Gender in a land-based theology

In Fijian Methodist discourse, the vanua (land and people) is often characterised as the foundation of the traditional order and all it entails. Indigenous theologians attend to the vanua in novel ways, especially as it is paired in a half-complementary, half-oppositional way to Christianity. The question of whether the vanua might be understood in gendered terms highlights a gap between theoretically universal values and practically patriarchal norms. In this article, I discuss several innovative thinkers on this subject: (1) women in the ‘Weavers’ theological collective; (2) the Methodist theologian and former church President Ilaitia Sevati Tuwere; and (3) a female Methodist minister, Tima, whom I interviewed in 2009. I focus especially on Tuwere's description of the ‘feminine face’ of the vanua and Tima's continual and wrenching conflict with the church's male-dominated hierarchy. Whereas Tuwere uses a quasi-feminist Christian theology to reconcile Christianity and the vanua in terms of gender, Tima implies that her experiences of conflict with older men demonstrate how Christianity and the vanua might not be fully reconcilable.Research was funded by a Discovery Project grant from the Australian Research Council (DP0878736)

Investigating foot-sock friction : a comparison of two different methodologies

Two different methodologies for assessing the friction between plantar skin and sock textiles are compared in this study. The first approach uses a custom-built friction plate rig. The rig consists of sock material mounted on a test plate attached to two load cells that measure normal and shear loads at the skin-sock textile interface. With this methodology, participants are required to slide their foot over the test plate whilst maintaining a targeted normal load and a relatively consistent sliding speed. The second approach uses a pneumatically-driven foot probe loading device. The device includes an instrumented probe with sock material on its contact surface. Participants are instructed to stand on a platform whilst the probe is applied to, and then driven across, the plantar aspect of foot. The cyclic motion of the probe is displacement-controlled and normal and shear loads are measured using load cells. Both approaches allow friction coefficients to be calculated fromload data collected during the sliding phase of movement. Data from both approaches was examined, collected from friction tests using the same six participants and sliding contact between the first metatarsal head (1MTH) region and textiles from two commercially available running socks. Both approaches were capable of measuring the friction between 1MTH skin and sock materials and good agreement was found between them. In the dry conditions tested, the cotton-rich sock was found to provide lower friction that the anti-blister sock material

Dialogues:Anthropology and theology

The past five years have witnessed an increased interest in a dialogue between anthropology and theology, evidenced in part by a suite of edited volumes (e.g. Lauterbach & Vähäkangas 2020; Lemons 2018; Tomlinson & Mathews 2018). Analyses informed by this interdisciplinary nexus have demonstrated the utility of theological concepts for anthropological inquiry (e.g. Robbins 2020; Tomlinson 2020; Williams Green 2021). The following series of dialogues between anthropologists and theologians builds on this growing body of work, expanding it at two main points. First, while the above conversations are all focused on Christian theology, mainly as a means of engaging Christian practice, our dialogues move beyond this religion. The following conversations engage the intersection of anthropology and Islamic, Buddhist, Hindu, as well as Christian, theology.1 Second, many of these dialogues foreground particular experiences of scholars in both anthropology and theology who identify in some way with the religious traditions they study. Some of these dialogues took place between scholars who had an established relationship; others involved partners who had not previously met, but who agreed to correspond in view of a shared interest in this interdisciplinary dialogue. As a starting point, participants were given a series of questions to orient their exchanges, such as, ‘How does faith relate to knowledge in both disciplines?’ Conversations mostly took place over email and were later edited with the help of one of the journal editors, Adam Reed, and one of the members of our Editorial Board, Naomi Haynes.Publisher PDFPeer reviewe

The effect of normal load force and roughness on the dynamic traction developed at the shoe-surface interface in tennis

During tennis-specific movements, such as accelerating and side stepping, the dynamic traction provided by the shoe-surface combination plays an important role in the injury risk and performance of the player. Acrylic hard court tennis surfaces have been reported to have increased injury occurrence, partly caused by increased traction that developed at the shoe-surface interface. Often mechanical test methods used for the testing and categorisation of playing surfaces do not tend to simulate loads occurring during participation on the surface, and thus are unlikely to predict the human response to the surface. A traction testing device, discussed in this paper, has been used to mechanically measure the dynamic traction force between the shoe and the surface under a range of normal loading conditions that are relevant to real-life play. Acrylic hard court tennis surfaces generally have a rough surface topography, due to their sand and acrylic paint mixed top coating. Surface micro-roughness will influence the friction mechanisms present during viscoelastic contacts, as found in footwear-surface interactions. This paper aims to further understand the influence micro-roughness and normal force has on the dynamic traction that develops at the shoe-surface interface on acrylic hard court tennis surfaces. The micro-roughness and traction of a controlled set of acrylic hard court tennis surfaces have been measured. The relationships between micro-roughness, normal force, and traction force are discussed. © 2013 The Author(s)

