69 research outputs found
Genomic and microbiological analyses of iron acquisition pathways among respiratory and environmental nontuberculous mycobacteria from Hawai’i
- Author
- Publication venue
- Frontiers Media S.A.
- Publication date
- 01/11/2023
- Field of study
As environmental opportunistic pathogens, nontuberculous mycobacteria (NTM) can cause severe and difficult to treat pulmonary disease. In the United States, Hawai’i has the highest prevalence of infection. Rapid growing mycobacteria (RGM) such as Mycobacterium abscessus and M. porcinum and the slow growing mycobacteria (SGM) including M. intracellulare subspecies chimaera are common environmental NTM species and subspecies in Hawai’i. Although iron acquisition is an essential process of many microorganisms, iron acquisition via siderophores among the NTM is not well-characterized. In this study, we apply genomic and microbiological methodologies to better understand iron acquisition via siderophores for environmental and respiratory isolates of M. abscessus, M. porcinum, and M. intracellulare subspecies chimaera from Hawai’i. Siderophore synthesis and transport genes, including mycobactin (mbt), mmpL/S, and esx-3 were compared among 47 reference isolates, 29 respiratory isolates, and 23 environmental Hawai’i isolates. Among all reference isolates examined, respiratory isolates showed significantly more siderophore pertinent genes compared to environmental isolates. Among the Hawai’i isolates, RGM M. abscessus and M. porcinum had significantly less esx-3 and mbt genes compared to SGM M. chimaera when stratified by growth classification. However, no significant differences were observed between the species when grown on low iron culture agar or siderophore production by the chrome azurol S (CAS) assay in vitro. These results indicate the complex mechanisms involved in iron sequestration and siderophore activity among diverse NTM species
Properties of an alkali-thermo stable xylanase from Geobacillus thermodenitrificans A333 and applicability in xylooligosaccharides generation
- Author
- A Anand
- A Archana
- A Coleri
- A Gessesse
- A Khasin
- A Moure
- A Sharma
- Alessandra Morana
- Anna Di Salle
- B Guo
- B Liu
- BL Cantarel
- C Vieille
- CM Fontes
- D Morrison
- D Scordia
- D Verma
- E Krasuska
- Elena Ionata
- F Kaya
- F Woldesenbet
- Francesco La Cara
- G Mamo
- G Menon
- GA Sellek
- Giovanni del Monaco
- H Nielsen
- J Gerasimova
- J Zhou
- KB Bastawde
- L Feng
- L Maurelli
- L Viikari
- Loredana Marcolongo
- Luis Alves
- MJ Tseng
- MJ Vazquez
- MM Bradford
- N Kulkarni
- N Li
- N Nelson
- P Biely
- P Biely
- P Matsudaira
- R Khandeparker
- R Yang
- S Canakci
- S Canakci
- S Subramaniyan
- S Wu
- SS Tan
- Susana M. Paixão
- T Collins
- T Satyanarayana
- TE Timell
- UK Laemmli
- V Juturu
- V Kumar
- Y Sato
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
An extracellular thermo-alkali-stable and cellulase-free xylanase from Geobacillus thermodenitrificans A333 was purified to homogeneity by ion exchange and size exclusion chromatography. Its molecular mass was 44 kDa as estimated in native and denaturing conditions by gel filtration and SDS-PAGE analysis, respectively. The xylanase (GtXyn) exhibited maximum activity at 70 °C and pH 7.5. It was stable over broad ranges of temperature and pH retaining 88 % of activity at 60 °C and up to 97 % in the pH range 7.5–10.0 after 24 h. Moreover, the enzyme was active up to 3.0 M sodium chloride concentration, exhibiting at that value 70 % residual activity after 1 h. The presence of other metal ions did not affect the activity with the sole exceptions of K+ that showed a stimulating effect, and Fe2+, Co2+ and Hg2+, which inhibited the enzyme. The xylanase was activated by non-ionic surfactants and was stable in organic solvents remaining fully active over 24 h of incubation in 40 % ethanol at 25 °C. Furthermore, the enzyme was resistant to most of the neutral and alkaline proteases tested. The enzyme was active only on xylan, showing no marked preference towards xylans from different origins. The hydrolysis of beechwood xylan and agriculture-based biomass materials yielded xylooligosaccharides with a polymerization degree ranging from 2 to 6 units and xylobiose and xylotriose as main products. These properties indicate G. thermodenitrificans A333 xylanase as a promising candidate for several biotechnological applications, such as xylooligosaccharides preparation
