilen yerel ürünlerin gastronomi turizmi açısından değerlendirilmesi gerektiği saptanmıştır.In this study, it has been discussed how local products obtained from grapes can be evaluated within the scope of gastronomy tourism by examining the current situation in viticulture in Cappadocia.The area of the study was determined as the Cappadocia region. The study took a qualitative research approach in which semi-structured interviews and document analysis were employed as major data collection techniques whereas content analysis was the primary method of analyzing the qualitative data. The interviews were conducted with 21 viticulture and tourism shareholders in the region. As a result of the research, it was determined that the development of viticulture in this region should be promoted and the local products obtained from grapes should be evaluated regarding gastronomy tourism

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

The frequency of Duchenne muscular dystrophy/Becker muscular dystrophy and Pompe disease in children with isolated transaminase elevation: results from the observational VICTORIA study

IntroductionElevated transaminases and/or creatine phosphokinase can indicate underlying muscle disease. Therefore, this study aims to determine the frequency of Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in male children and Pompe disease (PD) in male and female children with isolated hypertransaminasemia.MethodsThis multi-center, prospective study enrolled patients aged 3–216 months with serum alanine transaminase (ALT) and/or aspartate transaminase (AST) levels >2× the upper limit of normal (ULN) for ≥3 months. Patients with a known history of liver or muscle disease or physical examination findings suggestive of liver disease were excluded. Patients were screened for creatinine phosphokinase (CPK) levels, and molecular genetic tests for DMD/BMD in male patients and enzyme analysis for PD in male and female patients with elevated CPK levels were performed. Genetic analyses confirmed PD. Demographic, clinical, and laboratory characteristics of the patients were analyzed.ResultsOverall, 589 patients [66.8% male, mean age of 63.4 months (standard deviation: 60.5)] were included. In total, 251 patients (188 male and 63 female) had CPK levels above the ULN. Of the patients assessed, 47% (85/182) of male patients were diagnosed with DMD/BMD and 1% (3/228) of male and female patients were diagnosed with PD. The median ALT, AST, and CPK levels were statistically significantly higher, and the questioned neurological symptoms and previously unnoticed examination findings were more common in DMD/BMD patients than those without DMD/BMD or PD (p < 0.001).DiscussionQuestioning neurological symptoms, conducting a complete physical examination, and testing for CPK levels in patients with isolated hypertransaminasemia will prevent costly and time-consuming investigations for liver diseases and will lead to the diagnosis of occult neuromuscular diseases. Trial RegistrationClinicaltrials.gov NCT04120168