Перестановочный тест говорит в пользу гипотезы алтайской языковой макросемьи

This preprint uses the method of statistical processing of lexical lists developed by the authors: transcription of consonant classes and a weighted permutation test. The experiment involves five language families, presumably forming the Altai macrofamily: Turkic, Mongolian, Tunguska, Korean, Japanese. A strong signal was revealed between the so-nuclear Altai taxa: Türkic, Mongolian, Tunguska, which can be explained as a genealogical relationship, partially obscured by contacts. A signal of kinship was revealed in the Japanese-Turkic and Japanese-Tungusic couples (the contact scenario is poorly suited for these couples)

Mobile ECG Monitoring Device with Bioimpedance Measurement and Analysis

The paper describes the improvement of a portable ECG device, which allows increasing the reliability of cardiovascular disease diagnosis using an electrocardiogram during ambulatory monitoring in conditions of free motion activity. The results of hardware and software development for correction of an ECG form are presented, which minimizes the loss of diagnostic information due to the distortion of the ECG form by the bioimpedance of the tissues and organs of the body that are located between the heart and electrodes of an ECG device. A portable ECG device with a bioimpedance measurement channel between the electrodes is described. The measurement channel includes a programmable computing device. Software provides calculation based on the measurement results of the bioimpedance components of the parameters of the parasitic electric filter, and synthesis of the transfer characteristic of the correction digital filter. The simulation results of the correction procedure of the ECG form in the TINA environment are presented. The simulation results show that the proposed solution can be used in portable heart monitoring systems

Lipopolysaccharide triggers exacerbated microglial activation, excessive cytokine release and behavioural disturbances in mice with truncated Fused-in-Sarcoma Protein (FUS)

CNS inflammation, including microglial activation, in response to peripheral infections are known to contribute to the pathology of both familial and sporadic neurodegenerative disease. The relationship between Fused-in-Sarcoma Protein (FUS)-mediated disease in the transgenic FUS[1–359] animals and the systemic inflammatory response have not been explored. Here, we investigated microglial activation, inflammatory gene expression and the behavioural responses to lipopolysaccharide-induced (LPS; 0.1 mg/kg) systemic inflammation in the FUS[1–359] transgenic mice. The pathology of these mice recapitulates the key features of mutant FUS-associated familial frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Here, pre-symptomatic 8-week-old mutant or wild type controls were challenged with LPS or with saline and sucrose intake, novel cage exploration, marble burying and swimming behaviours were analyzed. The level of pro-inflammatory gene expression was also determined, and microglial activation was evaluated. In chronic experiments, to discover whether the LPS challenge would affect the onset of ALS-like paralysis, animals were evaluated for clinical signs from 5 to 7 weeks post-injection. Compared to controls, acutely challenged FUS[1–359]-tg mice exhibited decreased sucrose intake and increased floating behaviours. The FUS[1–359]-tg mice exhibited an increase in immunoreactivity for Iba1-positive cells in the prefrontal cortex and ventral horn of the spinal cord, which was accompanied by increased expression of interleukin-1β, tumour necrosis factor, cyclooxygenase-(COX)-1 and COX-2. However, the single LPS challenge did not alter the time to development of paralysis in the FUS[1–359]-tg mice. Thus, while the acute inflammatory response was enhanced in the FUS mutant animals, it did not have a lasting impact on disease progression

Measurement of nuclear modification factors of gamma(1S)), gamma(2S), and gamma(3S) mesons in PbPb collisions at root s(NN)=5.02 TeV

The cross sections for ϒ(1S), ϒ(2S), and ϒ(3S) production in lead-lead (PbPb) and proton-proton (pp) collisions at √sNN = 5.02 TeV have been measured using the CMS detector at the LHC. The nuclear modification factors, RAA, derived from the PbPb-to-pp ratio of yields for each state, are studied as functions of meson rapidity and transverse momentum, as well as PbPb collision centrality. The yields of all three states are found to be significantly suppressed, and compatible with a sequential ordering of the suppression, RAA(ϒ(1S)) > RAA(ϒ(2S)) > RAA(ϒ(3S)). The suppression of ϒ(1S) is larger than that seen at √sNN = 2.76 TeV, although the two are compatible within uncertainties. The upper limit on the RAA of ϒ(3S) integrated over pT, rapidity and centrality is 0.096 at 95% confidence level, which is the strongest suppression observed for a quarkonium state in heavy ion collisions to date. © 2019 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP3.Peer reviewe

Azimuthal separation in nearly back-to-back jet topologies in inclusive 2-and 3-jet events in pp collisions at root s=13TeV

A measurement for inclusive 2- and 3-jet events of the azimuthal correlation between the two jets with the largest transverse momenta, Delta phi(12), is presented. The measurement considers events where the two leading jets are nearly collinear ("back-to-back") in the transverse plane and is performed for several ranges of the leading jet transverse momentum. Proton-proton collision data collected with the CMS experiment at a center-of-mass energy of 13 TeV and corresponding to an integrated luminosity of 35.9 fb(-1) are used. Predictions based on calculations using matrix elements at leading-order and next-to-leading-order accuracy in perturbative quantum chromodynamics supplemented with leading-log parton showers and hadronization are generally in agreement with themeasurements. Discrepancies between the measurement and theoretical predictions are as large as 15%, mainly in the region 177 degrees <Delta phi(12) <180 degrees. The 2- and 3-jet measurements are not simultaneously described by any of models.Peer reviewe