Ariel: Enabling planetary science across light-years
- Author
- Abreu M
- Al-Refaie A
- Alonso G
- Alvarez JP
- Amiaux J
- Anisman L
- Aret A
- Arhancet A
- Ateca J
- Baeyens R
- Barnes JR
- Barstow J
- Beaulieu J-P
- Bell T
- Benatti S
- Berthé M
- Biazzo K
- Bishop G
- Bonomo AS
- Borsato L
- Bosch J
- Bossini D
- Boudin N
- Bourgalais J
- Bowles N
- Brienza D
- Brucalassi A
- Bruno G
- Buchhave L
- Błęcka M
- Caines H
- Calcutt S
- Caldwell A
- Campante T
- Canestrari R
- Cann N
- Cara C
- Carmona M
- Carmona M
- Carone L
- Carrasco N
- Casali G
- Casas A
- Casewell S
- Cassone G
- Changeat Q
- Changeat Q
- Charnay B
- Chioetto P
- Chubb KL
- Ciaravella A
- Civiš S
- Claret A
- Claudi R
- Codella C
- Coffey D
- Colomé J
- Comas MG
- Cortecchia F
- Coustenis A
- Cowan N
- Cracchiolo G
- Crook M
- Crouzet P-E
- Cubillos P
- Czupalla M
- Danielski C
- Decin L
- Dejabrun C
- Delgado-Mena E
- Demangeon O
- Diolaiti E
- Dorn C
- Doublier V
- Doumayrou E
- Dransfield G
- Drossart P
- Drummond R
- Dumaye L
- Dunford E
- Désjonqueres L
- Díaz JJ
- Eccleston P
- Edwards BN
- Encrenaz T
- Escobar AJ
- Eylen VV
- Farina M
- Fedele D
- Fernández A
- Ferus M
- Fleury B
- Focardi M
- Fonte S
- Fontignie J
- Foresto VCD
- Fossati L
- Funke B
- Galy C
- Garai Z
- García A
- García-Rigo A
- Garufi A
- Giacobbe P
- Gilli G
- Giorgio AD
- Gonzalez A
- Gonzalez-Galindo F
- Goujon A
- Grassi D
- Gressier A
- Griffin M
- Griffith C
- Grzegorczyk A
- Guarcello MG
- Guedel M
- Guillot T
- Guilluy G
- Gómez A
- Gómez JM
- Haag M
- Halain J-P
- Hargrave P
- Hartogh P
- Haswell C
- Helled R
- Hellin M-L
- Herrero E
- Hills M
- Holmes W
- Horeau B
- Hunt T
- Ikoma M
- Ito Y
- Jessen NC
- Kabath P
- Kama M
- Kawashima Y
- Kimura T
- Kiss C
- Knížek A
- Kohley R
- Kokori A
- Kovacs Z
- Kreidberg L
- Krijger M
- Kruid R
- Kruijssen DJM
- Kubelík P
- Kálmán S
- Lagage P-O
- Lara L
- Lebonnois S
- Leconte J
- Lee D
- Lefevre M
- Lichtenberg T
- Locci D
- Lombini M
- Lopez AS
- Lorenzani A
- Lüftinger T
- MacDonald R
- Machado P
- Machado R
- Magrini L
- Malaguti G
- Maldonado J
- Marcq E
- Mendonça J
- Micela G
- Migliorini A
- Miguel Y
- Min M
- Modirrousta-Galian D
- Molaverdikhani K
- Molinari S
- Mollière P
- Moneti A
- Morales JC
- Moreau V
- Morello G
- Morgante G
- Morinaud G
- Morvan M
- Moses JI
- Mouzali S
- Mugnai L
- Muñoz AG
- Nakhjiri N
- Naponiello L
- Narita N
- Nascimbeni V
- Nikolaou A
- Nikolaou N
- Noce V
- Oliva F
- Ollivier M
- Osorio MRZ
- Ottensamer R
- Pace E
- Pagano I
- Pagano T
- Palladino P
- Pallé E
- Panic O
- Papageorgiou A
- Parmentier V
- Pascale E
- Pearson C
- Pedersen SM
- Peppo VD
- Peres G
- Perez-Hoyos S
- Perger M
- Pestellini CC
- Petralia A
- Philippon A
- Piccialli A
- Pignatari M
- Pilbratt G
- Piotto G
- Pniel M
- Podio L
- Polenta G
- Preti G
- Pribulla T
- Puertas ML
- Puig L
- Pérez J
- Rainer M
- Rataj M
- Ratti F
- Ray T
- Reess J-M
- Rengel M
- Renk F
- Ribas I
- Rickman H
- Rimmer P
- Robert S
- Rocchetto M
- Roose S
- Rosich A
- Rossi L
- Rust D
- Sacco GG
- Saleh A
- Salvignol J-C
- Sanna N
- Sarkar S
- Savini G
- Scharmberg C
- Selsis F
- Stamper R
- Swain M
- Symonds K
- Szabó G
- Szabó R
- Szirovicza P
- Szoke J
- Tan J
- Tennyson J
- Testi L
- Tinetti G
- Tosh I
- Tsiaras A
- Turrini D
- Vandenbussche B
- Venot O
- Vida K
- Vilardell F
- Waldmann IP
- Werner S
- Yurchenko S
- Zellem R
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Enabling planetary science across light-years. Ariel Definition Study Report
- Author
- Abreu Manuel
- Al-Refaie Ahmed
- Alonso Gustavo
- Amiaux Jerome
- Anisman Lara
- Aret Anna
- Arhancet Axel
- Ateca Jaume
- Baeyens Robin
- Barstow Joanna
- Beaulieu Jean-Philippe
- Bell Taylor
- Benatti Serena
- Berthé Michel
- Biazzo Katia
- Bishop Georgia
- Borsato Luca
- Bosch José
- Bossini Diego
- Boudin Nathalie
- Bourgalais Jeremy
- Bowles Neil
- Brienza Daniele
- Brucalassi Anna
- Bruno Giovanni
- Buchhave Lars
- Błęcka Maria
