385 research outputs found

    Role of Quality Management in Pharmaceutical Development: Evidence from Islamabad and Lahore

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    The aim of this paper is to investigate the employee’s perceptions of the impact, of Total Quality Management (TQM), on their roles within the organization and how they perceived the effectiveness of the quality processes in Pakistan Pharmaceutical industry. The universe of this study was the employees of Pharmaceutical industry in Islamabad and Lahore. For this purpose survey method was used by using questionnaire as a tool for data collection. The results have shown that Employee Training and Development, Employee Performance, Quality Process and Team Work are significant factors with the Total Quality Management and correlated with each others. The result shows the application of TQM principles addresses some of the key challenges facing the organization. The study was faced by certain limitations and included time constraints and resources constraints which limited this research to only Islamabad and Lahore offices, of the Pharmaceutical companies. The present study found support that pharmaceutical companies faced the same difficulties with TQM implementations as experienced in other industries. These include achieving a culture of continuous improvement, overcoming a lack of trust and understanding the TQM process itself, and what they were, as a company, trying to achieve. These problems are not new and many companies have difficulties in implementing TQM. Pharmaceutical companies also followed the path of achieving a quality certification; namely, ISO 9000 accreditation, in the pursuit of excellence.Quality Management; pharmaceutical Development; Pakistan; Employee’s Perceptions

    Role of Quality Management in Pharmaceutical Development: Evidence from Islamabad and Lahore

    Get PDF
    The aim of this paper is to investigate the employee’s perceptions of the impact, of Total Quality Management (TQM), on their roles within the organization and how they perceived the effectiveness of the quality processes in Pakistan Pharmaceutical industry. The universe of this study was the employees of Pharmaceutical industry in Islamabad and Lahore. For this purpose survey method was used by using questionnaire as a tool for data collection. The results have shown that Employee Training and Development, Employee Performance, Quality Process and Team Work are significant factors with the Total Quality Management and correlated with each others. The result shows the application of TQM principles addresses some of the key challenges facing the organization. The study was faced by certain limitations and included time constraints and resources constraints which limited this research to only Islamabad and Lahore offices, of the Pharmaceutical companies. The present study found support that pharmaceutical companies faced the same difficulties with TQM implementations as experienced in other industries. These include achieving a culture of continuous improvement, overcoming a lack of trust and understanding the TQM process itself, and what they were, as a company, trying to achieve. These problems are not new and many companies have difficulties in implementing TQM. Pharmaceutical companies also followed the path of achieving a quality certification; namely, ISO 9000 accreditation, in the pursuit of excellence.Quality Management; pharmaceutical Development; Pakistan; Employee’s Perceptions

    Stem Cell Organoids in Primary Cultures of Human Non-Malignant and Malignant Colon

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    YesA sub-population of cells named cancer stem cells (CSCs) that initiate and promote tumour growth have been demonstrated to exist in several malignancies including colon carcinoma. The objective of our pilot study was to isolate CD133+CD26+CD44+ CSCs from patient colon tumours, culture spheres or organoids and observe their proliferation in primary cultures. Parallel cultures of non-cancer controls from colon normal lining and nonadenomatous polyps were set up. Magnetic activated cell sorting was used to isolate CD133+CD26+CD44+ cell populations followed by primary cell culturing under stem cell culture conditions. Number, cells/organoid and daughter generations of organoids were calculated using phase contrast microscope. Trypan blue exclusion method was used to test the viability of the cells. Both colon tumour and colon non-adenomatous polyp formed floating organoids in suspension; however non-adenomatous polyp cultures did not show self-renewal properties for more than 1 passage. Normal colon singlecell suspension did not create organoids. Metastatic colon tumours rapidly produce cancer cell organoids in less than 24 hours in larger numbers compared to non-metastatic colon tumours (1-3 weeks). Metastatic colon tumour organoids have the ability for proliferation for upto five daughter generations in primary culture compared to three generations for those grown from non-metastatic tumours. This in vitro CSC organoid model will help study colon cancer biology, in particular providing a valuable source of primary cell-derived tissue for studying personalized molecular profiling using ‘omics strategies to direct therapeutic intervention

    Role of Quality Management in Pharmaceutical Development: Evidence from Islamabad and Lahore

    Get PDF
    The aim of this paper is to investigate the employee’s perceptions of the impact, of Total Quality Management (TQM), on their roles within the organization and how they perceived the effectiveness of the quality processes in Pakistan Pharmaceutical industry. The universe of this study was the employees of Pharmaceutical industry in Islamabad and Lahore. For this purpose survey method was used by using questionnaire as a tool for data collection. The results have shown that Employee Training and Development, Employee Performance, Quality Process and Team Work are significant factors with the Total Quality Management and correlated with each others. The result shows the application of TQM principles addresses some of the key challenges facing the organization. The study was faced by certain limitations and included time constraints and resources constraints which limited this research to only Islamabad and Lahore offices, of the Pharmaceutical companies. The present study found support that pharmaceutical companies faced the same difficulties with TQM implementations as experienced in other industries. These include achieving a culture of continuous improvement, overcoming a lack of trust and understanding the TQM process itself, and what they were, as a company, trying to achieve. These problems are not new and many companies have difficulties in implementing TQM. Pharmaceutical companies also followed the path of achieving a quality certification; namely, ISO 9000 accreditation, in the pursuit of excellence

    Role of Quality Management in Pharmaceutical Development: Evidence from Islamabad and Lahore

    Get PDF
    The aim of this paper is to investigate the employee’s perceptions of the impact, of Total Quality Management (TQM), on their roles within the organization and how they perceived the effectiveness of the quality processes in Pakistan Pharmaceutical industry. The universe of this study was the employees of Pharmaceutical industry in Islamabad and Lahore. For this purpose survey method was used by using questionnaire as a tool for data collection. The results have shown that Employee Training and Development, Employee Performance, Quality Process and Team Work are significant factors with the Total Quality Management and correlated with each others. The result shows the application of TQM principles addresses some of the key challenges facing the organization. The study was faced by certain limitations and included time constraints and resources constraints which limited this research to only Islamabad and Lahore offices, of the Pharmaceutical companies. The present study found support that pharmaceutical companies faced the same difficulties with TQM implementations as experienced in other industries. These include achieving a culture of continuous improvement, overcoming a lack of trust and understanding the TQM process itself, and what they were, as a company, trying to achieve. These problems are not new and many companies have difficulties in implementing TQM. Pharmaceutical companies also followed the path of achieving a quality certification; namely, ISO 9000 accreditation, in the pursuit of excellence

    A smart rig for calibration of gas sensor nodes

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    Electrochemical gas sensors require regular maintenance to check and secure proper functioning. Standard procedures usually involve testing and recalibration of the sensors, for which working environments are needed. Periodic calibration is therefore necessary to ensure reliable and accurate measurements. This paper proposes a dedicated smart calibration rig with a set of novel features enabling simultaneous calibration of multiple sensors. The proposed calibration rig system comprises a gas mixing system, temperature control system, a test chamber, and a process-control PC that controls all calibration phases. The calibration process is automated by a LabVIEW-based platform that controls the calibration environment for the sensor nodes, logs sensor data, and best fit equation based on interpolation for every sensor on the node and uploads it to the sensor node for next deployments. The communication between the PC and the sensor nodes is performed using the same IEEE 802.15.4 (ZigBee) protocol that the nodes also use in field deployment for air quality measurement. The results presented demonstrate the effectiveness of the sensors calibration rig.Scopu

    Detector Description and Performance for the First Coincidence Observations between LIGO and GEO

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    For 17 days in August and September 2002, the LIGO and GEO interferometer gravitational wave detectors were operated in coincidence to produce their first data for scientific analysis. Although the detectors were still far from their design sensitivity levels, the data can be used to place better upper limits on the flux of gravitational waves incident on the earth than previous direct measurements. This paper describes the instruments and the data in some detail, as a companion to analysis papers based on the first data.Comment: 41 pages, 9 figures 17 Sept 03: author list amended, minor editorial change

    Measurement of jet suppression in central Pb-Pb collisions at root s(NN)=2.76 TeV

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    The transverse momentum(p(T)) spectrum and nuclear modification factor (R-AA) of reconstructed jets in 0-10% and 10-30% central Pb-Pb collisions at root s(NN) = 2.76 TeV were measured. Jets were reconstructed using the anti-k(T) jet algorithm with a resolution parameter of R = 0.2 from charged and neutral particles, utilizing the ALICE tracking detectors and Electromagnetic Calorimeter (EMCal). The jet p(T) spectra are reported in the pseudorapidity interval of \eta(jet)\ 5 GeV/c to suppress jets constructed from the combinatorial background in Pb-Pb collisions. The leading charged particle requirement applied to jet spectra both in pp and Pb-Pb collisions had a negligible effect on the R-AA. The nuclear modification factor R-AA was found to be 0.28 +/- 0.04 in 0-10% and 0.35 +/- 0.04 in 10-30% collisions, independent of p(T), jet within the uncertainties of the measurement. The observed suppression is in fair agreement with expectations from two model calculations with different approaches to jet quenching. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V.Peer reviewe
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