Nutrient concentrations and accumulations in precipitation over the north central region

The many facets of plant nutrients (e.g., N, P, and S) in the biosphere have become major environmental issues within the past decade. This concern is justified because of the increasing contamination of air and water resources by various substances on local and regional levels, especially in areas close to point sources. Little information is available, however, on variation in the amounts and concentrations of some of the substances present in air and natural water in various parts of the United States. Such information is essential for a better understanding of the transport and perhaps the fates of pollutants in the biosphere. The atmospheric component of the N and S cycles often can be a significant part of the various pools of their respective cycles (Allison, 1965; Erickson, 1963; Feth, 1966; Gambell and Fisher, 1964; Meetham, 1950; Robinson and Robbins, 1970), but the atmospheric component of the P cycle seems to be of minor significance to the cycling of this element in the environment. Among the various chemical elements present in precipitation (e.g., N, S, K, Cl, and Ca), N and S deserve special attention because N added by precipitation may contribute to nitrate pollution of surface and ground water. Sulfur and N may cause acid rain that can lead to increased leaching from soils of Ca and other nutrient elements, deterioration of aquatic ecosystems, damage to vegetation and buildings, and other agricultural and urban problems. On the other hand, the limited amounts of N and S brought down by precipitation might be useful to meet crop requirements for these elements in areas where soils have limited supplies of N and S (Allway et al., 1937; Erdman, 1923; Olson et al., 1973; Schuman and Burwell, 1974; Tabatabai and Bremner, 1972; Walker, 1969; Widdowson and Hanway, 1974)

Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures.

Non-invasive assessment of the biological aggressiveness of prostate cancer (PCa) is needed for men with localized disease. Hyperpolarized (HP) 13C magnetic resonance (MR) spectroscopy is a powerful approach to image metabolism, specifically the conversion of HP [1-13C]pyruvate to [1-13C]lactate, catalyzed by lactate dehydrogenase (LDH). Significant increase in tumor lactate was measured in high-grade PCa relative to benign and low-grade cancer, suggesting that HP 13C MR could distinguish low-risk (Gleason score ≤3 + 4) from high-risk (Gleason score ≥4 + 3) PCa. To test this and the ability of HP 13C MR to detect these metabolic changes, we cultured prostate tissues in an MR-compatible bioreactor under continuous perfusion. 31P spectra demonstrated good viability and dynamic HP 13C-pyruvate MR demonstrated that high-grade PCa had significantly increased lactate efflux compared to low-grade PCa and benign prostate tissue. These metabolic differences are attributed to significantly increased LDHA expression and LDH activity, as well as significantly increased monocarboxylate transporter 4 (MCT4) expression in high- versus low- grade PCa. Moreover, lactate efflux, LDH activity, and MCT4 expression were not different between low-grade PCa and benign prostate tissues, indicating that these metabolic alterations are specific for high-grade disease. These distinctive metabolic alterations can be used to differentiate high-grade PCa from low-grade PCa and benign prostate tissues using clinically translatable HP [1-13C]pyruvate MR

Causal Sets: Quantum gravity from a fundamentally discrete spacetime

In order to construct a quantum theory of gravity, we may have to abandon certain assumptions we were making. In particular, the concept of spacetime as a continuum substratum is questioned. Causal Sets is an attempt to construct a quantum theory of gravity starting with a fundamentally discrete spacetime. In this contribution we review the whole approach, focusing on some recent developments in the kinematics and dynamics of the approach.Comment: 10 pages, review of causal sets based on talk given at the 1st MCCQG conferenc

Dynamics & Predictions in the Co-Event Interpretation

Sorkin has introduced a new, observer independent, interpretation of quantum mechanics that can give a successful realist account of the 'quantum microworld' as well as explaining how classicality emerges at the level of observable events for a range of systems including single time 'Copenhagen measurements'. This 'co-event interpretation' presents us with a new ontology, in which a single 'co-event' is real. A new ontology necessitates a review of the dynamical & predictive mechanism of a theory, and in this paper we begin the process by exploring means of expressing the dynamical and predictive content of histories theories in terms of co-events.Comment: 35 pages. Revised after refereein

Heidelberg standard examination and "Heidelberg standard procedures" - Development of faculty-wide standards for physical examination techniques and clinical procedures in undergraduate medical education

The competent physical examination of patients and the safe and professional implementation of clinical procedures constitute essential components of medical practice in nearly all areas of medicine. The central objective of the projects "Heidelberg standard examination" and "Heidelberg standard procedures", which were initiated by students, was to establish uniform interdisciplinary standards for physical examination and clinical procedures, and to distribute them in coordination with all clinical disciplines at the Heidelberg University Hospital. The presented project report illuminates the background of the initiative and its methodological implementation. Moreover, it describes the multimedia documentation in the form of pocketbooks and a multimedia internet-based platform, as well as the integration into the curriculum. The project presentation aims to provide orientation and action guidelines to facilitate similar processes in other faculties

Distinguishing Initial State-Vectors from Each Other in Histories Formulations and the PBR Argument

Following the argument of Pusey, Barrett and Rudolph (Nature Phys. 8:476, 2012), new interest has been raised on whether one can interpret state-vectors (pure states) in a statistical way ($\psi$-epistemic theories), or if each of them corresponds to a different ontological entity. Each interpretation of quantum theory assumes different ontology and one could ask if the PBR argument carries over. Here we examine this question for histories formulations in general with particular attention to the co-event formulation. State-vectors appear as the initial state that enters into the quantum measure. While the PBR argument goes through up to a point, the failure to meet some of the assumptions they made does not allow one to reach their conclusion. However, the author believes that the "statistical interpretation" is still impossible for co-events even if this is not proven by the PBR argument.Comment: 25 pages, v2 published versio

Twistor form of massive 6D superparticle

The massive six-dimensional (6D) superparticle with manifest (n, 0) supersymmetry is shown to have a supertwistor formulation in which its “hidden” (0, n) supersymmetry is also manifest. The mass-shell constraint is replaced by Spin(5) spin-shell constraints which imply that the quantum superparticle has zero superspin; for n = 1 it propagates the 6D Proca supermultiplet.PKT acknowledges support from the UK Science and Technology Facilities Council (grant ST/L000385/1). AJR is supported by a grant from the London Mathematical Society.This is the final version of the article. It was first available from IOP Science via http://dx.doi.org/10.1088/1751-8113/49/2/02540