- Caines Hamish
- Calcutt Simon
- Caldwell Andrew
- Campante Tiago
- Canestrari Rodolfo
- Cann Nick
- Cara Christophe
- Carine Vandaele Ann
- Carlos Morales Juan
- Carmona Manuel
- Carone Ludmila
- Carrasco Nathalie
- Casali Giada
- Casas Albert
- Casewell Sarah
- Cassone Giuseppe
- Cecchi Pestellini Cesare
- Changeat Quentin
- Charnay Benjamin
- Chioetto Paolo
- Christian Jessen Niels
- Ciaravella Angela
- Civiš Svatopluk
- Claret Antonio
- Claudi Riccardo
- Codella Claudio
- Coffey Deirdre
- Colomé Josep
- Cortecchia Fausto
- Coudé du Foresto Vincent
- Coustenis Athena
- Cowan Nicolas
- Cracchiolo Gianluca
- Crook Martin
- Crouzet Pierre-Elie
- Cubillos Patricio
- Czupalla Markus
- Da Peppo Vania
- Danielski Camilla
- Decin Leen
- Dejabrun Clemence
- Del Vecchio Ciro
- Delgado-Mena Elisa
- Demangeon Olivier
- Di Giorgio Anna
- Diolaiti Emiliano
- Dorn Caroline
- Doublier Vanessa
- Doumayrou Eric
- Dransfield Georgina
- Drossart Pierre
- Drummond Rachel
- Dumaye Luc
- Dunford Emma
- Désjonqueres Lucile
- Eccleston Paul
- Encrenaz Therese
- Farina Maria
- Fedele Davide
- Fernández Alejandro
- Ferus Martin
- Fleury Benjamin
- Focardi Mauro
- Fonte Sergio
- Fontignie Jean
- Fossati Luca
- Funke Bernd
- Galy Camille
- Garai Zoltán
- Garcia Comas Maya
- García Muñoz Antonio
- García Andrés
- García-Rigo Alberto
- Garufi Antonio
- Germano Sacco Giuseppe
- Giacobbe Paolo
- Gilli Gabriella
- Giuseppe Guarcello Mario
- Gonzalez Arturo
- Gonzalez-Galindo Francisco
- Goujon Audrey
- Grassi Davide
- Gressier Amélie
- Griffin Matt
- Griffith Caitlin
- Grzegorczyk Aleksandra
- Guedel Manuel
- Guillot Tristan
- Guilluy Gloria
- Gómez Alejandro
- Haag Martin
- Halain Jean-Philippe
- Hargrave Peter
- Hartogh Paul
- Haswell Carole
- Helled Ravit
- Hellin Marie-Laure
- Herrero Enrique
- Hills Matt
- Holmes Warren
- Horeau Benoit
- Hou Yip Gordon
- Hunt Tom
- I. Moses Julianne
- Ikoma Masahiro
- Ito Yuichi
- J. Díaz José
- J. M. Kruijssen Diederik
- Jimenez Escobar Antonio
- Kabath Petr
- Kama Mihkel
- Kawashima Yui
- Kimura Tadahiro
- Kiss Csaba
- Knížek Antonín
- Kohley Ralf
- Kokori Anastasia
- Kovacs Zsolt
- Kreidberg Laura
- Krijger Matthijs
- Kruid Ronald
- Kubelík Petr
- Kálmán Szilárd
- L. Chubb Katy
- Lagage Pierre-Olivier
- Lara Luisa
- Lebonnois Sebastien
- Leconte Jérémy
- Lee David
- Lefevre Maxence
- Lichtenberg Tim
- Locci Daniele
- Lombini Matteo
- Lopez Puertas Manuel
- Lorenzani Andrea
- Lüftinger Theresa
- M. Gómez Jose
- MacDonald Ryan
- Machado Pedro
- Machado Richardo
- Magrini Laura
- Malaguti Giuseppe
- Maldonado Jesus
- Marcq Emmanuel
- Mendonça João
- Micela Giusi
- Migliorini Alessandra
- Miguel Yamila
- Min Michel
- Modirrousta-Galian Darius
- Molaverdikhani Karan
- Molinari Sergio
- Mollière Paul
- Moneti Andrea
- Moreau Vincent
- Morello Giuseppe
- Morgante Gianluca
- Morinaud Gilles
- Morvan Mario
- Mouzali Salima
- Mugnai Lorenzo
- Møller Pedersen Søren
- N. Edwards Billy
- Nakhjiri Nariman
- Naponiello Luca
- Narita Norio
- Nascimbeni Valerio
- Nikolaou Athanasia
- Nikolaou Nikos
- Noce Vladimiro
- Oliva Fabrizio
- Ollivier Marc
- Ottensamer Roland
- P. Waldmann Ingo
- Pace Emanuele
- Pagano Isabella
- Pagano Teresa
- Palladino Pietro
- Pallé Enric
- Panic Olja
- Papageorgiou Andreas
- Parmentier Vivien
- Pascale Enzo
- Pearson Chris
- Peres Giovanni
- Perez Alvarez Javier
- Perez-Hoyos Santiago
- Perger Manuel
- Petralia Antonino
- Philippon Anne
- Piccialli Arianna
- Pignatari Marco
- Pilbratt Göran
- Piotto Giampaolo
- Pniel Moshe
- Podio Linda
- Polenta Gianluca
- Preti Giampaolo
- Pribulla Theodor
- Puig Ludovic
- Pérez Javier
- R. Barnes John
- Rainer Monica
- Rataj Mirek
- Ratti Francesco
- Ray Tom
- Reess Jean-Michel
- Rengel Miriam
- Renk Florian
- Ribas Ignasi
- Rickman Hans
- Rimmer Paul
- Robert Séverine
- Rocchetto Marco
- Roose Stéphane
- Rosa Zapatero Osorio Maria
- Rosich Albert
- Rossi Loic
- Rust Duncan
- Saleh Ayman
- Salvignol Jean-Christophe
- Sanchez Lopez Alejandro
- Sanna Nicoletta
- Sarkar Subhajit
- Savini Giorgio
- Scharmberg Carsten
- Schisano Eugenio
- Schreiber Laura
- Schwartz Victor
- Scippa Antonio
- Seli Bálint
- Selsis Franck
- Shibata Sho
- Shorttle Oliver
- Simpson Caroline
- Skaf N.
- Skup Konrad
- Sobiecki Mateusz
- Sousa Sergio
- Sozzetti Alessandro
- Stamper Richard
- Stefano Bonomo Aldo
- Steiger Lukas
- Swain Mark
- Symonds Kate
- Szabó Gyula
- Szabó Robert
- Szirovicza Peter
- Szoke Janos
- Tackley Paul
- Tan Jonathan
- Tanga Paolo
- Taylor Jake
- Tecza Matthias
- Tennyson Jonathan
- Terenzi Luca
- Testi Leonardo
- Tinetti Giovanna
- Tosh Ian
- Tozzi Andrea
- Tremblin Pascal
- Triaud Amaury
- Trompet Loïc
- Tsai Shang-Min
- Tsantaki Maria
- Tsiaras Angelos
- Turrini Diego
- Valencia Diana
- Van der Swaelmen Mathieu
- Van Eylen Vincent
- Vandenbussche Bart
- Vardan Adibekyan
- Vasisht Gautam
- Vazan Allona
- Venot Olivia
- Vida Krisztián
- Vilardell Francesc
- Waltham Dave
- Wawer Piotr
- Werner Stephanie
- Widemann Thomas
- Wolkenberg Paulina
- Yung Yuk
- Yurchenko Sergey
- Zellem Rob
- Zilinskas Mantas
- Zingales Tiziano
- Zuppella Paola
- Šponer Judit
- Publication venue
- 'European Space Agency'
- Publication date
- 30/11/2020
- Field of study
Ariel, the Atmospheric Remote-sensing Infrared Exoplanet Large-survey, was adopted as the fourth medium-class mission in ESA's Cosmic Vision programme to be launched in 2029. During its 4-year mission, Ariel will study what exoplanets are made of, how they formed and how they evolve, by surveying a diverse sample of about 1000 extrasolar planets, simultaneously in visible and infrared wavelengths. It is the first mission dedicated to measuring the chemical composition and thermal structures of hundreds of transiting exoplanets, enabling planetary science far beyond the boundaries of the Solar System. The payload consists of an off-axis Cassegrain telescope (primary mirror 1100 mm x 730 mm ellipse) and two separate instruments (FGS and AIRS) covering simultaneously 0.5-7.8 micron spectral range. The satellite is best placed into an L2 orbit to maximise the thermal stability and the field of regard. The payload module is passively cooled via a series of V-Groove radiators; the detectors for the AIRS are the only items that require active cooling via an active Ne JT cooler. The Ariel payload is developed by a consortium of more than 50 institutes from 16 ESA countries, which include the UK, France, Italy, Belgium, Poland, Spain, Austria, Denmark, Ireland, Portugal, Czech Republic, Hungary, the Netherlands, Sweden, Norway, Estonia, and a NASA contribution
New genetic loci link adipose and insulin biology to body fat distribution.
- Author
- Aalto Ville
- Aasarød Knut
- Abecasis Goncalo R
- Abecasis Gonçalo
- Absher Devin
- Adair Linda S
- Adam Martin
- Adeyemo Adebowale
- Ahlqvist Emma
- Ahmadi Kourosh R
- Ahola Aila
- Ainali Chrysanthi
- Akylbekova Ermeg
- Ala-Korpela Mika
- Alavere Helen
- Albagha Omar M E
- Albrecht Eva
- Alen Markku
- Alexander Myriam
- Alhenc-Gelas François
- Alizadeh Behrooz Z
- Allison Matthew A
- Alonso Nerea
- Altshuler David
- Ambite Jose Luis
- Amin Najaf
- Amouyel Philippe
- An Ping
- Anderson Carl A
- Anderson Denise
- Anderson Garnet
- Andrews Jeanette S
- Antonella Mulas
- Antti Jula
- Aragaki Aaron K
- Arking Dan E
- Arnold Alice
- Arnold Alice M
- Arora Pankaj
- Arscott Gillian M
- Artigas Maria Soler
- Arveiler Dominique
- Asiki Gershim
- Aspelund Thor
- Assimes Themistocles L
- Atalay Mustafa
- Atkinson Elizabeth J
- Aulchenko Yurii
- Avery Christy
- Bain Stephen C
- Bakker Stephan J L
- Balcells Susana
- Balkau Beverley
- Ballantyne Christie M
- Balmforth Anthony J
- Bandinelli Stefania
- Barbalic Maja
- Barrett Amy
- Barroso Ines
- Barroso Inês
- Basart Hanneke
- Basart Hanneke V
- Bataille Veronique
- Baumert Jens
- Beckmann Jacques S
- Beekman Marian
- Been Latonya F
- Beilby John
- Beilby John P
- Bell Jordana T
- Bellis Claire
- Bennett Amanda J
- Bennett Franklyn
- Berenson Gerald S
- Bergman Richard N
- Bergmann Sven
- Berndt Sonja I
- Berne Christian
- Bidulescu Aurelian
- Bielak Lawrence F
- Bierut Laura J
- Biffar Reiner
- Bis Joshua C
- Blackburn Hannah
- Blangero John
- Blankenberg Stefan S
- Blüher Matthias
- Boban Mladen
- Bochud Murielle
- Boehm Bernhard O
- Boehnke Michael
- Boerwinkle Eric
- Boezen H Marike
- Bolton Jennifer L
- Bolton Judith A Hoffman
- Bonnet Fabrice
- Bonnycastle Lori L
- Boomsma Dorret I
- Borecki Ingrid
- Boright Andrew P
- Borja Judith B
- Bornstein Stefan R
- Boston Jonathan
- Bots Michiel L
- Bouatia-Naji Nabila
- Bouchard Claude
- Bovet Pascal
- Boyd Heather A
- Bragg-Gresham Jennifer L
- Brambilla Paolo
- Brand Eva
- Brand Stefan-Martin
- Brandi Maria Luisa
- Braund Peter S
- Brennan Eoin P
- Brismar Kerstin
- Brody Jennifer
- Broekmans Frank J
- Broer Linda
- Brown Matthew A
- Brown Morris J
- Brown-Gentry Kristin
- Bruinenberg Marcel
- Buchkovich Martin L
- Buckley Brendan M
- Buil Alfonso
- Bull Shelley B
- Burgdorf Christof
- Buring Julie E
- Burnett Mary S
- Burnier Michel
- Burri Andrea
- Burton Paul R
- Bush William S
- Busonero Fabio
- Buxbaum Sarah G
- Buyske Steve
- Buzkova Petra
- Byrne Enda M
- Böger Carsten A
- Böhringer Stefan
- Böttcher Yvonne
- Cambien Francois
- Campbell Harry
- Campbell Susan
- Carba Delia B
- Carlson Chris
- Carlson Olga D
- Carty Cara
- Casas Juan P
- Caspersen Ida H
- Castano-Betancourt Martha
- Cauchi Stéphane
- Cauley Jane A
- Caulfield Mark
- Cavalieri Margherita
- Cazier Jean-Baptiste
- Center Jacqueline R
- Cesana Giancarlo
- Chakravarti Aravinda
- Chambers John
- Chandak Giriraj R
- Chang Hsing-Yi
- Chang Yen-Pei C
- Chanock Stephen J
- Charchar Fadi J
- Chasman Dan
- Chaturvedi Nish
- Chen Constance
- Chen Han
- Chen Ida
- Chen Jin
- Chen Ming-Huei
- Chen Wei
- Chen Yii-Der Ida
- Cheng Iona
- Cheng Sulin
- Chines Peter S
- Cho Yoon Shin
- Choi Murim
- Chouraki Vincent
- Christiansen Claus
- Chu Audrey Y
- Cimponeriu Dan
- Ciullo Marina
- Clark Graeme R
- Clarke Robert
- Claudi-Boehm Simone
- Coassin Stefan
- Cochran Barbara
- Cole Shelley
- Colhoun Helen
- Colhoun Helen M
- Collins Francis S
- Collins Rory
- Connell John M
- Cooper Cyrus
- Cooper Jackie A
- Cooper Matthew N
- Cooper Richard S
- Coresh Josef
- Cornelis Marilyn C
- Corre Tanguy
- Corsi Anna Maria
- Couper David
- Cousminer Diana L
- Coviello Andrea D
- Cox David
- Crawford Dana
- Crisponi Laura
- Croteau-Chonka Damien C
- Cucca Francesco
- Cummings Steven R
- Cupples Adrienne L
- Cupples L Adrienne
- Curhan Gary
- d'Adamo Pio
- Dahgam Santosh
- Dailiana Zoe
- Danesh John
- Danoy Patrick
- Dastani Zari
- Davies Gail
- Daw E Warwick
- Day Felix R
- Day Ian N M
- de Andrade Mariza
- de Boer Ian H
- de Boer Rudolf A
- de Faire Ulf
- de Geus Eco J C
- Deary Ian J
- Dedoussis George
- Dedoussis George V
- Dedoussis George V Z
- Deelen Joris
- Deelman Ewa
- Dehghan Abbas
- Delgado Graciela
- Deloukas Panagiotis
- Deloukas Panos
- Demerath Ellen W
- Demirkan Ayse
- Demirkan Ayşe
- Den Hertog Heleen M
- Denniff Matthew
- Dennison Elaine M
- Dermitzakis Emmanouil T
- Deshmukh Harshal
- Deshmukh Harshal A
- Devuyst Olivier
- di Meglio Paola
- Diemert Patrick
- Dimas Antigone S
- Dimitriou Maria
- Ding Jingzhong
- Do Ron
- Dominiczak Anna F
- Doney Alex
- Dong Yanbin
- Donnelly Louise A
- Doumatey Ayo
- Dreisbach Albert W
- Drong Alexander W
- Duggan David
- Dumitrescu Logan
- Duncan Bruce B
- Duncan Emma L
- Dupuis Josee
- Dupuis Josée
- Durbin Richard
- Durda Peter
- Döring Angela
- Dörr Marcus
- Eastell Richard
- Easton Douglas F
- Ebrahim Shah
- Econs Michael J
- Edkins Sarah
- Egan Josephine
- Ehret Georg
- Eiriksdottir Gudny
- Eisman John A
- Eklund Niina
- El Mokhtari NourEddine
- Elks Cathy E
- Ellinghaus David
- Elliott Paul
- Elosua Roberto
- Emilsson Valur
- Endlich Karlhans
- Epstein Stephen E
- Erbel Raimund
- Erdmann Jeanette
- Erdos Michael R
- Eriksson Joel
- Eriksson Johan
- Eriksson Niclas
- Eriksson Per
- Ernst Florian
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- Vartiainen Erkki
- Vasan Ramachandran S
- Vedantam Sailaja
- Veldre Gudrun
- Verlaan Dominique
- Vernon Smith Albert
- Veronesi Giovanni
- Verweij Niek
- Verwoert Germaine
- Verwoert Germaine C
- Viigimaa Margus
- Viikari Jorma
- Vinay D G
- Vineis Paolo
- Vink Jacqueline M
- Virtamo Jarmo
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- Visser Jenny A
- Vitart Veronique
- Vohl Marie-Claude
- Voight Benjamin F
- Volcik Kelly A
- Vollenweider Peter
- Vonk Judith M
- Voorhuis Marlies
- Völker Uwe
- Völzke Henry
- Wadén Johan
- Waeber Gerard
- Waeber Gérard
- Wagenknecht Lynne E
- Waggott Daryl
- Wagner Peter J
- Wain Louise V
- Wainwright Nicholas
- Waite Lindsay L
- Walker Mark
- Wallace Leanne
- Wallaschofski Henri
- Wallentin Lars
- Wang Hansong
- Wang Jie Jin
- Wang Thomas J
- Wang Xiaoling
- Wareham Nicholas
- Wareham Nick J
- Warrington Nicole M
- Watanabe Richard M
- Waterworth Dawn
- Watkins Hugh
- Weder Alan B
- Weedon Michael N
- Welch Ryan P
- Wells George A
- Wennauer Roman
- Westra Harm-Jan
- Wheeler Eleanor
- Wheeler Heather E
- Whincup Peter H
- Whitfield John B
- Wichmann H Erich
- Wichmann H-Erich
- Widen Elisabeth
- Wiggins Kerri L
- Wijmenga Cisca
- Wijnands-van Gent Colette J M
- Wild Philipp S
- Wild Sarah H
- Wilk Alicja
- Wilkens Lynne
- Willems Sara M
- Willemsen Gonneke
- Willemsvan-vanDijk Ko
- Willenborg Christina
- Willer Cristen J
- Williams Frances M K
- Williams Rasheeda
- Williams Winfred W
- Willner Dana
- Wilsgaard Tom
- Wilson James F
- Wilson James G
- Wilson Sarah
- Wilson Scott G
- Winkler Thomas
- Witteman Jacqueline C
- Witteman Jacqueline C M
- Wojczynski Mary K
- Wolffenbuttel Bruce H R
- Wong Andrew
- Wong Tien Y
- Woo Jean
- Wood Andrew R
- Wood Andy
- Workalemahu Tsegaselassie
- Wright Alan F
- Wu Chunyuan
- Wu Joseph M W
- Wu Ying
- Würtz Peter
- Xiao Su-Mei
- Yajnik Chittaranjan S
- Yang Jian
- Yang Qiong
- Yang Tsun-Po
- Yao Jie
- Yengo Loïc
- Yerges-Armstrong Laura M
- Young Alicia
- Young Elizabeth H
- Young J H
- Young Lauren
- Yuan Xin
- Zaboli Ghazal
- Zalloua Pierre A
- Zarrabeitia María T
- Zelenika Diana
- Zemunik Tatijana
- Zerbini Gianpaolo
- Zgaga Lina
- Zhai Guangju
- Zhang Feng
- Zhang Qunyuan
- Zhang Weihua
- Zhao Jing Hua
- Zhao Wei
- Zheng Hou-Feng
- Zheng Wei
- Zhou Yanhua
- Zhu Haidong
- Zhu Kun
- Zhu Xiaofeng
- Zhuang Wei V
- Zhuang Wei Vivian
- Ziegler Andreas
- Zillikens M Carola
- Zimmermann Martina E
- Zitting Paavo
- Zondervan Krina T
- Zukowska-Szczechowska Ewa
- Zygmunt Marek
- Ärnlöv Johan
- Österholm Anne-May
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms
Properties of an alkali-thermo stable xylanase from Geobacillus thermodenitrificans A333 and applicability in xylooligosaccharides generation
- Author
- A Anand
- A Archana
- A Coleri
- A Gessesse
- A Khasin
- A Moure
- A Sharma
- Alessandra Morana
- Anna Di Salle
- B Guo
- B Liu
- BL Cantarel
- C Vieille
- CM Fontes
- D Morrison
- D Scordia
- D Verma
- E Krasuska
- Elena Ionata
- F Kaya
- F Woldesenbet
- Francesco La Cara
- G Mamo
- G Menon
- GA Sellek
- Giovanni del Monaco
- H Nielsen
- J Gerasimova
- J Zhou
- KB Bastawde
- L Feng
- L Maurelli
- L Viikari
- Loredana Marcolongo
- Luis Alves
- MJ Tseng
- MJ Vazquez
- MM Bradford
- N Kulkarni
- N Li
- N Nelson
- P Biely
- P Biely
- P Matsudaira
- R Khandeparker
- R Yang
- S Canakci
- S Canakci
- S Subramaniyan
- S Wu
- SS Tan
- Susana M. Paixão
- T Collins
- T Satyanarayana
- TE Timell
- UK Laemmli
- V Juturu
- V Kumar
- Y Sato
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard Véronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
- Baker Andrew
- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
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- Banerjee Ruby
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- Barbe Valérie
- Bardill Simon
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- Barker Darren
- Barker Gary
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- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
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- Beaudet Arthur
- Beck Alfred
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- Becker Michael
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- Berardinis Véronique de
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- Beugelsdijk Tony J.
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- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
- Blanks Tia
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- Blazej Robert
- Blitshsteyn Berta
- Blomstrom David B.
- Bloom Scott
- Bloom Toby
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- Bolton Christel
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- Bonnett Ralph
- Bonnin David
- Border Richard
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- Borzym Katja
- Boukhgalter Boris
- Bowen Eric
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- Brady Nicola
- Brandriff Brigitte F.
- Brannon Wade
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- Bray Jason
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- Brettin Thomas
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- Brokstein Peter
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- Carriere Jason
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- Chapple Jeffrey
- Charles Rachel
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- Chen Ellson
- Chen Hsiu-Chuan
- Chen Jianlong
- Chen Jie
- Chen Jin
- Chen Junbao
- Chen Lihong
- Chen Lixia
- Chen Ray
- Chen Shu
- Chen Tong
- Chen Xiaoyun
- Chen Xinyi
- Chen Yanjiong
- Chen Yiyu
- Chen Zhu
- Chen Zhu
- Chen Zhu
- Cheng Jan-Fang
- Cheng Zhihua
- Chertkov Olga
- Cheshatsang Yama
- Chi Cheng
- Chi Han C.
- Chillingworth Neil
- Chin Sylvia
- Chinn Corey
- Chinwalla Asif
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- Chothia Tom
- Christensen Mari
- Christopoulos Constantine
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- Chui Connie
- Chung A
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- Clee Chris
- Clegg Shelia
- Clerc Blankenburg Kerstin Petra
- Cleveland David
- Clifford Karen
- Clifton Sandra W.
- Coates Julia
- Cobley Victoria
- Cockrell Raynard
- Coffey Alison
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- Coggill Penelope
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- Collings Simon
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- Comstock Robin
- Cong Bin
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- Connolly Anthony
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- Conrad Ansgar
- Conroy Donald
- Considine Tony
- Constance Doug
- Cook April
- Cook Leanna
- Cooke Patrick
- Cooper Jonathan
- Cooper Rachel
- Cooper Robert
- Copeland Alex
- Coppola Maria
- Copsey Teresa
- Corby Nicole
- Cordes Matt
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- Cummings Kirsti
- Cummings Paul
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- Curran Adam
- Curwen Valery
- Cutts Jeffrey
- Czubayko Martin
- D\u27Souza Lisa Marie
- Da Silva Corinne
- Dai Li
- Dalin Eillen
- Dang Michelle
- Danganan Linda
- Daniels Rachael
- Dathorne Stephanie R.
- Daum Christopher
- David Robert
- Davidson Lucy
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- Davies Jonathon
- Davies Joy
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- Davis Candi Mon\u27et
- Davis Cheryl
- Davis Clay
- Davis Jayne
- Davis John
- Davis Matthew
- Davy-Carroll Latarsha
- Dawoe Tenzin
- Dawson Elisabeth
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- Deadman Rebecca
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- Dehal Paramvir
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- Diekhans Mark
- Dietz-Band Jeanne
- Digennaro Richard
- Dilts Karen
- Dimitrijevic-Bussod Mira
- Ding Hao
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- Ding Li
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- Do Long
- Dobbs Ruth
- Dobson Richard
- Dockree Catherine
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- Dodsworth Steven
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- Heiner Cheryl
- Heinze Ivonne
- Heitmann Katja
- Helfenbein Keven
- Heller Andrew
- Hellsten Uffe
- Hembry Cathy
- Henderson Carl
- Henderson Nicholas
- Henderson Nina
- Hendrix David
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
- Holden Jane
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- Holmes Sarah
- Holroyd Simon
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- Holtzer Caleb
- Homsi Deana K.
- Homsi Farah J.
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- Hood Leroy
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- Idlebird Devincent G.
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- Ishibashi Akiko
- Ishikawa Sabine K.
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- Nwokenkwo Stanley
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- Yang Hao
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- Yang Huanming
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- Yang Shudong
- Yang Xiaonan
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- Yao Zhijian
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- Ye Chen
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- Zhai Dong
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- Zhang Bo
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- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Endogenous CCL2 neutralization restricts HIV-1 replication in primary human macrophages by inhibiting viral DNA accumulation
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- A Berger
- A Cribier
- A Zalar
- Alessandra Mallano
- Andrea Cara
- AR Stacey
- Arturo Rinaldi
- AW Ansari
- BK Thielen
- C Goujon
- C Muratori
- C Muratori
- C Rollenhagen
- C Trapnell
- CA Wiley
- Cristina Purificato
- D Bischof
- D Blanco-Melo
- D Finkelshtein
- D Guha
- Daniela Covino
- DC Goldstone
- DR Negri
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- E Cassol
- E Gonzalez
- E Marini
- EA Diget
- EA Eugenin
- EW Refsland
- FA Koning
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- G Berger
- G Peng
- GR Campbell
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- Mauro Andreotti
- MH Lehmann
- MH Malim
- Michela Sabbatucci
- MK Lafferty
- MK Liszewski
- N Laguette
- O Haller
- P Cinque
- P Lusso
- R Goila-Gaur
- RD Powell
- RN Douville
- Roberta Bona
- RS Harris
- S Bernasconi
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- T Greenwell-Wild
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- V Mohanram
- VC Vieira
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- Z Yang
- Zuleika Michelini
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
The ALICE experiment at the CERN LHC
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- Závada P.
- Äysto J.
- Österman L.
- Černý V.
- Šafařík K.
- Šumbera M.
- Šándor L.
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2008
- Field of study
ALICE (A Large Ion Collider Experiment) is a general-purpose, heavy-ion detector at the CERN LHC which focuses on QCD, the strong-interaction sector of the Standard Model. It is designed to address the physics of strongly interacting matter and the quark-gluon plasma at extreme values of energy density and temperature in nucleus-nucleus collisions. Besides running with Pb ions, the physics programme includes collisions with lighter ions, lower energy running and dedicated proton-nucleus runs. ALICE will also take data with proton beams at the top LHC energy to collect reference data for the heavy-ion programme and to address several QCD topics for which ALICE is complementary to the other LHC detectors. The ALICE detector has been built by a collaboration including currently over 1000 physicists and engineers from 105 Institutes in 30 countries. Its overall dimensions are 161626 m3 with a total weight of approximately 10 000 t. The experiment consists of 18 different detector systems each with its own specific technology choice and design constraints, driven both by the physics requirements and the experimental conditions expected at LHC. The most stringent design constraint is to cope with the extreme particle multiplicity anticipated in central Pb-Pb collisions. The different subsystems were optimized to provide high-momentum resolution as well as excellent Particle Identification (PID) over a broad range in momentum, up to the highest multiplicities predicted for LHC. This will allow for comprehensive studies of hadrons, electrons, muons, and photons produced in the collision of heavy nuclei. Most detector systems are scheduled to be installed and ready for data taking by mid-2008 when the LHC is scheduled to start operation, with the exception of parts of the Photon Spectrometer (PHOS), Transition Radiation Detector (TRD) and Electro Magnetic Calorimeter (EMCal). These detectors will be completed for the high-luminosity ion run expected in 2010. This paper describes in detail the detector components as installed for the first data taking in the summer of 2008
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
- Author
- Ahn Jaeil
- Akbani Rehan
- Aldape Kenneth D.
- Ally Adrian
- Atkins Michael B.
- Auman J. Todd
- Ayala Brenda
- Baboud Julien
- Balasundaram Miruna
- Balu Saianand
- Baylin Stephen B.
- Benz Christopher C.
- Beroukhim Rameen
- Bhanot Gyan
- Biehl Michael
- Birol Inanc
- Black Aaron D.
- Bodenheimer Tom
- Boice Lori
- Bootwalla Moiz S.
- Bowen Jay
- Bristow Christopher A.
- Brooks Denise
- Buda Elizabeth
- Buhay Christian
- Butterfield Yaron S.N.
- Carter Scott L.
- Chao Hsu
- Chen Fengju
- Cherniack Andrew D.
- Cheville John
- Chin Lynda
- Cho Juok
- Choi Yoon La
- Choueiri Toni K.
- Chu Andy
- Chuah Eric
- Chudamani Sudha
- Clarke Amanda
- Coarfa Cristian
- Creighton Chad J.
- Czerniak Bogdan A.
- Dahdouli Mike
- Davidsen Tanja
- Davis Caleb F.
- Demchok John A.
- Dhalla Noreen
- Di-Cara Daniel
- Doddapaneni Harsha
- Donehower Lawrence A.
- Downs Brittany
- Drummond Jennifer
- Eley Greg
- English Adam
- Fahey Catherine C.
- Fan Yu
- Fargo David
- Felau Ina
- Frazer Scott
- Gabriel Stacey B.
- Gastier-Foster Julie M.
- Gehlenborg Nils
- Getz Gad
- Gibbs Richard A.
- Gordenin Dmitry A.
- Guin Ranabir
- Gunaratne Preethi H.
- Guyer Mark S.
- Hacker Kathryn E.
- Hadjipanayis Angela
- Hakimi A. Ari
- Hale Walker
- Hall Tracy M.
- Hanf Benjamin
- Haussler David
- Hawes Alicia
- Hayes D. Neil
- Heiman David I.
- Henske Elizabeth P.
- Hoadley Katherine A.
- Holt Robert A.
- Hoyle Alan P.
- Hsieh James J.
- Huang Mei
- Hutter Carolyn M.
- Jefferys Stuart R.
- Jensen Mark A.
- Jones Corbin D.
- Jones Steven J.M.
- Kaelin William G.
- Kaipparettu Benny A.
- Kakkar Nipun
- Kalra Divya
- Kang Hyojin
- Kasaian Katayoon
- Kim Jaegil
- Kim Sang Cheol
- Klimczak Leszek J.
- Kovar Christie
- Kucherlapati Raju
- Kwiatkowski David J.
- Lai Phillip H.
- Laird Peter W.
- Lang Martin
- Lawrence Michael S.
- Lee Darlene
- Lee Eunjung
- Lee June Koo
- Lee Junehawk
- Lee Semin
- Leraas Kristen M.
- Lewis Lora
- Li Haiyan I.
- Lichtenberg Tara M.
- Lim Emilia
- Lin Pei
- Linehan W. Marston
- Liu Jia
- Liu Yingchun
- Luquette Lovelace J.
- Ma Singer
- Ma Yussanne
- Marra Marco A.
- Mayo Michael
- Meng Qingchang
- Meng Shaowu
- Merino Maria
- Meyerson Matthew
- Mieczkowski Piotr A.
- Moore Richard A.
- Morgan Margaret
- Morton Donna
- Mose Lisle E.
- Mungall Andrew J.
- Murray Bradley A.
- Muzny Donna
- Noble Michael S.
- Ozenberger Bradley A.
- Pantazi Angeliki
- Parfenov Michael
- Park Peter J.
- Park Woong Yang
- Parker Joel S.
- Perou Charles M.
- Peterson James
- Pihl Todd
- Protopopov Alexei
- Radenbaugh Amie
- Ramirez Nilsa C.
- Rathmell W. Kimryn
- Reid Jeffrey G.
- Reuter Victor
- Ricketts Christopher J.
- Roach Jeffrey
- Roberts Steven A.
- Robertson A. Gordon
- Saksena Gordon
- Santoso Netty
- Schein Jacqueline E.
- Schmidt Laura S.
- Schumacher Steven E.
- Seidman Jonathan
- Seiler Michael
- Seth Sahil
- Shaw Kenna R.Mills
- Shen Hui
- Sheth Margi
- Shuch Brian
- Signoretti Sabina
- Simons Janae V.
- Sipahimalani Payal
- Smith Angela B.
- Sofia Heidi J.
- Soloway Mathew G.
- Song Xingzhi
- Sougnez Carrie
- Spellman Paul T.
- Stojanov Petar
- Stuart Josh M.
- Tabak Barbara
- Tam Angela
- Tamboli Pheroze
- Tan Donghui
- Tarnuzzer Roy W.
- Thiessen Nina
- Thompson R. Houston
- Thorne Leigh
- Tickoo Satish K.
- Triche Timothy
- Van Den Berg David J.
- Velaga Sudhakar
- Veluvolu Umadevi
- Vocke Cathy
- Voet Doug
- Walker Kimberly
- Wallen Eric M.
- Walton Jessica
- Wan Yunhu
- Wang Min
- Wang Qiaoyan
- Wang Wenyi
- Wang Zhining
- Waring Scot
- Weinstein John N.
- Weisenberger Daniel J.
- Wheeler David A.
- Wilkerson Matthew D.
- Wise Lisa
- Wong Tina
- Wood Christopher G.
- Worrell Robert
- Wu Junyuan
- Wu Ye
- Xi Liu
- Xu Andrew W.
- Yang Liming
- Yang Lixing
- Zack Travis I.
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Jianhua
- Zhang Jiashan
- Zhul Jingchun
- Zmuda Erik
- Zou Lihua
- Publication venue
- Publication date
- 01/01/2014
- Field of study
We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations
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