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Development and validation of HERWIG 7 tunes from CMS underlying-event measurements

This paper presents new sets of parameters (“tunes”) for the underlying-event model of the HERWIG7 event generator. These parameters control the description of multiple-parton interactions (MPI) and colour reconnection in HERWIG7, and are obtained from a fit to minimum-bias data collected by the CMS experiment at s=0.9, 7, and 13Te. The tunes are based on the NNPDF 3.1 next-to-next-to-leading-order parton distribution function (PDF) set for the parton shower, and either a leading-order or next-to-next-to-leading-order PDF set for the simulation of MPI and the beam remnants. Predictions utilizing the tunes are produced for event shape observables in electron-positron collisions, and for minimum-bias, inclusive jet, top quark pair, and Z and W boson events in proton-proton collisions, and are compared with data. Each of the new tunes describes the data at a reasonable level, and the tunes using a leading-order PDF for the simulation of MPI provide the best description of the dat

Measurement of the top quark Yukawa coupling from t(t)over-bar kinematic distributions in the dilepton final state in proton-proton collisions at root s=13 TeV

Peer reviewe

«Damage control» за тяжкої політравми: нейрохірургічні аспекти

Purpose: to estimate results of «Damage control» principles application in surgical treatment of patients with traumatic intracranial hematomas at severe polytrauma.Materials and methods. In the research 43 patients were included aged in average (45.5±17.6) years, there were 36 men and 7 women. Wakefulness according to GCS was (6.2±1.4) points, state according to ISS scale — (54.3±8.2) points. As a comparison group we examined 41 injured persons, been treated using standard methods according to the Guidelines for Treatment of patients with Severe Traumatic Brain Injury (2007).Results. Intraoperative mortality in the main group was 7.3%, in the comparison group — 30%. Using «Damage control» principles reduced mortality in the main group — up to 60.9% that was significantly lower than group of comparison (92.5%) and mortality rate, estimated according to APACHE II scale (P&lt;0,05).Conclusions. We have modified the technology «Damage control», which is applied for the treatment of 43 patients with severe concomitant traumatic brain injury. It is possible to improve the results of treatment.Цель работы: оценка результатов использования принципов «Damage control» в хирургическом лечении пациентов с травматическими внутричерепными гематомами на фоне тяжелой политравмы.Материалы и методы. В исследование включены 43 пострадавших в возрасте в среднем (45,5±17,6) года, мужчин — 36, женщин — 7. Уровень бодрствования по ШКГ при госпитализации составил (6,2±1,4) балла, состояние по шкале ISS — (54,3±8,2) балла. В качестве группы сравнения обследован 41 пострадавший, которым проведено стандартное лечение в соответствии с Рекомендациями по лечению пациентов с тяжелой черепно-мозговой травмой (2007).Результаты. Интраоперационная летальность в основной группе составила 7,3%, в группе сравнения — 30%. Использование принципов «Damage control» позволило уменьшить летальность в основной группе — до 60,9%, что значимо ниже как по сравнению с таковой в группе сравнения (92,5%), так и с предположительной летальностью по шкале APACHE II (Р&lt;0,05).Выводы. В небольшой серии наблюдений (43 пациента) показана возможность улучшения результатов лечения тяжелой сочетанной черепно-мозговой травмы с использованием модифицированной нами технологии «Damage control». Установлено достоверное уменьшение летальности в группе оболочечных гематом и тенденция к ее снижению при множественных и внутримозговых гематомах.Мета роботи: оцінка результатів використання принципів «Damage control» у хірургічному лікуванні постраждалих з травматичними внутрішньочерепними гематомами на тлі тяжкої політравми.Матеріали і методи. У дослідження включені 43 пацієнти віком у середньому (45,5±17,6) року, чоловіків — 36, жінок — 7. Рівень свідомості за ШКГ після госпіталізації становив (6,2±1,4) бала, стан за шкалою ISS — (54,3±8,2) бала. В групі порівняння (41 пацієнт) проводили стандартне лікування за Рекомендаціями з лікування пацієнтів з тяжкою черепно-мозковою травмою (2007).Результати. Інтраопераційна летальність в основній групі становила 7,3%, в групі порівняння — 30%. Використання принципів «Damage control» дозволило зменшити летальність в основній групі — до 60,9%, що значно менше такої в групі порівняння (92,5%) так ймовірної летальності за шкалою APACHE II (Р&lt;0,05).Висновки. У невеликій серії спостережень (43 пацієнта) доведена можливість поліпшення результатів лікування тяжкої поєднаної черепно-мозкової травми з використанням модифікованої нами технології «Damage control». Встановлене достовірне зменшення летальності в групі оболонкових гематом і тенденцію до її зменшення при множинних і внутрішньомозкових гематомах

The Permutation Test Speaks in Favor of the Hypothesis of the Altai Linguistic Macrofamily

This preprint uses the method of statistical processing of lexical lists developed by the authors: transcription of consonant classes and a weighted permutation test. The experiment involves five language families, presumably forming the Altai macrofamily: Turkic, Mongolian, Tunguska, Korean, Japanese. A strong signal was revealed between the so-nuclear Altai taxa: T&uuml;rkic, Mongolian, Tunguska, which can be explained as a genealogical relationship, partially obscured by contacts. A signal of kinship was revealed in the Japanese-Turkic and Japanese-Tungusic couples (the contact scenario is poorly suited for these couples)