Multiple Loci Are Associated with White Blood Cell Phenotypes

White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability estimates varying across cell types. We studied 19,509 subjects from seven cohorts in a discovery analysis, and 11,823 subjects from ten cohorts for replication analyses, to determine genetic factors influencing variability within the normal hematological range for total WBC count and five WBC subtype measures. Cohort specific data was supplied by the CHARGE, HeamGen, and INGI consortia, as well as independent collaborative studies. We identified and replicated ten associations with total WBC count and five WBC subtypes at seven different genomic loci (total WBC count—6p21 in the HLA region, 17q21 near ORMDL3, and CSF3; neutrophil count—17q21; basophil count- 3p21 near RPN1 and C3orf27; lymphocyte count—6p21, 19p13 at EPS15L1; monocyte count—2q31 at ITGA4, 3q21, 8q24 an intergenic region, 9q31 near EDG2), including three previously reported associations and seven novel associations. To investigate functional relationships among variants contributing to variability in the six WBC traits, we utilized gene expression- and pathways-based analyses. We implemented gene-clustering algorithms to evaluate functional connectivity among implicated loci and showed functional relationships across cell types. Gene expression data from whole blood was utilized to show that significant biological consequences can be extracted from our genome-wide analyses, with effect estimates for significant loci from the meta-analyses being highly corellated with the proximal gene expression. In addition, collaborative efforts between the groups contributing to this study and related studies conducted by the COGENT and RIKEN groups allowed for the examination of effect homogeneity for genome-wide significant associations across populations of diverse ancestral backgrounds

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records

BACKGROUND: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework. METHODS: In this cohort study, we used eight linked National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Data on COVID-19 testing, vaccination, primary and secondary care records, and death registrations were collected until Nov 30, 2021. We defined ten COVID-19 phenotypes reflecting clinically relevant stages of disease severity and encompassing five categories: positive SARS-CoV-2 test, primary care diagnosis, hospital admission, ventilation modality (four phenotypes), and death (three phenotypes). We constructed patient trajectories illustrating transition frequency and duration between phenotypes. Analyses were stratified by pandemic waves and vaccination status. FINDINGS: Among 57 032 174 individuals included in the cohort, 13 990 423 COVID-19 events were identified in 7 244 925 individuals, equating to an infection rate of 12·7% during the study period. Of 7 244 925 individuals, 460 737 (6·4%) were admitted to hospital and 158 020 (2·2%) died. Of 460 737 individuals who were admitted to hospital, 48 847 (10·6%) were admitted to the intensive care unit (ICU), 69 090 (15·0%) received non-invasive ventilation, and 25 928 (5·6%) received invasive ventilation. Among 384 135 patients who were admitted to hospital but did not require ventilation, mortality was higher in wave 1 (23 485 [30·4%] of 77 202 patients) than wave 2 (44 220 [23·1%] of 191 528 patients), but remained unchanged for patients admitted to the ICU. Mortality was highest among patients who received ventilatory support outside of the ICU in wave 1 (2569 [50·7%] of 5063 patients). 15 486 (9·8%) of 158 020 COVID-19-related deaths occurred within 28 days of the first COVID-19 event without a COVID-19 diagnoses on the death certificate. 10 884 (6·9%) of 158 020 deaths were identified exclusively from mortality data with no previous COVID-19 phenotype recorded. We observed longer patient trajectories in wave 2 than wave 1. INTERPRETATION: Our analyses illustrate the wide spectrum of disease trajectories as shown by differences in incidence, survival, and clinical pathways. We have provided a modular analytical framework that can be used to monitor the impact of the pandemic and generate evidence of clinical and policy relevance using multiple EHR sources. FUNDING: British Heart Foundation Data Science Centre, led by Health Data Research UK

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements