Temperature behavior of the magnon modes of the square lattice antiferromagnet

A spin-wave theory of short-range order in the square lattice Heisenberg antiferromagnet is formulated. With growing temperature from T=0 a gapless mode is shown to arise simultaneously with opening a gap in the conventional spin-wave mode. The spectral intensity is redistributed from the latter mode to the former. For low temperatures the theory reproduces results of the modified spin-wave theory by M.Takahashi, J.E.Hirsch et al. and without fitting parameters gives values of observables in good agreement with Monte Carlo results in the temperature range 0 <= T < 0.8J where J is the exchange constant.Comment: 12 pages, 2 figure

One-loop approximation for the Heisenberg antiferromagnet

We use the diagram technique for spin operators to calculate Green's functions and observables of the spin-1/2 quantum Heisenberg antiferromagnet on a square lattice. The first corrections to the self-energy and interaction are taken into account in the chain diagrams. The approximation reproduces main results of Takahashi's modified spin-wave theory [Phys. Rev. B 40, 2494 (1989)] and is applicable in a wider temperature range. The energy per spin calculated in this approximation is in good agreement with the Monte Carlo and small-cluster exact-diagonalization calculations in the range 0 <= T < 1.2J where J is the exchange constant. For the static uniform susceptibility the agreement is good for T < 0.6J and becomes somewhat worse for higher temperatures. Nevertheless the approximation is able to reproduce the maximum in the temperature dependence of the susceptibility near T = 0.9J.Comment: 15 pages, 6 ps figure

Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability/Unemployment, Current Smoking, and Associated Co-Morbidities

OBJECTIVES: Chronic pancreatitis (CP) has a profound independent effect on quality of life (QOL). Our aim was to identify factors that impact the QOL in CP patients. METHODS: We used data on 1,024 CP patients enrolled in the three NAPS2 studies. Information on demographics, risk factors, co-morbidities, disease phenotype, and treatments was obtained from responses to structured questionnaires. Physical and mental component summary (PCS and MCS, respectively) scores generated using responses to the Short Form-12 (SF-12) survey were used to assess QOL at enrollment. Multivariable linear regression models determined independent predictors of QOL. RESULTS: Mean PCS and MCS scores were 36.7+/-11.7 and 42.4+/-12.2, respectively. Significant (P \u3c 0.05) negative impact on PCS scores in multivariable analyses was noted owing to constant mild-moderate pain with episodes of severe pain or constant severe pain (10 points), constant mild-moderate pain (5.2), pain-related disability/unemployment (5.1), current smoking (2.9 points), and medical co-morbidities. Significant (P \u3c 0.05) negative impact on MCS scores was related to constant pain irrespective of severity (6.8-6.9 points), current smoking (3.9 points), and pain-related disability/unemployment (2.4 points). In women, disability/unemployment resulted in an additional 3.7 point reduction in MCS score. Final multivariable models explained 27% and 18% of the variance in PCS and MCS scores, respectively. Etiology, disease duration, pancreatic morphology, diabetes, exocrine insufficiency, and prior endotherapy/pancreatic surgery had no significant independent effect on QOL. CONCLUSIONS: Constant pain, pain-related disability/unemployment, current smoking, and concurrent co-morbidities significantly affect the QOL in CP. Further research is needed to identify factors impacting QOL not explained by our analyses

Fork-Free Hybrid Consensus with Flexible Proof-of-Activity

Bitcoin and its underlying blockchain mechanism have been attracting much attention. One of their core innovations, Proof-of-Work (PoW), is notoriously inefficient which potentially motivates a centralization of computing power, defeating the original goal of decentralization. Proof-of-Stake (PoS) is later proposed to replace PoW. However, both PoW and PoS have different inherent advantages and disadvantages, so does Proof-of-Activity (PoA) of Bentov et al. (SIGMETRICS 2014) which only offers limited combinations of two mechanisms. On the other hand, the hybrid consensus protocol of Pass and Shi (ePrint 16/917) aims to improve the efficiency by dynamically maintaining a rotating committee. Yet, there are unsatisfactory issues including chain forks and fair committee election. In this paper, we firstly devise a generalized variant of PoW. After that, we leverage our newly proposed generalized PoW to construct a fork-free hybrid consensus protocol, which addresses issues faced by the existing hybrid consensus mechanism. We further combine our fork-free hybrid consensus mechanism with PoS for a flexible version of PoA, which offers a flexible combination of PoW and PoS. Compared with Bentov et al.’s PoA, our “flexible PoA” improves the efficiency and provides more flexible combinations of PoW and PoS, resulting in a more powerful and applicable consensus protocol

DoubleMod and SingleMod: Simple Randomized Secret-Key Encryption with Bounded Homomorphicity

An encryption relation f Z Z with decryption function f 1 is “group-homomorphic” if, for any suitable plaintexts x1 and x2, x1+x2 = f 1( f (x1)+f (x2)). It is “ring-homomorphic” if furthermore x1x2 = f 1( f (x1) f (x2)); it is “field-homomorphic” if furthermore 1=x1 = f 1( f (1=x1)). Such relations would support oblivious processing of encrypted data. We propose a simple randomized encryption relation f over the integers, called DoubleMod, which is “bounded ring-homomorphic” or what some call ”somewhat homomorphic.” Here, “bounded” means that the number of additions and multiplications that can be performed, while not allowing the encrypted values to go out of range, is limited (any pre-specified bound on the operation-count can be accommodated). Let R be any large integer. For any plaintext x 2 ZR, DoubleMod encrypts x as f (x) = x + au + bv, where a and b are randomly chosen integers in some appropriate interval, while (u; v) is the secret key. Here u > R2 is a large prime and the smallest prime factor of v exceeds u. With knowledge of the key, but not of a and b, the receiver decrypts the ciphertext by computing f 1(y) = (y mod v) mod u. DoubleMod generalizes an independent idea of van Dijk et al. 2010. We present and refine a new CCA1 chosen-ciphertext attack that finds the secret key of both systems (ours and van Dijk et al.’s) in linear time in the bit length of the security parameter. Under a known-plaintext attack, breaking DoubleMod is at most as hard as solving the Approximate GCD (AGCD) problem. The complexity of AGCD is not known. We also introduce the SingleMod field-homomorphic cryptosystems. The simplest SingleMod system based on the integers can be broken trivially. We had hoped, that if SingleMod is implemented inside non-Euclidean quadratic or higher-order fields with large discriminants, where GCD computations appear di cult, it may be feasible to achieve a desired level of security. We show, however, that a variation of our chosen-ciphertext attack works against SingleMod even in non-Euclidean fields

DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection

Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic infections in humans and, during the infectious process, are exposed to a range of environmental insults, including the host's immune response. From the moment MTB is exhaled by infected individuals, through an active and latent phase in the body of the new host, until the time they reach the reactivation stage, MTB is exposed to many types of DNA-damaging agents. Like all cellular organisms, MTB has efficient DNA repair systems, and these are believed to play essential roles in mycobacterial pathogenesis. As different stages of infection have great variation in the conditions in which mycobacteria reside, it is possible that different repair systems are essential for progression to specific phases of infection. MTB possesses homologues of DNA repair systems that are found widely in other species of bacteria, such as nucleotide excision repair, base excision repair and repair by homologous recombination. MTB also possesses a system for non-homologous end-joining of DNA breaks, which appears to be widespread in prokaryotes, although its presence is sporadic within different species within a genus. However, MTB does not possess homologues of the typical mismatch repair system that is found in most bacteria. Recent studies have demonstrated that DNA repair genes are expressed differentially at each stage of infection. In the present review, we focus on different DNA repair systems from mycobacteria and identify questions that remain in our understanding of how these systems have an impact upon the infection processes of these important pathogens

Social and Non-social Brain Areas in Risk Behaviour: The Role of Social Context

This work was supported by the Spanish Ministry of Economy, Industry, and Competitiveness through a grant awarded (PSI2016-80558-R to A.Catena) and a postdoctoral contract of the University of Granada (to S. Baltruschat) .The human brain contains social areas that become active when interacting with another human. These are located in the ventral prefrontal and mediodorsal cortices, adjacent to areas involved in reward processing and cognitive control. Human behaviour is strongly influenced by the social context. This is particularly evident when observing greater risk propensity in the presence of a peer, particularly during adolescence and emerging adulthood. We explored the widely held view that enhanced risk propensity is the consequence of weak cognitive control. We used brain activity, estimated from EEG recordings in a sample of 114 emerging adult dyads whilst performing a risk perception task, to predict risk behaviour in a subsequent driving simulation task. Being with a peer reduced the ability to discriminate riskiness in images of traffic scenes, biased responses towards the perception of no-risk, and increased the rate of accidents in the driving simulation. Risk perception involved three sets of clusters showing activity only when being with a peer, only when being alone, and in both social contexts. Functional connectivity between the clusters accounted for the later driving simulation performance depending on the peer’s presence. In the light of our findings, greater risk-taking, when a peer is present, seems to be triggered by the activation of a different, less efficient brain network for risk-processing.Spanish Ministry of Economy, Industry, and Competitiveness PSI2016-80558-RUniversity of Granad

Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model

Background: This study characterizes the distribution and components of plaque structure by presenting a three-dimensional blood-vessel modelling with the aim of determining mechanical properties due to the effect of lipid core and calcification within a plaque. Numerical simulation has been used to answer how cap thickness and calcium distribution in lipids influence the biomechanical stress on the plaque.Method: Modelling atherosclerotic plaque based on structural analysis confirms the rationale for plaque mechanical examination and the feasibility of our simulation model. Meaningful validation of predictions from modelled atherosclerotic plaque model typically requires examination of bona fide atherosclerotic lesions. To analyze a more accurate plaque rupture, fluid-structure interaction is applied to three-dimensional blood-vessel carotid bifurcation modelling

Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer

Epithelial cells line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental substances including chemicals, carcinogens, ultraviolet-irradiation or toxins cause activation of epithelial cells with release of cytokines and chemokines as well as alterations in the expression of cell surface ligands. Such display of epithelial stress is rapidly sensed by tissue resident immunocytes, which can directly interact with self-moieties on epithelial cells and initiate both local and systemic immune responses. Epithelial cells are thus key drivers of immune surveillance at body surface tissues. However, epithelial cells have a propensity to drive type 2 immunity (rather than type 1) upon non-invasive challenge or stress – a type of immunity whose regulation and function still remain enigmatic. Here we review the induction and possible role of type 2 immunity in epithelial tissues and propose that rapid immune surveillance and type 2 immunity are key regulators of tissue homeostasis and carcinogenesis

The yeast P5 type ATPase, Spf1, regulates manganese transport into the endoplasmic reticulum

The endoplasmic reticulum (ER) is a large, multifunctional and essential organelle. Despite intense research, the function of more than a third of ER proteins remains unknown even in the well-studied model organism Saccharomyces cerevisiae. One such protein is Spf1, which is a highly conserved, ER localized, putative P-type ATPase. Deletion of SPF1 causes a wide variety of phenotypes including severe ER stress suggesting that this protein is essential for the normal function of the ER. The closest homologue of Spf1 is the vacuolar P-type ATPase Ypk9 that influences Mn2+ homeostasis. However in vitro reconstitution assays with Spf1 have not yielded insight into its transport specificity. Here we took an in vivo approach to detect the direct and indirect effects of deleting SPF1. We found a specific reduction in the luminal concentration of Mn2+ in ∆spf1 cells and an increase following it’s overexpression. In agreement with the observed loss of luminal Mn2+ we could observe concurrent reduction in many Mn2+-related process in the ER lumen. Conversely, cytosolic Mn2+-dependent processes were increased. Together, these data support a role for Spf1p in Mn2+ transport in the cell. We also demonstrate that the human sequence homologue, ATP13A1, is a functionally conserved orthologue. Since ATP13A1 is highly expressed in developing neuronal tissues and in the brain, this should help in the study of Mn2+-dependent neurological disorders